Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	3167
Gene name	H6 family homeobox 2
Gene symbol	HMX2
Synonyms (NCBI Gene)	H6LNkx5-2
Chromosome	10
Chromosome location	10q26.13
Summary	The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in pa

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Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	20371350
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT504397	hsa-miR-598-5p	PAR-CLIP	20371350
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT504394	hsa-miR-640	PAR-CLIP	20371350
MIRT529625	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT529624	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	23446348
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	23446348
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT504397	hsa-miR-598-5p	PAR-CLIP	23446348
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT504394	hsa-miR-640	PAR-CLIP	23446348
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	27292025
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	27292025
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	27292025
MIRT504397	hsa-miR-598-5p	PAR-CLIP	27292025
MIRT504394	hsa-miR-640	PAR-CLIP	27292025
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	20371350
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT504397	hsa-miR-598-5p	PAR-CLIP	20371350
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT504394	hsa-miR-640	PAR-CLIP	20371350
MIRT529625	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT529624	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	23446348
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	23446348
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT504397	hsa-miR-598-5p	PAR-CLIP	23446348
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT504394	hsa-miR-640	PAR-CLIP	23446348
MIRT2451290	hsa-miR-3127-3p	CLIP-seq
MIRT2451291	hsa-miR-4539	CLIP-seq
MIRT2451292	hsa-miR-4680-5p	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0007420	Process	Brain development	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0042472	Process	Inner ear morphogenesis	IEA
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IEA
GO:0050673	Process	Epithelial cell proliferation	IEA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IEA
GO:0072089	Process	Stem cell proliferation	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000648	Process	Positive regulation of stem cell proliferation	IEA

MIM	HGNC	e!Ensembl
600647	5018	ENSG00000188816

A2RU54

Protein name

Homeobox protein HMX2 (Homeobox protein H6 family member 2)

Protein function

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	150 → 206	Homeodomain	Domain

Sequence

MGSKEDAGKGCPAAGGVSSFTIQSILGGGPSEAPREPVGWPARKRSLSVSSEEEEPDDGW
KAPACFCPDQHGPKEQGPKHHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKEEK
ERLLPAGSPSPGSERPRDGGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERA
CLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVSMPLVFRDSSLLRV
PVPRSLAFPAPLYYPGSNLSALPLYNLYNKLDY

Sequence length

273

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
High myopia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HMX2-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Astrocytoma	Astrocytoma	Pubtator	33051600	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	19723660	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital sensorineural hearing loss	Congenital Sensorineural Hearing Loss	BEFREE	19253379		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hearing Loss Sensorineural	Hearing loss	Pubtator	19253379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	33048949	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Meniere Disease	Meniere Disease	BEFREE	31106404		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vestibular Diseases	Vestibular disease	Pubtator	19253379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HMX2 (H6 family homeobox 2)