Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	340485
Gene name	Alkaline ceramidase 2
Gene symbol	ACER2
Synonyms (NCBI Gene)	ALKCDase2ASAH3L
Chromosome	9
Chromosome location	9p22.1
Summary	The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [

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miRTarBase ID	miRNA	Experiments	Reference
MIRT639523	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT639522	hsa-miR-27a-5p	HITS-CLIP	23824327
MIRT639521	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT503209	hsa-miR-513b-3p	PAR-CLIP	22012620
MIRT503208	hsa-miR-4700-3p	PAR-CLIP	22012620
MIRT503207	hsa-miR-548v	PAR-CLIP	22012620
MIRT503206	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT503205	hsa-miR-498	PAR-CLIP	22012620
MIRT324734	hsa-miR-196a-5p	PAR-CLIP	24398324
MIRT324737	hsa-miR-196b-5p	PAR-CLIP	24398324
MIRT324731	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT324735	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT324730	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT324728	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT324727	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT324736	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT324729	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT324732	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT324741	hsa-miR-4458	PAR-CLIP	24398324
MIRT324733	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT324742	hsa-miR-4500	PAR-CLIP	24398324
MIRT324738	hsa-miR-541-5p	PAR-CLIP	24398324
MIRT503226	hsa-miR-1244	PAR-CLIP	24398324
MIRT324739	hsa-miR-4257	PAR-CLIP	24398324
MIRT503225	hsa-miR-140-3p	PAR-CLIP	24398324
MIRT503224	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT503223	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT503222	hsa-miR-1271-5p	PAR-CLIP	24398324
MIRT503221	hsa-miR-96-5p	PAR-CLIP	24398324
MIRT503220	hsa-miR-182-5p	PAR-CLIP	24398324
MIRT503219	hsa-miR-93-5p	PAR-CLIP	24398324
MIRT503218	hsa-miR-526b-3p	PAR-CLIP	24398324
MIRT503217	hsa-miR-519d-3p	PAR-CLIP	24398324
MIRT503216	hsa-miR-17-5p	PAR-CLIP	24398324
MIRT503215	hsa-miR-106a-5p	PAR-CLIP	24398324
MIRT503214	hsa-miR-20b-5p	PAR-CLIP	24398324
MIRT503213	hsa-miR-20a-5p	PAR-CLIP	24398324
MIRT503212	hsa-miR-106b-5p	PAR-CLIP	24398324
MIRT503211	hsa-miR-4512	PAR-CLIP	24398324
MIRT324750	hsa-miR-4464	PAR-CLIP	24398324
MIRT324753	hsa-miR-4748	PAR-CLIP	24398324
MIRT324747	hsa-miR-329-5p	PAR-CLIP	24398324
MIRT324749	hsa-miR-4280	PAR-CLIP	24398324
MIRT324748	hsa-miR-504-3p	PAR-CLIP	24398324
MIRT324745	hsa-miR-122-5p	PAR-CLIP	24398324
MIRT503210	hsa-miR-7150	PAR-CLIP	24398324
MIRT503209	hsa-miR-513b-3p	PAR-CLIP	24398324
MIRT503208	hsa-miR-4700-3p	PAR-CLIP	24398324
MIRT503207	hsa-miR-548v	PAR-CLIP	24398324
MIRT503206	hsa-miR-505-3p	PAR-CLIP	24398324
MIRT503205	hsa-miR-498	PAR-CLIP	24398324
MIRT639523	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT639522	hsa-miR-27a-5p	HITS-CLIP	23824327
MIRT639521	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT503209	hsa-miR-513b-3p	PAR-CLIP	22012620
MIRT503208	hsa-miR-4700-3p	PAR-CLIP	22012620
MIRT503207	hsa-miR-548v	PAR-CLIP	22012620
MIRT503206	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT503205	hsa-miR-498	PAR-CLIP	22012620
MIRT324734	hsa-miR-196a-5p	PAR-CLIP	24398324
MIRT324737	hsa-miR-196b-5p	PAR-CLIP	24398324
MIRT324731	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT324735	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT324730	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT324728	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT324727	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT324736	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT324729	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT324732	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT324741	hsa-miR-4458	PAR-CLIP	24398324
MIRT324733	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT324742	hsa-miR-4500	PAR-CLIP	24398324
MIRT324738	hsa-miR-541-5p	PAR-CLIP	24398324
MIRT503226	hsa-miR-1244	PAR-CLIP	24398324
MIRT324739	hsa-miR-4257	PAR-CLIP	24398324
MIRT503225	hsa-miR-140-3p	PAR-CLIP	24398324
MIRT503224	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT503223	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT503222	hsa-miR-1271-5p	PAR-CLIP	24398324
MIRT503221	hsa-miR-96-5p	PAR-CLIP	24398324
MIRT503220	hsa-miR-182-5p	PAR-CLIP	24398324
MIRT503219	hsa-miR-93-5p	PAR-CLIP	24398324
MIRT503218	hsa-miR-526b-3p	PAR-CLIP	24398324
MIRT503217	hsa-miR-519d-3p	PAR-CLIP	24398324
MIRT503216	hsa-miR-17-5p	PAR-CLIP	24398324
MIRT503215	hsa-miR-106a-5p	PAR-CLIP	24398324
MIRT503214	hsa-miR-20b-5p	PAR-CLIP	24398324
MIRT503213	hsa-miR-20a-5p	PAR-CLIP	24398324
MIRT503212	hsa-miR-106b-5p	PAR-CLIP	24398324
MIRT503211	hsa-miR-4512	PAR-CLIP	24398324
MIRT324750	hsa-miR-4464	PAR-CLIP	24398324
MIRT324753	hsa-miR-4748	PAR-CLIP	24398324
MIRT324747	hsa-miR-329-5p	PAR-CLIP	24398324
MIRT324749	hsa-miR-4280	PAR-CLIP	24398324
MIRT324748	hsa-miR-504-3p	PAR-CLIP	24398324
MIRT324745	hsa-miR-122-5p	PAR-CLIP	24398324
MIRT503210	hsa-miR-7150	PAR-CLIP	24398324
MIRT503209	hsa-miR-513b-3p	PAR-CLIP	24398324
MIRT503208	hsa-miR-4700-3p	PAR-CLIP	24398324
MIRT503207	hsa-miR-548v	PAR-CLIP	24398324
MIRT503206	hsa-miR-505-3p	PAR-CLIP	24398324
MIRT503205	hsa-miR-498	PAR-CLIP	24398324
MIRT324734	hsa-miR-196a-5p	Luciferase reporter assayqRT-PCR	36513872
MIRT324734	hsa-miR-196a-5p	Luciferase reporter assayqRT-PCR	36513872
MIRT762493	hsa-let-7a	CLIP-seq
MIRT762494	hsa-let-7b	CLIP-seq
MIRT762495	hsa-let-7c	CLIP-seq
MIRT762496	hsa-let-7d	CLIP-seq
MIRT762497	hsa-let-7e	CLIP-seq
MIRT762498	hsa-let-7f	CLIP-seq
MIRT762499	hsa-let-7g	CLIP-seq
MIRT762500	hsa-let-7i	CLIP-seq
MIRT762501	hsa-miR-1	CLIP-seq
MIRT762502	hsa-miR-105	CLIP-seq
MIRT762503	hsa-miR-1206	CLIP-seq
MIRT762504	hsa-miR-1264	CLIP-seq
MIRT762505	hsa-miR-136	CLIP-seq
MIRT762506	hsa-miR-193a-5p	CLIP-seq
MIRT762507	hsa-miR-196a	CLIP-seq
MIRT762508	hsa-miR-196b	CLIP-seq
MIRT762509	hsa-miR-206	CLIP-seq
MIRT762510	hsa-miR-218	CLIP-seq
MIRT762511	hsa-miR-27a	CLIP-seq
MIRT762512	hsa-miR-27b	CLIP-seq
MIRT762513	hsa-miR-3154	CLIP-seq
MIRT762514	hsa-miR-3188	CLIP-seq
MIRT762515	hsa-miR-3200-5p	CLIP-seq
MIRT762516	hsa-miR-3612	CLIP-seq
MIRT762517	hsa-miR-3671	CLIP-seq
MIRT762518	hsa-miR-3682-5p	CLIP-seq
MIRT762519	hsa-miR-377	CLIP-seq
MIRT762520	hsa-miR-4290	CLIP-seq
MIRT762521	hsa-miR-4426	CLIP-seq
MIRT762522	hsa-miR-4443	CLIP-seq
MIRT762523	hsa-miR-4647	CLIP-seq
MIRT762524	hsa-miR-4648	CLIP-seq
MIRT762525	hsa-miR-4654	CLIP-seq
MIRT762526	hsa-miR-4659a-3p	CLIP-seq
MIRT762527	hsa-miR-4659b-3p	CLIP-seq
MIRT762528	hsa-miR-4662b	CLIP-seq
MIRT762529	hsa-miR-4666-3p	CLIP-seq
MIRT762530	hsa-miR-4687-5p	CLIP-seq
MIRT762531	hsa-miR-4699-3p	CLIP-seq
MIRT762532	hsa-miR-4769-5p	CLIP-seq
MIRT762533	hsa-miR-4797-3p	CLIP-seq
MIRT762534	hsa-miR-4797-5p	CLIP-seq
MIRT762535	hsa-miR-4803	CLIP-seq
MIRT762536	hsa-miR-513a-3p	CLIP-seq
MIRT762537	hsa-miR-513a-5p	CLIP-seq
MIRT762538	hsa-miR-539	CLIP-seq
MIRT762539	hsa-miR-541	CLIP-seq
MIRT762540	hsa-miR-548c-3p	CLIP-seq
MIRT762541	hsa-miR-587	CLIP-seq
MIRT762542	hsa-miR-603	CLIP-seq
MIRT762543	hsa-miR-607	CLIP-seq
MIRT762544	hsa-miR-613	CLIP-seq
MIRT762545	hsa-miR-650	CLIP-seq
MIRT762546	hsa-miR-654-5p	CLIP-seq
MIRT762547	hsa-miR-9	CLIP-seq
MIRT762548	hsa-miR-98	CLIP-seq
MIRT762493	hsa-let-7a	CLIP-seq
MIRT762494	hsa-let-7b	CLIP-seq
MIRT762495	hsa-let-7c	CLIP-seq
MIRT762496	hsa-let-7d	CLIP-seq
MIRT762497	hsa-let-7e	CLIP-seq
MIRT762498	hsa-let-7f	CLIP-seq
MIRT762499	hsa-let-7g	CLIP-seq
MIRT762500	hsa-let-7i	CLIP-seq
MIRT762505	hsa-miR-136	CLIP-seq
MIRT762507	hsa-miR-196a	CLIP-seq
MIRT762508	hsa-miR-196b	CLIP-seq
MIRT1924779	hsa-miR-1972	CLIP-seq
MIRT1924780	hsa-miR-1976	CLIP-seq
MIRT762511	hsa-miR-27a	CLIP-seq
MIRT762512	hsa-miR-27b	CLIP-seq
MIRT1924781	hsa-miR-3125	CLIP-seq
MIRT1924782	hsa-miR-3133	CLIP-seq
MIRT1924783	hsa-miR-3143	CLIP-seq
MIRT1924784	hsa-miR-3145-5p	CLIP-seq
MIRT1924785	hsa-miR-3161	CLIP-seq
MIRT762514	hsa-miR-3188	CLIP-seq
MIRT1924786	hsa-miR-3194-5p	CLIP-seq
MIRT762515	hsa-miR-3200-5p	CLIP-seq
MIRT1924787	hsa-miR-3916	CLIP-seq
MIRT1924788	hsa-miR-4418	CLIP-seq
MIRT1924789	hsa-miR-4646-5p	CLIP-seq
MIRT1924790	hsa-miR-4690-5p	CLIP-seq
MIRT1924791	hsa-miR-4722-3p	CLIP-seq
MIRT1924792	hsa-miR-4790-3p	CLIP-seq
MIRT762535	hsa-miR-4803	CLIP-seq
MIRT1924793	hsa-miR-509-3-5p	CLIP-seq
MIRT1924794	hsa-miR-509-5p	CLIP-seq
MIRT762537	hsa-miR-513a-5p	CLIP-seq
MIRT1924795	hsa-miR-516b	CLIP-seq
MIRT762538	hsa-miR-539	CLIP-seq
MIRT1924796	hsa-miR-561	CLIP-seq
MIRT1924797	hsa-miR-566	CLIP-seq
MIRT1924798	hsa-miR-605	CLIP-seq
MIRT1924799	hsa-miR-661	CLIP-seq
MIRT762548	hsa-miR-98	CLIP-seq
MIRT762493	hsa-let-7a	CLIP-seq
MIRT762494	hsa-let-7b	CLIP-seq
MIRT762495	hsa-let-7c	CLIP-seq
MIRT762496	hsa-let-7d	CLIP-seq
MIRT762497	hsa-let-7e	CLIP-seq
MIRT762498	hsa-let-7f	CLIP-seq
MIRT762499	hsa-let-7g	CLIP-seq
MIRT762500	hsa-let-7i	CLIP-seq
MIRT762504	hsa-miR-1264	CLIP-seq
MIRT762507	hsa-miR-196a	CLIP-seq
MIRT762508	hsa-miR-196b	CLIP-seq
MIRT2165995	hsa-miR-217	CLIP-seq
MIRT762511	hsa-miR-27a	CLIP-seq
MIRT762512	hsa-miR-27b	CLIP-seq
MIRT1924782	hsa-miR-3133	CLIP-seq
MIRT2165996	hsa-miR-3162-3p	CLIP-seq
MIRT2165997	hsa-miR-4662a-5p	CLIP-seq
MIRT762537	hsa-miR-513a-5p	CLIP-seq
MIRT2165998	hsa-miR-520d-5p	CLIP-seq
MIRT2165999	hsa-miR-524-5p	CLIP-seq
MIRT762539	hsa-miR-541	CLIP-seq
MIRT1924798	hsa-miR-605	CLIP-seq
MIRT762546	hsa-miR-654-5p	CLIP-seq
MIRT762548	hsa-miR-98	CLIP-seq
MIRT2468519	hsa-miR-1321	CLIP-seq
MIRT2468520	hsa-miR-186	CLIP-seq
MIRT1924782	hsa-miR-3133	CLIP-seq
MIRT2468521	hsa-miR-3144-5p	CLIP-seq
MIRT2468522	hsa-miR-3162-5p	CLIP-seq
MIRT2468523	hsa-miR-3649	CLIP-seq
MIRT2468524	hsa-miR-3941	CLIP-seq
MIRT2468525	hsa-miR-466	CLIP-seq
MIRT2468526	hsa-miR-4668-3p	CLIP-seq
MIRT2468527	hsa-miR-4672	CLIP-seq
MIRT2468528	hsa-miR-4731-3p	CLIP-seq
MIRT2468529	hsa-miR-4739	CLIP-seq
MIRT2468530	hsa-miR-4744	CLIP-seq
MIRT2468531	hsa-miR-4756-5p	CLIP-seq
MIRT2468532	hsa-miR-4779	CLIP-seq
MIRT2468533	hsa-miR-4801	CLIP-seq
MIRT762540	hsa-miR-548c-3p	CLIP-seq
MIRT2468534	hsa-miR-642b	CLIP-seq
MIRT2468535	hsa-miR-765	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IDA	20089856
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001953	Process	Negative regulation of cell-matrix adhesion	IDA	18945876
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	IDA	16940153
GO:0005794	Component	Golgi apparatus	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0006672	Process	Ceramide metabolic process	IEA
GO:0006974	Process	DNA damage response	IDA	26943039
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	16940153
GO:0010506	Process	Regulation of autophagy	IMP	28294157
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016811	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IBA
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IDA	16940153, 20089856, 20628055
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IEA
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IMP	20207939
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	TAS
GO:0030149	Process	Sphingolipid catabolic process	TAS
GO:0030330	Process	DNA damage response, signal transduction by p53 class mediator	IMP	28294157, 29229990
GO:0032526	Process	Response to retinoic acid	IDA	18945876
GO:0033629	Process	Negative regulation of cell adhesion mediated by integrin	IDA	18945876
GO:0042981	Process	Regulation of apoptotic process	IMP	26943039, 28294157, 29229990
GO:0046512	Process	Sphingosine biosynthetic process	IBA
GO:0046512	Process	Sphingosine biosynthetic process	IDA	16940153, 20089856, 20628055
GO:0046512	Process	Sphingosine biosynthetic process	IEA
GO:0046512	Process	Sphingosine biosynthetic process	IMP	20207939
GO:0046514	Process	Ceramide catabolic process	IBA
GO:0046514	Process	Ceramide catabolic process	IMP	16940153, 20207939
GO:0046872	Function	Metal ion binding	IEA
GO:0060049	Process	Regulation of protein glycosylation	IMP	20089856
GO:0071466	Process	Cellular response to xenobiotic stimulus	IEP	20628055

MIM	HGNC	e!Ensembl
613492	23675	ENSG00000177076

Q5QJU3

Protein name

Alkaline ceramidase 2 (AlkCDase 2) (Alkaline CDase 2) (haCER2) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like)

Protein function

Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Ceramides, sphingosine, and its phosphory

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05875	Ceramidase	6 → 261	Ceramidase	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in placenta. {ECO:0000269|PubMed:16940153}.

Sequence

MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCF
NSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRN
DRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLF
SGLWWTLALFCWISDRAFCELLSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPE
QGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT

Sequence length

275

Interactions

View interactions

	KEGG		Reactome
	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway		Sphingolipid de novo biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arteriosclerosis	Arteriosclerosis	BEFREE	31668872		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	31668872		★★★★★ ★☆☆☆☆ Found in Text Mining only
Emphysema	Emphysema	Pubtator	30214182	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29229990		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20628055, 29229990		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	34555498	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	30214182	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACER2 (alkaline ceramidase 2)