CCDC18 (coiled-coil domain containing 18)

Gene

• Entrez ID: 343099
• Gene name: Coiled-coil domain containing 18
• Gene symbol: CCDC18
• Synonyms (NCBI Gene): NY-SAR-41
• Chromosome: 1
• Chromosome location: 1p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026476	hsa-miR-192-5p	Microarray	19074876
MIRT718248	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT718247	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT718246	hsa-miR-6844	HITS-CLIP	19536157
MIRT718245	hsa-miR-3161	HITS-CLIP	19536157
MIRT718248	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT718247	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT718246	hsa-miR-6844	HITS-CLIP	19536157
MIRT718245	hsa-miR-3161	HITS-CLIP	19536157
MIRT663685	hsa-miR-141-3p	HITS-CLIP	23824327
MIRT663684	hsa-miR-200a-3p	HITS-CLIP	23824327
MIRT663683	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT663682	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT663681	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT663680	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT663679	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT663678	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT718248	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT718247	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT718246	hsa-miR-6844	HITS-CLIP	19536157
MIRT718245	hsa-miR-3161	HITS-CLIP	19536157
MIRT718248	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT718247	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT718246	hsa-miR-6844	HITS-CLIP	19536157
MIRT718245	hsa-miR-3161	HITS-CLIP	19536157
MIRT663685	hsa-miR-141-3p	HITS-CLIP	23824327
MIRT663684	hsa-miR-200a-3p	HITS-CLIP	23824327
MIRT663683	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT663682	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT663681	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT663680	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT663679	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT663678	hsa-miR-136-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0034451	Component	Centriolar satellite	IDA	26638075
GO:0034451	Component	Centriolar satellite	IEA

Other IDs

• MIM: 621137
• HGNC: 30370
• e!Ensembl: ENSG00000122483

Protein

• UniProt ID: Q5T9S5
• Protein name: Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24)
• Sequence:

  MESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSR
  SEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKL
  NKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEA
  EVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNE
  ALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEI
  LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL
  MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQM
  SSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES
  SKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSD
  LKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAK
  NAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEK
  KDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSE
  ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQE
  TSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK
  MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH
  LSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST
  LRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL
  KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL
  REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTR
  EQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREA
  HLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAK
  LELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKISGHEKAEDIKFLPAP
  FTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRRSISASDLTFKIHGDEDLSEELLQDLKKM
  QLEQPSTLEESHKNLTYTQPDSFKPLTYNLEADSSENNDFNTLSGMLRYINKEVRLLKKS
  SMQTGAGLNQGENV

• Sequence length: 1454

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CCDC18-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC LYMPHOCYTIC LEUKEMIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	36160032	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37848987	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24146633	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	37227248	Associate	★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy Duchenne	Duchenne muscular dystrophy	Pubtator	36619896	Associate	★☆☆☆☆ Found in Text Mining only