TLX1 (T cell leukemia homeobox 1)

Gene

• Entrez ID: 3195
• Gene name: T cell leukemia homeobox 1
• Gene symbol: TLX1
• Synonyms (NCBI Gene): HOX11, TCL3
• Chromosome: 10
• Chromosome location: 10q24.31
• Summary: This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specif

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019615	hsa-miR-340-5p	Sequencing	20371350
MIRT029889	hsa-miR-26b-5p	Microarray	19088304
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT665822	hsa-miR-4427	HITS-CLIP	23824327
MIRT665821	hsa-miR-5187-3p	HITS-CLIP	23824327
MIRT665820	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652566	hsa-miR-4780	HITS-CLIP	23824327
MIRT652564	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT652553	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT652552	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT652551	hsa-miR-8089	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652547	hsa-miR-3144-5p	HITS-CLIP	23824327
MIRT652546	hsa-miR-3191-3p	HITS-CLIP	23824327
MIRT652545	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652543	hsa-miR-623	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652540	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT665822	hsa-miR-4427	HITS-CLIP	23824327
MIRT665821	hsa-miR-5187-3p	HITS-CLIP	23824327
MIRT665820	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652566	hsa-miR-4780	HITS-CLIP	23824327
MIRT652564	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT652553	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT652552	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT652551	hsa-miR-8089	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652547	hsa-miR-3144-5p	HITS-CLIP	23824327
MIRT652546	hsa-miR-3191-3p	HITS-CLIP	23824327
MIRT652545	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652543	hsa-miR-623	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652540	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT2127952	hsa-miR-3154	CLIP-seq
MIRT2127953	hsa-miR-3179	CLIP-seq
MIRT2127954	hsa-miR-3919	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYC	Unknown	20618946

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	19559479, 22516263, 35140242
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048513	Process	Animal organ development	IBA

Other IDs

• MIM: 186770
• HGNC: 5056
• e!Ensembl: ENSG00000107807

Protein

• UniProt ID: P31314
• Protein name: T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
• Protein function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	202 → 258	Homeodomain	Domain

• Sequence:

  MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG
  GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS
  GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN
  RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM
  TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN
  SSLFALQNLQPWSDDSTKITSVTSVASACE

• Sequence length: 330

Pathways

KEGG:

Transcriptional misregulation in cancer

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANEUPLOIDY	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA-LYMPHOMA, ADULT T-CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPLENIC DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
46, XY Disorders of Sex Development	46, XY disorder of sex development	BEFREE	24905461		★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	BEFREE	21326611, 7909304		★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	12750702, 16954520, 22382891, 22516263, 22563559, 24886876		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	22382891, 24886876		★☆☆☆☆ Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	16862188		★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	CTD_human_DG	1717256		★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	18082256, 7698766		★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	12086890, 17609427	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	18301381		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	16407851, 16862188		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	14659882		★☆☆☆☆ Found in Text Mining only
Breast Cancer, Familial	Breast Cancer	BEFREE	23051705		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19250546	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	22382891, 24886876, 7478554		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28351398	Associate	★☆☆☆☆ Found in Text Mining only
Congenital central hypoventilation	Congenital Central Hypoventilation	BEFREE	12407709		★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	12130513, 16398656, 16862188, 22563559		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	16862188		★☆☆☆☆ Found in Text Mining only
Familial paroxysmal dystonia	Paroxysmal dystonia	Pubtator	1717256	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	34238116	Associate	★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	28779353		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	10393251, 11066085, 14659882, 14975618, 20228800, 21326611, 21705452, 22516263, 26108691, 7478554, 7905617, 8559142, 9885434		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	12086890, 1717256, 22366949	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	LHGDN	17609427		★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	11342305, 16357834, 1676542, 1717256, 24001773, 2885838, 7596820, 7698766, 7905617, 8559142		★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	16954520, 22563559		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	11069299, 21326611, 9811890		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	39984035	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30106137		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12750702, 14659882, 16862188, 3054349, 7478554, 7719228, 7905617, 9116269		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11069299, 11520572, 18082256, 21326611, 21705452, 2326274, 26108691, 7478554, 9116269		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	14659882		★☆☆☆☆ Found in Text Mining only
Neuroectodermal Tumor, Primitive	Neuroectodermal Tumors	BEFREE	14659882		★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	16954520, 22563559, 3054349		★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	LHGDN	17713543, 18245528, 18368072		★☆☆☆☆ Found in Text Mining only
Precursor T-cell acute lymphoblastic leukemia	Lymphoblastic Leukemia	Orphanet			★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	10393251, 11066085, 11342305, 11587205, 12750702, 14582078, 14659882, 14975618, 15384172, 15637138, 15713800, 15897879, 16398656, 16407851, 1676542, 16862188, 1717256, 17369128, 17609427, 17934490, 19559479, 19835636, 19862821, 20124220, 20618946, 21112032, 21326611, 21705452, 22366949, 22563559, 2326274, 2542965, 26108691, 28592888, 30107177, 30659025, 7478554, 7621417, 7719228, 7902555, 7905617, 8559142, 9116269, 9695407, 9811890		★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	CTD_human_DG	20972433		★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	ORPHANET_DG	22516255, 22516263		★☆☆☆☆ Found in Text Mining only
Splenic Diseases	Splenic Diseases	CTD_human_DG	7908720		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30106137		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30106137	Associate	★☆☆☆☆ Found in Text Mining only