FAM174A (family with sequence similarity 174 member A)

Gene

• Entrez ID: 345757
• Gene name: Family with sequence similarity 174 member A
• Gene symbol: FAM174A
• Synonyms (NCBI Gene): HGS_RE408, NS5ATP6, TMEM157, UNQ1912
• Chromosome: 5
• Chromosome location: 5q21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440682	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT440682	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT982072	hsa-miR-101	CLIP-seq
MIRT982073	hsa-miR-1225-3p	CLIP-seq
MIRT982074	hsa-miR-1233	CLIP-seq
MIRT982075	hsa-miR-1305	CLIP-seq
MIRT982076	hsa-miR-144	CLIP-seq
MIRT982077	hsa-miR-3921	CLIP-seq
MIRT982078	hsa-miR-4303	CLIP-seq
MIRT982079	hsa-miR-4653-5p	CLIP-seq
MIRT982080	hsa-miR-556-3p	CLIP-seq
MIRT982081	hsa-miR-577	CLIP-seq
MIRT982082	hsa-miR-582-5p	CLIP-seq
MIRT982083	hsa-miR-607	CLIP-seq
MIRT982084	hsa-miR-944	CLIP-seq
MIRT2225199	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TBP5
• Protein name: Membrane protein FAM174A (Hepatitis C virus NS5A-transactivated protein 6) (HCV NS5A-transactivated protein 6) (Transmembrane protein 157)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06679	DUF1180	10 → 190	Protein of unknown function (DUF1180)	Family

• Sequence:

  MKASQCCCCLSHLLASVLLLLLLPELSGPLAVLLQAAEAAPGLGPPDPRPRTLPPLPPGP
  TPAQQPGRGLAEAAGPRGSEGGNGSNPVAGLETDDHGGKAGEGSVGGGLAVSPNPGDKPM
  TQRALTVLMVVSGAVLVYFVVRTVRMRRRNRKTRRYGVLDTNIENMELTPLEQDDEDDDN
  TLFDANHPRR

• Sequence length: 190

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PANIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations