NRBP2 (nuclear receptor binding protein 2)

Gene

• Entrez ID: 340371
• Gene name: Nuclear receptor binding protein 2
• Gene symbol: NRBP2
• Synonyms (NCBI Gene): TRG16, pp9320
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1193703	hsa-miR-1	CLIP-seq
MIRT1193704	hsa-miR-1202	CLIP-seq
MIRT1193705	hsa-miR-1252	CLIP-seq
MIRT1193706	hsa-miR-1257	CLIP-seq
MIRT1193707	hsa-miR-1264	CLIP-seq
MIRT1193708	hsa-miR-1283	CLIP-seq
MIRT1193709	hsa-miR-1321	CLIP-seq
MIRT1193710	hsa-miR-149	CLIP-seq
MIRT1193711	hsa-miR-1913	CLIP-seq
MIRT1193712	hsa-miR-1915	CLIP-seq
MIRT1193713	hsa-miR-1972	CLIP-seq
MIRT1193714	hsa-miR-206	CLIP-seq
MIRT1193715	hsa-miR-216a	CLIP-seq
MIRT1193716	hsa-miR-216b	CLIP-seq
MIRT1193717	hsa-miR-22	CLIP-seq
MIRT1193718	hsa-miR-2682	CLIP-seq
MIRT1193719	hsa-miR-296-5p	CLIP-seq
MIRT1193720	hsa-miR-3064-5p	CLIP-seq
MIRT1193721	hsa-miR-3121-3p	CLIP-seq
MIRT1193722	hsa-miR-3126-3p	CLIP-seq
MIRT1193723	hsa-miR-3136-3p	CLIP-seq
MIRT1193724	hsa-miR-3148	CLIP-seq
MIRT1193725	hsa-miR-3158-5p	CLIP-seq
MIRT1193726	hsa-miR-3163	CLIP-seq
MIRT1193727	hsa-miR-3189-5p	CLIP-seq
MIRT1193728	hsa-miR-3194-5p	CLIP-seq
MIRT1193729	hsa-miR-320e	CLIP-seq
MIRT1193730	hsa-miR-324-3p	CLIP-seq
MIRT1193731	hsa-miR-335	CLIP-seq
MIRT1193732	hsa-miR-3652	CLIP-seq
MIRT1193733	hsa-miR-3657	CLIP-seq
MIRT1193734	hsa-miR-3673	CLIP-seq
MIRT1193735	hsa-miR-3677-5p	CLIP-seq
MIRT1193736	hsa-miR-3689d	CLIP-seq
MIRT1193737	hsa-miR-3913-3p	CLIP-seq
MIRT1193738	hsa-miR-3972	CLIP-seq
MIRT1193739	hsa-miR-421	CLIP-seq
MIRT1193740	hsa-miR-4257	CLIP-seq
MIRT1193741	hsa-miR-4270	CLIP-seq
MIRT1193742	hsa-miR-4272	CLIP-seq
MIRT1193743	hsa-miR-4282	CLIP-seq
MIRT1193744	hsa-miR-4292	CLIP-seq
MIRT1193745	hsa-miR-4293	CLIP-seq
MIRT1193746	hsa-miR-4308	CLIP-seq
MIRT1193747	hsa-miR-431	CLIP-seq
MIRT1193748	hsa-miR-4426	CLIP-seq
MIRT1193749	hsa-miR-4430	CLIP-seq
MIRT1193750	hsa-miR-4441	CLIP-seq
MIRT1193751	hsa-miR-4443	CLIP-seq
MIRT1193752	hsa-miR-4466	CLIP-seq
MIRT1193753	hsa-miR-4470	CLIP-seq
MIRT1193754	hsa-miR-449c	CLIP-seq
MIRT1193755	hsa-miR-4505	CLIP-seq
MIRT1193756	hsa-miR-4530	CLIP-seq
MIRT1193757	hsa-miR-4534	CLIP-seq
MIRT1193758	hsa-miR-4645-5p	CLIP-seq
MIRT1193759	hsa-miR-4647	CLIP-seq
MIRT1193760	hsa-miR-4662b	CLIP-seq
MIRT1193761	hsa-miR-4666-5p	CLIP-seq
MIRT1193762	hsa-miR-4669	CLIP-seq
MIRT1193763	hsa-miR-4673	CLIP-seq
MIRT1193764	hsa-miR-4698	CLIP-seq
MIRT1193765	hsa-miR-4699-5p	CLIP-seq
MIRT1193766	hsa-miR-4709-5p	CLIP-seq
MIRT1193767	hsa-miR-4712-3p	CLIP-seq
MIRT1193768	hsa-miR-4714-3p	CLIP-seq
MIRT1193769	hsa-miR-4722-5p	CLIP-seq
MIRT1193770	hsa-miR-4727-5p	CLIP-seq
MIRT1193771	hsa-miR-4729	CLIP-seq
MIRT1193772	hsa-miR-4739	CLIP-seq
MIRT1193773	hsa-miR-4756-5p	CLIP-seq
MIRT1193774	hsa-miR-4758-3p	CLIP-seq
MIRT1193775	hsa-miR-4768-3p	CLIP-seq
MIRT1193776	hsa-miR-4769-3p	CLIP-seq
MIRT1193777	hsa-miR-4775	CLIP-seq
MIRT1193778	hsa-miR-4779	CLIP-seq
MIRT1193779	hsa-miR-4794	CLIP-seq
MIRT1193780	hsa-miR-4795-3p	CLIP-seq
MIRT1193781	hsa-miR-4795-5p	CLIP-seq
MIRT1193782	hsa-miR-4802-3p	CLIP-seq
MIRT1193783	hsa-miR-4802-5p	CLIP-seq
MIRT1193784	hsa-miR-489	CLIP-seq
MIRT1193785	hsa-miR-576-3p	CLIP-seq
MIRT1193786	hsa-miR-577	CLIP-seq
MIRT1193787	hsa-miR-590-3p	CLIP-seq
MIRT1193788	hsa-miR-596	CLIP-seq
MIRT1193789	hsa-miR-613	CLIP-seq
MIRT1193790	hsa-miR-646	CLIP-seq
MIRT1193791	hsa-miR-659	CLIP-seq
MIRT1193792	hsa-miR-675	CLIP-seq
MIRT1193793	hsa-miR-765	CLIP-seq
MIRT1193794	hsa-miR-889	CLIP-seq
MIRT1193795	hsa-miR-9	CLIP-seq
MIRT1193796	hsa-miR-940	CLIP-seq
MIRT1920694	hsa-miR-2681	CLIP-seq
MIRT1193722	hsa-miR-3126-3p	CLIP-seq
MIRT1920695	hsa-miR-4419a	CLIP-seq
MIRT1920696	hsa-miR-4510	CLIP-seq
MIRT1193778	hsa-miR-4779	CLIP-seq
MIRT1920694	hsa-miR-2681	CLIP-seq
MIRT1193722	hsa-miR-3126-3p	CLIP-seq
MIRT1920695	hsa-miR-4419a	CLIP-seq
MIRT1920696	hsa-miR-4510	CLIP-seq
MIRT1193778	hsa-miR-4779	CLIP-seq
MIRT1920694	hsa-miR-2681	CLIP-seq
MIRT1193722	hsa-miR-3126-3p	CLIP-seq
MIRT1920695	hsa-miR-4419a	CLIP-seq
MIRT1920696	hsa-miR-4510	CLIP-seq
MIRT1193778	hsa-miR-4779	CLIP-seq
MIRT2056201	hsa-miR-1343	CLIP-seq
MIRT1193731	hsa-miR-335	CLIP-seq
MIRT2056202	hsa-miR-3650	CLIP-seq
MIRT2056203	hsa-miR-3667-3p	CLIP-seq
MIRT2056204	hsa-miR-3714	CLIP-seq
MIRT2056205	hsa-miR-374c	CLIP-seq
MIRT2056206	hsa-miR-4297	CLIP-seq
MIRT2056207	hsa-miR-4476	CLIP-seq
MIRT2056208	hsa-miR-4494	CLIP-seq
MIRT1193783	hsa-miR-4802-5p	CLIP-seq
MIRT1193784	hsa-miR-489	CLIP-seq
MIRT2056209	hsa-miR-513a-3p	CLIP-seq
MIRT2056210	hsa-miR-550a	CLIP-seq
MIRT2056211	hsa-miR-563	CLIP-seq
MIRT2056212	hsa-miR-621	CLIP-seq
MIRT2056213	hsa-miR-655	CLIP-seq
MIRT1193796	hsa-miR-940	CLIP-seq
MIRT1193703	hsa-miR-1	CLIP-seq
MIRT2284789	hsa-miR-1207-5p	CLIP-seq
MIRT2284790	hsa-miR-122	CLIP-seq
MIRT2284791	hsa-miR-1827	CLIP-seq
MIRT2284792	hsa-miR-185	CLIP-seq
MIRT1193714	hsa-miR-206	CLIP-seq
MIRT2284793	hsa-miR-28-5p	CLIP-seq
MIRT2284794	hsa-miR-3139	CLIP-seq
MIRT2284795	hsa-miR-3160-3p	CLIP-seq
MIRT1193731	hsa-miR-335	CLIP-seq
MIRT2284796	hsa-miR-383	CLIP-seq
MIRT1193737	hsa-miR-3913-3p	CLIP-seq
MIRT1193741	hsa-miR-4270	CLIP-seq
MIRT2284797	hsa-miR-4306	CLIP-seq
MIRT2284798	hsa-miR-4433	CLIP-seq
MIRT1193750	hsa-miR-4441	CLIP-seq
MIRT2284799	hsa-miR-4481	CLIP-seq
MIRT2284800	hsa-miR-4644	CLIP-seq
MIRT1193771	hsa-miR-4729	CLIP-seq
MIRT2284801	hsa-miR-4745-5p	CLIP-seq
MIRT2284802	hsa-miR-4763-3p	CLIP-seq
MIRT1193783	hsa-miR-4802-5p	CLIP-seq
MIRT1193784	hsa-miR-489	CLIP-seq
MIRT1193788	hsa-miR-596	CLIP-seq
MIRT1193789	hsa-miR-613	CLIP-seq
MIRT2284803	hsa-miR-665	CLIP-seq
MIRT2284804	hsa-miR-708	CLIP-seq
MIRT2284805	hsa-miR-759	CLIP-seq
MIRT1193796	hsa-miR-940	CLIP-seq
MIRT2391729	hsa-miR-1205	CLIP-seq
MIRT2284790	hsa-miR-122	CLIP-seq
MIRT2391730	hsa-miR-1265	CLIP-seq
MIRT2391731	hsa-miR-1266	CLIP-seq
MIRT2391732	hsa-miR-214	CLIP-seq
MIRT2391733	hsa-miR-3150b-3p	CLIP-seq
MIRT2391734	hsa-miR-3198	CLIP-seq
MIRT2391735	hsa-miR-3619-5p	CLIP-seq
MIRT1193735	hsa-miR-3677-5p	CLIP-seq
MIRT2284796	hsa-miR-383	CLIP-seq
MIRT2391736	hsa-miR-4291	CLIP-seq
MIRT2391737	hsa-miR-4309	CLIP-seq
MIRT2391738	hsa-miR-4518	CLIP-seq
MIRT2391739	hsa-miR-4689	CLIP-seq
MIRT2391740	hsa-miR-4784	CLIP-seq
MIRT2391741	hsa-miR-512-3p	CLIP-seq
MIRT2284805	hsa-miR-759	CLIP-seq
MIRT2391742	hsa-miR-761	CLIP-seq
MIRT2391743	hsa-miR-922	CLIP-seq
MIRT2455443	hsa-miR-3155	CLIP-seq
MIRT2455444	hsa-miR-3155b	CLIP-seq
MIRT2455445	hsa-miR-3944-5p	CLIP-seq
MIRT2455446	hsa-miR-484	CLIP-seq
MIRT1193704	hsa-miR-1202	CLIP-seq
MIRT1193705	hsa-miR-1252	CLIP-seq
MIRT1193728	hsa-miR-3194-5p	CLIP-seq
MIRT1193733	hsa-miR-3657	CLIP-seq
MIRT2582605	hsa-miR-3691-5p	CLIP-seq
MIRT1193738	hsa-miR-3972	CLIP-seq
MIRT1193745	hsa-miR-4293	CLIP-seq
MIRT2582606	hsa-miR-4320	CLIP-seq
MIRT1193753	hsa-miR-4470	CLIP-seq
MIRT2582607	hsa-miR-4491	CLIP-seq
MIRT1193756	hsa-miR-4530	CLIP-seq
MIRT2582608	hsa-miR-4657	CLIP-seq
MIRT1193761	hsa-miR-4666-5p	CLIP-seq
MIRT1193762	hsa-miR-4669	CLIP-seq
MIRT1193764	hsa-miR-4698	CLIP-seq
MIRT2582609	hsa-miR-4715-3p	CLIP-seq
MIRT1193770	hsa-miR-4727-5p	CLIP-seq
MIRT2582610	hsa-miR-4752	CLIP-seq
MIRT1193776	hsa-miR-4769-3p	CLIP-seq
MIRT1193782	hsa-miR-4802-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006974	Process	DNA damage response	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0016242	Process	Negative regulation of macroautophagy	IMP	22354037
GO:0030182	Process	Neuron differentiation	IEA
GO:0030182	Process	Neuron differentiation	ISS
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS

Other IDs

• MIM: 615563
• HGNC: 19339
• e!Ensembl: ENSG00000185189

Protein

• UniProt ID: Q9NSY0
• Protein name: Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)
• Protein function: May regulate apoptosis of neural progenitor cells during their differentiation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	56 → 306	Protein kinase domain	Domain

• Sequence:

  MAAPEPAPRRAREREREREDESEDESDILEESPCGRWQKRREQVNQGNMPGLQSTFLAMD
  TEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPNIVKLHKYWLDTSEACARVI
  FITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDT
  IFIQHNGLIKIGSVWHRIFSNALPDDLRSPIRAEREELRNLHFFPPEYGEVADGTAVDIF
  SFGMCALEMAVLEIQTNGDTRVTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSL
  LFHRVLFEVHSLKLLAAHCFIQHQYLMPENVVEEKTKAMDLHAVLAELPRPRRPPLQWRY
  SEVSFMELDKFLEDVRNGIYPLMNFAATRPLGLPRVLAPPPEEVQKAKTPTPEPFDSETR
  KVIQMQCNLERSEDKARWHLTLLLVLEDRLHRQLTYDLLPTDSAQDLASELVHYGFLHED
  DRMKLAAFLESTFLKYRGTQA

• Sequence length: 501

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	31009519	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	18619852		★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	31009519		★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	30352594	Associate	★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	31009519	Associate	★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	31009519		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	30352594	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27634758		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27634758		★☆☆☆☆ Found in Text Mining only
Ventricular Dysfunction Left	Ventricular dysfunction	Pubtator	31009519	Associate	★☆☆☆☆ Found in Text Mining only