Gene Gene information from NCBI Gene database.
Entrez ID 302
Gene name Annexin A2
Gene symbol ANXA2
Synonyms (NCBI Gene)
ANX2ANX2L4CAL1HHEL-S-270LIP2LPC2LPC2DP36PAP-IV
Chromosome 15
Chromosome location 15q22.2
Summary This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor whi
miRNA miRNA information provided by mirtarbase database.
686
miRTarBase ID miRNA Experiments Reference
MIRT001388 hsa-miR-1-3p pSILAC 18668040
MIRT020897 hsa-miR-155-5p Proteomics 18668040
MIRT001388 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT001388 hsa-miR-1-3p Proteomics 18668040
MIRT045844 hsa-miR-132-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
109
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis IEP 11866539
GO:0001533 Component Cornified envelope IEA
GO:0001765 Process Membrane raft assembly IMP 23861394
GO:0001786 Function Phosphatidylserine binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
151740 537 ENSG00000182718
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07355
Protein name Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Protein function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation,
PDB 1W7B , 1XJL , 2HYU , 2HYV , 2HYW , 4DRW , 4FTG , 4HRH , 5LPU , 5LPX , 5LQ0 , 5LQ2 , 5N7D , 5N7F , 5N7G , 6TWQ , 6TWU , 6TWX , 6TWY , 7DTO , 7EQ7 , 7NMI , 7P70 , 7P71 , 7P72 , 7P73 , 7P74 , 7PC3 , 7PC4 , 7PC5 , 7PC7 , 7PC8 , 7PC9 , 7PCB , 7QQL , 7QQM , 7QQN , 7ZVN , 7ZVX , 8AEL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00191 Annexin 37 102 Annexin Family
PF00191 Annexin 109 174 Annexin Family
PF00191 Annexin 193 259 Annexin Family
PF00191 Annexin 269 334 Annexin Family
Sequence
Sequence length 339
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Salmonella infection   Neutrophil degranulation
Dissolution of Fibrin Clot
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
15
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASEPTIC NECROSIS OF HEAD AND/OR NECK OF FEMUR Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AVASCULAR NECROSIS OF BONE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 26465153
★☆☆☆☆
Found in Text Mining only
Acute Myeloid Leukemia (AML-M2) Leukemia CTD_human_DG 17330099
★☆☆☆☆
Found in Text Mining only
Acute Myeloid Leukemia, M1 Myeloid Leukemia CTD_human_DG 17330099
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 30474876
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 10099141, 11108960, 11795262, 12165291, 15070701, 15567461, 16197459, 21146216, 22855149, 28687976, 31370070
★☆☆☆☆
Found in Text Mining only
Adamantinous Craniopharyngioma Adamantinous Craniopharyngioma BEFREE 27640198
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 15526283
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 17054434, 22855149, 25347154, 28178129, 31325182, 8269629
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 20429620
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 31821092
★☆☆☆☆
Found in Text Mining only