CPLX4 (complexin 4)

Gene

• Entrez ID: 339302
• Gene name: Complexin 4
• Gene symbol: CPLX4
• Synonyms (NCBI Gene): CPX-IV, CPXIV
• Chromosome: 18
• Chromosome location: 18q21.32
• Summary: This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. [provided by RefSeq, Jan 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT906370	hsa-miR-1343	CLIP-seq
MIRT906371	hsa-miR-149	CLIP-seq
MIRT906372	hsa-miR-155	CLIP-seq
MIRT906373	hsa-miR-24	CLIP-seq
MIRT906374	hsa-miR-3140-3p	CLIP-seq
MIRT906375	hsa-miR-3150b-3p	CLIP-seq
MIRT906376	hsa-miR-3689a-3p	CLIP-seq
MIRT906377	hsa-miR-3689c	CLIP-seq
MIRT906378	hsa-miR-4284	CLIP-seq
MIRT906379	hsa-miR-4425	CLIP-seq
MIRT906380	hsa-miR-4659a-3p	CLIP-seq
MIRT906381	hsa-miR-4659b-3p	CLIP-seq
MIRT906382	hsa-miR-4728-5p	CLIP-seq
MIRT906383	hsa-miR-4784	CLIP-seq
MIRT906384	hsa-miR-765	CLIP-seq
MIRT1968638	hsa-miR-1243	CLIP-seq
MIRT1968639	hsa-miR-196a	CLIP-seq
MIRT1968640	hsa-miR-196b	CLIP-seq
MIRT1968641	hsa-miR-3202	CLIP-seq
MIRT1968642	hsa-miR-3654	CLIP-seq
MIRT1968643	hsa-miR-4533	CLIP-seq
MIRT1968644	hsa-miR-4699-3p	CLIP-seq
MIRT2204726	hsa-miR-1294	CLIP-seq
MIRT2204727	hsa-miR-136	CLIP-seq
MIRT2204728	hsa-miR-23a	CLIP-seq
MIRT2204729	hsa-miR-23b	CLIP-seq
MIRT2204730	hsa-miR-23c	CLIP-seq
MIRT2204731	hsa-miR-3174	CLIP-seq
MIRT2204732	hsa-miR-412	CLIP-seq
MIRT2204733	hsa-miR-4666-5p	CLIP-seq
MIRT2204734	hsa-miR-4701-5p	CLIP-seq
MIRT2204735	hsa-miR-4717-3p	CLIP-seq
MIRT2204736	hsa-miR-4720-3p	CLIP-seq
MIRT2204737	hsa-miR-4775	CLIP-seq
MIRT2204738	hsa-miR-4804-3p	CLIP-seq
MIRT2204739	hsa-miR-518a-5p	CLIP-seq
MIRT2204740	hsa-miR-527	CLIP-seq
MIRT2204741	hsa-miR-556-3p	CLIP-seq
MIRT2204742	hsa-miR-588	CLIP-seq
MIRT2204743	hsa-miR-590-3p	CLIP-seq
MIRT2204744	hsa-miR-921	CLIP-seq
MIRT2386408	hsa-miR-1208	CLIP-seq
MIRT2386409	hsa-miR-4420	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0006836	Process	Neurotransmitter transport	IEA
GO:0006887	Process	Exocytosis	IEA
GO:0007601	Process	Visual perception	IEA
GO:0016020	Component	Membrane	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	IBA
GO:0019905	Function	Syntaxin binding	IEA
GO:0031201	Component	SNARE complex	IBA
GO:0031630	Process	Regulation of synaptic vesicle fusion to presynaptic active zone membrane	IBA
GO:0043195	Component	Terminal bouton	IBA
GO:0045202	Component	Synapse	IEA
GO:0046928	Process	Regulation of neurotransmitter secretion	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IBA

Other IDs

• MIM: 609586
• HGNC: 24330
• e!Ensembl: ENSG00000166569

Protein

• UniProt ID: Q7Z7G2
• Protein name: Complexin-4 (Complexin IV) (CPX IV)
• Protein function: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through syna
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05835	Synaphin	1 → 140	Synaphin protein	Family

• Sequence:

  MAFLMKSMISNQVKNLGFGGGSEENKEEGGASDPAAAQGMTREEYEEYQKQMIEEKMERD
  AAFTQKKAERACLRVHLREKYRLPKSEMDENQIQMAGDDVDLPEDLRKMVDEDQEEEEDK
  DSILGQIQNLQNMDLDTIKEKAQATFTEIKQTAEQKCSVM

• Sequence length: 160

Pathways

KEGG:

Synaptic vesicle cycle

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations