Gene Gene information from NCBI Gene database.
Entrez ID 3309
Gene name Heat shock protein family A (Hsp70) member 5
Gene symbol HSPA5
Synonyms (NCBI Gene)
BIPGRP78HEL-S-89n
Chromosome 9
Chromosome location 9q33.3
Summary The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins
miRNA miRNA information provided by mirtarbase database.
690
miRTarBase ID miRNA Experiments Reference
MIRT018562 hsa-miR-335-5p Microarray 18185580
MIRT023362 hsa-miR-122-5p Other 21750653
MIRT031900 hsa-miR-16-5p Proteomics 18668040
MIRT038848 hsa-miR-93-3p CLASH 23622248
MIRT053102 hsa-miR-199a-5p Luciferase reporter assayqRT-PCRWestern blot 23598416
Transcription factors Transcription factors information provided by TRRUST V2 database.
11
Transcription factor Regulation Reference
ATF4 Repression 16205636
ATF6 Unknown 12713871
BRCA1 Repression 18776923
E2F1 Repression 18840615
GTF2I Activation 19097122;21503958
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
96
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005509 Function Calcium ion binding TAS 16130169
GO:0005515 Function Protein binding IPI 11907036, 12356756, 12577067, 12840015, 18064632, 18264092, 18502753, 18923428, 18923430, 19632185, 20335166, 20467437, 20477988, 20936779, 22613557, 22689054, 22735594, 22796945, 23220234, 23349634, 23769672, 23990668, 24189400, 24473200, 25601083, 26496610, 26551274, 27238082, 285
GO:0005524 Function ATP binding IDA 26655470
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
138120 5238 ENSG00000044574
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11021
Protein name Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin h
Protein function Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and
PDB 3IUC , 3LDL , 3LDN , 3LDO , 3LDP , 5E84 , 5E85 , 5E86 , 5EVZ , 5EX5 , 5EXW , 5EY4 , 5F0X , 5F1X , 5F2R , 6ASY , 6CZ1 , 6DFM , 6DFO , 6DO2 , 6DWS , 6ZMD , 7N1R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 30 636 Hsp70 protein Family
Sequence
Sequence length 654
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein export
Protein processing in endoplasmic reticulum
Antigen processing and presentation
Thyroid hormone synthesis
Parkinson disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Lipid and atherosclerosis
  Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASBESTOSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DOPAMINE BETA HYDROXYLASE DEFICIENCY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 21517817
★☆☆☆☆
Found in Text Mining only
Acute Undifferentiated Leukemia Leukemia BEFREE 25248926
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 18331622, 19277794, 19861963, 22297694, 30032821, 30121368
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 18331622
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30121368, 30297634, 30931255
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 16182273
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 24977433
★☆☆☆☆
Found in Text Mining only
Adrenocortical carcinoma Adrenocortical carcinoma BEFREE 29474877
★☆☆☆☆
Found in Text Mining only
Adrenoleukodystrophy Adrenoleukodystrophy BEFREE 24924946
★☆☆☆☆
Found in Text Mining only
Adult Hepatocellular Carcinoma Liver carcinoma BEFREE 28407787
★☆☆☆☆
Found in Text Mining only