ANXA1 (annexin A1)

Gene

• Entrez ID: 301
• Gene name: Annexin A1
• Gene symbol: ANXA1
• Synonyms (NCBI Gene): ANX1, LPC1
• Chromosome: 9
• Chromosome location: 9q21.13
• Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000709	hsa-miR-196a-5p	real time qRT-PCR, Luciferase reporter assay, Western blot	18663355
MIRT000709	hsa-miR-196a-5p	Luciferase reporter assay	18663355
MIRT018638	hsa-miR-335-5p	Microarray	18185580
MIRT000709	hsa-miR-196a-5p	Reporter assay;Other	18663355
MIRT028650	hsa-miR-30a-5p	Proteomics	18668040
MIRT030065	hsa-miR-26b-5p	Microarray	19088304
MIRT054354	hsa-miR-221-3p	Luciferase reporter assay, QRTPCR, Western blot	23630541
MIRT000709	hsa-miR-196a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25523631
MIRT737187	hsa-miR-196a-3p	qRT-PCR	31777500
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT786405	hsa-miR-4291	CLIP-seq
MIRT786406	hsa-miR-4310	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT1555950	hsa-miR-1267	CLIP-seq
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT1555951	hsa-miR-3185	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT1555952	hsa-miR-4709-3p	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT1555953	hsa-miR-653	CLIP-seq
MIRT2384265	hsa-miR-296-3p	CLIP-seq
MIRT2384266	hsa-miR-568	CLIP-seq
MIRT2384267	hsa-miR-584	CLIP-seq
MIRT2384268	hsa-miR-643	CLIP-seq
MIRT1555950	hsa-miR-1267	CLIP-seq
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT2426342	hsa-miR-2110	CLIP-seq
MIRT2426343	hsa-miR-221	CLIP-seq
MIRT2426344	hsa-miR-222	CLIP-seq
MIRT2426345	hsa-miR-28-3p	CLIP-seq
MIRT2384265	hsa-miR-296-3p	CLIP-seq
MIRT2426346	hsa-miR-3150a-3p	CLIP-seq
MIRT2426347	hsa-miR-3163	CLIP-seq
MIRT1555951	hsa-miR-3185	CLIP-seq
MIRT2426348	hsa-miR-3662	CLIP-seq
MIRT2426349	hsa-miR-3675-3p	CLIP-seq
MIRT2426350	hsa-miR-369-3p	CLIP-seq
MIRT2426351	hsa-miR-374a	CLIP-seq
MIRT2426352	hsa-miR-374b	CLIP-seq
MIRT2426353	hsa-miR-376c	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT2426354	hsa-miR-4260	CLIP-seq
MIRT2426355	hsa-miR-4271	CLIP-seq
MIRT786405	hsa-miR-4291	CLIP-seq
MIRT786406	hsa-miR-4310	CLIP-seq
MIRT2426356	hsa-miR-4484	CLIP-seq
MIRT2426357	hsa-miR-4668-5p	CLIP-seq
MIRT2426358	hsa-miR-4694-3p	CLIP-seq
MIRT1555952	hsa-miR-4709-3p	CLIP-seq
MIRT2426359	hsa-miR-4725-3p	CLIP-seq
MIRT2426360	hsa-miR-4773	CLIP-seq
MIRT2426361	hsa-miR-4789-5p	CLIP-seq
MIRT2426362	hsa-miR-4797-5p	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT2426363	hsa-miR-548an	CLIP-seq
MIRT2426364	hsa-miR-548c-3p	CLIP-seq
MIRT2384266	hsa-miR-568	CLIP-seq
MIRT2426365	hsa-miR-570	CLIP-seq
MIRT2384267	hsa-miR-584	CLIP-seq
MIRT2384268	hsa-miR-643	CLIP-seq
MIRT1555953	hsa-miR-653	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IDA	10908733
GO:0001533	Component	Cornified envelope	IEA
GO:0001780	Process	Neutrophil homeostasis	IEA
GO:0001780	Process	Neutrophil homeostasis	IMP	21957127
GO:0001786	Function	Phosphatidylserine binding	IBA
GO:0001891	Component	Phagocytic cup	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002548	Process	Monocyte chemotaxis	IDA	15187149
GO:0002685	Process	Regulation of leukocyte migration	IEA
GO:0002685	Process	Regulation of leukocyte migration	ISS
GO:0004859	Function	Phospholipase inhibitor activity	IEA
GO:0005102	Function	Signaling receptor binding	TAS	10882119
GO:0005509	Function	Calcium ion binding	EXP	11078886
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005509	Function	Calcium ion binding	TAS	2967291
GO:0005515	Function	Protein binding	IPI	20029029, 21383699, 24189400, 31980649, 32296183, 32814053, 34237247
GO:0005543	Function	Phospholipid binding	TAS	2967291
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IDA	2138016
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	22664934, 23580065
GO:0005615	Component	Extracellular space	IDA	17008549, 19625660, 25664854
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10772777, 22056994
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10772777, 17008549, 19625660, 22056994
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005768	Component	Endosome	IDA	18767904
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005884	Component	Actin filament	IDA	22773844
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	10772777
GO:0005886	Component	Plasma membrane	IEA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005929	Component	Cilium	IEA
GO:0006909	Process	Phagocytosis	IBA
GO:0006909	Process	Phagocytosis	IEA
GO:0006909	Process	Phagocytosis	ISS
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	ISS
GO:0006954	Process	Inflammatory response	TAS	10882119
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	16130169
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10882119
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA	25664854
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP	15187149
GO:0008289	Function	Lipid binding	EXP	8756690
GO:0008360	Process	Regulation of cell shape	IDA	15187149
GO:0009986	Component	Cell surface	IDA	22056994
GO:0010008	Component	Endosome membrane	IEA
GO:0012506	Component	Vesicle membrane	IBA
GO:0014839	Process	Myoblast migration involved in skeletal muscle regeneration	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	ISS
GO:0018149	Process	Peptide cross-linking	IDA	10908733
GO:0019834	Function	Phospholipase A2 inhibitor activity	IDA	2936963, 3013422
GO:0019834	Function	Phospholipase A2 inhibitor activity	IEA
GO:0030036	Process	Actin cytoskeleton organization	IDA	15187149
GO:0030216	Process	Keratinocyte differentiation	IDA	10908733
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28344315, 28675934
GO:0031340	Process	Positive regulation of vesicle fusion	IDA	2138016
GO:0031340	Process	Positive regulation of vesicle fusion	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0031514	Component	Motile cilium	ISS
GO:0031901	Component	Early endosome membrane	ISS
GO:0031982	Component	Vesicle	HDA	19190083
GO:0032652	Process	Regulation of interleukin-1 production	IEA
GO:0032652	Process	Regulation of interleukin-1 production	ISS
GO:0032717	Process	Negative regulation of interleukin-8 production	IMP	22056994
GO:0032743	Process	Positive regulation of interleukin-2 production	IDA	17008549
GO:0033031	Process	Positive regulation of neutrophil apoptotic process	IEA
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IDA	22773844
GO:0042102	Process	Positive regulation of T cell proliferation	IDA	17008549
GO:0042119	Process	Neutrophil activation	IDA	22879591
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0045087	Process	Innate immune response	IEA
GO:0045627	Process	Positive regulation of T-helper 1 cell differentiation	IDA	17008549
GO:0045629	Process	Negative regulation of T-helper 2 cell differentiation	IDA	17008549
GO:0045920	Process	Negative regulation of exocytosis	IMP	19625660
GO:0046632	Process	Alpha-beta T cell differentiation	IEA
GO:0046632	Process	Alpha-beta T cell differentiation	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0046883	Process	Regulation of hormone secretion	IMP	19625660
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IPI	15226301
GO:0050482	Process	Arachidonate secretion	IEA
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0051051	Process	Negative regulation of transport	IEA
GO:0051240	Process	Positive regulation of multicellular organismal process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 21362503, 23533145
GO:0070062	Component	Extracellular exosome	IDA	25664854
GO:0070062	Component	Extracellular exosome	IEA
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IBA
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IDA	2936963
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IEA
GO:0071621	Process	Granulocyte chemotaxis	IDA	15187149
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	22773844
GO:0090303	Process	Positive regulation of wound healing	IDA	25664854
GO:0097350	Process	Neutrophil clearance	IMP	21957127
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IEA

Other IDs

• MIM: 151690
• HGNC: 533
• e!Ensembl: ENSG00000135046

Protein

• UniProt ID: P04083
• Protein name: Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]
• Protein function: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulat
• PDB: 1AIN, 1BO9, 1QLS, 5VFW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00191	Annexin	46 → 111	Annexin	Family
  PF00191	Annexin	118 → 183	Annexin	Family
  PF00191	Annexin	201 → 267	Annexin	Family
  PF00191	Annexin	277 → 342	Annexin	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy d
• Sequence:

  MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGV
  DEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDA
  DELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNAL
  LSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKY
  TKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM
  VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN

• Sequence length: 346

Pathways

Reactome:

G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Interleukin-4 and Interleukin-13 signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXA1-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ISCHEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CRANIOFACIAL ABNORMALITIES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL SQUAMOUS CELL CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHATIC METASTASIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOUTH NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Coronary Syndrome	Coronary Syndrome	BEFREE	28329022		★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	28569789, 7718618		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	LHGDN	15526283, 16324197, 16899607		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	16324197, 29254791		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma Of Esophagus	Esophageal Cancer	BEFREE	30249885		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	17351649, 29552220, 9563852		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	19381893		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	16324197		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	29763932	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer Disease, Early Onset	Alzheimer disease	BEFREE	15917097		★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	28912154		★☆☆☆☆ Found in Text Mining only
Anaplastic carcinoma	Anaplastic Carcinoma	CTD_human_DG	12376462, 16316942		★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	16627980		★☆☆☆☆ Found in Text Mining only
Anemia Sickle Cell	Sickle cell anemia	Pubtator	27802331	Associate	★☆☆☆☆ Found in Text Mining only
Anemia, Sickle Cell	Anemia	BEFREE	27802331, 28207871		★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	21825040, 31124054		★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety disorder	Pubtator	28969474	Associate	★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	27860536, 28062503, 28111551		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	25634111, 29301525		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	11228158, 18260157, 19767728, 30286327		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	18260157, 19767728	Stimulate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	27860536, 28062503, 28111551		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	28329022	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	25533809, 25619792, 29751523, 31462505		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	15070421, 29749523, 30272262		★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	BEFREE	19773200		★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet Syndrome	BEFREE	18205865, 28963375		★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	28963375	Associate	★☆☆☆☆ Found in Text Mining only
Bile duct carcinoma	Bile duct carcinoma	BEFREE	25038797		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	17019707, 17994624, 25337195		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	LHGDN	17019707		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	37906427	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	15567174, 18776816, 19208747, 20163912, 20308542, 20821804, 21383699, 22640735, 25028131, 25344217, 25536365, 26000884, 26137966, 27105503, 27778118, 28212890, 29021293, 29233185, 29263330, 29932988, 30122097, 30142511		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25536365, 26000884, 26137966, 26657294, 26957268, 27612479, 29333087, 35626741, 36414640, 36867680	Associate	★☆☆☆☆ Found in Text Mining only
Bronchial Diseases	Bronchial disease	Pubtator	29749523	Associate	★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	BEFREE	24187664		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	16627980, 19833546, 21127395, 22385607, 22929401, 23167407, 23431236, 24282368, 24719523, 26137966, 27240147, 28355254, 30984541, 33804148	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	12242662, 20821804, 23341933		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma	Carcinoma	CTD_human_DG	12376462, 16316942		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma	Carcinoma	Pubtator	16627980	Inhibit	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma	Carcinoma	Pubtator	16675446	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	29333087	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	23651211, 26431426, 29391759	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37117324	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	17019707, 17994624, 25337195		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	22696682, 22929401, 25300907, 25344217, 28009433, 28551657, 29552220		★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	31882477	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	23167407, 25854353, 26644413, 31926587	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35974388	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37464398	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	23341933	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	8919037		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	20603238		★☆☆☆☆ Found in Text Mining only
Carcinoma, Spindle-Cell	Carcinoma	CTD_human_DG	12376462, 16316942		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	29085990		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	25038797, 27860536		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	25038797	Associate	★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Carotid artery stenosis	BEFREE	21195640		★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Carotid artery stenosis	Pubtator	21195640	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Cerebral Infarction	BEFREE	29769639, 29844306		★☆☆☆☆ Found in Text Mining only
Cerebral Thrombosis	Cerebral Thrombosis	BEFREE	31154815		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	17493033, 18262660, 30158515, 31154815		★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	26072160, 30984541		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	26072160, 30984541		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	23674846		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	35225485	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	31148248		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	29440885, 29544524, 30121452		★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	35693826	Associate	★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	21544067		★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	22723974, 37891214	Associate	★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	18541673	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21127395, 25242330		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	18071363	Stimulate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20872967, 21127395, 29091952, 32823596, 33172883, 33596760, 37986009	Associate	★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	23674846		★☆☆☆☆ Found in Text Mining only
Congenital thrombotic disease due to Protein C deficiency	Congenital thrombotic thrombocytopenic purpura	Pubtator	35428170	Associate	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30506742		★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	28329022, 29192208		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	28329022		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	28329022	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	28329022		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	11118734, 22488912, 24130820, 9502407		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	24130820, 37891214	Associate	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	16014420		★☆☆☆☆ Found in Text Mining only
Deficiency of butyryl-CoA dehydrogenase	Deficiency Of Butyryl-CoA Dehydrogenase	BEFREE	28329022		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	31654714		★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	BEFREE	30650525		★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	30650525		★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	29605649, 30650525		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	24591769, 29085990, 30972066, 31114582		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	24591769, 29085990, 30972066, 31114582		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	10593565, 12496451, 29085990		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	11574426, 29677533, 30972066		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	32778679, 35991124, 36401196	Associate	★☆☆☆☆ Found in Text Mining only
Diarrhea 5 With Tufting Enteropathy Congenital	Congenital diarrhea	Pubtator	14695321	Associate	★☆☆☆☆ Found in Text Mining only
Dysferlinopathy	Dysferlinopathy	Pubtator	39350328	Associate	★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	BEFREE	30972066		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	30650525		★☆☆☆☆ Found in Text Mining only
Encephalitis	Encephalitis	BEFREE	31297095		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	21305022, 34195683, 36745330	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	18706208, 25201101, 30096622		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	LHGDN	18706208		★☆☆☆☆ Found in Text Mining only
Ependymoma	Ependymoma	BEFREE	17549010, 19767728		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	31618599		★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	18663355, 28392898, 29254791		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	18663355, 28392898		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	LHGDN	18663355		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	21517111, 24551299, 28035369, 30249885, 36963399, 38085519	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial Alzheimer Disease (FAD)	Alzheimer disease	BEFREE	28912154		★☆☆☆☆ Found in Text Mining only
Familial multiple trichoepitheliomata	Multiple Trichoepithelioma	BEFREE	19773200		★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	24668763		★☆☆☆☆ Found in Text Mining only
Fleck corneal dystrophy	Fleck Corneal Dystrophy	BEFREE	18075258		★☆☆☆☆ Found in Text Mining only
FOCAL CORTICAL DYSPLASIA OF TAYLOR	Focal cortical dysplasia	BEFREE	31618599		★☆☆☆☆ Found in Text Mining only
Fragile X Syndrome	Fragile X Syndrome	BEFREE	12112448		★☆☆☆☆ Found in Text Mining only
Fuchs' Endothelial Dystrophy	Fuchs endothelial dystrophy	Pubtator	35239706	Associate	★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	33261560	Associate	★☆☆☆☆ Found in Text Mining only
Ganglioglioma	Ganglioglioma	BEFREE	15175076		★☆☆☆☆ Found in Text Mining only
Gastric Adenocarcinoma	Gastric Cancer	BEFREE	23431236		★☆☆☆☆ Found in Text Mining only
Gastric ulcer	Gastric ulcer	BEFREE	24719523		★☆☆☆☆ Found in Text Mining only
Gastritis	Gastritis	BEFREE	23431236		★☆☆☆☆ Found in Text Mining only
Gastritis	Gastritis	Pubtator	23431236	Associate	★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Gastrointestinal neoplasm	Pubtator	29091952	Associate	★☆☆☆☆ Found in Text Mining only
Giant Cell Arteritis	Giant Cell Arteritis	BEFREE	29731755		★☆☆☆☆ Found in Text Mining only
Gingivitis	Gingivitis	BEFREE	18588867, 29608211		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	19767728		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	19767728, 27770278, 34345995, 35770335, 37434432	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	18260157, 25853691		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	18260157, 23991102		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	23991102, 28901452, 33706561, 38049523	Associate	★☆☆☆☆ Found in Text Mining only
Granulomatosis with Polyangiitis	Granulomatosis with polyangiitis	Pubtator	31142442	Associate	★☆☆☆☆ Found in Text Mining only
Hairy Cell Leukemia	Hairy Cell Leukemia	BEFREE	15183626, 28608720		★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	25322804, 30142511		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	14695321	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	30157864	Stimulate	★☆☆☆☆ Found in Text Mining only
Hemoglobinopathies	Hemoglobinopathy	BEFREE	27802331		★☆☆☆☆ Found in Text Mining only
Hemolysis	Hemolysis	Pubtator	27802331	Associate	★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	25899628	Inhibit	★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	15070421		★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	BEFREE	31715265		★☆☆☆☆ Found in Text Mining only
Hypersensitivity Immediate	Hypersensitivity	Pubtator	34627197	Inhibit	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	CTD_human_DG	22228705		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypoxia	Hypoxia	Pubtator	27834582, 33804148	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	32215176	Stimulate	★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	18566442		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	LHGDN	18566442		★☆☆☆☆ Found in Text Mining only
Immune thrombocytopenic purpura	Immune Thrombocytopenic Purpura	BEFREE	24994465		★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	8656012		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	21544067		★☆☆☆☆ Found in Text Mining only
Inflammatory abnormality of the eye	Inflammatory abnormality of the eye	BEFREE	28257834		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	24130820		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	24130820	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory dermatosis	Dermatitis	BEFREE	30650525		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	26469698		★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Intestinal Diseases	BEFREE	22723974		★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Intestinal disease	Pubtator	24719523	Associate	★☆☆☆☆ Found in Text Mining only
Intrahepatic Cholangiocarcinoma	Intrahepatic Cholangiocarcinoma	BEFREE	28357490		★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	29844306		★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	CTD_human_DG	20484890		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Kidney Diseases	Kidney Disease	BEFREE	29085990, 29402790		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Kidney Failure, Acute	Kidney Failure	BEFREE	29402790		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	35974388	Associate	★☆☆☆☆ Found in Text Mining only
Laryngeal neoplasm	Laryngeal neoplasm	LHGDN	17340616		★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	25490767	Associate	★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	17340616, 19076685		★☆☆☆☆ Found in Text Mining only
Leprosy	Leprosy	BEFREE	29605649		★☆☆☆☆ Found in Text Mining only
Leprosy	Leprosy	Pubtator	33263684	Associate	★☆☆☆☆ Found in Text Mining only
Leprosy Lepromatous	Leprosy	Pubtator	33263684	Stimulate	★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	28569789, 31912375, 36651527	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Hairy Cell	Hairy cell leukemia	Pubtator	23347903, 24903677, 31077558	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	28569789, 37302023	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	28569789	Associate	★☆☆☆☆ Found in Text Mining only
Lipodystrophy	Lipodystrophy	Pubtator	35684160	Inhibit	★☆☆☆☆ Found in Text Mining only
Lipoid nephrosis	Lipoid Nephrosis	BEFREE	24591769		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	19020748, 23674846, 25412936, 26709725		★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Liver neoplasm	Pubtator	26644413	Associate	★☆☆☆☆ Found in Text Mining only
Lung diseases	Lung Diseases	BEFREE	22777765, 28009433		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	11504947		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	18794547		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	22929401, 28009433	Stimulate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	33959206	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	10525320, 11014347, 12472178, 28300427, 29751523, 31724735		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	14695321, 25854353	Inhibit	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Lymphatic Metastasis	CTD_human_DG	19381893		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Lymphatic Metastasis	BEFREE	22929401		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	22929401, 24282368	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	35225485	Stimulate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Lymphoma	BEFREE	20359522		★☆☆☆☆ Found in Text Mining only
Lymphoma, Large-Cell, Follicular	Lymphoma	BEFREE	12153001		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	12153001		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	12153001		★☆☆☆☆ Found in Text Mining only
Macular dystrophy, corneal type 1	Macular corneal dystrophy	BEFREE	24591769		★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	28901452		★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	25322804, 30142511		★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	28608720		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	15070421, 15567174, 18318472, 18776816, 19208747, 20163912, 20308542, 20821804, 21383699, 22640735, 25028131, 25344217, 25536365, 26000884, 26137966, 27105503, 27778118, 28212890, 29021293, 29233185, 29263330, 29932988, 30122097, 30142511		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	15070421, 18663355, 28392898		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gastrointestinal tract	Malignant gastrointestinal tract tumors	BEFREE	29091952		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of larynx	Larynx cancer	BEFREE	17340616		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31807177		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	22696682, 22929401, 25300907, 25344217, 28009433, 28551657, 29552220		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	CTD_human_DG	15274141		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	19833546		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	20603238		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	21825040, 29986379, 30518142, 31124054, 31472403		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of penis	Penile cancer	BEFREE	23341933		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	11801547, 12629510, 16182442, 16324197, 16741918, 20227822, 26312765, 26369530, 27834582		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	17566973		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	23431236, 25038797, 27941907, 29254791		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	16627980		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	17019707, 17994624, 25337195		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15070421, 16247483, 16324197, 18663355, 19767728, 20181942, 20603238, 22640735, 22659075, 24242295, 24810927, 25038797, 25536365, 25983101, 27035116, 28212890, 29233185, 29614751, 30122097, 30286327, 30871809, 31118675		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	26072160, 30984541		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	16949910, 19208747		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	20930115, 28212890		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	28608720		★☆☆☆☆ Found in Text Mining only
Medullary carcinoma of thyroid	Megalencephaly, Polymicrogyria, Polydactyly, Hydrocephalus Syndrome	BEFREE	17145757		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	23056502, 27612479	Associate	★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	26469698		★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	Mental retardation	BEFREE	31618599		★☆☆☆☆ Found in Text Mining only
Motor Neuron Disease	Motor Neuron Disease	BEFREE	15009685		★☆☆☆☆ Found in Text Mining only
Mouth Diseases	Mouth disease	Pubtator	19351789	Inhibit	★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth Neoplasms	CTD_human_DG	15274141		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mouth Neoplasms	Mouth neoplasm	Pubtator	19833546, 22335413, 23786757, 29937423, 34157171	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moyamoya Disease	Moyamoya disease	Pubtator	39948449	Associate	★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	Pubtator	35692878	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	30292410		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	23277546		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy	Muscular dystrophy	BEFREE	16100712		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy	Muscular dystrophy	LHGDN	16100712		★☆☆☆☆ Found in Text Mining only
MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1C	Limb-Girdle Muscular Dystrophy	BEFREE	21412170		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	29192208, 29720616, 31001111, 31132398, 31196457		★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	BEFREE	29192208		★☆☆☆☆ Found in Text Mining only
Nasal Polyps	Nasal polyposis	BEFREE	17014434, 20549082		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	25322804, 28355254, 29357787, 30459351		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	28355254, 30459351	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11358987, 12242662, 12460909, 15447985, 16247483, 16627980, 16741918, 16763609, 16823838, 17019707, 17340616, 19208747, 19767728, 19833546, 20163912, 20603238, 23341933, 23403091, 24810927, 25322804, 26137966, 26760764, 27834582, 28212890, 28216224, 28442415, 28640256, 29091952, 29187872, 29201239, 29254791, 29263330, 29357787, 29705927, 30122097, 30142511, 30249885, 30286327, 30292410, 30518142, 30756482, 30871809, 30984541, 31118675, 31461932, 31686810		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	21338355		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	15485494, 27590054		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	33935041	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	15307952, 17979810, 21844361, 24725413		★☆☆☆☆ Found in Text Mining only
Niemann-Pick Disease, Type C	Niemann-Pick Disease	BEFREE	16525053		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	27035116, 28551657, 30756482		★☆☆☆☆ Found in Text Mining only
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	BEFREE	24668763		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	24668763, 29677533		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	25856673	Associate	★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	19767728		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	24480285	Associate	★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	31814858		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	20181942		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	33291071	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	20603238		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	21825040, 29986379, 30518142, 31124054, 31472403		★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	21825040		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	25038797, 35428170	Stimulate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	25510623, 29986379, 30518142, 33353163, 33804148, 34944403	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	25880590		★☆☆☆☆ Found in Text Mining only
Paraparesis Tropical Spastic	Tropical spastic paraparesis	Pubtator	33632146	Associate	★☆☆☆☆ Found in Text Mining only
Paratuberculosis	Paratuberculosis	BEFREE	11118734		★☆☆☆☆ Found in Text Mining only
Penile Neoplasms	Penile neoplasm	Pubtator	23341933	Associate	★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	BEFREE	18588867		★☆☆☆☆ Found in Text Mining only
Peritonitis	Peritonitis	Pubtator	20665809	Associate	★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	31654714		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	11801547, 12629510, 15123618, 16182442, 16324197, 16741918, 20227822, 26312765, 26369530, 27834582		★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasias	Prostatic Neoplasms	LHGDN	15944914, 16324197		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	15944914, 16741918		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	17566973		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19351789	Inhibit	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21703393, 24086397, 26312765, 27834582, 30027097, 32215176, 32858191	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	26369530		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Proteinuria	Proteinuria	Pubtator	33351137	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	29802736		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	29440885, 29544524, 35129068	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	18566442		★☆☆☆☆ Found in Text Mining only
Rectal Carcinoma	Rectal Carcinoma	BEFREE	24810927		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30506742		★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Renal Insufficiency	BEFREE	29085990		★☆☆☆☆ Found in Text Mining only
Retinopathy of Prematurity	Retinopathy	BEFREE	31317786, 31788758		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	LHGDN	17008549		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	25697137, 29751523, 30426384		★☆☆☆☆ Found in Text Mining only
Russell-Silver syndrome	Russell-Silver Syndrome	BEFREE	31618599		★☆☆☆☆ Found in Text Mining only
Salivary Gland Neoplasms	Salivary gland neoplasms	Pubtator	39201484	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Sarcoidosis	BEFREE	9572000		★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	36988561	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	21772061		★☆☆☆☆ Found in Text Mining only
Schwartz-Jampel Syndrome	Schwartz-Jampel Syndrome	BEFREE	27154258		★☆☆☆☆ Found in Text Mining only
Seborrheic keratosis	Seborrheic keratosis	BEFREE	8919037		★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	31366407	Associate	★☆☆☆☆ Found in Text Mining only
Skin lesion	Skin Lesion	BEFREE	29605649, 30650525, 31800923		★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	21138858, 26135980		★☆☆☆☆ Found in Text Mining only
Spinal Muscular Atrophy	Spinal Muscular Atrophy	BEFREE	25878277		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	12242662, 18673418, 23403091, 29201239, 8919037		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	12679902, 15447985, 18297688		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	CTD_human_DG	15274141		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	15447985, 17187659, 25983101, 30249885, 31186736		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	CTD_human_DG	21517111		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	14695321, 20497865, 23786757, 25490767, 30157864, 34157171	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	19833546, 28754915	Inhibit	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	25523631, 28754915, 30142511		★☆☆☆☆ Found in Text Mining only
Status Epilepticus	Status Epilepticus	BEFREE	30755225		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	23431236, 25038797, 27941907		★☆☆☆☆ Found in Text Mining only
Stomach Diseases	Stomach Diseases	CTD_human_DG	15472012		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	20665809, 23431236, 24282368, 27941907, 28058586	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	25038797	Inhibit	★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	34345995	Associate	★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	29535807		★☆☆☆☆ Found in Text Mining only
TARSAL-CARPAL COALITION SYNDROME	Tarsal-Carpal Coalition Syndrome	BEFREE	17994624		★☆☆☆☆ Found in Text Mining only
Thrombosis of cerebral veins	Thrombosis	BEFREE	31154815		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	16627980	Stimulate	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	24023790, 25880590, 34723715, 34767591	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	16627980		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	16627980		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	LHGDN	16627980		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	16627980, 38203548	Associate	★☆☆☆☆ Found in Text Mining only
Toxic Epidermal Necrolysis	Stevens-Johnson Syndrome	BEFREE	18706208, 27154258		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	29021293, 29416802, 29932988, 30884823, 31461932		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	31461932	Associate	★☆☆☆☆ Found in Text Mining only
Tuberous Sclerosis	Tuberous Sclerosis	BEFREE	22612807		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	22723974		★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	CTD_human_DG	12376462, 16316942		★☆☆☆☆ Found in Text Mining only
Ureteral Calculi	Ureteral calculi	Pubtator	34160472	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Calculi (disorder)	Urinary Bladder Calculi	BEFREE	17994624		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	25337195, 32802870, 33830879, 35090432, 37950728	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Dysplasia	Uterine disease	Pubtator	32768930	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	26738866	Stimulate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	27240147, 32768930, 37400149	Associate	★☆☆☆☆ Found in Text Mining only
Uveitis	Uveitis	BEFREE	25619792		★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	19767728		★☆☆☆☆ Found in Text Mining only
X-Linked Lissencephaly	Lissencephaly, X-Linked	BEFREE	10826984		★☆☆☆☆ Found in Text Mining only