Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	345274
Gene name	Solute carrier family 10 member 6
Gene symbol	SLC10A6
Synonyms (NCBI Gene)	SOAT
Chromosome	4
Chromosome location	4q21.3

195

Show/Hide all (195)

miRTarBase ID	miRNA	Experiments	Reference
MIRT699495	hsa-miR-302f	HITS-CLIP	23313552
MIRT699494	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT699493	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT699492	hsa-miR-940	HITS-CLIP	23313552
MIRT699491	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT699490	hsa-miR-4667-5p	HITS-CLIP	23313552
MIRT699489	hsa-miR-4700-5p	HITS-CLIP	23313552
MIRT699487	hsa-miR-8089	HITS-CLIP	23313552
MIRT699488	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT699486	hsa-miR-1253	HITS-CLIP	23313552
MIRT699485	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT699484	hsa-miR-4434	HITS-CLIP	23313552
MIRT699482	hsa-miR-4516	HITS-CLIP	23313552
MIRT699483	hsa-miR-5703	HITS-CLIP	23313552
MIRT699481	hsa-miR-3175	HITS-CLIP	23313552
MIRT699480	hsa-miR-1343-5p	HITS-CLIP	23313552
MIRT699479	hsa-miR-939-5p	HITS-CLIP	23313552
MIRT699478	hsa-miR-6825-5p	HITS-CLIP	23313552
MIRT699477	hsa-miR-1273e	HITS-CLIP	23313552
MIRT699476	hsa-miR-3150a-3p	HITS-CLIP	23313552
MIRT699475	hsa-miR-6763-5p	HITS-CLIP	23313552
MIRT672383	hsa-miR-665	HITS-CLIP	23313552
MIRT685445	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT685444	hsa-miR-193a-3p	HITS-CLIP	23313552
MIRT685443	hsa-miR-193b-3p	HITS-CLIP	23313552
MIRT685442	hsa-miR-4463	HITS-CLIP	23313552
MIRT685441	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT685440	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT685439	hsa-miR-3926	HITS-CLIP	23313552
MIRT685438	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT685437	hsa-miR-548s	HITS-CLIP	23313552
MIRT677518	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT677517	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT677516	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT677515	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677514	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT677513	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT677512	hsa-miR-1281	HITS-CLIP	23824327
MIRT677511	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT677510	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT677509	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT677508	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT677507	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT677506	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT677505	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT677504	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT677503	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT677502	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT677501	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT672424	hsa-miR-3929	HITS-CLIP	23824327
MIRT672423	hsa-miR-4419b	HITS-CLIP	23824327
MIRT672422	hsa-miR-4478	HITS-CLIP	23824327
MIRT672421	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT672420	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT672419	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT672418	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672417	hsa-miR-7112-5p	HITS-CLIP	23824327
MIRT672416	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT672415	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT672414	hsa-miR-769-5p	HITS-CLIP	23824327
MIRT672413	hsa-miR-3197	HITS-CLIP	23824327
MIRT672412	hsa-miR-6087	HITS-CLIP	23824327
MIRT672411	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT672410	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT672409	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT672408	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT672407	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT672406	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT672405	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT672404	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT672403	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672402	hsa-miR-7977	HITS-CLIP	23824327
MIRT672401	hsa-miR-3672	HITS-CLIP	23824327
MIRT672400	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT672399	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT672398	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT672397	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT672396	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT672395	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT672394	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT672393	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT672392	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT672391	hsa-miR-3689c	HITS-CLIP	23824327
MIRT672390	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT672389	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672388	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT672387	hsa-miR-3122	HITS-CLIP	23824327
MIRT672386	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT672385	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT672384	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT672383	hsa-miR-665	HITS-CLIP	23824327
MIRT699495	hsa-miR-302f	HITS-CLIP	23313552
MIRT699494	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT699493	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT699492	hsa-miR-940	HITS-CLIP	23313552
MIRT699491	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT699490	hsa-miR-4667-5p	HITS-CLIP	23313552
MIRT699489	hsa-miR-4700-5p	HITS-CLIP	23313552
MIRT699487	hsa-miR-8089	HITS-CLIP	23313552
MIRT699488	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT699486	hsa-miR-1253	HITS-CLIP	23313552
MIRT699485	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT699484	hsa-miR-4434	HITS-CLIP	23313552
MIRT699482	hsa-miR-4516	HITS-CLIP	23313552
MIRT699483	hsa-miR-5703	HITS-CLIP	23313552
MIRT699481	hsa-miR-3175	HITS-CLIP	23313552
MIRT699480	hsa-miR-1343-5p	HITS-CLIP	23313552
MIRT699479	hsa-miR-939-5p	HITS-CLIP	23313552
MIRT699478	hsa-miR-6825-5p	HITS-CLIP	23313552
MIRT699477	hsa-miR-1273e	HITS-CLIP	23313552
MIRT699476	hsa-miR-3150a-3p	HITS-CLIP	23313552
MIRT699475	hsa-miR-6763-5p	HITS-CLIP	23313552
MIRT672383	hsa-miR-665	HITS-CLIP	23313552
MIRT685445	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT685444	hsa-miR-193a-3p	HITS-CLIP	23313552
MIRT685443	hsa-miR-193b-3p	HITS-CLIP	23313552
MIRT685442	hsa-miR-4463	HITS-CLIP	23313552
MIRT685441	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT685440	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT685439	hsa-miR-3926	HITS-CLIP	23313552
MIRT685438	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT685437	hsa-miR-548s	HITS-CLIP	23313552
MIRT677518	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT677517	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT677516	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT677515	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677514	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT677513	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT677512	hsa-miR-1281	HITS-CLIP	23824327
MIRT677511	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT677510	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT677509	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT677508	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT677507	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT677506	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT677505	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT677504	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT677503	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT677502	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT677501	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT672424	hsa-miR-3929	HITS-CLIP	23824327
MIRT672423	hsa-miR-4419b	HITS-CLIP	23824327
MIRT672422	hsa-miR-4478	HITS-CLIP	23824327
MIRT672421	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT672420	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT672419	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT672418	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672417	hsa-miR-7112-5p	HITS-CLIP	23824327
MIRT672416	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT672415	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT672414	hsa-miR-769-5p	HITS-CLIP	23824327
MIRT672413	hsa-miR-3197	HITS-CLIP	23824327
MIRT672412	hsa-miR-6087	HITS-CLIP	23824327
MIRT672411	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT672410	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT672409	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT672408	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT672407	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT672406	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT672405	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT672404	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT672403	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672402	hsa-miR-7977	HITS-CLIP	23824327
MIRT672401	hsa-miR-3672	HITS-CLIP	23824327
MIRT672400	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT672399	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT672398	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT672397	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT672396	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT672395	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT672394	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT672393	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT672392	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT672391	hsa-miR-3689c	HITS-CLIP	23824327
MIRT672390	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT672389	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672388	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT672387	hsa-miR-3122	HITS-CLIP	23824327
MIRT672386	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT672385	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT672384	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT672383	hsa-miR-665	HITS-CLIP	23824327
MIRT1351658	hsa-miR-125a-5p	CLIP-seq
MIRT1351659	hsa-miR-125b	CLIP-seq
MIRT1351660	hsa-miR-203	CLIP-seq
MIRT1351661	hsa-miR-4319	CLIP-seq
MIRT1351662	hsa-miR-4732-3p	CLIP-seq
MIRT1351663	hsa-miR-515-5p	CLIP-seq
MIRT1351664	hsa-miR-548t	CLIP-seq
MIRT1351665	hsa-miR-670	CLIP-seq
MIRT2328400	hsa-miR-1207-3p	CLIP-seq
MIRT2328401	hsa-miR-193b	CLIP-seq
MIRT2328402	hsa-miR-3607-5p	CLIP-seq
MIRT2328403	hsa-miR-592	CLIP-seq
MIRT2328404	hsa-miR-597	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0008508	Function	Bile acid:sodium symporter activity	IBA
GO:0008508	Function	Bile acid:sodium symporter activity	TAS
GO:0015293	Function	Symporter activity	IEA
GO:0015721	Process	Bile acid and bile salt transport	IBA
GO:0016020	Component	Membrane	IEA
GO:0043250	Function	Sodium-dependent organic anion transmembrane transporter activity	IEA
GO:0043251	Process	Sodium-dependent organic anion transport	IEA
GO:0055085	Process	Transmembrane transport	TAS

MIM	HGNC	e!Ensembl
613366	30603	ENSG00000145283

Q3KNW5

Protein name

Sodium-dependent organic anion transporter (SOAT) (Solute carrier family 10 member 6) (SLC10A6)

Protein function

Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:17491011, PubMed:23667501, PubMed:24717977, PubMed:28951227). Steroid sulfate hormones are co

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01758	SBF	39 → 217	Sodium Bile acid symporter family	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus. {ECO:0000269|PubMed:1749101

Sequence

MRANCSSSSACPANSSEEELPVGLEVHGNLELVFTVVSTVMMGLLMFSLGCSVEIRKLWS
HIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAIAVLIMGCCPGGTISNIFTFWVD
GDMDLSISMTTCSTVAALGMMPLCIYLYTWSWSLQQNLTIPYQNIGITLVCLTIPVAFGV
YVNYRWPKQSKIILKIGAVVGGVLLLVVAVAGVVLAKGSWNSDITLLTISFIFPLIGHVT
GFLLALFTHQSWQRCRTISLETGAQNIQMCITMLQLSFTAEHLVQMLSFPLAYGLFQLID
GFLIVAAYQTYKRRLKNKHGKKNSGCTEVCHTRKSTSSRETNAFLEVNEEGAITPGPPGP
MDCHRALEPVGHITSCE

Sequence length

377

Interactions

View interactions

	Reactome
			Transport of bile salts and organic acids, metal ions and amine compounds

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	30186172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	30186172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36059531	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30186172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	30186172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	30186172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	30186172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	30186172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oligospermia	Oligospermia	BEFREE	23667501, 28951225		★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC10A6 (solute carrier family 10 member 6)