HOXB6 (homeobox B6)

Gene

• Entrez ID: 3216
• Gene name: Homeobox B6
• Gene symbol: HOXB6
• Synonyms (NCBI Gene): HOX2, HOX2B, HU-2, Hox-2.2
• Chromosome: 17
• Chromosome location: 17q21.32
• Summary: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623683	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623683	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623683	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT623682	hsa-miR-126-5p	HITS-CLIP	23824327
MIRT623681	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT508472	hsa-miR-619-3p	PAR-CLIP	20371350
MIRT508471	hsa-miR-3614-3p	PAR-CLIP	20371350
MIRT508470	hsa-miR-4688	PAR-CLIP	20371350
MIRT508468	hsa-miR-6743-5p	PAR-CLIP	20371350
MIRT508469	hsa-miR-6765-3p	PAR-CLIP	20371350
MIRT508467	hsa-miR-4254	PAR-CLIP	20371350
MIRT508466	hsa-miR-3179	PAR-CLIP	20371350
MIRT508465	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT508464	hsa-miR-6134	PAR-CLIP	20371350
MIRT508463	hsa-miR-6804-3p	PAR-CLIP	20371350
MIRT508462	hsa-miR-3202	PAR-CLIP	20371350
MIRT508461	hsa-miR-505-5p	PAR-CLIP	20371350
MIRT508460	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT508459	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT508472	hsa-miR-619-3p	PAR-CLIP	20371350
MIRT508471	hsa-miR-3614-3p	PAR-CLIP	20371350
MIRT508470	hsa-miR-4688	PAR-CLIP	20371350
MIRT508468	hsa-miR-6743-5p	PAR-CLIP	20371350
MIRT508469	hsa-miR-6765-3p	PAR-CLIP	20371350
MIRT508467	hsa-miR-4254	PAR-CLIP	20371350
MIRT508466	hsa-miR-3179	PAR-CLIP	20371350
MIRT508465	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT508464	hsa-miR-6134	PAR-CLIP	20371350
MIRT508463	hsa-miR-6804-3p	PAR-CLIP	20371350
MIRT508462	hsa-miR-3202	PAR-CLIP	20371350
MIRT508461	hsa-miR-505-5p	PAR-CLIP	20371350
MIRT508460	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT508459	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT508472	hsa-miR-619-3p	PAR-CLIP	23446348
MIRT508471	hsa-miR-3614-3p	PAR-CLIP	23446348
MIRT508470	hsa-miR-4688	PAR-CLIP	23446348
MIRT508468	hsa-miR-6743-5p	PAR-CLIP	23446348
MIRT508469	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT508467	hsa-miR-4254	PAR-CLIP	23446348
MIRT508466	hsa-miR-3179	PAR-CLIP	23446348
MIRT508465	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT508464	hsa-miR-6134	PAR-CLIP	23446348
MIRT508463	hsa-miR-6804-3p	PAR-CLIP	23446348
MIRT508462	hsa-miR-3202	PAR-CLIP	23446348
MIRT508461	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT508460	hsa-miR-4747-5p	PAR-CLIP	23446348
MIRT508459	hsa-miR-5196-5p	PAR-CLIP	23446348
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623683	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623683	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623683	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT623682	hsa-miR-126-5p	HITS-CLIP	23824327
MIRT623681	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609512	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT609511	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT609510	hsa-miR-6803-3p	HITS-CLIP	23824327
MIRT609509	hsa-miR-4469	HITS-CLIP	23824327
MIRT609508	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT609507	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT508472	hsa-miR-619-3p	PAR-CLIP	20371350
MIRT508471	hsa-miR-3614-3p	PAR-CLIP	20371350
MIRT508470	hsa-miR-4688	PAR-CLIP	20371350
MIRT508468	hsa-miR-6743-5p	PAR-CLIP	20371350
MIRT508469	hsa-miR-6765-3p	PAR-CLIP	20371350
MIRT508467	hsa-miR-4254	PAR-CLIP	20371350
MIRT508466	hsa-miR-3179	PAR-CLIP	20371350
MIRT508465	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT508464	hsa-miR-6134	PAR-CLIP	20371350
MIRT508463	hsa-miR-6804-3p	PAR-CLIP	20371350
MIRT508462	hsa-miR-3202	PAR-CLIP	20371350
MIRT508461	hsa-miR-505-5p	PAR-CLIP	20371350
MIRT508460	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT508459	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT508472	hsa-miR-619-3p	PAR-CLIP	20371350
MIRT508471	hsa-miR-3614-3p	PAR-CLIP	20371350
MIRT508470	hsa-miR-4688	PAR-CLIP	20371350
MIRT508468	hsa-miR-6743-5p	PAR-CLIP	20371350
MIRT508469	hsa-miR-6765-3p	PAR-CLIP	20371350
MIRT508467	hsa-miR-4254	PAR-CLIP	20371350
MIRT508466	hsa-miR-3179	PAR-CLIP	20371350
MIRT508465	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT508464	hsa-miR-6134	PAR-CLIP	20371350
MIRT508463	hsa-miR-6804-3p	PAR-CLIP	20371350
MIRT508462	hsa-miR-3202	PAR-CLIP	20371350
MIRT508461	hsa-miR-505-5p	PAR-CLIP	20371350
MIRT508460	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT508459	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT508472	hsa-miR-619-3p	PAR-CLIP	23446348
MIRT508471	hsa-miR-3614-3p	PAR-CLIP	23446348
MIRT508470	hsa-miR-4688	PAR-CLIP	23446348
MIRT508468	hsa-miR-6743-5p	PAR-CLIP	23446348
MIRT508469	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT508467	hsa-miR-4254	PAR-CLIP	23446348
MIRT508466	hsa-miR-3179	PAR-CLIP	23446348
MIRT508465	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT508464	hsa-miR-6134	PAR-CLIP	23446348
MIRT508463	hsa-miR-6804-3p	PAR-CLIP	23446348
MIRT508462	hsa-miR-3202	PAR-CLIP	23446348
MIRT508461	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT508460	hsa-miR-4747-5p	PAR-CLIP	23446348
MIRT508459	hsa-miR-5196-5p	PAR-CLIP	23446348
MIRT1053370	hsa-miR-1470	CLIP-seq
MIRT1053371	hsa-miR-204	CLIP-seq
MIRT1053372	hsa-miR-211	CLIP-seq
MIRT1053373	hsa-miR-23a	CLIP-seq
MIRT1053374	hsa-miR-23b	CLIP-seq
MIRT1053375	hsa-miR-23c	CLIP-seq
MIRT1053376	hsa-miR-3180-5p	CLIP-seq
MIRT1053377	hsa-miR-4287	CLIP-seq
MIRT1053378	hsa-miR-4444	CLIP-seq
MIRT1053379	hsa-miR-4667-3p	CLIP-seq
MIRT1053380	hsa-miR-4685-3p	CLIP-seq
MIRT1053381	hsa-miR-5096	CLIP-seq
MIRT1053370	hsa-miR-1470	CLIP-seq
MIRT1053371	hsa-miR-204	CLIP-seq
MIRT1053372	hsa-miR-211	CLIP-seq
MIRT1053376	hsa-miR-3180-5p	CLIP-seq
MIRT1053377	hsa-miR-4287	CLIP-seq
MIRT1053379	hsa-miR-4667-3p	CLIP-seq
MIRT1053380	hsa-miR-4685-3p	CLIP-seq
MIRT2012149	hsa-miR-4649-3p	CLIP-seq
MIRT2012150	hsa-miR-939	CLIP-seq
MIRT2244395	hsa-miR-185	CLIP-seq
MIRT2244396	hsa-miR-3682-5p	CLIP-seq
MIRT2244397	hsa-miR-4268	CLIP-seq
MIRT2244398	hsa-miR-550b	CLIP-seq
MIRT2012150	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0034101	Process	Erythrocyte homeostasis	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IEA
GO:0048706	Process	Embryonic skeletal system development	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 142961
• HGNC: 5117
• e!Ensembl: ENSG00000108511

Protein

• UniProt ID: P17509
• Protein name: Homeobox protein Hox-B6 (Homeobox protein Hox-2.2) (Homeobox protein Hox-2B) (Homeobox protein Hu-2)
• Protein function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	147 → 203	Homeodomain	Domain

• Sequence:

  MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYP
  PAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEE
  QKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIA
  HALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE

• Sequence length: 224

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DIVERTICULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HOXB6-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MECKEL SYNDROME TYPE 1	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	1351762		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	32745807	Associate	★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	BEFREE	22603795		★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	Pubtator	22603795	Stimulate	★☆☆☆☆ Found in Text Mining only
CAMPOMELIC DYSPLASIA	Campomelic Dysplasia	BEFREE	8348155		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	29532406	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Small Cell	Small cell carcinoma	Pubtator	33664492	Associate	★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	Pubtator	27836013	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	10833444, 9126347		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29532406	Associate	★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	35299244	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	36532015	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	1360433		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	1360433		★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	BEFREE	17003840		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	1351762		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	37027440	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	12094253, 7678830		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	15867264		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	1360433		★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	2491782, 2491784, 2896630		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	15867264		★☆☆☆☆ Found in Text Mining only
Penile hypospadias	Penile Hypospadias	BEFREE	17003840		★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	37534217	Associate	★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	1351762		★☆☆☆☆ Found in Text Mining only
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	1351762		★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	1351762		★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	1379214		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	1379214		★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	15210573		★☆☆☆☆ Found in Text Mining only