CDKL4 (cyclin dependent kinase like 4)

Gene

• Entrez ID: 344387
• Gene name: Cyclin dependent kinase like 4
• Gene symbol: CDKL4
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT881622	hsa-miR-132	CLIP-seq
MIRT881623	hsa-miR-1323	CLIP-seq
MIRT881624	hsa-miR-1910	CLIP-seq
MIRT881625	hsa-miR-2052	CLIP-seq
MIRT881626	hsa-miR-212	CLIP-seq
MIRT881627	hsa-miR-3128	CLIP-seq
MIRT881628	hsa-miR-409-3p	CLIP-seq
MIRT881629	hsa-miR-4264	CLIP-seq
MIRT881630	hsa-miR-4470	CLIP-seq
MIRT881631	hsa-miR-455-3p	CLIP-seq
MIRT881632	hsa-miR-4704-3p	CLIP-seq
MIRT881633	hsa-miR-539	CLIP-seq
MIRT881634	hsa-miR-548o	CLIP-seq
MIRT881635	hsa-miR-580	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5MAI5
• Protein name: Cyclin-dependent kinase-like 4 (EC 2.7.11.22)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	4 → 286	Protein kinase domain	Domain

• Sequence:

  MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH
  PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH
  NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS
  SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP
  EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARN
  EGRNRRRQQQAPKSAFPRLFLKTKICQVQRNETQTSGNQILPNGPILQNSMVTVMTNINS
  AVYQVTVLHLLSENFEVKS

• Sequence length: 379

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25904054		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25904054	Associate	★☆☆☆☆ Found in Text Mining only