EIF4E3 (eukaryotic translation initiation factor 4E family member 3)

Gene

• Entrez ID: 317649
• Gene name: Eukaryotic translation initiation factor 4E family member 3
• Gene symbol: EIF4E3
• Synonyms (NCBI Gene): eIF-4E3, eIF4E-3
• Chromosome: 3
• Chromosome location: 3p13
• Summary: EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT537790	hsa-miR-5584-5p	PAR-CLIP	22012620
MIRT537789	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT537788	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT537786	hsa-miR-9500	PAR-CLIP	22012620
MIRT537787	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT537785	hsa-miR-3162-5p	PAR-CLIP	22012620
MIRT537784	hsa-miR-2909	PAR-CLIP	22012620
MIRT537790	hsa-miR-5584-5p	PAR-CLIP	22012620
MIRT537789	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT537788	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT537786	hsa-miR-9500	PAR-CLIP	22012620
MIRT537787	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT537785	hsa-miR-3162-5p	PAR-CLIP	22012620
MIRT537784	hsa-miR-2909	PAR-CLIP	22012620
MIRT958230	hsa-miR-1275	CLIP-seq
MIRT958231	hsa-miR-203	CLIP-seq
MIRT958232	hsa-miR-3145-5p	CLIP-seq
MIRT958233	hsa-miR-34b	CLIP-seq
MIRT958234	hsa-miR-4271	CLIP-seq
MIRT958235	hsa-miR-4496	CLIP-seq
MIRT958236	hsa-miR-4521	CLIP-seq
MIRT958237	hsa-miR-4525	CLIP-seq
MIRT958238	hsa-miR-4665-5p	CLIP-seq
MIRT958239	hsa-miR-4711-3p	CLIP-seq
MIRT958240	hsa-miR-4723-5p	CLIP-seq
MIRT958241	hsa-miR-4725-3p	CLIP-seq
MIRT958242	hsa-miR-579	CLIP-seq
MIRT958243	hsa-miR-625	CLIP-seq
MIRT958244	hsa-miR-637	CLIP-seq
MIRT958245	hsa-miR-1	CLIP-seq
MIRT958246	hsa-miR-1197	CLIP-seq
MIRT958247	hsa-miR-122	CLIP-seq
MIRT958248	hsa-miR-1252	CLIP-seq
MIRT958230	hsa-miR-1275	CLIP-seq
MIRT958249	hsa-miR-144	CLIP-seq
MIRT958250	hsa-miR-147	CLIP-seq
MIRT958251	hsa-miR-186	CLIP-seq
MIRT958252	hsa-miR-1910	CLIP-seq
MIRT958253	hsa-miR-1912	CLIP-seq
MIRT958231	hsa-miR-203	CLIP-seq
MIRT958254	hsa-miR-205	CLIP-seq
MIRT958255	hsa-miR-206	CLIP-seq
MIRT958256	hsa-miR-2113	CLIP-seq
MIRT958257	hsa-miR-216a	CLIP-seq
MIRT958258	hsa-miR-219-1-3p	CLIP-seq
MIRT958259	hsa-miR-2682	CLIP-seq
MIRT958260	hsa-miR-27a	CLIP-seq
MIRT958261	hsa-miR-27b	CLIP-seq
MIRT958262	hsa-miR-29a	CLIP-seq
MIRT958263	hsa-miR-29b	CLIP-seq
MIRT958264	hsa-miR-29c	CLIP-seq
MIRT958265	hsa-miR-300	CLIP-seq
MIRT958266	hsa-miR-3065-3p	CLIP-seq
MIRT958267	hsa-miR-3065-5p	CLIP-seq
MIRT958268	hsa-miR-3120-5p	CLIP-seq
MIRT958269	hsa-miR-3125	CLIP-seq
MIRT958270	hsa-miR-3129-3p	CLIP-seq
MIRT958271	hsa-miR-3130-5p	CLIP-seq
MIRT958272	hsa-miR-3133	CLIP-seq
MIRT958273	hsa-miR-3152-3p	CLIP-seq
MIRT958274	hsa-miR-3153	CLIP-seq
MIRT958275	hsa-miR-3163	CLIP-seq
MIRT958276	hsa-miR-3182	CLIP-seq
MIRT958277	hsa-miR-3200-5p	CLIP-seq
MIRT958278	hsa-miR-33a	CLIP-seq
MIRT958279	hsa-miR-33b	CLIP-seq
MIRT958280	hsa-miR-340	CLIP-seq
MIRT958281	hsa-miR-3646	CLIP-seq
MIRT958282	hsa-miR-3647-3p	CLIP-seq
MIRT958283	hsa-miR-3660	CLIP-seq
MIRT958284	hsa-miR-3663-3p	CLIP-seq
MIRT958285	hsa-miR-381	CLIP-seq
MIRT958286	hsa-miR-3909	CLIP-seq
MIRT958287	hsa-miR-3916	CLIP-seq
MIRT958288	hsa-miR-4259	CLIP-seq
MIRT958289	hsa-miR-4267	CLIP-seq
MIRT958290	hsa-miR-4280	CLIP-seq
MIRT958291	hsa-miR-4303	CLIP-seq
MIRT958292	hsa-miR-4310	CLIP-seq
MIRT958293	hsa-miR-4328	CLIP-seq
MIRT958294	hsa-miR-433	CLIP-seq
MIRT958295	hsa-miR-4422	CLIP-seq
MIRT958296	hsa-miR-448	CLIP-seq
MIRT958297	hsa-miR-4482	CLIP-seq
MIRT958298	hsa-miR-4484	CLIP-seq
MIRT958299	hsa-miR-449c	CLIP-seq
MIRT958300	hsa-miR-450b-5p	CLIP-seq
MIRT958301	hsa-miR-4514	CLIP-seq
MIRT958302	hsa-miR-4526	CLIP-seq
MIRT958303	hsa-miR-4539	CLIP-seq
MIRT958304	hsa-miR-4663	CLIP-seq
MIRT958238	hsa-miR-4665-5p	CLIP-seq
MIRT958305	hsa-miR-4666-3p	CLIP-seq
MIRT958306	hsa-miR-4666-5p	CLIP-seq
MIRT958307	hsa-miR-4692	CLIP-seq
MIRT958308	hsa-miR-4698	CLIP-seq
MIRT958309	hsa-miR-4729	CLIP-seq
MIRT958310	hsa-miR-4762-3p	CLIP-seq
MIRT958311	hsa-miR-4789-3p	CLIP-seq
MIRT958312	hsa-miR-4802-5p	CLIP-seq
MIRT958313	hsa-miR-488	CLIP-seq
MIRT958314	hsa-miR-491-3p	CLIP-seq
MIRT958315	hsa-miR-495	CLIP-seq
MIRT958316	hsa-miR-513a-5p	CLIP-seq
MIRT958317	hsa-miR-548an	CLIP-seq
MIRT958318	hsa-miR-548p	CLIP-seq
MIRT958319	hsa-miR-561	CLIP-seq
MIRT958320	hsa-miR-570	CLIP-seq
MIRT958321	hsa-miR-571	CLIP-seq
MIRT958322	hsa-miR-583	CLIP-seq
MIRT958323	hsa-miR-586	CLIP-seq
MIRT958324	hsa-miR-592	CLIP-seq
MIRT958325	hsa-miR-597	CLIP-seq
MIRT958326	hsa-miR-599	CLIP-seq
MIRT958327	hsa-miR-606	CLIP-seq
MIRT958328	hsa-miR-613	CLIP-seq
MIRT958329	hsa-miR-617	CLIP-seq
MIRT958243	hsa-miR-625	CLIP-seq
MIRT958330	hsa-miR-656	CLIP-seq
MIRT958331	hsa-miR-767-5p	CLIP-seq
MIRT958332	hsa-miR-888	CLIP-seq
MIRT958291	hsa-miR-4303	CLIP-seq
MIRT958301	hsa-miR-4514	CLIP-seq
MIRT958304	hsa-miR-4663	CLIP-seq
MIRT958307	hsa-miR-4692	CLIP-seq
MIRT1983792	hsa-miR-4753-3p	CLIP-seq
MIRT1983793	hsa-miR-4775	CLIP-seq
MIRT958311	hsa-miR-4789-3p	CLIP-seq
MIRT1983794	hsa-miR-4799-5p	CLIP-seq
MIRT1983795	hsa-miR-590-3p	CLIP-seq
MIRT1983796	hsa-miR-942	CLIP-seq
MIRT2219079	hsa-miR-1253	CLIP-seq
MIRT2219080	hsa-miR-1283	CLIP-seq
MIRT2219081	hsa-miR-130a	CLIP-seq
MIRT2219082	hsa-miR-130b	CLIP-seq
MIRT2219083	hsa-miR-1343	CLIP-seq
MIRT958250	hsa-miR-147	CLIP-seq
MIRT2219084	hsa-miR-148a	CLIP-seq
MIRT2219085	hsa-miR-148b	CLIP-seq
MIRT2219086	hsa-miR-152	CLIP-seq
MIRT2219087	hsa-miR-19a	CLIP-seq
MIRT2219088	hsa-miR-19b	CLIP-seq
MIRT2219089	hsa-miR-223	CLIP-seq
MIRT2219090	hsa-miR-301a	CLIP-seq
MIRT2219091	hsa-miR-301b	CLIP-seq
MIRT2219092	hsa-miR-3074-3p	CLIP-seq
MIRT2219093	hsa-miR-3074-5p	CLIP-seq
MIRT2219094	hsa-miR-3143	CLIP-seq
MIRT958233	hsa-miR-34b	CLIP-seq
MIRT2219095	hsa-miR-3612	CLIP-seq
MIRT2219096	hsa-miR-3666	CLIP-seq
MIRT2219097	hsa-miR-3681	CLIP-seq
MIRT2219098	hsa-miR-3689a-5p	CLIP-seq
MIRT2219099	hsa-miR-3689b	CLIP-seq
MIRT2219100	hsa-miR-3689e	CLIP-seq
MIRT2219101	hsa-miR-3689f	CLIP-seq
MIRT2219102	hsa-miR-3936	CLIP-seq
MIRT2219103	hsa-miR-3945	CLIP-seq
MIRT2219104	hsa-miR-410	CLIP-seq
MIRT2219105	hsa-miR-4253	CLIP-seq
MIRT2219106	hsa-miR-4295	CLIP-seq
MIRT958291	hsa-miR-4303	CLIP-seq
MIRT2219107	hsa-miR-4423-3p	CLIP-seq
MIRT2219108	hsa-miR-4433	CLIP-seq
MIRT2219109	hsa-miR-4443	CLIP-seq
MIRT2219110	hsa-miR-4459	CLIP-seq
MIRT2219111	hsa-miR-4464	CLIP-seq
MIRT2219112	hsa-miR-454	CLIP-seq
MIRT2219113	hsa-miR-4639-5p	CLIP-seq
MIRT2219114	hsa-miR-4659a-3p	CLIP-seq
MIRT2219115	hsa-miR-4659b-3p	CLIP-seq
MIRT958305	hsa-miR-4666-3p	CLIP-seq
MIRT2219116	hsa-miR-4679	CLIP-seq
MIRT2219117	hsa-miR-4697-3p	CLIP-seq
MIRT2219118	hsa-miR-4705	CLIP-seq
MIRT2219119	hsa-miR-4720-5p	CLIP-seq
MIRT2219120	hsa-miR-4748	CLIP-seq
MIRT1983792	hsa-miR-4753-3p	CLIP-seq
MIRT958310	hsa-miR-4762-3p	CLIP-seq
MIRT2219121	hsa-miR-4768-3p	CLIP-seq
MIRT2219122	hsa-miR-4768-5p	CLIP-seq
MIRT958311	hsa-miR-4789-3p	CLIP-seq
MIRT2219123	hsa-miR-4799-3p	CLIP-seq
MIRT2219124	hsa-miR-515-3p	CLIP-seq
MIRT2219125	hsa-miR-515-5p	CLIP-seq
MIRT2219126	hsa-miR-519e	CLIP-seq
MIRT2219127	hsa-miR-543	CLIP-seq
MIRT2219128	hsa-miR-550a	CLIP-seq
MIRT958242	hsa-miR-579	CLIP-seq
MIRT958326	hsa-miR-599	CLIP-seq
MIRT2219129	hsa-miR-626	CLIP-seq
MIRT2219130	hsa-miR-650	CLIP-seq
MIRT2219131	hsa-miR-9	CLIP-seq
MIRT2219089	hsa-miR-223	CLIP-seq
MIRT2219117	hsa-miR-4697-3p	CLIP-seq
MIRT2219129	hsa-miR-626	CLIP-seq
MIRT2436944	hsa-miR-4795-3p	CLIP-seq
MIRT2436944	hsa-miR-4795-3p	CLIP-seq
MIRT2219081	hsa-miR-130a	CLIP-seq
MIRT2219082	hsa-miR-130b	CLIP-seq
MIRT2219084	hsa-miR-148a	CLIP-seq
MIRT2219085	hsa-miR-148b	CLIP-seq
MIRT2219086	hsa-miR-152	CLIP-seq
MIRT2219087	hsa-miR-19a	CLIP-seq
MIRT2219088	hsa-miR-19b	CLIP-seq
MIRT2219089	hsa-miR-223	CLIP-seq
MIRT2448752	hsa-miR-23a	CLIP-seq
MIRT2448753	hsa-miR-23b	CLIP-seq
MIRT2448754	hsa-miR-23c	CLIP-seq
MIRT2448755	hsa-miR-28-5p	CLIP-seq
MIRT2219090	hsa-miR-301a	CLIP-seq
MIRT2219091	hsa-miR-301b	CLIP-seq
MIRT2448756	hsa-miR-3139	CLIP-seq
MIRT2448757	hsa-miR-3662	CLIP-seq
MIRT2219096	hsa-miR-3666	CLIP-seq
MIRT2219106	hsa-miR-4295	CLIP-seq
MIRT2448758	hsa-miR-4434	CLIP-seq
MIRT958300	hsa-miR-450b-5p	CLIP-seq
MIRT2448759	hsa-miR-4516	CLIP-seq
MIRT2448760	hsa-miR-4531	CLIP-seq
MIRT2219112	hsa-miR-454	CLIP-seq
MIRT2219117	hsa-miR-4697-3p	CLIP-seq
MIRT2448761	hsa-miR-4708-3p	CLIP-seq
MIRT2448762	hsa-miR-4790-3p	CLIP-seq
MIRT2219129	hsa-miR-626	CLIP-seq
MIRT2448763	hsa-miR-708	CLIP-seq
MIRT958274	hsa-miR-3153	CLIP-seq
MIRT2679881	hsa-miR-4468	CLIP-seq
MIRT958309	hsa-miR-4729	CLIP-seq
MIRT2679882	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000340	Function	RNA 7-methylguanosine cap binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003743	Function	Translation initiation factor activity	IBA
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IBA
GO:0006413	Process	Translational initiation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	IBA

Other IDs

• MIM: 609896
• HGNC: 31837
• e!Ensembl: ENSG00000163412

Protein

• UniProt ID: Q8N5X7
• Protein name: Eukaryotic translation initiation factor 4E type 3 (eIF-4E type 3) (eIF-4E3) (eIF4E type 3) (eIF4E-3)
• Protein function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01652	IF4E	48 → 208	Eukaryotic initiation factor 4E	Domain

• Sequence:

  MALPPAAAPPAGAREPPGSRAAAAAAAPEPPLGLQQLSALQPEPGGVPLHSSWTFWLDRS
  LPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESN
  AKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDREDVVQVWNV
  NASLVGEATVLEKIYELLPHITFKAVFYKPHEEHHAFEGGRGKH

• Sequence length: 224

Pathways

Reactome:

ISG15 antiviral mechanism

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-MELANOMA SKIN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult Medulloblastoma	Medulloblastoma	BEFREE	30382096		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	36952494	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23667251		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23667251, 37353728, 39940786	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	30382096		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21088106		★☆☆☆☆ Found in Text Mining only
Contracture	Contracture	Pubtator	19332160	Associate	★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	25403230		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	40658715	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	23667251	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27840964		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23667251		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23431134		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	30382096		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36473947	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	27626179	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23431134		★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	36952494	Associate	★☆☆☆☆ Found in Text Mining only