Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	3215
Gene name	Homeobox B5
Gene symbol	HOXB5
Synonyms (NCBI Gene)	HHO.C10HOX2HOX2AHU-1Hox2.1
Chromosome	17
Chromosome location	17q21.32
Summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcriptio

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Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001971	hsa-miR-221-3p	Gluc assay	18794255
MIRT006902	hsa-miR-7-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	22768238
MIRT016641	hsa-miR-429	Reporter assay	20005803
MIRT020354	hsa-miR-200a-3p	Reporter assay	20005803
MIRT021075	hsa-miR-200c-3p	Reporter assay	20005803
MIRT021658	hsa-miR-141-3p	Reporter assay	20005803
MIRT024129	hsa-miR-200b-3p	Reporter assay	20005803
MIRT657301	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT657300	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT657299	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT657298	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT657297	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT657296	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT657295	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT657294	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT657293	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT657292	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT657291	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT657290	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT657289	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT657288	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT657287	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT657286	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT491458	hsa-miR-4779	PAR-CLIP	23592263
MIRT491457	hsa-miR-1321	PAR-CLIP	23592263
MIRT491456	hsa-miR-4739	PAR-CLIP	23592263
MIRT491454	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT491455	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT491453	hsa-miR-4784	PAR-CLIP	23592263
MIRT491452	hsa-miR-4419a	PAR-CLIP	23592263
MIRT491451	hsa-miR-4510	PAR-CLIP	23592263
MIRT491450	hsa-miR-6127	PAR-CLIP	23592263
MIRT491449	hsa-miR-6129	PAR-CLIP	23592263
MIRT491448	hsa-miR-6130	PAR-CLIP	23592263
MIRT491447	hsa-miR-6133	PAR-CLIP	23592263
MIRT491446	hsa-miR-765	PAR-CLIP	23592263
MIRT491445	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT491444	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT491443	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT491442	hsa-miR-4689	PAR-CLIP	23592263
MIRT491441	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT657301	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT657300	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT657299	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT657298	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT657297	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT657296	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT657295	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT657294	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT657293	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT657292	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT657291	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT657290	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT657289	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT657288	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT657287	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT657286	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT491458	hsa-miR-4779	PAR-CLIP	23592263
MIRT491457	hsa-miR-1321	PAR-CLIP	23592263
MIRT491456	hsa-miR-4739	PAR-CLIP	23592263
MIRT491454	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT491455	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT491453	hsa-miR-4784	PAR-CLIP	23592263
MIRT491452	hsa-miR-4419a	PAR-CLIP	23592263
MIRT491451	hsa-miR-4510	PAR-CLIP	23592263
MIRT491450	hsa-miR-6127	PAR-CLIP	23592263
MIRT491449	hsa-miR-6129	PAR-CLIP	23592263
MIRT491448	hsa-miR-6130	PAR-CLIP	23592263
MIRT491447	hsa-miR-6133	PAR-CLIP	23592263
MIRT491446	hsa-miR-765	PAR-CLIP	23592263
MIRT491445	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT491444	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT491443	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT491442	hsa-miR-4689	PAR-CLIP	23592263
MIRT491441	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT1053358	hsa-miR-1343	CLIP-seq
MIRT1053359	hsa-miR-141	CLIP-seq
MIRT1053360	hsa-miR-181a	CLIP-seq
MIRT1053361	hsa-miR-181b	CLIP-seq
MIRT1053362	hsa-miR-181c	CLIP-seq
MIRT1053363	hsa-miR-181d	CLIP-seq
MIRT1053364	hsa-miR-200a	CLIP-seq
MIRT1053365	hsa-miR-3153	CLIP-seq
MIRT1053366	hsa-miR-4262	CLIP-seq
MIRT1053367	hsa-miR-4730	CLIP-seq
MIRT1053368	hsa-miR-543	CLIP-seq
MIRT1053369	hsa-miR-625	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	3000607
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0045446	Process	Endothelial cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IEA
GO:0048706	Process	Embryonic skeletal system development	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
142960	5116	ENSG00000120075

P09067

Protein name

Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1)

Protein function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	195 → 251	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Spinal cord.

Sequence

MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSS
ASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPESLPCTNGDSHGAKPSASSPSDQ
ATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWM
RKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKI
WFQNRRMKWKKDNKLKSMSLATAGSAFQP

Sequence length

269

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (46)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	Pubtator	22603795	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	22768238, 30170380		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	25999793, 30115380		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25999793	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	30115380	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
CAMPOMELIC DYSPLASIA	Campomelic Dysplasia	BEFREE	8348155		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	21552713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	32382535	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	22768238, 30170380		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Small Cell	Small cell carcinoma	Pubtator	33664492	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	1360433		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	1360433		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35044082	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	BEFREE	21677782, 22648184, 24794774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung disease	Pubtator	22648184	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	1372255	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	7678830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	21552713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25999793, 30115380		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	21552713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	26467157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	22768238, 30170380		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	14578171, 21552713, 30115380, 31115501		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	1360433, 24794774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	2491782, 2491784, 2896630		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28337958, 29170127, 31115501		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	GWASCAT_DG	22484627		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	CTD_human_DG	22484627		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	GWASDB_DG	22484627		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	BEFREE	24670271		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	25999793		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	17623056	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	30286759	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	1379214		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	1379214		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	30018711		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	21552713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	21552713, 32319550	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	26467157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	22768238, 30170380	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HOXB5 (homeobox B5)