Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	33
Gene name	Acyl-CoA dehydrogenase long chain
Gene symbol	ACADL
Synonyms (NCBI Gene)	ACAD4LCAD
Chromosome	2
Chromosome location	2q34
Summary	The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022288	hsa-miR-124-3p	Microarray	18668037
MIRT715136	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT715135	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT715134	hsa-miR-3183	HITS-CLIP	19536157
MIRT715133	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT715132	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT715131	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT715130	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT715129	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT715128	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT715127	hsa-miR-4279	HITS-CLIP	19536157
MIRT715126	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT715125	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT715124	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT462192	hsa-miR-34b-3p	PAR-CLIP	23592263
MIRT462191	hsa-miR-1228-3p	PAR-CLIP	23592263
MIRT462190	hsa-miR-383-3p	PAR-CLIP	23592263
MIRT462189	hsa-miR-6089	PAR-CLIP	23592263
MIRT462188	hsa-miR-6134	PAR-CLIP	23592263
MIRT462186	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT462187	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT462185	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT462184	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT462183	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT462182	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT462181	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT462180	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT462179	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT462178	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT462177	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT462176	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT462175	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT462174	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT462173	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT462172	hsa-miR-3689c	PAR-CLIP	23592263
MIRT462170	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT462171	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT462169	hsa-miR-450a-1-3p	PAR-CLIP	23592263
MIRT462168	hsa-miR-3122	PAR-CLIP	23592263
MIRT462167	hsa-miR-3913-5p	PAR-CLIP	23592263
MIRT462166	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT462164	hsa-miR-6513-5p	PAR-CLIP	23592263
MIRT715136	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT715135	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT715134	hsa-miR-3183	HITS-CLIP	19536157
MIRT715133	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT715132	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT715131	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT715130	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT715129	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT715128	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT715127	hsa-miR-4279	HITS-CLIP	19536157
MIRT715126	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT715125	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT715124	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT462192	hsa-miR-34b-3p	PAR-CLIP	23592263
MIRT462191	hsa-miR-1228-3p	PAR-CLIP	23592263
MIRT462190	hsa-miR-383-3p	PAR-CLIP	23592263
MIRT462189	hsa-miR-6089	PAR-CLIP	23592263
MIRT462188	hsa-miR-6134	PAR-CLIP	23592263
MIRT462186	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT462187	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT462185	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT462184	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT462183	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT462182	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT462181	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT462180	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT462179	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT462178	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT462177	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT462176	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT462175	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT462174	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT462173	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT462172	hsa-miR-3689c	PAR-CLIP	23592263
MIRT462170	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT462171	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT462169	hsa-miR-450a-1-3p	PAR-CLIP	23592263
MIRT462168	hsa-miR-3122	PAR-CLIP	23592263
MIRT462167	hsa-miR-3913-5p	PAR-CLIP	23592263
MIRT462166	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT462164	hsa-miR-6513-5p	PAR-CLIP	23592263
MIRT761440	hsa-miR-323-3p	CLIP-seq
MIRT761441	hsa-miR-3682-5p	CLIP-seq
MIRT761442	hsa-miR-4684-3p	CLIP-seq
MIRT761443	hsa-miR-4699-3p	CLIP-seq
MIRT761444	hsa-miR-4724-3p	CLIP-seq
MIRT761445	hsa-miR-518a-5p	CLIP-seq
MIRT761446	hsa-miR-527	CLIP-seq
MIRT1920213	hsa-miR-4289	CLIP-seq
MIRT1920213	hsa-miR-4289	CLIP-seq

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Transcription factor	Regulation	Reference
PPARA	Unknown	20110263

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001659	Process	Temperature homeostasis	ISS
GO:0003995	Function	Acyl-CoA dehydrogenase activity	IEA
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	IBA
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	IDA	1945557
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	IEA
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	ISS
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0016042	Process	Lipid catabolic process	ISS
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0019254	Process	Carnitine metabolic process, CoA-linked	IBA
GO:0019254	Process	Carnitine metabolic process, CoA-linked	ISS
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	IEA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISS
GO:0042413	Process	Carnitine catabolic process	ISS
GO:0042758	Process	Long-chain fatty acid catabolic process	IBA
GO:0042758	Process	Long-chain fatty acid catabolic process	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0045717	Process	Negative regulation of fatty acid biosynthetic process	ISS
GO:0046322	Process	Negative regulation of fatty acid oxidation	ISS
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0090181	Process	Regulation of cholesterol metabolic process	ISS
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	9802886

MIM	HGNC	e!Ensembl
609576	88	ENSG00000115361

P28330

Protein name

Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)

Protein function

Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of

PDB

8W0T , 8W0U , 8W0Z

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02771	Acyl-CoA_dh_N	54 → 165	Acyl-CoA dehydrogenase, N-terminal domain	Domain
PF02770	Acyl-CoA_dh_M	169 → 266	Acyl-CoA dehydrogenase, middle domain	Domain
PF00441	Acyl-CoA_dh_1	278 → 427	Acyl-CoA dehydrogenase, C-terminal domain	Domain

Sequence

MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
LIAREIVFDK

Sequence length

430

Interactions

View interactions

	KEGG		Reactome
	Fatty acid degradation Metabolic pathways Fatty acid metabolism PPAR signaling pathway		Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ACADL-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long chain acyl-CoA dehydrogenase deficiency	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Very long chain acyl-CoA dehydrogenase deficiency	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)

Show/Hide Text Mining Associations (25)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autistic behavior	Autism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37151879	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	GWASCAT_DG	29545352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32953885	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24403596	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	BEFREE	23933733		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	GWASCAT_DG	29545352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Long chain acyl-CoA dehydrogenase deficiency	Acyl CoA Dehydrogenase Deficiency	ORPHANET_DG	10790204		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long chain acyl-CoA dehydrogenase deficiency	Acyl CoA Dehydrogenase Deficiency	CLINGEN_DG	24591516, 6401712, 8356011, 9861014		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung Neoplasms	Lung neoplasms	Pubtator	34970420	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	25242319		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30464513		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	37014425	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mild expressive language delay	Expressive language delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	34970420	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myasthenias	Myasthenia Gravis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27807832, 30464513, 31451071		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	38292759	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	29504848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	30464513		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32961983	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	26330360	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACADL (acyl-CoA dehydrogenase long chain)