ARHGAP40 (Rho GTPase activating protein 40)

Gene

• Entrez ID: 343578
• Gene name: Rho GTPase activating protein 40
• Gene symbol: ARHGAP40
• Synonyms (NCBI Gene): C20orf95, dJ1100H13.4
• Chromosome: 20
• Chromosome location: 20q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT722159	hsa-miR-4532	HITS-CLIP	19536157
MIRT722158	hsa-miR-6784-5p	HITS-CLIP	19536157
MIRT722157	hsa-miR-4508	HITS-CLIP	19536157
MIRT722156	hsa-miR-187-5p	HITS-CLIP	19536157
MIRT722155	hsa-miR-6131	HITS-CLIP	19536157
MIRT722154	hsa-miR-4492	HITS-CLIP	19536157
MIRT722153	hsa-miR-4498	HITS-CLIP	19536157
MIRT722152	hsa-miR-5001-5p	HITS-CLIP	19536157
MIRT722151	hsa-miR-762	HITS-CLIP	19536157
MIRT722150	hsa-miR-185-3p	HITS-CLIP	19536157
MIRT722149	hsa-miR-4474-3p	HITS-CLIP	19536157
MIRT722159	hsa-miR-4532	HITS-CLIP	19536157
MIRT722158	hsa-miR-6784-5p	HITS-CLIP	19536157
MIRT722157	hsa-miR-4508	HITS-CLIP	19536157
MIRT722156	hsa-miR-187-5p	HITS-CLIP	19536157
MIRT722155	hsa-miR-6131	HITS-CLIP	19536157
MIRT722154	hsa-miR-4492	HITS-CLIP	19536157
MIRT722153	hsa-miR-4498	HITS-CLIP	19536157
MIRT722152	hsa-miR-5001-5p	HITS-CLIP	19536157
MIRT722151	hsa-miR-762	HITS-CLIP	19536157
MIRT722150	hsa-miR-185-3p	HITS-CLIP	19536157
MIRT722149	hsa-miR-4474-3p	HITS-CLIP	19536157
MIRT794880	hsa-miR-125a-5p	CLIP-seq
MIRT794881	hsa-miR-125b	CLIP-seq
MIRT794882	hsa-miR-1976	CLIP-seq
MIRT794883	hsa-miR-3135b	CLIP-seq
MIRT794884	hsa-miR-3183	CLIP-seq
MIRT794885	hsa-miR-326	CLIP-seq
MIRT794886	hsa-miR-330-5p	CLIP-seq
MIRT794887	hsa-miR-3652	CLIP-seq
MIRT794888	hsa-miR-3907	CLIP-seq
MIRT794889	hsa-miR-4287	CLIP-seq
MIRT794890	hsa-miR-4299	CLIP-seq
MIRT794891	hsa-miR-4319	CLIP-seq
MIRT794892	hsa-miR-4430	CLIP-seq
MIRT794893	hsa-miR-4456	CLIP-seq
MIRT794894	hsa-miR-4469	CLIP-seq
MIRT794895	hsa-miR-4649-3p	CLIP-seq
MIRT794896	hsa-miR-4685-3p	CLIP-seq
MIRT794897	hsa-miR-4723-3p	CLIP-seq
MIRT794898	hsa-miR-4732-3p	CLIP-seq
MIRT794899	hsa-miR-516a-3p	CLIP-seq
MIRT794900	hsa-miR-544b	CLIP-seq
MIRT794901	hsa-miR-548q	CLIP-seq
MIRT794902	hsa-miR-593	CLIP-seq
MIRT794903	hsa-miR-670	CLIP-seq
MIRT794885	hsa-miR-326	CLIP-seq
MIRT794886	hsa-miR-330-5p	CLIP-seq
MIRT794890	hsa-miR-4299	CLIP-seq
MIRT1934710	hsa-miR-4446-3p	CLIP-seq
MIRT794893	hsa-miR-4456	CLIP-seq
MIRT794901	hsa-miR-548q	CLIP-seq
MIRT794902	hsa-miR-593	CLIP-seq
MIRT2174433	hsa-miR-3974	CLIP-seq
MIRT2174434	hsa-miR-4641	CLIP-seq
MIRT794900	hsa-miR-544b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5TG30
• Protein name: Rho GTPase-activating protein 40 (Rho-type GTPase-activating protein 40)
• Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	289 → 441	RhoGAP domain	Domain

• Sequence:

  MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE
  GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV
  RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA
  YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE
  LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE
  KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL
  LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT
  LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR
  KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP
  STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD
  AYLLDLYRANPHGEWVLKQNPT

• Sequence length: 622

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations