Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3355
Gene name	5-hydroxytryptamine receptor 1F
Gene symbol	HTR1F
Synonyms (NCBI Gene)	5-HT-1F5-HT1F5HT6HTR1ELMR77
Chromosome	3
Chromosome location	3p11.2-p11.1

117

Show/Hide all (117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT663891	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT663890	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT663889	hsa-miR-4518	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT663891	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT663890	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT663889	hsa-miR-4518	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT1057170	hsa-miR-105	CLIP-seq
MIRT1057171	hsa-miR-1252	CLIP-seq
MIRT1057172	hsa-miR-3153	CLIP-seq
MIRT1057173	hsa-miR-3168	CLIP-seq
MIRT1057174	hsa-miR-3671	CLIP-seq
MIRT1057175	hsa-miR-4282	CLIP-seq
MIRT1057176	hsa-miR-4476	CLIP-seq
MIRT1057177	hsa-miR-4533	CLIP-seq
MIRT1057178	hsa-miR-4728-3p	CLIP-seq
MIRT1057179	hsa-miR-4799-5p	CLIP-seq
MIRT1057180	hsa-miR-513a-3p	CLIP-seq
MIRT1057181	hsa-miR-548a-5p	CLIP-seq
MIRT1057182	hsa-miR-548ab	CLIP-seq
MIRT1057183	hsa-miR-548ag	CLIP-seq
MIRT1057184	hsa-miR-548ai	CLIP-seq
MIRT1057185	hsa-miR-548ak	CLIP-seq
MIRT1057186	hsa-miR-548b-5p	CLIP-seq
MIRT1057187	hsa-miR-548c-3p	CLIP-seq
MIRT1057188	hsa-miR-548c-5p	CLIP-seq
MIRT1057189	hsa-miR-548d-5p	CLIP-seq
MIRT1057190	hsa-miR-548h	CLIP-seq
MIRT1057191	hsa-miR-548i	CLIP-seq
MIRT1057192	hsa-miR-548j	CLIP-seq
MIRT1057193	hsa-miR-548k	CLIP-seq
MIRT1057194	hsa-miR-548l	CLIP-seq
MIRT1057195	hsa-miR-548w	CLIP-seq
MIRT1057196	hsa-miR-548y	CLIP-seq
MIRT1057197	hsa-miR-559	CLIP-seq
MIRT1057198	hsa-miR-607	CLIP-seq
MIRT1057199	hsa-miR-873	CLIP-seq
MIRT2013071	hsa-miR-2964a-3p	CLIP-seq
MIRT2013072	hsa-miR-302f	CLIP-seq
MIRT2389212	hsa-miR-1321	CLIP-seq
MIRT2389213	hsa-miR-202	CLIP-seq
MIRT2389214	hsa-miR-2053	CLIP-seq
MIRT1057174	hsa-miR-3671	CLIP-seq
MIRT2389215	hsa-miR-4419a	CLIP-seq
MIRT2389216	hsa-miR-4510	CLIP-seq
MIRT2389217	hsa-miR-4739	CLIP-seq
MIRT2389218	hsa-miR-4756-5p	CLIP-seq
MIRT2389219	hsa-miR-4781-3p	CLIP-seq
MIRT2389220	hsa-miR-4802-5p	CLIP-seq
MIRT2389221	hsa-miR-567	CLIP-seq
MIRT2389222	hsa-miR-569	CLIP-seq
MIRT1057198	hsa-miR-607	CLIP-seq
MIRT2429708	hsa-miR-3646	CLIP-seq
MIRT2548586	hsa-miR-4768-3p	CLIP-seq
MIRT2548587	hsa-miR-539	CLIP-seq
MIRT2429708	hsa-miR-3646	CLIP-seq
MIRT2548586	hsa-miR-4768-3p	CLIP-seq
MIRT2548587	hsa-miR-539	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001586	Function	Gi/o-coupled serotonin receptor activity	IDA	34239069
GO:0001586	Function	Gi/o-coupled serotonin receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IDA	8380639
GO:0004993	Function	G protein-coupled serotonin receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IMP	21422162
GO:0004993	Function	G protein-coupled serotonin receptor activity	TAS	8380639
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	21422162
GO:0005886	Component	Plasma membrane	TAS	8380639
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8380639
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	21422162
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA	34239069, 35610220, 35835867
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IEA
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	TAS	8380639
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0045202	Component	Synapse	IEA
GO:0051378	Function	Serotonin binding	IDA	8380639
GO:0051378	Function	Serotonin binding	IEA
GO:0099589	Function	Serotonin receptor activity	IDA	34239069
GO:0099589	Function	Serotonin receptor activity	IEA

MIM	HGNC	e!Ensembl
182134	5292	ENSG00000179097

P30939

Protein name

5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F)

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:21422162, PubMed:8380639, P

PDB

7EXD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	40 → 347	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY
LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD
RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIV
STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKS
VSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG
AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK
LVRCRC

Sequence length

366

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction		Serotonin receptors G alpha (i) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROFACIAL CLEFT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	15531082	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	11442897	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	11287786	★★★★★ ★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 1	Major Affective Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 2	Major Affective Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 4	Major Affective Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 6	Major Affective Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 7	Major Affective Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 8	Major Affective Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 9	Major Affective Disorder	BEFREE	10893499, 8723053	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	11702016	★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	BEFREE	17691977, 27465216, 28749698, 31132795, 9632173	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	BEFREE	10581475	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	10893499, 11287786, 12057822, 14741325, 15048641, 15205874, 8723053	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	11287786, 14741325	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

HTR1F (5-hydroxytryptamine receptor 1F)