Gene Gene information from NCBI Gene database.
Entrez ID 339896
Gene name Glutamate decarboxylase like 1
Gene symbol GADL1
Synonyms (NCBI Gene)
ADCCSADCHuADCHuCSADC
Chromosome 3
Chromosome location 3p24.1-p23
miRNA miRNA information provided by mirtarbase database.
126
miRTarBase ID miRNA Experiments Reference
MIRT613531 hsa-miR-4311 HITS-CLIP 23824327
MIRT607370 hsa-miR-8485 HITS-CLIP 23824327
MIRT613531 hsa-miR-4311 HITS-CLIP 23824327
MIRT607370 hsa-miR-8485 HITS-CLIP 23824327
MIRT613531 hsa-miR-4311 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0004068 Function Aspartate 1-decarboxylase activity IEA
GO:0004782 Function Sulfinoalanine decarboxylase activity IEA
GO:0005737 Component Cytoplasm IBA
GO:0005829 Component Cytosol TAS
GO:0016829 Function Lyase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615601 27949 ENSG00000144644
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZQY3
Protein name Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)
Protein function May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate. {ECO:0000269|Pu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00282 Pyridoxal_deC 77 445 Pyridoxal-dependent decarboxylase conserved domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed very weakly in neurons and not detected in astrocytes, brain or liver. {ECO:0000269|PubMed:26327310}.
Sequence
Sequence length 521
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  beta-Alanine metabolism
Taurine and hypotaurine metabolism
Pantothenate and CoA biosynthesis
Metabolic pathways
  Degradation of cysteine and homocysteine
Aspartate and asparagine metabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANGIOEDEMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EATING DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute pancreatitis Pancreatitis BEFREE 28068586
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 18957720, 20686609, 22031317, 22865300, 22963397, 23266446, 23723294, 25194563, 26211588, 26252352, 28263037, 29027397, 29074606, 29110846, 29871672
View all (4 more)
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 22080568, 23677397, 29045509, 29301782
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 28152252
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of rectum Adenocarcinoma Of Rectum BEFREE 31642964
★☆☆☆☆
Found in Text Mining only
Agenesis of corpus callosum Agenesis Of Corpus Callosum BEFREE 30846400
★☆☆☆☆
Found in Text Mining only
Amnesia, Transient Global Amnesia BEFREE 28112030
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 30128146
★☆☆☆☆
Found in Text Mining only
Anal carcinoma Anal Cancer BEFREE 30339668
★☆☆☆☆
Found in Text Mining only
Aplasia Cutis Congenita Aplasia Cutis Congenita BEFREE 30846400
★☆☆☆☆
Found in Text Mining only