Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	3275
Gene name	Protein arginine methyltransferase 2
Gene symbol	PRMT2
Synonyms (NCBI Gene)	HRMT1L1
Chromosome	21
Chromosome location	21q22.3

180

Show/Hide all (180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050766	hsa-miR-17-3p	CLASH	23622248
MIRT1264528	hsa-miR-1208	CLIP-seq
MIRT1264529	hsa-miR-1224-3p	CLIP-seq
MIRT1264530	hsa-miR-1260	CLIP-seq
MIRT1264531	hsa-miR-1260b	CLIP-seq
MIRT1264532	hsa-miR-1280	CLIP-seq
MIRT1264533	hsa-miR-21	CLIP-seq
MIRT1264534	hsa-miR-3144-5p	CLIP-seq
MIRT1264535	hsa-miR-3166	CLIP-seq
MIRT1264536	hsa-miR-3190	CLIP-seq
MIRT1264537	hsa-miR-3191	CLIP-seq
MIRT1264538	hsa-miR-338-5p	CLIP-seq
MIRT1264539	hsa-miR-3616-3p	CLIP-seq
MIRT1264540	hsa-miR-3670	CLIP-seq
MIRT1264541	hsa-miR-3682-5p	CLIP-seq
MIRT1264542	hsa-miR-3684	CLIP-seq
MIRT1264543	hsa-miR-3689d	CLIP-seq
MIRT1264544	hsa-miR-3914	CLIP-seq
MIRT1264545	hsa-miR-4266	CLIP-seq
MIRT1264546	hsa-miR-4436b-3p	CLIP-seq
MIRT1264547	hsa-miR-4491	CLIP-seq
MIRT1264548	hsa-miR-4652-5p	CLIP-seq
MIRT1264549	hsa-miR-4657	CLIP-seq
MIRT1264550	hsa-miR-4695-5p	CLIP-seq
MIRT1264551	hsa-miR-4704-3p	CLIP-seq
MIRT1264552	hsa-miR-4777-5p	CLIP-seq
MIRT1264553	hsa-miR-4779	CLIP-seq
MIRT1264554	hsa-miR-4803	CLIP-seq
MIRT1264555	hsa-miR-491-5p	CLIP-seq
MIRT1264556	hsa-miR-5096	CLIP-seq
MIRT1264557	hsa-miR-513b	CLIP-seq
MIRT1264558	hsa-miR-518d-5p	CLIP-seq
MIRT1264559	hsa-miR-519b-5p	CLIP-seq
MIRT1264560	hsa-miR-519c-5p	CLIP-seq
MIRT1264561	hsa-miR-520c-5p	CLIP-seq
MIRT1264562	hsa-miR-526a	CLIP-seq
MIRT1264563	hsa-miR-590-5p	CLIP-seq
MIRT1264564	hsa-miR-1913	CLIP-seq
MIRT1264565	hsa-miR-22	CLIP-seq
MIRT1264566	hsa-miR-3136-5p	CLIP-seq
MIRT1264567	hsa-miR-320a	CLIP-seq
MIRT1264568	hsa-miR-320b	CLIP-seq
MIRT1264569	hsa-miR-320c	CLIP-seq
MIRT1264570	hsa-miR-320d	CLIP-seq
MIRT1264571	hsa-miR-324-3p	CLIP-seq
MIRT1264572	hsa-miR-4429	CLIP-seq
MIRT1264573	hsa-miR-4439	CLIP-seq
MIRT1264574	hsa-miR-4513	CLIP-seq
MIRT1264575	hsa-miR-4667-3p	CLIP-seq
MIRT1264576	hsa-miR-4749-3p	CLIP-seq
MIRT1264577	hsa-miR-4766-5p	CLIP-seq
MIRT1264578	hsa-miR-1291	CLIP-seq
MIRT1264579	hsa-miR-134	CLIP-seq
MIRT1264580	hsa-miR-1470	CLIP-seq
MIRT1264581	hsa-miR-23a	CLIP-seq
MIRT1264582	hsa-miR-23b	CLIP-seq
MIRT1264583	hsa-miR-23c	CLIP-seq
MIRT1264584	hsa-miR-2467-5p	CLIP-seq
MIRT1264585	hsa-miR-3118	CLIP-seq
MIRT1264586	hsa-miR-3128	CLIP-seq
MIRT1264587	hsa-miR-328	CLIP-seq
MIRT1264588	hsa-miR-342-5p	CLIP-seq
MIRT1264589	hsa-miR-34a	CLIP-seq
MIRT1264590	hsa-miR-34c-5p	CLIP-seq
MIRT1264591	hsa-miR-365	CLIP-seq
MIRT1264592	hsa-miR-3925-5p	CLIP-seq
MIRT1264593	hsa-miR-4469	CLIP-seq
MIRT1264594	hsa-miR-449a	CLIP-seq
MIRT1264595	hsa-miR-449b	CLIP-seq
MIRT1264596	hsa-miR-4651	CLIP-seq
MIRT1264597	hsa-miR-4664-5p	CLIP-seq
MIRT1264575	hsa-miR-4667-3p	CLIP-seq
MIRT1264598	hsa-miR-4715-3p	CLIP-seq
MIRT1264599	hsa-miR-4720-5p	CLIP-seq
MIRT1264600	hsa-miR-4799-3p	CLIP-seq
MIRT1264601	hsa-miR-483-3p	CLIP-seq
MIRT1264556	hsa-miR-5096	CLIP-seq
MIRT1264602	hsa-miR-608	CLIP-seq
MIRT1264603	hsa-miR-628-5p	CLIP-seq
MIRT1264604	hsa-miR-652	CLIP-seq
MIRT1264605	hsa-miR-760	CLIP-seq
MIRT1264581	hsa-miR-23a	CLIP-seq
MIRT1264582	hsa-miR-23b	CLIP-seq
MIRT1264583	hsa-miR-23c	CLIP-seq
MIRT1552569	hsa-miR-3647-3p	CLIP-seq
MIRT1552570	hsa-miR-4282	CLIP-seq
MIRT1264598	hsa-miR-4715-3p	CLIP-seq
MIRT1264556	hsa-miR-5096	CLIP-seq
MIRT1556846	hsa-miR-3613-5p	CLIP-seq
MIRT2077815	hsa-miR-190	CLIP-seq
MIRT2077816	hsa-miR-190b	CLIP-seq
MIRT2077817	hsa-miR-4656	CLIP-seq
MIRT2077818	hsa-miR-513a-5p	CLIP-seq
MIRT2077819	hsa-miR-602	CLIP-seq
MIRT2457197	hsa-miR-1285	CLIP-seq
MIRT1264535	hsa-miR-3166	CLIP-seq
MIRT2457198	hsa-miR-3187-5p	CLIP-seq
MIRT1264539	hsa-miR-3616-3p	CLIP-seq
MIRT1264546	hsa-miR-4436b-3p	CLIP-seq
MIRT1264552	hsa-miR-4777-5p	CLIP-seq
MIRT1264558	hsa-miR-518d-5p	CLIP-seq
MIRT1264559	hsa-miR-519b-5p	CLIP-seq
MIRT1264560	hsa-miR-519c-5p	CLIP-seq
MIRT1264561	hsa-miR-520c-5p	CLIP-seq
MIRT1264562	hsa-miR-526a	CLIP-seq
MIRT2457199	hsa-miR-612	CLIP-seq
MIRT2457200	hsa-miR-885-3p	CLIP-seq
MIRT2601183	hsa-miR-122	CLIP-seq
MIRT2601184	hsa-miR-1255a	CLIP-seq
MIRT2601185	hsa-miR-1255b	CLIP-seq
MIRT2601186	hsa-miR-146b-3p	CLIP-seq
MIRT2601187	hsa-miR-188-3p	CLIP-seq
MIRT2077815	hsa-miR-190	CLIP-seq
MIRT2077816	hsa-miR-190b	CLIP-seq
MIRT2601188	hsa-miR-1914	CLIP-seq
MIRT2601189	hsa-miR-19a	CLIP-seq
MIRT2601190	hsa-miR-19b	CLIP-seq
MIRT1264533	hsa-miR-21	CLIP-seq
MIRT2601191	hsa-miR-3681	CLIP-seq
MIRT1264542	hsa-miR-3684	CLIP-seq
MIRT2601192	hsa-miR-3691-5p	CLIP-seq
MIRT1264544	hsa-miR-3914	CLIP-seq
MIRT2601193	hsa-miR-4261	CLIP-seq
MIRT2601194	hsa-miR-4265	CLIP-seq
MIRT2601195	hsa-miR-4280	CLIP-seq
MIRT2601196	hsa-miR-4296	CLIP-seq
MIRT2601197	hsa-miR-4318	CLIP-seq
MIRT2601198	hsa-miR-4322	CLIP-seq
MIRT2601199	hsa-miR-4417	CLIP-seq
MIRT2601200	hsa-miR-4633-3p	CLIP-seq
MIRT2077817	hsa-miR-4656	CLIP-seq
MIRT2601201	hsa-miR-4691-3p	CLIP-seq
MIRT2601202	hsa-miR-4802-3p	CLIP-seq
MIRT2077818	hsa-miR-513a-5p	CLIP-seq
MIRT2601203	hsa-miR-551a	CLIP-seq
MIRT2601204	hsa-miR-551b	CLIP-seq
MIRT1264563	hsa-miR-590-5p	CLIP-seq
MIRT2077819	hsa-miR-602	CLIP-seq
MIRT2601205	hsa-miR-619	CLIP-seq
MIRT2601206	hsa-miR-875-3p	CLIP-seq
MIRT2601183	hsa-miR-122	CLIP-seq
MIRT2601184	hsa-miR-1255a	CLIP-seq
MIRT2601185	hsa-miR-1255b	CLIP-seq
MIRT2601186	hsa-miR-146b-3p	CLIP-seq
MIRT2601187	hsa-miR-188-3p	CLIP-seq
MIRT2077815	hsa-miR-190	CLIP-seq
MIRT2077816	hsa-miR-190b	CLIP-seq
MIRT2601188	hsa-miR-1914	CLIP-seq
MIRT2601189	hsa-miR-19a	CLIP-seq
MIRT2601190	hsa-miR-19b	CLIP-seq
MIRT1264533	hsa-miR-21	CLIP-seq
MIRT2601191	hsa-miR-3681	CLIP-seq
MIRT1264541	hsa-miR-3682-5p	CLIP-seq
MIRT1264542	hsa-miR-3684	CLIP-seq
MIRT2601192	hsa-miR-3691-5p	CLIP-seq
MIRT1264544	hsa-miR-3914	CLIP-seq
MIRT2601193	hsa-miR-4261	CLIP-seq
MIRT2601194	hsa-miR-4265	CLIP-seq
MIRT2601195	hsa-miR-4280	CLIP-seq
MIRT2601196	hsa-miR-4296	CLIP-seq
MIRT2601197	hsa-miR-4318	CLIP-seq
MIRT2601198	hsa-miR-4322	CLIP-seq
MIRT2601199	hsa-miR-4417	CLIP-seq
MIRT2601200	hsa-miR-4633-3p	CLIP-seq
MIRT2077817	hsa-miR-4656	CLIP-seq
MIRT2601201	hsa-miR-4691-3p	CLIP-seq
MIRT1264552	hsa-miR-4777-5p	CLIP-seq
MIRT2601202	hsa-miR-4802-3p	CLIP-seq
MIRT2077818	hsa-miR-513a-5p	CLIP-seq
MIRT1264558	hsa-miR-518d-5p	CLIP-seq
MIRT1264559	hsa-miR-519b-5p	CLIP-seq
MIRT1264560	hsa-miR-519c-5p	CLIP-seq
MIRT1264561	hsa-miR-520c-5p	CLIP-seq
MIRT1264562	hsa-miR-526a	CLIP-seq
MIRT2601203	hsa-miR-551a	CLIP-seq
MIRT2601204	hsa-miR-551b	CLIP-seq
MIRT1264563	hsa-miR-590-5p	CLIP-seq
MIRT2077819	hsa-miR-602	CLIP-seq
MIRT2601205	hsa-miR-619	CLIP-seq
MIRT2601206	hsa-miR-875-3p	CLIP-seq

Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IDA	12039952
GO:0005515	Function	Protein binding	IPI	11513728, 12039952, 16616919, 16648481, 17500595, 17925405, 21653829, 22093364, 26420826, 26871637, 28514442, 33961781, 38892217
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11513728, 17587566
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9545638
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	11513728, 17587566, 38892217
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	17587566
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006479	Process	Protein methylation	TAS	9545638
GO:0007165	Process	Signal transduction	TAS	9545638
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016274	Function	Protein-arginine N-methyltransferase activity	IBA
GO:0016274	Function	Protein-arginine N-methyltransferase activity	IEA
GO:0016274	Function	Protein-arginine N-methyltransferase activity	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0030331	Function	Nuclear estrogen receptor binding	IDA	17587566
GO:0030331	Function	Nuclear estrogen receptor binding	IPI	12039952
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	16648481
GO:0032259	Process	Methylation	IEA
GO:0033142	Function	Nuclear progesterone receptor binding	IPI	12039952
GO:0035242	Function	Protein-arginine omega-N asymmetric methyltransferase activity	IEA
GO:0042054	Function	Histone methyltransferase activity	IBA
GO:0042054	Function	Histone methyltransferase activity	IDA	19405910
GO:0042054	Function	Histone methyltransferase activity	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	12039952
GO:0042974	Function	Nuclear retinoic acid receptor binding	IPI	12039952
GO:0042975	Function	Peroxisome proliferator activated receptor binding	IPI	12039952
GO:0043065	Process	Positive regulation of apoptotic process	IGI	16648481
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IMP	38892217
GO:0044877	Function	Protein-containing complex binding	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	16648481
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	12039952
GO:0046966	Function	Nuclear thyroid hormone receptor binding	IPI	12039952
GO:0048588	Process	Developmental cell growth	ISS
GO:0050681	Function	Nuclear androgen receptor binding	IPI	17587566
GO:0050728	Process	Negative regulation of inflammatory response	IMP	38892217
GO:0060765	Process	Regulation of androgen receptor signaling pathway	IDA	17587566
GO:0140592	Function	Histone H3R8 methyltransferase activity	ISS
GO:0140938	Function	Histone H3 methyltransferase activity	ISS
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	ISS

MIM	HGNC	e!Ensembl
601961	5186	ENSG00000160310

P55345

Protein name

Protein arginine N-methyltransferase 2 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT2)

Protein function

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (

PDB

1X2P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00018	SH3_1	36 → 81	SH3 domain	Domain
PF05175	MTS	125 → 212	Methyltransferase small domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. {ECO:0000269|PubMed:17587566}.

Sequence

MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILIL
RQTTADWWWGERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQP
RTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVI
WPTMAALHLVPCSADKDYRSKVLFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCL
SEPCTILQLDMRTVQISDLETLRGELRFDIRKAGTLHGFTAWFSVHFQSLQEGQPPQVLS
TGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVALSWAVTSRQDPT
SQKVGEKVFPIWR

Sequence length

433

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	21820040, 22093364, 24911119, 28677794, 29620287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22093364, 24911119, 29620287, 37173306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24911119, 37173306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37863263	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37173306	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37863263	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	21047530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	32121248	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	21047530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslexia	Dyslexia	BEFREE	18521840		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30382083		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	30382083	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	37173306, 37863263	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30382083		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	30382083	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	21047530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21820040, 22093364, 24911119, 28677794, 29620287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24911119, 30382083		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	28677794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	24911119		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyarteritis Nodosa	Polyarteritis Nodosa	BEFREE	24911119		★★★★★ ★☆☆☆☆ Found in Text Mining only
POLYARTERITIS NODOSA, CHILDHOOD-ONSET	Polyarteritis Nodosa	BEFREE	24911119		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34439753	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

PRMT2 (protein arginine methyltransferase 2)