Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3191
Gene name	Heterogeneous nuclear ribonucleoprotein L
Gene symbol	HNRNPL
Synonyms (NCBI Gene)	HNRPLP/OKcl.14hnRNP-L
Chromosome	19
Chromosome location	19q13.2
Summary	Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are sta

133

Show/Hide all (133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016285	hsa-miR-193b-3p	Proteomics	21512034
MIRT025002	hsa-miR-183-5p	Sequencing	20371350
MIRT051924	hsa-let-7b-5p	CLASH	23622248
MIRT051122	hsa-miR-16-5p	CLASH	23622248
MIRT051122	hsa-miR-16-5p	CLASH	23622248
MIRT046364	hsa-miR-23b-3p	CLASH	23622248
MIRT045182	hsa-miR-186-5p	CLASH	23622248
MIRT044366	hsa-miR-106b-5p	CLASH	23622248
MIRT043796	hsa-miR-328-3p	CLASH	23622248
MIRT043110	hsa-miR-324-5p	CLASH	23622248
MIRT039633	hsa-miR-615-3p	CLASH	23622248
MIRT036902	hsa-miR-877-3p	CLASH	23622248
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT567289	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT567288	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT567287	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT567286	hsa-miR-4738-5p	PAR-CLIP	20371350
MIRT567285	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT567284	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567283	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT567282	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT567281	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT567280	hsa-miR-587	PAR-CLIP	20371350
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT732831	hsa-miR-30a-3p	ImmunofluorescenceLuciferase reporter assayRNA-seqWestern blotting	33397440
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT567289	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT567288	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT567287	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT567286	hsa-miR-4738-5p	PAR-CLIP	20371350
MIRT567285	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT567284	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567283	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT567282	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT567281	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT567280	hsa-miR-587	PAR-CLIP	20371350
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT1051839	hsa-miR-1227	CLIP-seq
MIRT1051840	hsa-miR-1283	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT1051845	hsa-miR-338-5p	CLIP-seq
MIRT1051846	hsa-miR-3609	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051851	hsa-miR-4480	CLIP-seq
MIRT1051852	hsa-miR-455-5p	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT1051855	hsa-miR-4717-3p	CLIP-seq
MIRT1051856	hsa-miR-4775	CLIP-seq
MIRT1051857	hsa-miR-493	CLIP-seq
MIRT1051858	hsa-miR-548ah	CLIP-seq
MIRT1051859	hsa-miR-548c-3p	CLIP-seq
MIRT1051860	hsa-miR-548n	CLIP-seq
MIRT1051861	hsa-miR-548t	CLIP-seq
MIRT1051862	hsa-miR-590-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT1051839	hsa-miR-1227	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051864	hsa-miR-203	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT1051865	hsa-miR-3148	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT1051846	hsa-miR-3609	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051851	hsa-miR-4480	CLIP-seq
MIRT1051852	hsa-miR-455-5p	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT1051857	hsa-miR-493	CLIP-seq
MIRT1051858	hsa-miR-548ah	CLIP-seq
MIRT1051861	hsa-miR-548t	CLIP-seq
MIRT1051862	hsa-miR-590-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT1051839	hsa-miR-1227	CLIP-seq
MIRT2244048	hsa-miR-1236	CLIP-seq
MIRT2244049	hsa-miR-1245b-3p	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051864	hsa-miR-203	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT2244050	hsa-miR-3074-5p	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT2244051	hsa-miR-3199	CLIP-seq
MIRT2244052	hsa-miR-3622a-5p	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT2244053	hsa-miR-370	CLIP-seq
MIRT2244054	hsa-miR-384	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT2244055	hsa-miR-4330	CLIP-seq
MIRT2244056	hsa-miR-4423-3p	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051851	hsa-miR-4480	CLIP-seq
MIRT1051852	hsa-miR-455-5p	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT2244057	hsa-miR-539	CLIP-seq
MIRT1051862	hsa-miR-590-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT2244058	hsa-miR-767-3p	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IEA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IMP	25623890
GO:0000785	Component	Chromatin	IDA	33174841
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	11809897
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	2687284
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	11809897, 18669861, 23976881, 26979993, 33174841, 35271311, 36537238
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15798186, 33174841
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	2687284
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS	2687284
GO:0005737	Component	Cytoplasm	IDA	33174841
GO:0005737	Component	Cytoplasm	IEA
GO:0006396	Process	RNA processing	TAS	2687284
GO:0006397	Process	MRNA processing	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0035770	Component	Ribonucleoprotein granule	IDA	17289661
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0043484	Process	Regulation of RNA splicing	IEA
GO:0045120	Component	Pronucleus	IEA
GO:0045202	Component	Synapse	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	33174841
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097157	Function	Pre-mRNA intronic binding	IDA	25623890
GO:1990904	Component	Ribonucleoprotein complex	IDA	2687284, 17289661, 33174841
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603083	5045	ENSG00000104824

P14866

Protein name

Heterogeneous nuclear ribonucleoprotein L (hnRNP L)

Protein function

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:

PDB

3R27 , 3TO8 , 7EVR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	104 → 162	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF11835	RRM_8	184 → 270	RRM-like domain	Domain
PF13893	RRM_5	356 → 480		Domain

Sequence

MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKR
LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVE
ALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKIS
RPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDS
VQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNP
NKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYG
PQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPG
AAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSES
RNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSE
RSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS

Sequence length

589

Interactions

View interactions

	Reactome
			mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC SCLERODERMA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (51)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	32915499	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	36930682	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	21507955	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30530525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	28088793		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	29484035	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31828152		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	20972326, 28088793, 28520992, 31828152	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	28088793		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	34779408	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Palsy	Cerebral palsy	Pubtator	29484035	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	31018621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29720400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31320608		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31320608	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	32915499	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	35982900	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	36930682	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31492748		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31492748		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	BEFREE	10441480		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	28520992	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	29908545	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29790588, 31844595		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31828152		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28038443, 28611215		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	28088793		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27808105, 29720400, 31138119		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29720400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28038443, 30530525, 31213844		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	31213844		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	30746871		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31355266	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	BEFREE	30746871		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28038443, 28611215		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	28611215		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	28611215, 33542227	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	34662337	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	31828152		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	31828152	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	31828152		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	26805816	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	28088793	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HNRNPL (heterogeneous nuclear ribonucleoprotein L)