Gene Gene information from NCBI Gene database.
Entrez ID 338773
Gene name Transmembrane protein 119
Gene symbol TMEM119
Synonyms (NCBI Gene)
OBIF
Chromosome 12
Chromosome location 12q23.3
miRNA miRNA information provided by mirtarbase database.
496
miRTarBase ID miRNA Experiments Reference
MIRT533799 hsa-miR-1323 HITS-CLIP 23824327
MIRT533798 hsa-miR-548o-3p HITS-CLIP 23824327
MIRT533797 hsa-miR-4301 HITS-CLIP 23824327
MIRT533796 hsa-miR-532-3p HITS-CLIP 23824327
MIRT533795 hsa-miR-1236-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IEA
GO:0001649 Process Osteoblast differentiation IEA
GO:0001958 Process Endochondral ossification IEA
GO:0001958 Process Endochondral ossification ISS
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618989 27884 ENSG00000183160
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q4V9L6
Protein name Transmembrane protein 119 (Osteoblast induction factor) (OBIF)
Protein function Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhanc
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15724 TMEM119 25 277 TMEM119 family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain microglia (at protein level) (PubMed:26250788). Detected in urine (at protein level) (PubMed:37453717). Elevated expression levels seen in the brain of patients with Alzheimer disease (PubMed:26250788). Expressed by
Sequence
Sequence length 283
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANGIOEDEMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 34655926, 35247551 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 34334123 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 32311840 Associate
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Cerebral Infarction BEFREE 26250788
★☆☆☆☆
Found in Text Mining only
Creutzfeldt-Jakob Disease, Sporadic Creutzfeldt-Jakob disease BEFREE 30318820
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Major Major depressive disorder Pubtator 32917850 Associate
★☆☆☆☆
Found in Text Mining only
Developmental Dysplasia of the Hip Developmental dysplasia of the hip Pubtator 33522290 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes Mellitus BEFREE 29113923
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple Sclerosis BEFREE 26250788, 30867424, 31829283
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple sclerosis Pubtator 30867424 Associate
★☆☆☆☆
Found in Text Mining only