Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	338339
Gene name	C-type lectin domain family 4 member D
Gene symbol	CLEC4D
Synonyms (NCBI Gene)	CD368CLEC-6CLEC6CLECSF8Dectin-3MCLMPCL
Chromosome	12
Chromosome location	12p13.31
Summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles

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Show/Hide all (282)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021599	hsa-miR-142-3p	Microarray	17612493
MIRT049934	hsa-miR-30a-5p	CLASH	23622248
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT530827	hsa-miR-3653-3p	PAR-CLIP	22012620
MIRT530826	hsa-miR-4477a	PAR-CLIP	22012620
MIRT530824	hsa-miR-3658	PAR-CLIP	22012620
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT530827	hsa-miR-3653-3p	PAR-CLIP	22012620
MIRT530826	hsa-miR-4477a	PAR-CLIP	22012620
MIRT530824	hsa-miR-3658	PAR-CLIP	22012620
MIRT896035	hsa-miR-134	CLIP-seq
MIRT896036	hsa-miR-203	CLIP-seq
MIRT896037	hsa-miR-2054	CLIP-seq
MIRT896038	hsa-miR-30a	CLIP-seq
MIRT896039	hsa-miR-30b	CLIP-seq
MIRT896040	hsa-miR-30c	CLIP-seq
MIRT896041	hsa-miR-30d	CLIP-seq
MIRT896042	hsa-miR-30e	CLIP-seq
MIRT896043	hsa-miR-3118	CLIP-seq
MIRT896044	hsa-miR-3121-5p	CLIP-seq
MIRT896045	hsa-miR-3136-5p	CLIP-seq
MIRT896046	hsa-miR-3164	CLIP-seq
MIRT896047	hsa-miR-380	CLIP-seq
MIRT896048	hsa-miR-4439	CLIP-seq
MIRT896049	hsa-miR-4501	CLIP-seq
MIRT896050	hsa-miR-4513	CLIP-seq
MIRT896051	hsa-miR-4764-5p	CLIP-seq
MIRT896052	hsa-miR-561	CLIP-seq
MIRT896053	hsa-miR-938	CLIP-seq
MIRT1965650	hsa-miR-1238	CLIP-seq
MIRT1965651	hsa-miR-450b-5p	CLIP-seq
MIRT1965652	hsa-miR-518a-5p	CLIP-seq
MIRT1965653	hsa-miR-527	CLIP-seq
MIRT1965654	hsa-miR-610	CLIP-seq
MIRT2201599	hsa-miR-3124-3p	CLIP-seq
MIRT2201600	hsa-miR-4753-3p	CLIP-seq
MIRT2201601	hsa-miR-4768-5p	CLIP-seq
MIRT2201602	hsa-miR-587	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002292	Process	T cell differentiation involved in immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	23911656, 25910212, 32296183
GO:0005537	Function	D-mannose binding	IDA	23911656
GO:0005886	Component	Plasma membrane	IDA	23911656
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IBA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030887	Process	Positive regulation of myeloid dendritic cell activation	IEA
GO:0030887	Process	Positive regulation of myeloid dendritic cell activation	ISS
GO:0034987	Function	Immunoglobulin receptor binding	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0038094	Process	Fc-gamma receptor signaling pathway	IEA
GO:0038187	Function	Pattern recognition receptor activity	IBA
GO:0038187	Function	Pattern recognition receptor activity	IDA	23911656
GO:0042742	Process	Defense response to bacterium	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061760	Process	Antifungal innate immune response	IBA
GO:0061760	Process	Antifungal innate immune response	IDA	23911656
GO:0061760	Process	Antifungal innate immune response	IEA
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

MIM	HGNC	e!Ensembl
609964	14554	ENSG00000166527

Q8WXI8

Protein name

C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368)

Protein function

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602

PDB

2LS8 , 3WHD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00059	Lectin_C	101 → 209	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. {ECO:0000269|PubMed:14971047}.

Sequence

MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLSVCFIASCLVTHHNFSRCKRGTGVHKLEH
HAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLM
TISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGE
NCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN

Sequence length

215

Interactions

View interactions

	KEGG		Reactome
	C-type lectin receptor signaling pathway		Dectin-2 family Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LUNG DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (63)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	12537975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	14646600		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	12537975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Allergic rhinitis (disorder)	Allergic rhinitis	BEFREE	24094722		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Dissection	Aortic dissection	Pubtator	35178459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	30867470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	30867470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	31725411		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	29545910, 29632722, 8897513		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-CELL MALIGNANCY, LOW-GRADE	Lymphocytic Leukemia	BEFREE	10397742		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	27599564		★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	15682442, 9720711		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	27099439	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinomatosis of peritoneal cavity	Peritoneal Carcinomatosis	BEFREE	30224373		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	12537975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholesteatoma	Cholesteatoma	BEFREE	28440726, 30609964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	10397742, 8897513		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic otitis media	Otitis media	BEFREE	30609964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	22674328		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	30822653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20846378	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	36688193	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	28190086		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	28849222, 29778418		★★★★★ ★☆☆☆☆ Found in Text Mining only
Generalized enlarged lymph nodes	Enlarged Lymph Nodes	BEFREE	11961299		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	32292405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
High Grade Lymphoma (neoplasm)	High Grade Lymphoma	BEFREE	24683001		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin disease	Pubtator	12824192	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	8204893		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31075107, 31118680		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung diseases	Lung Diseases	CTD_human_DG	21602193		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung Diseases Interstitial	Lung disease	Pubtator	36979470	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	36979470	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	29765528, 8897513		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	9720711		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	11961299, 19562619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	11961299, 19562619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoproliferative Disorders	Lymphoproliferative Disorder	BEFREE	12620290		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	26703963, 29096668, 29545910, 29765528, 8204893, 8761301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27599564, 30224373		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	27599564		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28416797, 31118680		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	30822653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	12620412, 26703963, 29096668, 29545910, 29765528, 8204893, 8761301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mastocytosis, Systemic	Mastocytosis	BEFREE	16505282, 24281161		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	37991344	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	29122991		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	31725411		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	32594092	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	22234694	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24373788, 28552434, 30224373, 8204893		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	29719597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Otitis Media with Effusion	Otitis media	BEFREE	24094722, 30609964		★★★★★ ★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE, LATE-ONSET	Parkinson disease	BEFREE	29641175		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Emphysema	Pulmonary Emphysema	BEFREE	30025865		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rectal Carcinoma	Rectal Carcinoma	BEFREE	30822653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	29641175		★★★★★ ★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Systemic sclerosis	Pubtator	36979470	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	28988116		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sinusitis	Sinusitis	BEFREE	24094722		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	34313877	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	27599564		★★★★★ ★☆☆☆☆ Found in Text Mining only
von Willebrand Disease Type 1	Von willebrand disorder	Pubtator	29389944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CLEC4D (C-type lectin domain family 4 member D)