Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	3214
Gene name	Homeobox B4
Gene symbol	HOXB4
Synonyms (NCBI Gene)	HOX-2.6HOX2HOX2F
Chromosome	17
Chromosome location	17q21.32
Summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcriptio

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Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052567	hsa-let-7a-5p	CLASH	23622248
MIRT437889	hsa-miR-23a-3p	Luciferase reporter assayWestern blot	23630040
MIRT1053331	hsa-miR-1	CLIP-seq
MIRT1053332	hsa-miR-1262	CLIP-seq
MIRT1053333	hsa-miR-206	CLIP-seq
MIRT1053334	hsa-miR-3184	CLIP-seq
MIRT1053335	hsa-miR-3190	CLIP-seq
MIRT1053336	hsa-miR-3192	CLIP-seq
MIRT1053337	hsa-miR-3653	CLIP-seq
MIRT1053338	hsa-miR-3658	CLIP-seq
MIRT1053339	hsa-miR-3673	CLIP-seq
MIRT1053340	hsa-miR-3689a-3p	CLIP-seq
MIRT1053341	hsa-miR-3689c	CLIP-seq
MIRT1053342	hsa-miR-423-5p	CLIP-seq
MIRT1053343	hsa-miR-4274	CLIP-seq
MIRT1053344	hsa-miR-4279	CLIP-seq
MIRT1053345	hsa-miR-4311	CLIP-seq
MIRT1053346	hsa-miR-4463	CLIP-seq
MIRT1053347	hsa-miR-4468	CLIP-seq
MIRT1053348	hsa-miR-4494	CLIP-seq
MIRT1053349	hsa-miR-451b	CLIP-seq
MIRT1053350	hsa-miR-4688	CLIP-seq
MIRT1053351	hsa-miR-4701-3p	CLIP-seq
MIRT1053352	hsa-miR-4728-5p	CLIP-seq
MIRT1053353	hsa-miR-4747-3p	CLIP-seq
MIRT1053354	hsa-miR-4792	CLIP-seq
MIRT1053355	hsa-miR-4795-5p	CLIP-seq
MIRT1053356	hsa-miR-613	CLIP-seq
MIRT1053357	hsa-miR-942	CLIP-seq
MIRT1053334	hsa-miR-3184	CLIP-seq
MIRT1053336	hsa-miR-3192	CLIP-seq
MIRT1053340	hsa-miR-3689a-3p	CLIP-seq
MIRT1053341	hsa-miR-3689c	CLIP-seq
MIRT1053342	hsa-miR-423-5p	CLIP-seq
MIRT1053346	hsa-miR-4463	CLIP-seq
MIRT1053348	hsa-miR-4494	CLIP-seq
MIRT1053350	hsa-miR-4688	CLIP-seq
MIRT1053352	hsa-miR-4728-5p	CLIP-seq
MIRT1053334	hsa-miR-3184	CLIP-seq
MIRT1053336	hsa-miR-3192	CLIP-seq
MIRT1053340	hsa-miR-3689a-3p	CLIP-seq
MIRT1053341	hsa-miR-3689c	CLIP-seq
MIRT1053342	hsa-miR-423-5p	CLIP-seq
MIRT1053346	hsa-miR-4463	CLIP-seq
MIRT1053348	hsa-miR-4494	CLIP-seq
MIRT1053350	hsa-miR-4688	CLIP-seq
MIRT1053352	hsa-miR-4728-5p	CLIP-seq
MIRT2547338	hsa-miR-1184	CLIP-seq
MIRT2547339	hsa-miR-1269	CLIP-seq
MIRT2547340	hsa-miR-1269b	CLIP-seq
MIRT2547341	hsa-miR-135a	CLIP-seq
MIRT2547342	hsa-miR-135b	CLIP-seq
MIRT2547343	hsa-miR-151-5p	CLIP-seq
MIRT2547344	hsa-miR-151b	CLIP-seq
MIRT2547345	hsa-miR-193a-3p	CLIP-seq
MIRT2547346	hsa-miR-193b	CLIP-seq
MIRT2547347	hsa-miR-28-5p	CLIP-seq
MIRT2547348	hsa-miR-3125	CLIP-seq
MIRT2547349	hsa-miR-3139	CLIP-seq
MIRT2547350	hsa-miR-3189-3p	CLIP-seq
MIRT2547351	hsa-miR-320a	CLIP-seq
MIRT2547352	hsa-miR-320b	CLIP-seq
MIRT2547353	hsa-miR-320c	CLIP-seq
MIRT2547354	hsa-miR-320d	CLIP-seq
MIRT2547355	hsa-miR-3620	CLIP-seq
MIRT2547356	hsa-miR-371-3p	CLIP-seq
MIRT2547357	hsa-miR-371b-3p	CLIP-seq
MIRT2547358	hsa-miR-3916	CLIP-seq
MIRT2547359	hsa-miR-3921	CLIP-seq
MIRT2547360	hsa-miR-3942-3p	CLIP-seq
MIRT2547361	hsa-miR-4257	CLIP-seq
MIRT2547362	hsa-miR-4267	CLIP-seq
MIRT2547363	hsa-miR-4290	CLIP-seq
MIRT2547364	hsa-miR-4429	CLIP-seq
MIRT2547365	hsa-miR-4476	CLIP-seq
MIRT2547366	hsa-miR-4480	CLIP-seq
MIRT2547367	hsa-miR-4493	CLIP-seq
MIRT2547368	hsa-miR-4529-3p	CLIP-seq
MIRT2547369	hsa-miR-4532	CLIP-seq
MIRT2547370	hsa-miR-4653-5p	CLIP-seq
MIRT2547371	hsa-miR-4682	CLIP-seq
MIRT2547372	hsa-miR-4722-3p	CLIP-seq
MIRT2547373	hsa-miR-4749-3p	CLIP-seq
MIRT2547374	hsa-miR-4753-3p	CLIP-seq
MIRT2547375	hsa-miR-502-5p	CLIP-seq
MIRT2547376	hsa-miR-515-3p	CLIP-seq
MIRT2547377	hsa-miR-519e	CLIP-seq
MIRT2547378	hsa-miR-548ad	CLIP-seq
MIRT2547379	hsa-miR-558	CLIP-seq
MIRT2547380	hsa-miR-570	CLIP-seq
MIRT2547381	hsa-miR-593	CLIP-seq
MIRT2547382	hsa-miR-627	CLIP-seq
MIRT2547383	hsa-miR-708	CLIP-seq
MIRT2547384	hsa-miR-924	CLIP-seq
MIRT2547341	hsa-miR-135a	CLIP-seq
MIRT2547342	hsa-miR-135b	CLIP-seq
MIRT2547345	hsa-miR-193a-3p	CLIP-seq
MIRT2547346	hsa-miR-193b	CLIP-seq
MIRT2547348	hsa-miR-3125	CLIP-seq
MIRT2547355	hsa-miR-3620	CLIP-seq
MIRT2547356	hsa-miR-371-3p	CLIP-seq
MIRT2547357	hsa-miR-371b-3p	CLIP-seq
MIRT2547358	hsa-miR-3916	CLIP-seq
MIRT2547360	hsa-miR-3942-3p	CLIP-seq
MIRT2547361	hsa-miR-4257	CLIP-seq
MIRT2547362	hsa-miR-4267	CLIP-seq
MIRT2547363	hsa-miR-4290	CLIP-seq
MIRT2547365	hsa-miR-4476	CLIP-seq
MIRT2547366	hsa-miR-4480	CLIP-seq
MIRT2547367	hsa-miR-4493	CLIP-seq
MIRT2547369	hsa-miR-4532	CLIP-seq
MIRT2547372	hsa-miR-4722-3p	CLIP-seq
MIRT2547373	hsa-miR-4749-3p	CLIP-seq
MIRT2547376	hsa-miR-515-3p	CLIP-seq
MIRT2547377	hsa-miR-519e	CLIP-seq
MIRT2547381	hsa-miR-593	CLIP-seq

Show/Hide all (6)

Transcription factor	Regulation	Reference
MITF	Unknown	11085749
NFYA	Activation	12791656
USF1	Activation	12791656
USF1	Unknown	11085749
USF2	Activation	12791656
USF2	Unknown	11085749

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0002011	Process	Morphogenesis of an epithelial sheet	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	18932205
GO:0048103	Process	Somatic stem cell division	IEA
GO:0048536	Process	Spleen development	IEA
GO:0048539	Process	Bone marrow development	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IBA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IEA
GO:0048705	Process	Skeletal system morphogenesis	IEA
GO:0060216	Process	Definitive hemopoiesis	IEA
GO:0060218	Process	Hematopoietic stem cell differentiation	IDA	18932205
GO:0071425	Process	Hematopoietic stem cell proliferation	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000738	Process	Positive regulation of stem cell differentiation	IDA	18932205

MIM	HGNC	e!Ensembl
142965	5115	ENSG00000182742

P17483

Protein name

Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F)

Protein function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	163 → 219	Homeodomain	Domain

Sequence

MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAAC
TVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPP
PCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKE
FHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGAAGSAGGP
PGRPNGGPRAL

Sequence length

251

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (46)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	BEFREE	27827825		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	27782156		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Medulloblastoma	Medulloblastoma	BEFREE	29039487		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia Aplastic	Aplastic anemia	Pubtator	23028422	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aplastic Anemia	Aplastic anemia	BEFREE	23028422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	11984874	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29085460		★★★★★ ★☆☆☆☆ Found in Text Mining only
CAMPOMELIC DYSPLASIA	Campomelic Dysplasia	BEFREE	8348155		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	11984874	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	22976466, 33634306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	11984874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	29039487		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	21876633	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Demyelinating Diseases	Demyelinating Diseases	BEFREE	20424597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	11984874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	28969513		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	1360433		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	1360433		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	30419846		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematopoietic Neoplasms	Hematopoietic Neoplasms	BEFREE	25082879		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune thrombocytopenic purpura	Immune Thrombocytopenic Purpura	BEFREE	23028422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	18617691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	11085749	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	1351762, 14966272, 25082879		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	22664110, 25996682	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	22664110, 25996682, 7678830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukodystrophy, Metachromatic	Metachromatic Leukodystrophy	BEFREE	20424597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28592245, 34620221	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29085460		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11984874, 23630040, 29085460		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	29039487		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma	Mesothelioma	BEFREE	26867567		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	20424597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloproliferative disease	Myeloproliferative disorder	BEFREE	30419846		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23630040		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	23630040		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	1360433		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	2491782, 2491784, 2896630		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	1351762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	1379214		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	1379214		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Diseases	Skin disease	Pubtator	11984874	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	16445654, 22120585	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HOXB4 (homeobox B4)