Gene Gene information from NCBI Gene database.
Entrez ID 332
Gene name Baculoviral IAP repeat containing 5
Gene symbol BIRC5
Synonyms (NCBI Gene)
API4EPR-1
Chromosome 17
Chromosome location 17q25.3
Summary This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes pro
miRNA miRNA information provided by mirtarbase database.
542
miRTarBase ID miRNA Experiments Reference
MIRT005363 hsa-miR-542-3p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 20728447
MIRT006046 hsa-miR-218-5p ImmunoblotLuciferase reporter assayMicroarrayqRT-PCR 21385904
MIRT006141 hsa-miR-708-5p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 21852381
MIRT006141 hsa-miR-708-5p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 21852381
MIRT006141 hsa-miR-708-5p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 21852381
Transcription factors Transcription factors information provided by TRRUST V2 database.
32
Transcription factor Regulation Reference
APC Unknown 11751382
CTNNB1 Unknown 19662654;19778454
DNMT1 Repression 17124180
E2F1 Activation 17848598;19102934
E2F1 Repression 19102934
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
78
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 9859993
GO:0000228 Component Nuclear chromosome IDA 16322459
GO:0000278 Process Mitotic cell cycle NAS 17956729
GO:0000278 Process Mitotic cell cycle TAS 16291752
GO:0000281 Process Mitotic cytokinesis IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603352 593 ENSG00000089685
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15392
Protein name Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Protein function Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CPC) which
PDB 1E31 , 1F3H , 1XOX , 2QFA , 2RAW , 2RAX , 3UEC , 3UED , 3UEE , 3UEF , 3UEG , 3UEH , 3UEI , 3UIG , 3UIH , 3UII , 3UIJ , 3UIK , 4A0I , 4A0J , 4A0N , 6SHO , 6YIE , 6YIF , 6YIH , 7LBK , 7LBO , 7LBP , 7LBQ , 8RUP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00653 BIR 18 88 Inhibitor of Apoptosis domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed
Sequence
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLS
VKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAKKVRRAIEQLAAMD
Sequence length 142
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Platinum drug resistance
Apoptosis
Apoptosis - multiple species
Hippo signaling pathway
Hepatitis B
Pathways in cancer
Chemical carcinogenesis - receptor activation
Colorectal cancer
  Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Mitotic Prometaphase
Neddylation
EML4 and NUDC in mitotic spindle formation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
18
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 11086180, 21715311, 24995804
★☆☆☆☆
Found in Text Mining only
Acute Megakaryocytic Leukemias Megakaryocytic Leukemia CTD_human_DG 16166298
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 24127439
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia CTD_human_DG 27770503
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 12168867, 16671090, 16826583
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 15112339, 29416000, 31093306
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma CTD_human_DG 26432044
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 17254769, 29416000, 31093306
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Basal Cell Adenocarcinoma CTD_human_DG 26432044
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Oxyphilic Adenocarcinoma CTD_human_DG 26432044
★☆☆☆☆
Found in Text Mining only