RFESD (Rieske Fe-S domain containing)

Gene

• Entrez ID: 317671
• Gene name: Rieske Fe-S domain containing
• Gene symbol: RFESD
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q15

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1301673	hsa-miR-24	CLIP-seq
MIRT1301674	hsa-miR-3133	CLIP-seq
MIRT1301675	hsa-miR-4284	CLIP-seq
MIRT1301676	hsa-miR-4420	CLIP-seq
MIRT1301677	hsa-miR-4427	CLIP-seq
MIRT1301678	hsa-miR-1297	CLIP-seq
MIRT1301679	hsa-miR-1305	CLIP-seq
MIRT1301680	hsa-miR-132	CLIP-seq
MIRT1301681	hsa-miR-140-5p	CLIP-seq
MIRT1301682	hsa-miR-212	CLIP-seq
MIRT1301683	hsa-miR-214	CLIP-seq
MIRT1301684	hsa-miR-26a	CLIP-seq
MIRT1301685	hsa-miR-26b	CLIP-seq
MIRT1301686	hsa-miR-3149	CLIP-seq
MIRT1301687	hsa-miR-3619-5p	CLIP-seq
MIRT1301688	hsa-miR-4291	CLIP-seq
MIRT1301689	hsa-miR-4465	CLIP-seq
MIRT1301690	hsa-miR-498	CLIP-seq
MIRT1301691	hsa-miR-548a-3p	CLIP-seq
MIRT1301692	hsa-miR-548e	CLIP-seq
MIRT1301693	hsa-miR-548f	CLIP-seq
MIRT1301694	hsa-miR-568	CLIP-seq
MIRT1301695	hsa-miR-651	CLIP-seq
MIRT1301696	hsa-miR-761	CLIP-seq
MIRT1301697	hsa-miR-922	CLIP-seq
MIRT1301698	hsa-miR-4728-3p	CLIP-seq
MIRT1301699	hsa-miR-7	CLIP-seq
MIRT2089523	hsa-miR-548c-3p	CLIP-seq
MIRT2610857	hsa-miR-1290	CLIP-seq
MIRT2610858	hsa-miR-337-3p	CLIP-seq
MIRT2610859	hsa-miR-3685	CLIP-seq
MIRT2610860	hsa-miR-384	CLIP-seq
MIRT2610857	hsa-miR-1290	CLIP-seq
MIRT2610858	hsa-miR-337-3p	CLIP-seq
MIRT2610859	hsa-miR-3685	CLIP-seq
MIRT2610860	hsa-miR-384	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IBA
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TAC1
• Protein name: Rieske domain-containing protein
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00355	Rieske	16 → 109	Rieske [2Fe-2S] domain	Domain

• Sequence:

  MNLDGSAQDPEKREYSSVCVGREDDIKKSERMTAVVHDREVVIFYHKGEYHAMDIRCYHS
  GGPLHLGDIEDFDGRPCIVCPWHKYKITLATGEGLYQSINPKDPSAKPKWCSKGIKQRIH
  TVTVDNGNIYVTLSNEPFKCDSDFYATGDFKVIKSSS

• Sequence length: 157

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARDIAC EMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOEMBOLIC STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autism Spectrum Disorder	Autism	Pubtator	33159718	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	25944848		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35681134	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	25944848		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	25944848		★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	GWASCAT_DG	25944848		★☆☆☆☆ Found in Text Mining only