IGSF3 (immunoglobulin superfamily member 3)

Gene

• Entrez ID: 3321
• Gene name: Immunoglobulin superfamily member 3
• Gene symbol: IGSF3
• Synonyms (NCBI Gene): EWI-3, LCDD, V8
• Chromosome: 1
• Chromosome location: 1p13.1
• Summary: The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs724160030	G>-	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025690	hsa-miR-7-5p	Microarray	19073608
MIRT027022	hsa-miR-103a-3p	Sequencing	20371350
MIRT029114	hsa-miR-26b-5p	Microarray	19088304
MIRT032291	hsa-let-7b-5p	Proteomics	18668040
MIRT043984	hsa-miR-378a-5p	CLASH	23622248
MIRT039143	hsa-miR-769-5p	CLASH	23622248
MIRT036548	hsa-miR-1224-3p	CLASH	23622248
MIRT502189	hsa-miR-107	PAR-CLIP	20371350
MIRT027022	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT502188	hsa-miR-3646	PAR-CLIP	20371350
MIRT502187	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT502186	hsa-miR-34a-3p	PAR-CLIP	20371350
MIRT502185	hsa-miR-8066	PAR-CLIP	20371350
MIRT502184	hsa-miR-6800-3p	PAR-CLIP	20371350
MIRT502183	hsa-miR-3617-3p	PAR-CLIP	20371350
MIRT502182	hsa-miR-4310	PAR-CLIP	20371350
MIRT502181	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT502180	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT502189	hsa-miR-107	PAR-CLIP	20371350
MIRT027022	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT502188	hsa-miR-3646	PAR-CLIP	20371350
MIRT502187	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT502186	hsa-miR-34a-3p	PAR-CLIP	20371350
MIRT502185	hsa-miR-8066	PAR-CLIP	20371350
MIRT502184	hsa-miR-6800-3p	PAR-CLIP	20371350
MIRT502183	hsa-miR-3617-3p	PAR-CLIP	20371350
MIRT502182	hsa-miR-4310	PAR-CLIP	20371350
MIRT502181	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT567157	hsa-miR-486-5p	PAR-CLIP	20371350
MIRT502180	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT502189	hsa-miR-107	PAR-CLIP	24398324
MIRT027022	hsa-miR-103a-3p	PAR-CLIP	24398324
MIRT502188	hsa-miR-3646	PAR-CLIP	24398324
MIRT502187	hsa-miR-1252-3p	PAR-CLIP	24398324
MIRT502186	hsa-miR-34a-3p	PAR-CLIP	24398324
MIRT502185	hsa-miR-8066	PAR-CLIP	24398324
MIRT502184	hsa-miR-6800-3p	PAR-CLIP	24398324
MIRT502183	hsa-miR-3617-3p	PAR-CLIP	24398324
MIRT502182	hsa-miR-4310	PAR-CLIP	24398324
MIRT502181	hsa-miR-7157-5p	PAR-CLIP	24398324
MIRT502180	hsa-miR-580-3p	PAR-CLIP	24398324
MIRT495086	hsa-miR-6165	PAR-CLIP	23708386
MIRT495087	hsa-miR-4690-5p	PAR-CLIP	23708386
MIRT495085	hsa-miR-6510-5p	PAR-CLIP	23708386
MIRT495084	hsa-miR-1972	PAR-CLIP	23708386
MIRT495083	hsa-miR-2114-3p	PAR-CLIP	23708386
MIRT495082	hsa-miR-6823-3p	PAR-CLIP	23708386
MIRT495081	hsa-miR-6807-5p	PAR-CLIP	23708386
MIRT502189	hsa-miR-107	PAR-CLIP	20371350
MIRT027022	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT502188	hsa-miR-3646	PAR-CLIP	20371350
MIRT502187	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT502186	hsa-miR-34a-3p	PAR-CLIP	20371350
MIRT502185	hsa-miR-8066	PAR-CLIP	20371350
MIRT502184	hsa-miR-6800-3p	PAR-CLIP	20371350
MIRT502183	hsa-miR-3617-3p	PAR-CLIP	20371350
MIRT502182	hsa-miR-4310	PAR-CLIP	20371350
MIRT502181	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT502180	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT502189	hsa-miR-107	PAR-CLIP	20371350
MIRT027022	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT502188	hsa-miR-3646	PAR-CLIP	20371350
MIRT502187	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT502186	hsa-miR-34a-3p	PAR-CLIP	20371350
MIRT502185	hsa-miR-8066	PAR-CLIP	20371350
MIRT502184	hsa-miR-6800-3p	PAR-CLIP	20371350
MIRT502183	hsa-miR-3617-3p	PAR-CLIP	20371350
MIRT502182	hsa-miR-4310	PAR-CLIP	20371350
MIRT502181	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT567157	hsa-miR-486-5p	PAR-CLIP	20371350
MIRT502180	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT502189	hsa-miR-107	PAR-CLIP	24398324
MIRT027022	hsa-miR-103a-3p	PAR-CLIP	24398324
MIRT502188	hsa-miR-3646	PAR-CLIP	24398324
MIRT502187	hsa-miR-1252-3p	PAR-CLIP	24398324
MIRT502186	hsa-miR-34a-3p	PAR-CLIP	24398324
MIRT502185	hsa-miR-8066	PAR-CLIP	24398324
MIRT502184	hsa-miR-6800-3p	PAR-CLIP	24398324
MIRT502183	hsa-miR-3617-3p	PAR-CLIP	24398324
MIRT502182	hsa-miR-4310	PAR-CLIP	24398324
MIRT502181	hsa-miR-7157-5p	PAR-CLIP	24398324
MIRT502180	hsa-miR-580-3p	PAR-CLIP	24398324
MIRT495086	hsa-miR-6165	PAR-CLIP	23708386
MIRT495087	hsa-miR-4690-5p	PAR-CLIP	23708386
MIRT495085	hsa-miR-6510-5p	PAR-CLIP	23708386
MIRT495084	hsa-miR-1972	PAR-CLIP	23708386
MIRT495083	hsa-miR-2114-3p	PAR-CLIP	23708386
MIRT495082	hsa-miR-6823-3p	PAR-CLIP	23708386
MIRT495081	hsa-miR-6807-5p	PAR-CLIP	23708386
MIRT1062576	hsa-miR-103a	CLIP-seq
MIRT1062577	hsa-miR-1238	CLIP-seq
MIRT1062578	hsa-miR-1286	CLIP-seq
MIRT1062579	hsa-miR-18a	CLIP-seq
MIRT1062580	hsa-miR-18b	CLIP-seq
MIRT1062581	hsa-miR-214	CLIP-seq
MIRT1062582	hsa-miR-3126-5p	CLIP-seq
MIRT1062583	hsa-miR-3159	CLIP-seq
MIRT1062584	hsa-miR-3170	CLIP-seq
MIRT1062585	hsa-miR-320a	CLIP-seq
MIRT1062586	hsa-miR-320b	CLIP-seq
MIRT1062587	hsa-miR-320c	CLIP-seq
MIRT1062588	hsa-miR-320d	CLIP-seq
MIRT1062589	hsa-miR-342-3p	CLIP-seq
MIRT1062590	hsa-miR-3619-5p	CLIP-seq
MIRT1062591	hsa-miR-3692	CLIP-seq
MIRT1062592	hsa-miR-3925-3p	CLIP-seq
MIRT1062593	hsa-miR-3978	CLIP-seq
MIRT1062594	hsa-miR-411	CLIP-seq
MIRT1062595	hsa-miR-4252	CLIP-seq
MIRT1062596	hsa-miR-4256	CLIP-seq
MIRT1062597	hsa-miR-4260	CLIP-seq
MIRT1062598	hsa-miR-4267	CLIP-seq
MIRT1062599	hsa-miR-4269	CLIP-seq
MIRT1062600	hsa-miR-4283	CLIP-seq
MIRT1062601	hsa-miR-4330	CLIP-seq
MIRT1062602	hsa-miR-4419a	CLIP-seq
MIRT1062603	hsa-miR-4429	CLIP-seq
MIRT1062604	hsa-miR-4489	CLIP-seq
MIRT1062605	hsa-miR-4506	CLIP-seq
MIRT1062606	hsa-miR-4510	CLIP-seq
MIRT1062607	hsa-miR-4514	CLIP-seq
MIRT1062608	hsa-miR-4537	CLIP-seq
MIRT1062609	hsa-miR-4643	CLIP-seq
MIRT1062610	hsa-miR-4668-5p	CLIP-seq
MIRT1062611	hsa-miR-4691-3p	CLIP-seq
MIRT1062612	hsa-miR-4692	CLIP-seq
MIRT1062613	hsa-miR-4712-5p	CLIP-seq
MIRT1062614	hsa-miR-4722-5p	CLIP-seq
MIRT1062615	hsa-miR-4735-3p	CLIP-seq
MIRT1062616	hsa-miR-4742-5p	CLIP-seq
MIRT1062617	hsa-miR-4764-3p	CLIP-seq
MIRT1062618	hsa-miR-4775	CLIP-seq
MIRT1062619	hsa-miR-491-3p	CLIP-seq
MIRT1062620	hsa-miR-501-3p	CLIP-seq
MIRT1062621	hsa-miR-502-3p	CLIP-seq
MIRT1062622	hsa-miR-508-5p	CLIP-seq
MIRT1062623	hsa-miR-520d-5p	CLIP-seq
MIRT1062624	hsa-miR-524-5p	CLIP-seq
MIRT1062625	hsa-miR-549	CLIP-seq
MIRT1062626	hsa-miR-580	CLIP-seq
MIRT1062627	hsa-miR-595	CLIP-seq
MIRT1062628	hsa-miR-600	CLIP-seq
MIRT1062629	hsa-miR-761	CLIP-seq
MIRT1062630	hsa-miR-766	CLIP-seq
MIRT1062631	hsa-miR-770-5p	CLIP-seq
MIRT1062632	hsa-miR-936	CLIP-seq
MIRT1062633	hsa-let-7a	CLIP-seq
MIRT1062634	hsa-let-7b	CLIP-seq
MIRT1062635	hsa-let-7c	CLIP-seq
MIRT1062636	hsa-let-7d	CLIP-seq
MIRT1062637	hsa-let-7e	CLIP-seq
MIRT1062638	hsa-let-7f	CLIP-seq
MIRT1062639	hsa-let-7g	CLIP-seq
MIRT1062640	hsa-let-7i	CLIP-seq
MIRT1062576	hsa-miR-103a	CLIP-seq
MIRT1062641	hsa-miR-1228	CLIP-seq
MIRT1062577	hsa-miR-1238	CLIP-seq
MIRT1062642	hsa-miR-1275	CLIP-seq
MIRT1062643	hsa-miR-128	CLIP-seq
MIRT1062644	hsa-miR-1291	CLIP-seq
MIRT1062645	hsa-miR-1292	CLIP-seq
MIRT1062646	hsa-miR-1297	CLIP-seq
MIRT1062647	hsa-miR-1305	CLIP-seq
MIRT1062648	hsa-miR-130a	CLIP-seq
MIRT1062649	hsa-miR-130b	CLIP-seq
MIRT1062650	hsa-miR-1321	CLIP-seq
MIRT1062579	hsa-miR-18a	CLIP-seq
MIRT1062580	hsa-miR-18b	CLIP-seq
MIRT1062651	hsa-miR-193a-3p	CLIP-seq
MIRT1062652	hsa-miR-193b	CLIP-seq
MIRT1062653	hsa-miR-200b	CLIP-seq
MIRT1062654	hsa-miR-200c	CLIP-seq
MIRT1062655	hsa-miR-2110	CLIP-seq
MIRT1062581	hsa-miR-214	CLIP-seq
MIRT1062656	hsa-miR-223	CLIP-seq
MIRT1062657	hsa-miR-26a	CLIP-seq
MIRT1062658	hsa-miR-26b	CLIP-seq
MIRT1062659	hsa-miR-301a	CLIP-seq
MIRT1062660	hsa-miR-301b	CLIP-seq
MIRT1062661	hsa-miR-3130-3p	CLIP-seq
MIRT1062662	hsa-miR-3145-3p	CLIP-seq
MIRT1062663	hsa-miR-3153	CLIP-seq
MIRT1062583	hsa-miR-3159	CLIP-seq
MIRT1062664	hsa-miR-3163	CLIP-seq
MIRT1062665	hsa-miR-3175	CLIP-seq
MIRT1062666	hsa-miR-3176	CLIP-seq
MIRT1062667	hsa-miR-323-5p	CLIP-seq
MIRT1062668	hsa-miR-331-3p	CLIP-seq
MIRT1062589	hsa-miR-342-3p	CLIP-seq
MIRT1062669	hsa-miR-34c-3p	CLIP-seq
MIRT1062670	hsa-miR-3591-3p	CLIP-seq
MIRT1062671	hsa-miR-3591-5p	CLIP-seq
MIRT1062672	hsa-miR-3613-5p	CLIP-seq
MIRT1062673	hsa-miR-3616-5p	CLIP-seq
MIRT1062674	hsa-miR-3617	CLIP-seq
MIRT1062590	hsa-miR-3619-5p	CLIP-seq
MIRT1062675	hsa-miR-3647-5p	CLIP-seq
MIRT1062676	hsa-miR-3660	CLIP-seq
MIRT1062677	hsa-miR-3662	CLIP-seq
MIRT1062678	hsa-miR-3666	CLIP-seq
MIRT1062679	hsa-miR-3674	CLIP-seq
MIRT1062591	hsa-miR-3692	CLIP-seq
MIRT1062680	hsa-miR-3714	CLIP-seq
MIRT1062681	hsa-miR-376c	CLIP-seq
MIRT1062682	hsa-miR-377	CLIP-seq
MIRT1062683	hsa-miR-3913-3p	CLIP-seq
MIRT1062684	hsa-miR-3919	CLIP-seq
MIRT1062685	hsa-miR-3921	CLIP-seq
MIRT1062686	hsa-miR-3922-3p	CLIP-seq
MIRT1062687	hsa-miR-3927	CLIP-seq
MIRT1062688	hsa-miR-3935	CLIP-seq
MIRT1062689	hsa-miR-410	CLIP-seq
MIRT1062690	hsa-miR-412	CLIP-seq
MIRT1062691	hsa-miR-4261	CLIP-seq
MIRT1062599	hsa-miR-4269	CLIP-seq
MIRT1062692	hsa-miR-4270	CLIP-seq
MIRT1062693	hsa-miR-4271	CLIP-seq
MIRT1062694	hsa-miR-4280	CLIP-seq
MIRT1062695	hsa-miR-429	CLIP-seq
MIRT1062696	hsa-miR-4295	CLIP-seq
MIRT1062697	hsa-miR-4307	CLIP-seq
MIRT1062698	hsa-miR-4308	CLIP-seq
MIRT1062699	hsa-miR-4441	CLIP-seq
MIRT1062700	hsa-miR-4458	CLIP-seq
MIRT1062701	hsa-miR-4459	CLIP-seq
MIRT1062702	hsa-miR-4465	CLIP-seq
MIRT1062703	hsa-miR-4471	CLIP-seq
MIRT1062704	hsa-miR-4473	CLIP-seq
MIRT1062705	hsa-miR-4477a	CLIP-seq
MIRT1062706	hsa-miR-4500	CLIP-seq
MIRT1062707	hsa-miR-4511	CLIP-seq
MIRT1062607	hsa-miR-4514	CLIP-seq
MIRT1062708	hsa-miR-4525	CLIP-seq
MIRT1062709	hsa-miR-4526	CLIP-seq
MIRT1062608	hsa-miR-4537	CLIP-seq
MIRT1062710	hsa-miR-454	CLIP-seq
MIRT1062711	hsa-miR-4639-3p	CLIP-seq
MIRT1062609	hsa-miR-4643	CLIP-seq
MIRT1062712	hsa-miR-4646-5p	CLIP-seq
MIRT1062713	hsa-miR-4653-5p	CLIP-seq
MIRT1062714	hsa-miR-4665-5p	CLIP-seq
MIRT1062715	hsa-miR-4667-5p	CLIP-seq
MIRT1062610	hsa-miR-4668-5p	CLIP-seq
MIRT1062716	hsa-miR-4671-3p	CLIP-seq
MIRT1062717	hsa-miR-4672	CLIP-seq
MIRT1062718	hsa-miR-4685-5p	CLIP-seq
MIRT1062612	hsa-miR-4692	CLIP-seq
MIRT1062719	hsa-miR-4697-3p	CLIP-seq
MIRT1062720	hsa-miR-4699-3p	CLIP-seq
MIRT1062721	hsa-miR-4700-5p	CLIP-seq
MIRT1062722	hsa-miR-4703-3p	CLIP-seq
MIRT1062723	hsa-miR-4723-5p	CLIP-seq
MIRT1062724	hsa-miR-4725-3p	CLIP-seq
MIRT1062725	hsa-miR-4733-3p	CLIP-seq
MIRT1062615	hsa-miR-4735-3p	CLIP-seq
MIRT1062726	hsa-miR-4739	CLIP-seq
MIRT1062616	hsa-miR-4742-5p	CLIP-seq
MIRT1062727	hsa-miR-4756-5p	CLIP-seq
MIRT1062728	hsa-miR-4757-5p	CLIP-seq
MIRT1062729	hsa-miR-4763-5p	CLIP-seq
MIRT1062730	hsa-miR-4768-5p	CLIP-seq
MIRT1062731	hsa-miR-4779	CLIP-seq
MIRT1062732	hsa-miR-4787-3p	CLIP-seq
MIRT1062733	hsa-miR-4793-3p	CLIP-seq
MIRT1062734	hsa-miR-4795-5p	CLIP-seq
MIRT1062735	hsa-miR-4803	CLIP-seq
MIRT1062736	hsa-miR-498	CLIP-seq
MIRT1062737	hsa-miR-499-3p	CLIP-seq
MIRT1062738	hsa-miR-499a-3p	CLIP-seq
MIRT1062620	hsa-miR-501-3p	CLIP-seq
MIRT1062621	hsa-miR-502-3p	CLIP-seq
MIRT1062739	hsa-miR-513a-5p	CLIP-seq
MIRT1062740	hsa-miR-515-5p	CLIP-seq
MIRT1062623	hsa-miR-520d-5p	CLIP-seq
MIRT1062624	hsa-miR-524-5p	CLIP-seq
MIRT1062741	hsa-miR-539	CLIP-seq
MIRT1062742	hsa-miR-548ac	CLIP-seq
MIRT1062743	hsa-miR-548an	CLIP-seq
MIRT1062744	hsa-miR-548b-3p	CLIP-seq
MIRT1062745	hsa-miR-548d-3p	CLIP-seq
MIRT1062746	hsa-miR-548z	CLIP-seq
MIRT1062625	hsa-miR-549	CLIP-seq
MIRT1062747	hsa-miR-550a	CLIP-seq
MIRT1062748	hsa-miR-552	CLIP-seq
MIRT1062749	hsa-miR-573	CLIP-seq
MIRT1062626	hsa-miR-580	CLIP-seq
MIRT1062750	hsa-miR-593	CLIP-seq
MIRT1062628	hsa-miR-600	CLIP-seq
MIRT1062751	hsa-miR-603	CLIP-seq
MIRT1062752	hsa-miR-622	CLIP-seq
MIRT1062753	hsa-miR-625	CLIP-seq
MIRT1062754	hsa-miR-626	CLIP-seq
MIRT1062755	hsa-miR-641	CLIP-seq
MIRT1062756	hsa-miR-661	CLIP-seq
MIRT1062757	hsa-miR-7	CLIP-seq
MIRT1062629	hsa-miR-761	CLIP-seq
MIRT1062758	hsa-miR-767-3p	CLIP-seq
MIRT1062759	hsa-miR-875-3p	CLIP-seq
MIRT1062760	hsa-miR-876-3p	CLIP-seq
MIRT1062761	hsa-miR-890	CLIP-seq
MIRT1062762	hsa-miR-892b	CLIP-seq
MIRT1062763	hsa-miR-940	CLIP-seq
MIRT1062764	hsa-miR-944	CLIP-seq
MIRT1062765	hsa-miR-98	CLIP-seq
MIRT1062596	hsa-miR-4256	CLIP-seq
MIRT1062597	hsa-miR-4260	CLIP-seq
MIRT1062600	hsa-miR-4283	CLIP-seq
MIRT1062604	hsa-miR-4489	CLIP-seq
MIRT1062740	hsa-miR-515-5p	CLIP-seq
MIRT1550093	hsa-miR-660	CLIP-seq
MIRT1062633	hsa-let-7a	CLIP-seq
MIRT1062634	hsa-let-7b	CLIP-seq
MIRT1062635	hsa-let-7c	CLIP-seq
MIRT1062636	hsa-let-7d	CLIP-seq
MIRT1062637	hsa-let-7e	CLIP-seq
MIRT1062638	hsa-let-7f	CLIP-seq
MIRT1062639	hsa-let-7g	CLIP-seq
MIRT1062640	hsa-let-7i	CLIP-seq
MIRT1062576	hsa-miR-103a	CLIP-seq
MIRT2014762	hsa-miR-1207-5p	CLIP-seq
MIRT2014763	hsa-miR-1226	CLIP-seq
MIRT1062641	hsa-miR-1228	CLIP-seq
MIRT1062577	hsa-miR-1238	CLIP-seq
MIRT2014764	hsa-miR-1249	CLIP-seq
MIRT2014765	hsa-miR-1251	CLIP-seq
MIRT1062643	hsa-miR-128	CLIP-seq
MIRT1062644	hsa-miR-1291	CLIP-seq
MIRT2014766	hsa-miR-129-5p	CLIP-seq
MIRT1062650	hsa-miR-1321	CLIP-seq
MIRT1062581	hsa-miR-214	CLIP-seq
MIRT1062656	hsa-miR-223	CLIP-seq
MIRT2014767	hsa-miR-2681	CLIP-seq
MIRT2014768	hsa-miR-3119	CLIP-seq
MIRT1062662	hsa-miR-3145-3p	CLIP-seq
MIRT2014769	hsa-miR-3158-5p	CLIP-seq
MIRT1062670	hsa-miR-3591-3p	CLIP-seq
MIRT1062672	hsa-miR-3613-5p	CLIP-seq
MIRT1062590	hsa-miR-3619-5p	CLIP-seq
MIRT2014770	hsa-miR-3665	CLIP-seq
MIRT2014771	hsa-miR-3667-3p	CLIP-seq
MIRT1062679	hsa-miR-3674	CLIP-seq
MIRT2014772	hsa-miR-3675-5p	CLIP-seq
MIRT1062681	hsa-miR-376c	CLIP-seq
MIRT1062682	hsa-miR-377	CLIP-seq
MIRT1062684	hsa-miR-3919	CLIP-seq
MIRT1062687	hsa-miR-3927	CLIP-seq
MIRT1062688	hsa-miR-3935	CLIP-seq
MIRT1062690	hsa-miR-412	CLIP-seq
MIRT2014773	hsa-miR-421	CLIP-seq
MIRT1062691	hsa-miR-4261	CLIP-seq
MIRT1062692	hsa-miR-4270	CLIP-seq
MIRT1062600	hsa-miR-4283	CLIP-seq
MIRT2014774	hsa-miR-4291	CLIP-seq
MIRT1062698	hsa-miR-4308	CLIP-seq
MIRT2014775	hsa-miR-4328	CLIP-seq
MIRT2014776	hsa-miR-4329	CLIP-seq
MIRT2014777	hsa-miR-4437	CLIP-seq
MIRT1062699	hsa-miR-4441	CLIP-seq
MIRT1062700	hsa-miR-4458	CLIP-seq
MIRT1062604	hsa-miR-4489	CLIP-seq
MIRT1062706	hsa-miR-4500	CLIP-seq
MIRT2014778	hsa-miR-4523	CLIP-seq
MIRT2014779	hsa-miR-4684-5p	CLIP-seq
MIRT1062718	hsa-miR-4685-5p	CLIP-seq
MIRT2014780	hsa-miR-4691-5p	CLIP-seq
MIRT1062719	hsa-miR-4697-3p	CLIP-seq
MIRT1062722	hsa-miR-4703-3p	CLIP-seq
MIRT2014781	hsa-miR-4709-5p	CLIP-seq
MIRT2014782	hsa-miR-4732-3p	CLIP-seq
MIRT1062725	hsa-miR-4733-3p	CLIP-seq
MIRT2014783	hsa-miR-4736	CLIP-seq
MIRT1062726	hsa-miR-4739	CLIP-seq
MIRT1062727	hsa-miR-4756-5p	CLIP-seq
MIRT2014784	hsa-miR-4763-3p	CLIP-seq
MIRT2014785	hsa-miR-496	CLIP-seq
MIRT1062737	hsa-miR-499-3p	CLIP-seq
MIRT1062738	hsa-miR-499a-3p	CLIP-seq
MIRT2014786	hsa-miR-514	CLIP-seq
MIRT2014787	hsa-miR-514b-3p	CLIP-seq
MIRT2014788	hsa-miR-520a-5p	CLIP-seq
MIRT2014789	hsa-miR-525-5p	CLIP-seq
MIRT2014790	hsa-miR-548a-5p	CLIP-seq
MIRT2014791	hsa-miR-548ab	CLIP-seq
MIRT1062742	hsa-miR-548ac	CLIP-seq
MIRT2014792	hsa-miR-548ak	CLIP-seq
MIRT2014793	hsa-miR-548b-5p	CLIP-seq
MIRT2014794	hsa-miR-548c-5p	CLIP-seq
MIRT1062745	hsa-miR-548d-3p	CLIP-seq
MIRT2014795	hsa-miR-548d-5p	CLIP-seq
MIRT2014796	hsa-miR-548h	CLIP-seq
MIRT2014797	hsa-miR-548i	CLIP-seq
MIRT2014798	hsa-miR-548j	CLIP-seq
MIRT2014799	hsa-miR-548w	CLIP-seq
MIRT2014800	hsa-miR-548y	CLIP-seq
MIRT1062746	hsa-miR-548z	CLIP-seq
MIRT2014801	hsa-miR-554	CLIP-seq
MIRT2014802	hsa-miR-559	CLIP-seq
MIRT1062626	hsa-miR-580	CLIP-seq
MIRT1062754	hsa-miR-626	CLIP-seq
MIRT2014803	hsa-miR-657	CLIP-seq
MIRT2014804	hsa-miR-668	CLIP-seq
MIRT1062629	hsa-miR-761	CLIP-seq
MIRT2014805	hsa-miR-767-5p	CLIP-seq
MIRT1062759	hsa-miR-875-3p	CLIP-seq
MIRT1062762	hsa-miR-892b	CLIP-seq
MIRT2014806	hsa-miR-922	CLIP-seq
MIRT1062765	hsa-miR-98	CLIP-seq
MIRT2014807	hsa-miR-1271	CLIP-seq
MIRT2014766	hsa-miR-129-5p	CLIP-seq
MIRT2014808	hsa-miR-3941	CLIP-seq
MIRT2014809	hsa-miR-96	CLIP-seq
MIRT1062633	hsa-let-7a	CLIP-seq
MIRT1062634	hsa-let-7b	CLIP-seq
MIRT1062635	hsa-let-7c	CLIP-seq
MIRT1062636	hsa-let-7d	CLIP-seq
MIRT1062637	hsa-let-7e	CLIP-seq
MIRT1062638	hsa-let-7f	CLIP-seq
MIRT1062639	hsa-let-7g	CLIP-seq
MIRT1062640	hsa-let-7i	CLIP-seq
MIRT1062576	hsa-miR-103a	CLIP-seq
MIRT2014762	hsa-miR-1207-5p	CLIP-seq
MIRT2014763	hsa-miR-1226	CLIP-seq
MIRT1062641	hsa-miR-1228	CLIP-seq
MIRT1062577	hsa-miR-1238	CLIP-seq
MIRT2014764	hsa-miR-1249	CLIP-seq
MIRT2247056	hsa-miR-1269	CLIP-seq
MIRT2247057	hsa-miR-1269b	CLIP-seq
MIRT1062643	hsa-miR-128	CLIP-seq
MIRT2247058	hsa-miR-1283	CLIP-seq
MIRT2247059	hsa-miR-1288	CLIP-seq
MIRT1062646	hsa-miR-1297	CLIP-seq
MIRT1062647	hsa-miR-1305	CLIP-seq
MIRT1062650	hsa-miR-1321	CLIP-seq
MIRT2247060	hsa-miR-140-5p	CLIP-seq
MIRT2247061	hsa-miR-147	CLIP-seq
MIRT2247062	hsa-miR-148a	CLIP-seq
MIRT2247063	hsa-miR-148b	CLIP-seq
MIRT2247064	hsa-miR-152	CLIP-seq
MIRT2247065	hsa-miR-2114	CLIP-seq
MIRT1062581	hsa-miR-214	CLIP-seq
MIRT1062656	hsa-miR-223	CLIP-seq
MIRT2014767	hsa-miR-2681	CLIP-seq
MIRT1062657	hsa-miR-26a	CLIP-seq
MIRT1062658	hsa-miR-26b	CLIP-seq
MIRT2247066	hsa-miR-302f	CLIP-seq
MIRT2247067	hsa-miR-3065-3p	CLIP-seq
MIRT1062582	hsa-miR-3126-5p	CLIP-seq
MIRT2247068	hsa-miR-3128	CLIP-seq
MIRT1062661	hsa-miR-3130-3p	CLIP-seq
MIRT1062662	hsa-miR-3145-3p	CLIP-seq
MIRT2247069	hsa-miR-3160-5p	CLIP-seq
MIRT1062585	hsa-miR-320a	CLIP-seq
MIRT1062586	hsa-miR-320b	CLIP-seq
MIRT1062587	hsa-miR-320c	CLIP-seq
MIRT1062588	hsa-miR-320d	CLIP-seq
MIRT2247070	hsa-miR-323b-3p	CLIP-seq
MIRT1062589	hsa-miR-342-3p	CLIP-seq
MIRT1062670	hsa-miR-3591-3p	CLIP-seq
MIRT1062672	hsa-miR-3613-5p	CLIP-seq
MIRT2247071	hsa-miR-361-3p	CLIP-seq
MIRT2247072	hsa-miR-3616-3p	CLIP-seq
MIRT1062590	hsa-miR-3619-5p	CLIP-seq
MIRT2247073	hsa-miR-3654	CLIP-seq
MIRT1062676	hsa-miR-3660	CLIP-seq
MIRT2014771	hsa-miR-3667-3p	CLIP-seq
MIRT2247074	hsa-miR-3671	CLIP-seq
MIRT2247075	hsa-miR-3672	CLIP-seq
MIRT2247076	hsa-miR-3682-5p	CLIP-seq
MIRT2247077	hsa-miR-3685	CLIP-seq
MIRT2247078	hsa-miR-3691-3p	CLIP-seq
MIRT1062591	hsa-miR-3692	CLIP-seq
MIRT1062682	hsa-miR-377	CLIP-seq
MIRT2247079	hsa-miR-378	CLIP-seq
MIRT2247080	hsa-miR-378b	CLIP-seq
MIRT2247081	hsa-miR-378c	CLIP-seq
MIRT2247082	hsa-miR-378d	CLIP-seq
MIRT2247083	hsa-miR-378e	CLIP-seq
MIRT2247084	hsa-miR-378f	CLIP-seq
MIRT2247085	hsa-miR-378h	CLIP-seq
MIRT2247086	hsa-miR-378i	CLIP-seq
MIRT2247087	hsa-miR-384	CLIP-seq
MIRT1062683	hsa-miR-3913-3p	CLIP-seq
MIRT1062685	hsa-miR-3921	CLIP-seq
MIRT1062592	hsa-miR-3925-3p	CLIP-seq
MIRT1062687	hsa-miR-3927	CLIP-seq
MIRT1062688	hsa-miR-3935	CLIP-seq
MIRT2014808	hsa-miR-3941	CLIP-seq
MIRT2247088	hsa-miR-3944-5p	CLIP-seq
MIRT1062594	hsa-miR-411	CLIP-seq
MIRT2247089	hsa-miR-422a	CLIP-seq
MIRT1062595	hsa-miR-4252	CLIP-seq
MIRT1062598	hsa-miR-4267	CLIP-seq
MIRT1062692	hsa-miR-4270	CLIP-seq
MIRT2247090	hsa-miR-4276	CLIP-seq
MIRT1062600	hsa-miR-4283	CLIP-seq
MIRT2014774	hsa-miR-4291	CLIP-seq
MIRT2014775	hsa-miR-4328	CLIP-seq
MIRT1062601	hsa-miR-4330	CLIP-seq
MIRT1062602	hsa-miR-4419a	CLIP-seq
MIRT2247091	hsa-miR-4420	CLIP-seq
MIRT1062603	hsa-miR-4429	CLIP-seq
MIRT1062699	hsa-miR-4441	CLIP-seq
MIRT1062700	hsa-miR-4458	CLIP-seq
MIRT1062702	hsa-miR-4465	CLIP-seq
MIRT1062604	hsa-miR-4489	CLIP-seq
MIRT1062706	hsa-miR-4500	CLIP-seq
MIRT1062606	hsa-miR-4510	CLIP-seq
MIRT2247092	hsa-miR-4515	CLIP-seq
MIRT1062709	hsa-miR-4526	CLIP-seq
MIRT2247093	hsa-miR-4638-3p	CLIP-seq
MIRT1062711	hsa-miR-4639-3p	CLIP-seq
MIRT1062609	hsa-miR-4643	CLIP-seq
MIRT1062713	hsa-miR-4653-5p	CLIP-seq
MIRT2247094	hsa-miR-466	CLIP-seq
MIRT1062610	hsa-miR-4668-5p	CLIP-seq
MIRT1062718	hsa-miR-4685-5p	CLIP-seq
MIRT2247095	hsa-miR-4690-3p	CLIP-seq
MIRT1062611	hsa-miR-4691-3p	CLIP-seq
MIRT2014780	hsa-miR-4691-5p	CLIP-seq
MIRT1062719	hsa-miR-4697-3p	CLIP-seq
MIRT1062613	hsa-miR-4712-5p	CLIP-seq
MIRT2247096	hsa-miR-4720-5p	CLIP-seq
MIRT1062725	hsa-miR-4733-3p	CLIP-seq
MIRT2014783	hsa-miR-4736	CLIP-seq
MIRT2247097	hsa-miR-4738-5p	CLIP-seq
MIRT1062726	hsa-miR-4739	CLIP-seq
MIRT2247098	hsa-miR-4740-5p	CLIP-seq
MIRT1062727	hsa-miR-4756-5p	CLIP-seq
MIRT2014784	hsa-miR-4763-3p	CLIP-seq
MIRT1062617	hsa-miR-4764-3p	CLIP-seq
MIRT1062730	hsa-miR-4768-5p	CLIP-seq
MIRT2247099	hsa-miR-4773	CLIP-seq
MIRT2247100	hsa-miR-4789-3p	CLIP-seq
MIRT1062733	hsa-miR-4793-3p	CLIP-seq
MIRT2247101	hsa-miR-4796-3p	CLIP-seq
MIRT2247102	hsa-miR-4799-3p	CLIP-seq
MIRT2247103	hsa-miR-489	CLIP-seq
MIRT1062736	hsa-miR-498	CLIP-seq
MIRT1062622	hsa-miR-508-5p	CLIP-seq
MIRT2247104	hsa-miR-513a-3p	CLIP-seq
MIRT1062740	hsa-miR-515-5p	CLIP-seq
MIRT2014788	hsa-miR-520a-5p	CLIP-seq
MIRT1062623	hsa-miR-520d-5p	CLIP-seq
MIRT2247105	hsa-miR-520f	CLIP-seq
MIRT2247106	hsa-miR-520g	CLIP-seq
MIRT2247107	hsa-miR-520h	CLIP-seq
MIRT1062624	hsa-miR-524-5p	CLIP-seq
MIRT2014789	hsa-miR-525-5p	CLIP-seq
MIRT1062741	hsa-miR-539	CLIP-seq
MIRT2247108	hsa-miR-545	CLIP-seq
MIRT2247109	hsa-miR-548l	CLIP-seq
MIRT2247110	hsa-miR-548p	CLIP-seq
MIRT1062625	hsa-miR-549	CLIP-seq
MIRT2014801	hsa-miR-554	CLIP-seq
MIRT2247111	hsa-miR-587	CLIP-seq
MIRT2247112	hsa-miR-599	CLIP-seq
MIRT1062751	hsa-miR-603	CLIP-seq
MIRT2247113	hsa-miR-607	CLIP-seq
MIRT1062752	hsa-miR-622	CLIP-seq
MIRT1062754	hsa-miR-626	CLIP-seq
MIRT2247114	hsa-miR-646	CLIP-seq
MIRT1550093	hsa-miR-660	CLIP-seq
MIRT1062629	hsa-miR-761	CLIP-seq
MIRT1062630	hsa-miR-766	CLIP-seq
MIRT1062758	hsa-miR-767-3p	CLIP-seq
MIRT2014805	hsa-miR-767-5p	CLIP-seq
MIRT1062631	hsa-miR-770-5p	CLIP-seq
MIRT2247115	hsa-miR-885-5p	CLIP-seq
MIRT2014806	hsa-miR-922	CLIP-seq
MIRT1062632	hsa-miR-936	CLIP-seq
MIRT1062765	hsa-miR-98	CLIP-seq
MIRT1062591	hsa-miR-3692	CLIP-seq
MIRT1062609	hsa-miR-4643	CLIP-seq
MIRT1062625	hsa-miR-549	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0009986	Component	Cell surface	HDA	19581412
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0032808	Process	Lacrimal gland development	IMP	24372406

Other IDs

• MIM: 603491
• HGNC: 5950
• e!Ensembl: ENSG00000143061

Protein

• UniProt ID: O75054
• Protein name: Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	26 → 141	Immunoglobulin V-set domain	Domain
  PF07686	V-set	150 → 264	Immunoglobulin V-set domain	Domain
  PF07686	V-set	684 → 809	Immunoglobulin V-set domain	Domain
  PF07686	V-set	821 → 946	Immunoglobulin V-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in a wide range of tissues with High expression in Placenta, kidney and lung. {ECO:0000269|PubMed:9790749}.
• Sequence:

  MKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPSEQNFQWSIY
  LPSSPEREVQIVSTMDSSFPYAIYTQRVRGGKIFIERVQGNSTLLHITDLQARDAGEYEC
  HTPSTDKQYFGSYSAKMNLVVIPDSLQTTAMPQTLHRVEQDPLELTCEVASETIQHSHLS
  VAWLRQKVGEKPVEVISLSRDFMLHSSSEYAQRQSLGEVRLDKLGRTTFRLTIFHLQPSD
  QGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETEKRLHTVGEPVEF
  RCILEAQNVPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREARGQLKVAKESDSVFV
  LKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIIVLPLKSSISVEVASNAS
  VILEGEDLRFSCSVRTAGRPQGRFSVIWQLVDRQNRRSNIMWLDRDGTVQPGSSYWERSS
  FGGVQMEQVQPNSFSLGIFNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTPISITA
  LEMGFAVTAISRTPGVTYSDSFDLQCIIKPHYPAWVPVSVTWRFQPVGTVEFHDLVTFTR
  DGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRKNYNNTWTR
  LAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENKPIQLNCSVKSQTSQNSHFAVLWYVH
  KPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHVSGGLFSLTVQRAEVSDSGSY
  YCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLRLSQAQGNLSVLETRQVQLECVV
  LNRTSITSQLMVEWFVWKPNHPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGV
  YRLFIQNVAVQDSGTYSCHVEEWLPSPSGMWYKRAEDTAGQTALTVMRPDASLQVDTVVP
  NATVSEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRSSPGLEEQEEEREEEEEED
  DDDDDDPTERTALLSVGPDAVFGPEGSPWEGRLRFQRLSPVLYRLTVLQASPQDTGNYSC
  HVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSPTLQSIICSNDALFYFVFFYPFPIFGIL
  IITILLVRFKSRNSSKNSDGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID

• Sequence length: 1194

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Familial congenital nasolacrimal duct obstruction	Pathogenic; Likely pathogenic	rs724160030, rs61730489	RCV000149880 RCV003989127	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal atresia	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
IGSF3-related disorder	Likely benign; Benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pyloric stenosis	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult Fanconi syndrome	Fanconi syndrome	BEFREE	30200082		★☆☆☆☆ Found in Text Mining only
Adult Rickets	Rickets	BEFREE	30200082		★☆☆☆☆ Found in Text Mining only
Atresia of nasolacrimal duct	Atresia Of Nasolacrimal Duct	HPO_DG			★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	29991755	Associate	★☆☆☆☆ Found in Text Mining only
Excessive tearing	Excessive Tearing	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	27328461		★☆☆☆☆ Found in Text Mining only
Lacrimal mucocele	Lacrimal Mucocele	HPO_DG			★☆☆☆☆ Found in Text Mining only
Lacrimal Puncta, Absence of	Absent lacrimal punctum	ORPHANET_DG	24372406		★☆☆☆☆ Found in Text Mining only
Monoclonal Gammopathy of Undetermined Significance	Monoclonal Gammapathies	BEFREE	30200082		★☆☆☆☆ Found in Text Mining only
Nephritis, Interstitial	Nephritis	BEFREE	30200082		★☆☆☆☆ Found in Text Mining only
Nephritis, Tubulointerstitial	Nephritis	BEFREE	30200082		★☆☆☆☆ Found in Text Mining only
Osteomalacia	Osteomalacia	BEFREE	30200082		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	32573489	Associate	★☆☆☆☆ Found in Text Mining only
Retinopathy of Prematurity	Retinopathy of prematurity	Pubtator	40084286	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Sarcoidosis	Pubtator	29510755	Associate	★☆☆☆☆ Found in Text Mining only