HOXC5 (homeobox C5)

Gene

• Entrez ID: 3222
• Gene name: Homeobox C5
• Gene symbol: HOXC5
• Synonyms (NCBI Gene): CP11, HOX3, HOX3D
• Chromosome: 12
• Chromosome location: 12q13.13
• Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene cluster

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1053606	hsa-miR-1912	CLIP-seq
MIRT1053607	hsa-miR-3120-3p	CLIP-seq
MIRT1053608	hsa-miR-3121-3p	CLIP-seq
MIRT1053609	hsa-miR-3908	CLIP-seq
MIRT1053610	hsa-miR-4259	CLIP-seq
MIRT1053611	hsa-miR-4433	CLIP-seq
MIRT1053612	hsa-miR-4459	CLIP-seq
MIRT1053613	hsa-miR-4476	CLIP-seq
MIRT1053614	hsa-miR-4506	CLIP-seq
MIRT1053615	hsa-miR-4520a-3p	CLIP-seq
MIRT1053616	hsa-miR-4520b-3p	CLIP-seq
MIRT1053617	hsa-miR-4533	CLIP-seq
MIRT1053618	hsa-miR-4715-5p	CLIP-seq
MIRT1053619	hsa-miR-4768-3p	CLIP-seq
MIRT1053620	hsa-miR-711	CLIP-seq
MIRT1053621	hsa-miR-873	CLIP-seq
MIRT1549633	hsa-miR-1470	CLIP-seq
MIRT1549634	hsa-miR-4271	CLIP-seq
MIRT1549635	hsa-miR-4290	CLIP-seq
MIRT1549636	hsa-miR-4687-5p	CLIP-seq
MIRT1549637	hsa-miR-4725-3p	CLIP-seq
MIRT1549638	hsa-miR-486-5p	CLIP-seq
MIRT1549633	hsa-miR-1470	CLIP-seq
MIRT1549634	hsa-miR-4271	CLIP-seq
MIRT1549635	hsa-miR-4290	CLIP-seq
MIRT2012186	hsa-miR-4505	CLIP-seq
MIRT1549636	hsa-miR-4687-5p	CLIP-seq
MIRT2012187	hsa-miR-4690-5p	CLIP-seq
MIRT1549637	hsa-miR-4725-3p	CLIP-seq
MIRT2244563	hsa-miR-1204	CLIP-seq
MIRT2244564	hsa-miR-1207-5p	CLIP-seq
MIRT2244565	hsa-miR-1302	CLIP-seq
MIRT1053606	hsa-miR-1912	CLIP-seq
MIRT2244566	hsa-miR-2467-5p	CLIP-seq
MIRT1053607	hsa-miR-3120-3p	CLIP-seq
MIRT2244567	hsa-miR-3188	CLIP-seq
MIRT2244568	hsa-miR-3192	CLIP-seq
MIRT2244569	hsa-miR-3616-3p	CLIP-seq
MIRT2244570	hsa-miR-3975	CLIP-seq
MIRT2244571	hsa-miR-4298	CLIP-seq
MIRT2244572	hsa-miR-4300	CLIP-seq
MIRT1053613	hsa-miR-4476	CLIP-seq
MIRT2012186	hsa-miR-4505	CLIP-seq
MIRT1053617	hsa-miR-4533	CLIP-seq
MIRT2244573	hsa-miR-4731-5p	CLIP-seq
MIRT2244574	hsa-miR-4736	CLIP-seq
MIRT2244575	hsa-miR-4763-3p	CLIP-seq
MIRT2244576	hsa-miR-485-5p	CLIP-seq
MIRT2244577	hsa-miR-545	CLIP-seq
MIRT1053620	hsa-miR-711	CLIP-seq
MIRT1053621	hsa-miR-873	CLIP-seq
MIRT2244578	hsa-miR-920	CLIP-seq
MIRT1549634	hsa-miR-4271	CLIP-seq
MIRT1549637	hsa-miR-4725-3p	CLIP-seq
MIRT2389145	hsa-miR-4752	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	1346761
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	1346761
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0030054	Component	Cell junction	IDA
GO:0048706	Process	Embryonic skeletal system development	IEA

Other IDs

• MIM: 142973
• HGNC: 5127
• e!Ensembl: ENSG00000172789

Protein

• UniProt ID: Q00444
• Protein name: Homeobox protein Hox-C5 (Homeobox protein CP11) (Homeobox protein Hox-3D)
• Protein function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	156 → 212	Homeodomain	Domain

• Sequence:

  MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHG
  VDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKE
  EQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYL
  TRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL

• Sequence length: 222

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Erythroblastic Leukemia	Erythroblastic Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
Acute Megakaryocytic Leukemias	Megakaryocytic Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
Acute Myeloid Leukemia, M1	Myeloid Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
Acute myelomonocytic leukemia	Myelomonocytic Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	9354682		★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart Diseases	LHGDN	16215934		★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Hydatidiform Mole	BEFREE	1971215		★☆☆☆☆ Found in Text Mining only
Ki-1+ Anaplastic Large Cell Lymphoma	Anaplastic Lymphoma	BEFREE	9327740		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	8634419, 9823947		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	8634419	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	9327740		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	9327740, 9354682		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	9327740, 9354682	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma Primary Cutaneous Anaplastic Large Cell	Primary cutaneous anaplastic large cell lymphoma	Pubtator	9354682	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	9354682		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	9354682		★☆☆☆☆ Found in Text Mining only
Mucosa-Associated Lymphoid Tissue Lymphoma	Mucosa-associated lymphoma	BEFREE	9354682		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia	Myeloid Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	9823947		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	20935156	Associate	★☆☆☆☆ Found in Text Mining only
T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	9327740		★☆☆☆☆ Found in Text Mining only