Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	334
Gene name	Amyloid beta precursor like protein 2
Gene symbol	APLP2
Synonyms (NCBI Gene)	APLP-2APPHAPPL2CDEBP
Chromosome	11
Chromosome location	11q24.3
Summary	This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025806	hsa-miR-7-5p	Microarray	17612493
MIRT025806	hsa-miR-7-5p	Microarray	19073608
MIRT048819	hsa-miR-93-5p	CLASH	23622248
MIRT044252	hsa-miR-106b-5p	CLASH	23622248
MIRT042713	hsa-miR-346	CLASH	23622248
MIRT052735	hsa-miR-1260b	CLASH	23622248
MIRT705594	hsa-miR-1324	HITS-CLIP	23313552
MIRT495981	hsa-miR-3185	HITS-CLIP	23313552
MIRT705593	hsa-miR-30a-5p	HITS-CLIP	23313552
MIRT705592	hsa-miR-30b-5p	HITS-CLIP	23313552
MIRT705591	hsa-miR-30c-5p	HITS-CLIP	23313552
MIRT705590	hsa-miR-30d-5p	HITS-CLIP	23313552
MIRT705589	hsa-miR-30e-5p	HITS-CLIP	23313552
MIRT495982	hsa-miR-513b-3p	PAR-CLIP	22291592
MIRT495981	hsa-miR-3185	PAR-CLIP	22291592
MIRT495980	hsa-miR-548v	PAR-CLIP	22291592
MIRT495979	hsa-miR-3671	PAR-CLIP	22291592
MIRT495982	hsa-miR-513b-3p	PAR-CLIP	22291592
MIRT495981	hsa-miR-3185	PAR-CLIP	22291592
MIRT495980	hsa-miR-548v	PAR-CLIP	22291592
MIRT495979	hsa-miR-3671	PAR-CLIP	22291592
MIRT705594	hsa-miR-1324	HITS-CLIP	23313552
MIRT495981	hsa-miR-3185	HITS-CLIP	23313552
MIRT705593	hsa-miR-30a-5p	HITS-CLIP	23313552
MIRT705592	hsa-miR-30b-5p	HITS-CLIP	23313552
MIRT705591	hsa-miR-30c-5p	HITS-CLIP	23313552
MIRT705590	hsa-miR-30d-5p	HITS-CLIP	23313552
MIRT705589	hsa-miR-30e-5p	HITS-CLIP	23313552
MIRT495982	hsa-miR-513b-3p	PAR-CLIP	22291592
MIRT495981	hsa-miR-3185	PAR-CLIP	22291592
MIRT495980	hsa-miR-548v	PAR-CLIP	22291592
MIRT495979	hsa-miR-3671	PAR-CLIP	22291592
MIRT495982	hsa-miR-513b-3p	PAR-CLIP	22291592
MIRT495981	hsa-miR-3185	PAR-CLIP	22291592
MIRT495980	hsa-miR-548v	PAR-CLIP	22291592
MIRT495979	hsa-miR-3671	PAR-CLIP	22291592
MIRT789618	hsa-miR-1243	CLIP-seq
MIRT789619	hsa-miR-1252	CLIP-seq
MIRT789620	hsa-miR-1264	CLIP-seq
MIRT789621	hsa-miR-1265	CLIP-seq
MIRT789622	hsa-miR-15a	CLIP-seq
MIRT789623	hsa-miR-15b	CLIP-seq
MIRT789624	hsa-miR-16	CLIP-seq
MIRT789625	hsa-miR-195	CLIP-seq
MIRT789626	hsa-miR-216a	CLIP-seq
MIRT789627	hsa-miR-216b	CLIP-seq
MIRT789628	hsa-miR-298	CLIP-seq
MIRT789629	hsa-miR-3173-3p	CLIP-seq
MIRT789630	hsa-miR-3190	CLIP-seq
MIRT789631	hsa-miR-331-3p	CLIP-seq
MIRT789632	hsa-miR-34a	CLIP-seq
MIRT789633	hsa-miR-34c-5p	CLIP-seq
MIRT789634	hsa-miR-3669	CLIP-seq
MIRT789635	hsa-miR-3674	CLIP-seq
MIRT789636	hsa-miR-3677-3p	CLIP-seq
MIRT789637	hsa-miR-3913-3p	CLIP-seq
MIRT789638	hsa-miR-424	CLIP-seq
MIRT789639	hsa-miR-4320	CLIP-seq
MIRT789640	hsa-miR-4428	CLIP-seq
MIRT789641	hsa-miR-4438	CLIP-seq
MIRT789642	hsa-miR-4477a	CLIP-seq
MIRT789643	hsa-miR-4477b	CLIP-seq
MIRT789644	hsa-miR-448	CLIP-seq
MIRT789645	hsa-miR-449a	CLIP-seq
MIRT789646	hsa-miR-449b	CLIP-seq
MIRT789647	hsa-miR-450b-3p	CLIP-seq
MIRT789648	hsa-miR-4519	CLIP-seq
MIRT789649	hsa-miR-4654	CLIP-seq
MIRT789650	hsa-miR-4670-3p	CLIP-seq
MIRT789651	hsa-miR-4671-5p	CLIP-seq
MIRT789652	hsa-miR-4700-3p	CLIP-seq
MIRT789653	hsa-miR-4713-3p	CLIP-seq
MIRT789654	hsa-miR-4769-5p	CLIP-seq
MIRT789655	hsa-miR-4802-5p	CLIP-seq
MIRT789656	hsa-miR-4803	CLIP-seq
MIRT789657	hsa-miR-497	CLIP-seq
MIRT789658	hsa-miR-503	CLIP-seq
MIRT789659	hsa-miR-5095	CLIP-seq
MIRT789660	hsa-miR-596	CLIP-seq
MIRT789661	hsa-miR-638	CLIP-seq
MIRT789662	hsa-miR-671-5p	CLIP-seq
MIRT789663	hsa-miR-769-3p	CLIP-seq
MIRT789664	hsa-miR-885-3p	CLIP-seq
MIRT789619	hsa-miR-1252	CLIP-seq
MIRT789622	hsa-miR-15a	CLIP-seq
MIRT789623	hsa-miR-15b	CLIP-seq
MIRT789624	hsa-miR-16	CLIP-seq
MIRT789625	hsa-miR-195	CLIP-seq
MIRT789638	hsa-miR-424	CLIP-seq
MIRT789651	hsa-miR-4671-5p	CLIP-seq
MIRT789652	hsa-miR-4700-3p	CLIP-seq
MIRT789665	hsa-miR-4729	CLIP-seq
MIRT789666	hsa-miR-4795-3p	CLIP-seq
MIRT789655	hsa-miR-4802-5p	CLIP-seq
MIRT789657	hsa-miR-497	CLIP-seq
MIRT789658	hsa-miR-503	CLIP-seq
MIRT789667	hsa-miR-1251	CLIP-seq
MIRT789668	hsa-miR-1257	CLIP-seq
MIRT789669	hsa-miR-132	CLIP-seq
MIRT789670	hsa-miR-148a	CLIP-seq
MIRT789671	hsa-miR-148b	CLIP-seq
MIRT789672	hsa-miR-152	CLIP-seq
MIRT789622	hsa-miR-15a	CLIP-seq
MIRT789623	hsa-miR-15b	CLIP-seq
MIRT789624	hsa-miR-16	CLIP-seq
MIRT789673	hsa-miR-1914	CLIP-seq
MIRT789625	hsa-miR-195	CLIP-seq
MIRT789674	hsa-miR-212	CLIP-seq
MIRT789675	hsa-miR-2276	CLIP-seq
MIRT789628	hsa-miR-298	CLIP-seq
MIRT789676	hsa-miR-3074-3p	CLIP-seq
MIRT789677	hsa-miR-30a	CLIP-seq
MIRT789678	hsa-miR-30b	CLIP-seq
MIRT789679	hsa-miR-30c	CLIP-seq
MIRT789680	hsa-miR-30d	CLIP-seq
MIRT789681	hsa-miR-30e	CLIP-seq
MIRT789682	hsa-miR-3163	CLIP-seq
MIRT789683	hsa-miR-3179	CLIP-seq
MIRT789684	hsa-miR-3184	CLIP-seq
MIRT789685	hsa-miR-3187-3p	CLIP-seq
MIRT789686	hsa-miR-3202	CLIP-seq
MIRT789687	hsa-miR-3662	CLIP-seq
MIRT789634	hsa-miR-3669	CLIP-seq
MIRT789636	hsa-miR-3677-3p	CLIP-seq
MIRT789688	hsa-miR-3677-5p	CLIP-seq
MIRT789689	hsa-miR-3689d	CLIP-seq
MIRT789690	hsa-miR-378	CLIP-seq
MIRT789691	hsa-miR-378b	CLIP-seq
MIRT789692	hsa-miR-378c	CLIP-seq
MIRT789693	hsa-miR-378d	CLIP-seq
MIRT789694	hsa-miR-378e	CLIP-seq
MIRT789695	hsa-miR-378f	CLIP-seq
MIRT789696	hsa-miR-378h	CLIP-seq
MIRT789697	hsa-miR-378i	CLIP-seq
MIRT789637	hsa-miR-3913-3p	CLIP-seq
MIRT789698	hsa-miR-3977	CLIP-seq
MIRT789699	hsa-miR-422a	CLIP-seq
MIRT789700	hsa-miR-423-5p	CLIP-seq
MIRT789638	hsa-miR-424	CLIP-seq
MIRT789701	hsa-miR-4259	CLIP-seq
MIRT789702	hsa-miR-4271	CLIP-seq
MIRT789703	hsa-miR-4276	CLIP-seq
MIRT789704	hsa-miR-4432	CLIP-seq
MIRT789705	hsa-miR-4436a	CLIP-seq
MIRT789706	hsa-miR-4459	CLIP-seq
MIRT789643	hsa-miR-4477b	CLIP-seq
MIRT789647	hsa-miR-450b-3p	CLIP-seq
MIRT789648	hsa-miR-4519	CLIP-seq
MIRT789707	hsa-miR-4529-5p	CLIP-seq
MIRT789708	hsa-miR-4533	CLIP-seq
MIRT789709	hsa-miR-4638-3p	CLIP-seq
MIRT789710	hsa-miR-4651	CLIP-seq
MIRT789649	hsa-miR-4654	CLIP-seq
MIRT789711	hsa-miR-4686	CLIP-seq
MIRT789652	hsa-miR-4700-3p	CLIP-seq
MIRT789712	hsa-miR-4704-3p	CLIP-seq
MIRT789713	hsa-miR-4704-5p	CLIP-seq
MIRT789714	hsa-miR-4710	CLIP-seq
MIRT789653	hsa-miR-4713-3p	CLIP-seq
MIRT789715	hsa-miR-4715-5p	CLIP-seq
MIRT789716	hsa-miR-4725-3p	CLIP-seq
MIRT789665	hsa-miR-4729	CLIP-seq
MIRT789717	hsa-miR-4742-3p	CLIP-seq
MIRT789718	hsa-miR-4766-5p	CLIP-seq
MIRT789654	hsa-miR-4769-5p	CLIP-seq
MIRT789719	hsa-miR-4772-3p	CLIP-seq
MIRT789720	hsa-miR-4779	CLIP-seq
MIRT789721	hsa-miR-4789-5p	CLIP-seq
MIRT789655	hsa-miR-4802-5p	CLIP-seq
MIRT789722	hsa-miR-487a	CLIP-seq
MIRT789657	hsa-miR-497	CLIP-seq
MIRT789723	hsa-miR-499-3p	CLIP-seq
MIRT789724	hsa-miR-499a-3p	CLIP-seq
MIRT789658	hsa-miR-503	CLIP-seq
MIRT789725	hsa-miR-513a-5p	CLIP-seq
MIRT789726	hsa-miR-519e	CLIP-seq
MIRT789727	hsa-miR-520d-5p	CLIP-seq
MIRT789728	hsa-miR-524-5p	CLIP-seq
MIRT789729	hsa-miR-542-3p	CLIP-seq
MIRT789730	hsa-miR-548c-3p	CLIP-seq
MIRT789731	hsa-miR-548u	CLIP-seq
MIRT789732	hsa-miR-579	CLIP-seq
MIRT789733	hsa-miR-582-5p	CLIP-seq
MIRT789660	hsa-miR-596	CLIP-seq
MIRT789734	hsa-miR-608	CLIP-seq
MIRT789661	hsa-miR-638	CLIP-seq
MIRT789735	hsa-miR-765	CLIP-seq
MIRT789663	hsa-miR-769-3p	CLIP-seq
MIRT789736	hsa-miR-885-5p	CLIP-seq
MIRT789737	hsa-miR-887	CLIP-seq
MIRT1545456	hsa-miR-101	CLIP-seq
MIRT1545457	hsa-miR-1278	CLIP-seq
MIRT1545458	hsa-miR-139-5p	CLIP-seq
MIRT1545459	hsa-miR-144	CLIP-seq
MIRT1545460	hsa-miR-199a-3p	CLIP-seq
MIRT1545461	hsa-miR-199b-3p	CLIP-seq
MIRT1545462	hsa-miR-3129-5p	CLIP-seq
MIRT1545463	hsa-miR-3168	CLIP-seq
MIRT1545464	hsa-miR-4277	CLIP-seq
MIRT1545465	hsa-miR-4540	CLIP-seq
MIRT1545456	hsa-miR-101	CLIP-seq
MIRT789620	hsa-miR-1264	CLIP-seq
MIRT789621	hsa-miR-1265	CLIP-seq
MIRT1545457	hsa-miR-1278	CLIP-seq
MIRT1932933	hsa-miR-128	CLIP-seq
MIRT1932934	hsa-miR-1343	CLIP-seq
MIRT1545458	hsa-miR-139-5p	CLIP-seq
MIRT1545459	hsa-miR-144	CLIP-seq
MIRT1932935	hsa-miR-1976	CLIP-seq
MIRT1545460	hsa-miR-199a-3p	CLIP-seq
MIRT1545461	hsa-miR-199b-3p	CLIP-seq
MIRT1932936	hsa-miR-2117	CLIP-seq
MIRT1545462	hsa-miR-3129-5p	CLIP-seq
MIRT1545463	hsa-miR-3168	CLIP-seq
MIRT1932937	hsa-miR-3692	CLIP-seq
MIRT1932938	hsa-miR-4273	CLIP-seq
MIRT1545464	hsa-miR-4277	CLIP-seq
MIRT1932939	hsa-miR-4328	CLIP-seq
MIRT789706	hsa-miR-4459	CLIP-seq
MIRT789644	hsa-miR-448	CLIP-seq
MIRT1545465	hsa-miR-4540	CLIP-seq
MIRT1932940	hsa-miR-455-3p	CLIP-seq
MIRT1932941	hsa-miR-4640-5p	CLIP-seq
MIRT1932942	hsa-miR-4726-5p	CLIP-seq
MIRT789665	hsa-miR-4729	CLIP-seq
MIRT1932943	hsa-miR-4768-5p	CLIP-seq
MIRT789666	hsa-miR-4795-3p	CLIP-seq
MIRT789660	hsa-miR-596	CLIP-seq
MIRT1932944	hsa-miR-665	CLIP-seq
MIRT1545456	hsa-miR-101	CLIP-seq
MIRT2173088	hsa-miR-1182	CLIP-seq
MIRT2173089	hsa-miR-1200	CLIP-seq
MIRT789618	hsa-miR-1243	CLIP-seq
MIRT789667	hsa-miR-1251	CLIP-seq
MIRT789619	hsa-miR-1252	CLIP-seq
MIRT2173090	hsa-miR-1254	CLIP-seq
MIRT789668	hsa-miR-1257	CLIP-seq
MIRT789620	hsa-miR-1264	CLIP-seq
MIRT789621	hsa-miR-1265	CLIP-seq
MIRT1545457	hsa-miR-1278	CLIP-seq
MIRT2173091	hsa-miR-1279	CLIP-seq
MIRT1932933	hsa-miR-128	CLIP-seq
MIRT1545458	hsa-miR-139-5p	CLIP-seq
MIRT2173092	hsa-miR-141	CLIP-seq
MIRT1545459	hsa-miR-144	CLIP-seq
MIRT789670	hsa-miR-148a	CLIP-seq
MIRT789671	hsa-miR-148b	CLIP-seq
MIRT789672	hsa-miR-152	CLIP-seq
MIRT789622	hsa-miR-15a	CLIP-seq
MIRT789623	hsa-miR-15b	CLIP-seq
MIRT789624	hsa-miR-16	CLIP-seq
MIRT2173093	hsa-miR-186	CLIP-seq
MIRT789673	hsa-miR-1914	CLIP-seq
MIRT789625	hsa-miR-195	CLIP-seq
MIRT1545460	hsa-miR-199a-3p	CLIP-seq
MIRT1545461	hsa-miR-199b-3p	CLIP-seq
MIRT2173094	hsa-miR-200a	CLIP-seq
MIRT2173095	hsa-miR-200b	CLIP-seq
MIRT2173096	hsa-miR-200c	CLIP-seq
MIRT2173097	hsa-miR-23a	CLIP-seq
MIRT2173098	hsa-miR-23b	CLIP-seq
MIRT2173099	hsa-miR-23c	CLIP-seq
MIRT789677	hsa-miR-30a	CLIP-seq
MIRT789678	hsa-miR-30b	CLIP-seq
MIRT789679	hsa-miR-30c	CLIP-seq
MIRT789680	hsa-miR-30d	CLIP-seq
MIRT789681	hsa-miR-30e	CLIP-seq
MIRT2173100	hsa-miR-3116	CLIP-seq
MIRT2173101	hsa-miR-3127-5p	CLIP-seq
MIRT1545462	hsa-miR-3129-5p	CLIP-seq
MIRT2173102	hsa-miR-3140-5p	CLIP-seq
MIRT789682	hsa-miR-3163	CLIP-seq
MIRT1545463	hsa-miR-3168	CLIP-seq
MIRT2173103	hsa-miR-3170	CLIP-seq
MIRT789629	hsa-miR-3173-3p	CLIP-seq
MIRT789683	hsa-miR-3179	CLIP-seq
MIRT789684	hsa-miR-3184	CLIP-seq
MIRT789685	hsa-miR-3187-3p	CLIP-seq
MIRT789630	hsa-miR-3190	CLIP-seq
MIRT789686	hsa-miR-3202	CLIP-seq
MIRT2173104	hsa-miR-330-3p	CLIP-seq
MIRT789631	hsa-miR-331-3p	CLIP-seq
MIRT789632	hsa-miR-34a	CLIP-seq
MIRT789633	hsa-miR-34c-5p	CLIP-seq
MIRT2173105	hsa-miR-3654	CLIP-seq
MIRT789687	hsa-miR-3662	CLIP-seq
MIRT789635	hsa-miR-3674	CLIP-seq
MIRT789688	hsa-miR-3677-5p	CLIP-seq
MIRT2173106	hsa-miR-3688-3p	CLIP-seq
MIRT789689	hsa-miR-3689d	CLIP-seq
MIRT2173107	hsa-miR-3690	CLIP-seq
MIRT1932937	hsa-miR-3692	CLIP-seq
MIRT789690	hsa-miR-378	CLIP-seq
MIRT789691	hsa-miR-378b	CLIP-seq
MIRT789692	hsa-miR-378c	CLIP-seq
MIRT789693	hsa-miR-378d	CLIP-seq
MIRT789694	hsa-miR-378e	CLIP-seq
MIRT789695	hsa-miR-378f	CLIP-seq
MIRT789696	hsa-miR-378h	CLIP-seq
MIRT789697	hsa-miR-378i	CLIP-seq
MIRT789637	hsa-miR-3913-3p	CLIP-seq
MIRT2173108	hsa-miR-3920	CLIP-seq
MIRT2173109	hsa-miR-3922-5p	CLIP-seq
MIRT2173110	hsa-miR-3941	CLIP-seq
MIRT789698	hsa-miR-3977	CLIP-seq
MIRT789699	hsa-miR-422a	CLIP-seq
MIRT789700	hsa-miR-423-5p	CLIP-seq
MIRT789638	hsa-miR-424	CLIP-seq
MIRT789701	hsa-miR-4259	CLIP-seq
MIRT2173111	hsa-miR-4261	CLIP-seq
MIRT2173112	hsa-miR-4270	CLIP-seq
MIRT789702	hsa-miR-4271	CLIP-seq
MIRT789703	hsa-miR-4276	CLIP-seq
MIRT1545464	hsa-miR-4277	CLIP-seq
MIRT2173113	hsa-miR-429	CLIP-seq
MIRT789639	hsa-miR-4320	CLIP-seq
MIRT1932939	hsa-miR-4328	CLIP-seq
MIRT789640	hsa-miR-4428	CLIP-seq
MIRT789704	hsa-miR-4432	CLIP-seq
MIRT2173114	hsa-miR-4441	CLIP-seq
MIRT2173115	hsa-miR-4457	CLIP-seq
MIRT789706	hsa-miR-4459	CLIP-seq
MIRT2173116	hsa-miR-4461	CLIP-seq
MIRT789642	hsa-miR-4477a	CLIP-seq
MIRT789643	hsa-miR-4477b	CLIP-seq
MIRT789644	hsa-miR-448	CLIP-seq
MIRT789645	hsa-miR-449a	CLIP-seq
MIRT789646	hsa-miR-449b	CLIP-seq
MIRT2173117	hsa-miR-450a	CLIP-seq
MIRT789707	hsa-miR-4529-5p	CLIP-seq
MIRT789708	hsa-miR-4533	CLIP-seq
MIRT1545465	hsa-miR-4540	CLIP-seq
MIRT1932940	hsa-miR-455-3p	CLIP-seq
MIRT789709	hsa-miR-4638-3p	CLIP-seq
MIRT789710	hsa-miR-4651	CLIP-seq
MIRT2173118	hsa-miR-466	CLIP-seq
MIRT2173119	hsa-miR-4666-3p	CLIP-seq
MIRT789651	hsa-miR-4671-5p	CLIP-seq
MIRT2173120	hsa-miR-4672	CLIP-seq
MIRT789713	hsa-miR-4704-5p	CLIP-seq
MIRT789714	hsa-miR-4710	CLIP-seq
MIRT789715	hsa-miR-4715-5p	CLIP-seq
MIRT789716	hsa-miR-4725-3p	CLIP-seq
MIRT789665	hsa-miR-4729	CLIP-seq
MIRT2173121	hsa-miR-4731-3p	CLIP-seq
MIRT2173122	hsa-miR-4737	CLIP-seq
MIRT2173123	hsa-miR-4738-3p	CLIP-seq
MIRT789717	hsa-miR-4742-3p	CLIP-seq
MIRT2173124	hsa-miR-4762-3p	CLIP-seq
MIRT789718	hsa-miR-4766-5p	CLIP-seq
MIRT789720	hsa-miR-4779	CLIP-seq
MIRT789721	hsa-miR-4789-5p	CLIP-seq
MIRT789666	hsa-miR-4795-3p	CLIP-seq
MIRT2173125	hsa-miR-4795-5p	CLIP-seq
MIRT2173126	hsa-miR-4801	CLIP-seq
MIRT789656	hsa-miR-4803	CLIP-seq
MIRT789657	hsa-miR-497	CLIP-seq
MIRT789658	hsa-miR-503	CLIP-seq
MIRT2173127	hsa-miR-5096	CLIP-seq
MIRT2173128	hsa-miR-513b	CLIP-seq
MIRT789726	hsa-miR-519e	CLIP-seq
MIRT789727	hsa-miR-520d-5p	CLIP-seq
MIRT789728	hsa-miR-524-5p	CLIP-seq
MIRT789729	hsa-miR-542-3p	CLIP-seq
MIRT789731	hsa-miR-548u	CLIP-seq
MIRT2173129	hsa-miR-556-3p	CLIP-seq
MIRT2173130	hsa-miR-570	CLIP-seq
MIRT2173131	hsa-miR-582-3p	CLIP-seq
MIRT789733	hsa-miR-582-5p	CLIP-seq
MIRT2173132	hsa-miR-592	CLIP-seq
MIRT789660	hsa-miR-596	CLIP-seq
MIRT2173133	hsa-miR-597	CLIP-seq
MIRT789734	hsa-miR-608	CLIP-seq
MIRT2173134	hsa-miR-656	CLIP-seq
MIRT2173135	hsa-miR-660	CLIP-seq
MIRT1932944	hsa-miR-665	CLIP-seq
MIRT789662	hsa-miR-671-5p	CLIP-seq
MIRT789735	hsa-miR-765	CLIP-seq
MIRT789664	hsa-miR-885-3p	CLIP-seq
MIRT789736	hsa-miR-885-5p	CLIP-seq
MIRT789737	hsa-miR-887	CLIP-seq
MIRT2173136	hsa-miR-891b	CLIP-seq
MIRT789620	hsa-miR-1264	CLIP-seq
MIRT1545457	hsa-miR-1278	CLIP-seq
MIRT1545458	hsa-miR-139-5p	CLIP-seq
MIRT1545460	hsa-miR-199a-3p	CLIP-seq
MIRT1545461	hsa-miR-199b-3p	CLIP-seq
MIRT2173101	hsa-miR-3127-5p	CLIP-seq
MIRT1545462	hsa-miR-3129-5p	CLIP-seq
MIRT2173110	hsa-miR-3941	CLIP-seq
MIRT2173112	hsa-miR-4270	CLIP-seq
MIRT1932939	hsa-miR-4328	CLIP-seq
MIRT2173114	hsa-miR-4441	CLIP-seq
MIRT789706	hsa-miR-4459	CLIP-seq
MIRT789644	hsa-miR-448	CLIP-seq
MIRT1545465	hsa-miR-4540	CLIP-seq
MIRT1932940	hsa-miR-455-3p	CLIP-seq
MIRT2173118	hsa-miR-466	CLIP-seq
MIRT2173120	hsa-miR-4672	CLIP-seq
MIRT2173121	hsa-miR-4731-3p	CLIP-seq
MIRT2173126	hsa-miR-4801	CLIP-seq
MIRT789656	hsa-miR-4803	CLIP-seq
MIRT789660	hsa-miR-596	CLIP-seq
MIRT1932944	hsa-miR-665	CLIP-seq
MIRT789641	hsa-miR-4438	CLIP-seq
MIRT789659	hsa-miR-5095	CLIP-seq
MIRT789620	hsa-miR-1264	CLIP-seq
MIRT2476302	hsa-miR-140-3p	CLIP-seq
MIRT789670	hsa-miR-148a	CLIP-seq
MIRT789671	hsa-miR-148b	CLIP-seq
MIRT789672	hsa-miR-152	CLIP-seq
MIRT2173103	hsa-miR-3170	CLIP-seq
MIRT789683	hsa-miR-3179	CLIP-seq
MIRT789684	hsa-miR-3184	CLIP-seq
MIRT789686	hsa-miR-3202	CLIP-seq
MIRT2476303	hsa-miR-3647-3p	CLIP-seq
MIRT789689	hsa-miR-3689d	CLIP-seq
MIRT789690	hsa-miR-378	CLIP-seq
MIRT789691	hsa-miR-378b	CLIP-seq
MIRT789692	hsa-miR-378c	CLIP-seq
MIRT789693	hsa-miR-378d	CLIP-seq
MIRT789694	hsa-miR-378e	CLIP-seq
MIRT789695	hsa-miR-378f	CLIP-seq
MIRT789696	hsa-miR-378h	CLIP-seq
MIRT789697	hsa-miR-378i	CLIP-seq
MIRT2173108	hsa-miR-3920	CLIP-seq
MIRT2173109	hsa-miR-3922-5p	CLIP-seq
MIRT2173110	hsa-miR-3941	CLIP-seq
MIRT789699	hsa-miR-422a	CLIP-seq
MIRT789700	hsa-miR-423-5p	CLIP-seq
MIRT789701	hsa-miR-4259	CLIP-seq
MIRT789702	hsa-miR-4271	CLIP-seq
MIRT2173115	hsa-miR-4457	CLIP-seq
MIRT789706	hsa-miR-4459	CLIP-seq
MIRT2173116	hsa-miR-4461	CLIP-seq
MIRT789644	hsa-miR-448	CLIP-seq
MIRT789708	hsa-miR-4533	CLIP-seq
MIRT789709	hsa-miR-4638-3p	CLIP-seq
MIRT789710	hsa-miR-4651	CLIP-seq
MIRT2173118	hsa-miR-466	CLIP-seq
MIRT2173119	hsa-miR-4666-3p	CLIP-seq
MIRT2173120	hsa-miR-4672	CLIP-seq
MIRT789714	hsa-miR-4710	CLIP-seq
MIRT789715	hsa-miR-4715-5p	CLIP-seq
MIRT789716	hsa-miR-4725-3p	CLIP-seq
MIRT789665	hsa-miR-4729	CLIP-seq
MIRT2173121	hsa-miR-4731-3p	CLIP-seq
MIRT2173124	hsa-miR-4762-3p	CLIP-seq
MIRT2476304	hsa-miR-4775	CLIP-seq
MIRT789720	hsa-miR-4779	CLIP-seq
MIRT789666	hsa-miR-4795-3p	CLIP-seq
MIRT2173125	hsa-miR-4795-5p	CLIP-seq
MIRT2173126	hsa-miR-4801	CLIP-seq
MIRT789656	hsa-miR-4803	CLIP-seq
MIRT789723	hsa-miR-499-3p	CLIP-seq
MIRT789724	hsa-miR-499a-3p	CLIP-seq
MIRT789725	hsa-miR-513a-5p	CLIP-seq
MIRT2173128	hsa-miR-513b	CLIP-seq
MIRT789726	hsa-miR-519e	CLIP-seq
MIRT789729	hsa-miR-542-3p	CLIP-seq
MIRT789730	hsa-miR-548c-3p	CLIP-seq
MIRT2173132	hsa-miR-592	CLIP-seq
MIRT789660	hsa-miR-596	CLIP-seq
MIRT2173133	hsa-miR-597	CLIP-seq
MIRT789734	hsa-miR-608	CLIP-seq
MIRT789735	hsa-miR-765	CLIP-seq
MIRT789737	hsa-miR-887	CLIP-seq
MIRT789620	hsa-miR-1264	CLIP-seq
MIRT789670	hsa-miR-148a	CLIP-seq
MIRT789671	hsa-miR-148b	CLIP-seq
MIRT789672	hsa-miR-152	CLIP-seq
MIRT789626	hsa-miR-216a	CLIP-seq
MIRT789627	hsa-miR-216b	CLIP-seq
MIRT2173103	hsa-miR-3170	CLIP-seq
MIRT789683	hsa-miR-3179	CLIP-seq
MIRT789684	hsa-miR-3184	CLIP-seq
MIRT789686	hsa-miR-3202	CLIP-seq
MIRT2476303	hsa-miR-3647-3p	CLIP-seq
MIRT789689	hsa-miR-3689d	CLIP-seq
MIRT789690	hsa-miR-378	CLIP-seq
MIRT789691	hsa-miR-378b	CLIP-seq
MIRT789692	hsa-miR-378c	CLIP-seq
MIRT789693	hsa-miR-378d	CLIP-seq
MIRT789694	hsa-miR-378e	CLIP-seq
MIRT789695	hsa-miR-378f	CLIP-seq
MIRT789696	hsa-miR-378h	CLIP-seq
MIRT789697	hsa-miR-378i	CLIP-seq
MIRT2173108	hsa-miR-3920	CLIP-seq
MIRT2173109	hsa-miR-3922-5p	CLIP-seq
MIRT2173110	hsa-miR-3941	CLIP-seq
MIRT789699	hsa-miR-422a	CLIP-seq
MIRT789700	hsa-miR-423-5p	CLIP-seq
MIRT789701	hsa-miR-4259	CLIP-seq
MIRT789702	hsa-miR-4271	CLIP-seq
MIRT789641	hsa-miR-4438	CLIP-seq
MIRT2173115	hsa-miR-4457	CLIP-seq
MIRT789706	hsa-miR-4459	CLIP-seq
MIRT2173116	hsa-miR-4461	CLIP-seq
MIRT789644	hsa-miR-448	CLIP-seq
MIRT789708	hsa-miR-4533	CLIP-seq
MIRT789709	hsa-miR-4638-3p	CLIP-seq
MIRT789710	hsa-miR-4651	CLIP-seq
MIRT2173118	hsa-miR-466	CLIP-seq
MIRT2173119	hsa-miR-4666-3p	CLIP-seq
MIRT2173120	hsa-miR-4672	CLIP-seq
MIRT789714	hsa-miR-4710	CLIP-seq
MIRT789715	hsa-miR-4715-5p	CLIP-seq
MIRT789716	hsa-miR-4725-3p	CLIP-seq
MIRT789665	hsa-miR-4729	CLIP-seq
MIRT2173121	hsa-miR-4731-3p	CLIP-seq
MIRT2173124	hsa-miR-4762-3p	CLIP-seq
MIRT2476304	hsa-miR-4775	CLIP-seq
MIRT789720	hsa-miR-4779	CLIP-seq
MIRT789666	hsa-miR-4795-3p	CLIP-seq
MIRT2173125	hsa-miR-4795-5p	CLIP-seq
MIRT2173126	hsa-miR-4801	CLIP-seq
MIRT789656	hsa-miR-4803	CLIP-seq
MIRT789723	hsa-miR-499-3p	CLIP-seq
MIRT789724	hsa-miR-499a-3p	CLIP-seq
MIRT789659	hsa-miR-5095	CLIP-seq
MIRT2173128	hsa-miR-513b	CLIP-seq
MIRT789726	hsa-miR-519e	CLIP-seq
MIRT789729	hsa-miR-542-3p	CLIP-seq
MIRT2173132	hsa-miR-592	CLIP-seq
MIRT789660	hsa-miR-596	CLIP-seq
MIRT2173133	hsa-miR-597	CLIP-seq
MIRT789734	hsa-miR-608	CLIP-seq
MIRT789735	hsa-miR-765	CLIP-seq
MIRT789737	hsa-miR-887	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	NAS	7702756
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IDA	25301953
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	8855266, 9461550, 16193067, 20195357, 20936779, 21293490, 26948053, 32814053, 33961781, 34446781, 37207277
GO:0005634	Component	Nucleus	IDA	7702756
GO:0005634	Component	Nucleus	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	8220435
GO:0007409	Process	Axonogenesis	IBA
GO:0007417	Process	Central nervous system development	IBA
GO:0008201	Function	Heparin binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	8485127
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0031091	Component	Platelet alpha granule	IEA
GO:0031092	Component	Platelet alpha granule membrane	TAS
GO:0042802	Function	Identical protein binding	IPI	16193067
GO:0046872	Function	Metal ion binding	IEA
GO:0046914	Function	Transition metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

MIM	HGNC	e!Ensembl
104776	598	ENSG00000084234

Q06481

Protein name

Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II)

Protein function

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin

PDB

5JBT , 5TPT , 8RQ6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02177	APP_N	49 → 147	Amyloid A4 N-terminal heparin-binding	Domain
PF12924	APP_Cu_bd	148 → 204	Copper-binding of amyloid precursor, CuBD	Domain
PF00014	Kunitz_BPTI	309 → 361	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
PF12925	APP_E2	365 → 547	E2 domain of amyloid precursor protein	Domain
PF10515	APP_amyloid	709 → 759	Beta-amyloid precursor protein C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

Sequence

MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD
VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ
YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI

Sequence length

763

Interactions

View interactions

	Reactome
			Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (38)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	14970211, 8863657, 9729270	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer disease, familial, type 3	Alzheimer disease	BEFREE	16645641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	20732423, 29663738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	22351750	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	38148084	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carotid Artery Thrombosis	Carotid Artery Thrombosis	BEFREE	19403832		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Thrombosis	Cerebral Thrombosis	BEFREE	19403832		★★★★★ ★☆☆☆☆ Found in Text Mining only
Clear-cell metastatic renal cell carcinoma	Renal Carcinoma	BEFREE	30655794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30655794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	32716039	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Follicular thyroid carcinoma	Follicular Thyroid Carcinoma	BEFREE	27796194		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29663738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	29663738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29663738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29663738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	29663738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperopia	Hyperopia	BEFREE	26313004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	23122428	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intestinal Neoplasms	Intestinal neoplasm	Pubtator	35796776	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	25576918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23122428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	22797723, 25576918, 30700038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30608876, 30655794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	CTD_human_DG	16214533		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myopia	Myopia	BEFREE	26313004, 27232389		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25576918, 26840089, 27796194, 29663738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	11501497, 16150056	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	16279945, 9121703		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	36875133	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	31653214		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	22797723, 25576918, 30700038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	BEFREE	25576918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	22797723, 30810435	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30655794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	23792571	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxia Type 7	Spinocerebellar Ataxia	BEFREE	20732423		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombasthenia	Thrombasthenia	Pubtator	40239810	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis of cerebral veins	Thrombosis	BEFREE	19403832		★★★★★ ★☆☆☆☆ Found in Text Mining only

APLP2 (amyloid beta precursor like protein 2)