Gene Gene information from NCBI Gene database.
Entrez ID 342357
Gene name Zinc finger with KRAB and SCAN domains 2
Gene symbol ZKSCAN2
Synonyms (NCBI Gene)
ZNF694ZSCAN31ZSCAN34
Chromosome 16
Chromosome location 16p12.1
miRNA miRNA information provided by mirtarbase database.
256
miRTarBase ID miRNA Experiments Reference
MIRT016989 hsa-miR-335-5p Microarray 18185580
MIRT663786 hsa-miR-4645-5p HITS-CLIP 23824327
MIRT663785 hsa-miR-4673 HITS-CLIP 23824327
MIRT647434 hsa-miR-6872-3p HITS-CLIP 23824327
MIRT647433 hsa-miR-3127-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0003700 Function DNA-binding transcription factor activity IEA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q63HK3
Protein name Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694)
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02023 SCAN 41 129 SCAN domain Domain
PF01352 KRAB 230 269 KRAB box Family
PF13837 Myb_DNA-bind_4 340 425 Domain
PF13837 Myb_DNA-bind_4 497 582 Domain
PF00096 zf-C2H2 775 797 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 803 825 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 831 853 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 859 881 Zinc finger, C2H2 type Domain
Sequence
MAVALDSQIDAPLEVEGCLIMKVEKDPEWASEPILEGSDSSETFRKCFRQFCYEDVTGPH
EAFSKLWELCCRWLKPEMRSKEQILELLVIEQFLTILPEKIQAWAQKQCPQSGEEAVALV
VHLEKETGR
LRQQVSSPVHREKHSPLGAAWEVADFQPEQVETQPRAVSREEPGSLHSGHQ
EQLNRKRERRPLPKNARPSPWVPALADEWNTLDQEVTTTRLPAGSQEPVKDVHVARGFSY
RKSVHQIPAQRDLYRDFRKENVGNVVSLG
SAVSTSNKITRLEQRKEPWTLGLHSSNKRSI
LRSNYVKEKSVHAIQVPARSAGKTWREQQQWGLEDEKIAGVHWSYEETKTFLAILKESRF
YETLQACPRNSQVYGAVAEWLRECGFLRTPEQCRTKFKSLQKSYRKVRNGHMLEPCAFFE
DMDAL
LNPAARAPSTDKPKEMIPVPRLKRIAISAKEHISLVEEEEAAEDSDDDEIGIEFI
RKSEIHGAPVLFQNLSGVHWGYEETKTFLDILRETRFYEALQACHRKSKLYGAVAEQLRE
CGFLRTPEQCRTKFKSLQKSYRKVKNGHVLESCAFYKEMDAL
INSRASAPSPSTPEEVPS
PSRQERGGIEVEPQEPTGWEPEETSQEAVIEDSCSERMSEEEIVQEPEFQGPPGLLQSPN
DFEIGSSIKEDPTQIVYKDMEQHRALIEKSKRVVSQSTDPSKYRKRECISGRQWENLQGI
RQGKPMSQPRDLGKAVVHQRPFVGKRPYRLLKYGESFGRSTRLMCRMTHHKENPYKCGVC
GKCFGRSRSLIRHQRIH
TGEKPFKCLDCGKSFNDSSNFGAHQRIHTGEKPYRCGECGKCF
SQSSSLIIHQRTH
TGEKPYQCGECGKSFTNSSHFSAHRRVHTGENPYKCVDCEKSFNNCT
RFREHRRIHTGEKPYGCAQCGKRFSKSSVLTKHREVHVREKPLPHPPSLYCPENPHKGKT
DEFRKTF
Sequence length 967
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arthritis, Gouty Gouty arthritis GWASDB_DG 23263486
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma GWASCAT_DG 28604730
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 28722770
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 37072493 Associate
★☆☆☆☆
Found in Text Mining only
Coronary heart disease Coronary Heart Disease GWASDB_DG 21971053
★☆☆☆☆
Found in Text Mining only
Gout Gout GWASDB_DG 23263486
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus, Systemic Lupus Erythematosus GWASDB_DG 24871463
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression GWASCAT_DG 27089181
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 28722770
★☆☆☆☆
Found in Text Mining only
Nonorganic psychosis Nonorganic Psychosis BEFREE 24888570
★☆☆☆☆
Found in Text Mining only