Gene Gene information from NCBI Gene database.
Entrez ID 3320
Gene name Heat shock protein 90 alpha family class A member 1
Gene symbol HSP90AA1
Synonyms (NCBI Gene)
EL52HEL-S-65pHSP86HSP89AHSP90AHSP90NHSPC1HSPCAHSPCAL1HSPCAL4HSPNHsp103Hsp89Hsp90LAP-2LAP2
Chromosome 14
Chromosome location 14q32.31
Summary The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript
miRNA miRNA information provided by mirtarbase database.
923
miRTarBase ID miRNA Experiments Reference
MIRT020063 hsa-miR-375 Microarray 20215506
MIRT031959 hsa-miR-16-5p Proteomics 18668040
MIRT052238 hsa-let-7b-5p CLASH 23622248
MIRT050979 hsa-miR-17-5p CLASH 23622248
MIRT050304 hsa-miR-25-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
POU4F1 Activation 15818685
POU4F2 Activation 15818685
STAT1 Repression 12940076
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
150
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001764 Process Neuron migration IEA
GO:0002134 Function UTP binding IEA
GO:0002135 Function CTP binding IEA
GO:0002218 Process Activation of innate immune response IDA 20628368
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
140571 5253 ENSG00000080824
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07900
Protein name Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Protein function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its AT
PDB 1BYQ , 1OSF , 1UY6 , 1UY7 , 1UY8 , 1UY9 , 1UYC , 1UYD , 1UYE , 1UYF , 1UYG , 1UYH , 1UYI , 1UYK , 1UYL , 1YC1 , 1YC3 , 1YC4 , 1YER , 1YES , 1YET , 2BSM , 2BT0 , 2BUG , 2BYH , 2BYI , 2BZ5 , 2C2L , 2CCS , 2CCT , 2CCU , 2FWY , 2FWZ , 2H55 , 2JJC , 2K5B , 2QF6 , 2QFO , 2QG0 , 2QG2 , 2UWD , 2VCI , 2VCJ , 2WI1 , 2WI2 , 2WI3 , 2WI4 , 2WI5 , 2WI6 , 2WI7 , 2XAB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02518 HATPase_c 40 194 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Domain
PF00183 HSP90 196 723 Hsp90 protein Family
Sequence
Sequence length 732
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum
PI3K-Akt signaling pathway
Necroptosis
Antigen processing and presentation
NOD-like receptor signaling pathway
IL-17 signaling pathway
Th17 cell differentiation
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Salmonella infection
Pathways in cancer
Chemical carcinogenesis - receptor activation
Prostate cancer
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
vRNP Assembly
Regulation of actin dynamics for phagocytic cup formation
eNOS activation
Regulation of PLK1 Activity at G2/M Transition
Scavenging by Class F Receptors
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
Uptake and function of diphtheria toxin
Anchoring of the basal body to the plasma membrane
Constitutive Signaling by EGFRvIII
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Downregulation of ERBB2 signaling
ESR-mediated signaling
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONTACT DERMATITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DERMATITIS, CONTACT CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 25665180
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 29396434
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 12886242, 26416354, 26443624
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 30536958
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 23874879, 25075042, 27829290, 30930968
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 25075042, 31527404
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 19451690, 20952506, 26517240, 27880046, 30154228, 31370342
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 30844069
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 26320184
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Neoplasms Adrenal neoplasia BEFREE 30315857
★☆☆☆☆
Found in Text Mining only