Gene Gene information from NCBI Gene database.
Entrez ID 3069
Gene name High density lipoprotein binding protein
Gene symbol HDLBP
Synonyms (NCBI Gene)
HBPPRO2900VGL
Chromosome 2
Chromosome location 2q37.3
Summary The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
miRNA miRNA information provided by mirtarbase database.
785
miRTarBase ID miRNA Experiments Reference
MIRT025358 hsa-miR-34a-5p Proteomics 21566225
MIRT025358 hsa-miR-34a-5p Proteomics 21566225
MIRT025699 hsa-miR-7-5p Microarray 19073608
MIRT046605 hsa-miR-222-3p CLASH 23622248
MIRT044029 hsa-miR-365a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
GO:0003729 Function MRNA binding IBA
GO:0005515 Function Protein binding IPI 24725430, 33941620
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
142695 4857 ENSG00000115677
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q00341
Protein name Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)
Protein function Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
PDB 1VIG , 1VIH , 2CTE , 2CTF , 2CTJ , 2CTK , 2CTL , 2CTM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00013 KH_1 152 214 KH domain Domain
PF00013 KH_1 224 286 KH domain Domain
PF00013 KH_1 297 359 KH domain Domain
PF00013 KH_1 366 426 KH domain Domain
PF00013 KH_1 437 499 KH domain Domain
PF00013 KH_1 509 572 KH domain Domain
PF00013 KH_1 581 645 KH domain Domain
PF00013 KH_1 655 718 KH domain Domain
PF00013 KH_1 729 792 KH domain Domain
PF00013 KH_1 802 865 KH domain Domain
PF00013 KH_1 875 969 KH domain Domain
PF00013 KH_1 974 1036 KH domain Domain
PF00013 KH_1 1054 1119 KH domain Domain
PF00013 KH_1 1129 1192 KH domain Domain
Sequence
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEP
SGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA
KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLL
ISAEQDKRAVERLEVEKAFHPFIAGP
YNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKK
IYEEKKKKTTTIAV
EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYA
K
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVA
QEQIEG
MVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNL
IRIEGDPQGVQQAKRELLE
LASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQK
MVADLVENSYSISVPIFKQFHKNIIGKG
GANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILS
IQKDLANIAEVEVSI
PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLH
LA
EEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKE
DAVREAQKELEA
LIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRS
GTQSDKVTLKGAKDCVEAAKKRIQE
IIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQIT
RDFSVQIKFPDREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKC
EAAKEALEA
LVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAI
TGLAANLDRAKAGLLE
RVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRL
EHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILR
IVGELEQMVSEDVPLDHRVHA
RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILN
LEEEYLAD
VVDSEALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPK
TLPWGPKR
Sequence length 1268
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HDL clearance
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
30
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arteriosclerosis Arteriosclerosis BEFREE 9409201
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 9409201
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Autism Pubtator 33941620 Associate
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 19365831
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autistic Disorder Autism CTD_human_DG 19365831
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autistic Disorder Autism Pubtator 33941620 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Brain Ischemia Cerebral Ischemia BEFREE 30993971
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 20974809, 30292064
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 20974809 Inhibit
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 22302350, 33941620 Associate
★☆☆☆☆
Found in Text Mining only