Gene Gene information from NCBI Gene database.
Entrez ID 3151
Gene name High mobility group nucleosomal binding domain 2
Gene symbol HMGN2
Synonyms (NCBI Gene)
HMG17
Chromosome 1
Chromosome location 1p36.11
Summary The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The pr
miRNA miRNA information provided by mirtarbase database.
679
miRTarBase ID miRNA Experiments Reference
MIRT007264 hsa-miR-23a-3p Luciferase reporter assay 23437179
MIRT007264 hsa-miR-23a-3p Luciferase reporter assay 23437179
MIRT007264 hsa-miR-23a-3p Luciferase reporter assay 23437179
MIRT052523 hsa-let-7a-5p CLASH 23622248
MIRT047960 hsa-miR-30c-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IEA
GO:0003677 Function DNA binding IEA
GO:0003682 Function Chromatin binding IBA
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 21044950, 21812934, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
163910 4986 ENSG00000198830
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05204
Protein name Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2)
Protein function Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:000
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01101 HMG14_17 1 89 HMG14 and HMG17 Family
Sequence
Sequence length 90
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 2317791
★☆☆☆☆
Found in Text Mining only
AL-RAQAD SYNDROME AL-Raqad Syndrome BEFREE 23975681
★☆☆☆☆
Found in Text Mining only
Arthritis, Psoriatic Psoriatic Arthritis BEFREE 28408162
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 12523645
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 27358110, 28035005, 30655878
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 28035005 Associate
★☆☆☆☆
Found in Text Mining only
Dental Enamel Hypoplasia Dental Enamel Hypoplasia BEFREE 23975681
★☆☆☆☆
Found in Text Mining only
Down Syndrome Down syndrome Pubtator 34946949 Stimulate
★☆☆☆☆
Found in Text Mining only
Fibroid Tumor Leiomyoma BEFREE 9973936
★☆☆☆☆
Found in Text Mining only
Glucagonoma Glucagonoma BEFREE 2169420
★☆☆☆☆
Found in Text Mining only