Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	3221
Gene name	Homeobox C4
Gene symbol	HOXC4
Synonyms (NCBI Gene)	HOX3HOX3Ecp19
Chromosome	12
Chromosome location	12q13.13
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene cluster

193

Show/Hide all (193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019246	hsa-miR-331-3p	Sequencing	20371350
MIRT021293	hsa-miR-125a-5p	Sequencing	20371350
MIRT022277	hsa-miR-124-3p	Microarray	18668037
MIRT029035	hsa-miR-26b-5p	Microarray	19088304
MIRT052528	hsa-let-7a-5p	CLASH	23622248
MIRT040437	hsa-miR-615-3p	CLASH	23622248
MIRT707180	hsa-miR-3133	HITS-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	HITS-CLIP	21572407
MIRT550174	hsa-miR-548b-3p	HITS-CLIP	21572407
MIRT273692	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508617	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	HITS-CLIP	21572407
MIRT273692	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508617	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT273692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508617	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT508616	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT273689	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508617	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT550174	hsa-miR-548b-3p	PAR-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT508617	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT273692	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508617	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	23446348
MIRT273692	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508617	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT453131	hsa-miR-132-3p	PAR-CLIP	23592263
MIRT453130	hsa-miR-212-3p	PAR-CLIP	23592263
MIRT453128	hsa-miR-4779	PAR-CLIP	23592263
MIRT453129	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT453127	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT453126	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT453125	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT453124	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT453123	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT453122	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT453121	hsa-miR-4419a	PAR-CLIP	23592263
MIRT453120	hsa-miR-4510	PAR-CLIP	23592263
MIRT453119	hsa-miR-6127	PAR-CLIP	23592263
MIRT453118	hsa-miR-6129	PAR-CLIP	23592263
MIRT453117	hsa-miR-6130	PAR-CLIP	23592263
MIRT453116	hsa-miR-6133	PAR-CLIP	23592263
MIRT453115	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT453114	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT453113	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT453112	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT453111	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT453110	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT453109	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT453108	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT453107	hsa-miR-8085	PAR-CLIP	23592263
MIRT453106	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT453105	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453104	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453103	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453101	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453102	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT453100	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT453099	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT453098	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT453097	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT453096	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT453095	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT453094	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT453093	hsa-miR-3689c	PAR-CLIP	23592263
MIRT453092	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT453090	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT707180	hsa-miR-3133	HITS-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	HITS-CLIP	21572407
MIRT550174	hsa-miR-548b-3p	HITS-CLIP	21572407
MIRT273692	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508617	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	HITS-CLIP	21572407
MIRT273692	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508617	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT273692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508617	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT508616	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT273689	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508617	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT550174	hsa-miR-548b-3p	PAR-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT508617	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT273692	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508617	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT508618	hsa-miR-10a-3p	PAR-CLIP	23446348
MIRT273692	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508617	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT508616	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT273689	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT453131	hsa-miR-132-3p	PAR-CLIP	23592263
MIRT453130	hsa-miR-212-3p	PAR-CLIP	23592263
MIRT453128	hsa-miR-4779	PAR-CLIP	23592263
MIRT453129	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT453127	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT453126	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT453125	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT453124	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT453123	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT453122	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT453121	hsa-miR-4419a	PAR-CLIP	23592263
MIRT453120	hsa-miR-4510	PAR-CLIP	23592263
MIRT453119	hsa-miR-6127	PAR-CLIP	23592263
MIRT453118	hsa-miR-6129	PAR-CLIP	23592263
MIRT453117	hsa-miR-6130	PAR-CLIP	23592263
MIRT453116	hsa-miR-6133	PAR-CLIP	23592263
MIRT453115	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT453114	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT453113	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT453112	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT453111	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT453110	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT453109	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT453108	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT453107	hsa-miR-8085	PAR-CLIP	23592263
MIRT453106	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT453105	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453104	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453103	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453101	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453102	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT453100	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT453099	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT453098	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT453097	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT453096	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT453095	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT453094	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT453093	hsa-miR-3689c	PAR-CLIP	23592263
MIRT453092	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT453090	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT1053599	hsa-miR-23a	CLIP-seq
MIRT1053600	hsa-miR-23b	CLIP-seq
MIRT1053601	hsa-miR-23c	CLIP-seq
MIRT1053602	hsa-miR-3117-5p	CLIP-seq
MIRT1053603	hsa-miR-369-3p	CLIP-seq
MIRT1053604	hsa-miR-374c	CLIP-seq
MIRT1053605	hsa-miR-655	CLIP-seq
MIRT2012181	hsa-miR-188-3p	CLIP-seq
MIRT2012182	hsa-miR-3124-3p	CLIP-seq
MIRT2012183	hsa-miR-4279	CLIP-seq
MIRT2012184	hsa-miR-4282	CLIP-seq
MIRT2012185	hsa-miR-532-3p	CLIP-seq
MIRT2244553	hsa-miR-1297	CLIP-seq
MIRT2244554	hsa-miR-1910	CLIP-seq
MIRT1053599	hsa-miR-23a	CLIP-seq
MIRT1053600	hsa-miR-23b	CLIP-seq
MIRT1053601	hsa-miR-23c	CLIP-seq
MIRT2244555	hsa-miR-26a	CLIP-seq
MIRT2244556	hsa-miR-26b	CLIP-seq
MIRT2244557	hsa-miR-299-5p	CLIP-seq
MIRT2244558	hsa-miR-3129-3p	CLIP-seq
MIRT2244559	hsa-miR-4465	CLIP-seq
MIRT2244560	hsa-miR-455-3p	CLIP-seq
MIRT2244561	hsa-miR-4760-3p	CLIP-seq
MIRT2244562	hsa-miR-4795-3p	CLIP-seq
MIRT2547399	hsa-miR-3183	CLIP-seq
MIRT2547400	hsa-miR-3545-3p	CLIP-seq
MIRT2547401	hsa-miR-3921	CLIP-seq
MIRT2547402	hsa-miR-4539	CLIP-seq
MIRT2547403	hsa-miR-4653-5p	CLIP-seq
MIRT2547404	hsa-miR-4723-3p	CLIP-seq
MIRT2547405	hsa-miR-4766-5p	CLIP-seq
MIRT2547406	hsa-miR-579	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	15252056
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	15252056
GO:0001501	Process	Skeletal system development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	23275563, 23455924, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	15252056
GO:0048562	Process	Embryonic organ morphogenesis	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IBA
GO:0051216	Process	Cartilage development	IEA
GO:0071837	Function	HMG box domain binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
142974	5126	ENSG00000198353

P09017

Protein name

Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E)

Protein function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	157 → 213	Homeodomain	Domain

Sequence

MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRP
SYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQP
APDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRY
LTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATP
GTSEDHSQSATPPEQQRAEDITRL

Sequence length

264

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOPOROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (22)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Actinic keratosis	Actinic keratosis	BEFREE	7915745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adrenocortical carcinoma	Adrenocortical carcinoma	BEFREE	9723041		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	7915745	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	39766812	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32957968, 37434131	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29518789		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28055976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	28055976	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Hydatidiform Mole	BEFREE	1971215		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	8634419	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	9354682, 9823947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	9823947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	9327740	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia	Myeloid Leukemia	BEFREE	9823947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	9823947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	7915745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26213922	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	20935156, 32012197	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin Neoplasms	BEFREE	7915745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	7915745	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	36691064	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HOXC4 (homeobox C4)