Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	30001
Gene name	Endoplasmic reticulum oxidoreductase 1 alpha
Gene symbol	ERO1A
Synonyms (NCBI Gene)	ERO1-LERO1-L-alphaERO1-alphaERO1LERO1LAEro1alpha
Chromosome	14
Chromosome location	14q22.1

Show/Hide all (98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT713192	hsa-miR-141-3p	HITS-CLIP	19536157
MIRT713191	hsa-miR-200a-3p	HITS-CLIP	19536157
MIRT713190	hsa-miR-433-5p	HITS-CLIP	19536157
MIRT713189	hsa-miR-6502-3p	HITS-CLIP	19536157
MIRT713188	hsa-miR-6888-5p	HITS-CLIP	19536157
MIRT713187	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT558074	hsa-miR-4768-3p	HITS-CLIP	19536157
MIRT558073	hsa-miR-4459	HITS-CLIP	19536157
MIRT558072	hsa-miR-4433a-3p	HITS-CLIP	19536157
MIRT713186	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT713185	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT713184	hsa-miR-8073	HITS-CLIP	19536157
MIRT713183	hsa-miR-4794	HITS-CLIP	19536157
MIRT713182	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT713181	hsa-miR-494-3p	HITS-CLIP	19536157
MIRT713180	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713179	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713178	hsa-miR-4683	HITS-CLIP	19536157
MIRT633500	hsa-miR-583	HITS-CLIP	23824327
MIRT638749	hsa-miR-6089	HITS-CLIP	23824327
MIRT633499	hsa-miR-4284	HITS-CLIP	23824327
MIRT633498	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633497	hsa-miR-1268a	HITS-CLIP	23824327
MIRT633496	hsa-miR-1268b	HITS-CLIP	23824327
MIRT633495	hsa-miR-7977	HITS-CLIP	23824327
MIRT633494	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT633500	hsa-miR-583	HITS-CLIP	23824327
MIRT638749	hsa-miR-6089	HITS-CLIP	23824327
MIRT633499	hsa-miR-4284	HITS-CLIP	23824327
MIRT633498	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633497	hsa-miR-1268a	HITS-CLIP	23824327
MIRT633496	hsa-miR-1268b	HITS-CLIP	23824327
MIRT633495	hsa-miR-7977	HITS-CLIP	23824327
MIRT633494	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT633500	hsa-miR-583	HITS-CLIP	23824327
MIRT633499	hsa-miR-4284	HITS-CLIP	23824327
MIRT633498	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633497	hsa-miR-1268a	HITS-CLIP	23824327
MIRT633496	hsa-miR-1268b	HITS-CLIP	23824327
MIRT633495	hsa-miR-7977	HITS-CLIP	23824327
MIRT633494	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT558077	hsa-miR-548p	PAR-CLIP	21572407
MIRT558076	hsa-miR-4433b-3p	PAR-CLIP	21572407
MIRT558075	hsa-miR-4698	PAR-CLIP	21572407
MIRT558074	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT558073	hsa-miR-4459	PAR-CLIP	21572407
MIRT558072	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT558071	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT558070	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT740559	hsa-miR-141-3p	HITS-CLIP	19536157
MIRT740560	hsa-miR-200a-3p	HITS-CLIP	19536157
MIRT740561	hsa-miR-433-5p	HITS-CLIP	19536157
MIRT740562	hsa-miR-6502-3p	HITS-CLIP	19536157
MIRT740563	hsa-miR-6888-5p	HITS-CLIP	19536157
MIRT740564	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT740565	hsa-miR-4768-3p	HITS-CLIP	19536157
MIRT740566	hsa-miR-4459	HITS-CLIP	19536157
MIRT740567	hsa-miR-4433a-3p	HITS-CLIP	19536157
MIRT740568	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT740569	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT740570	hsa-miR-8073	HITS-CLIP	19536157
MIRT740571	hsa-miR-4794	HITS-CLIP	19536157
MIRT740572	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT740573	hsa-miR-494-3p	HITS-CLIP	19536157
MIRT740574	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT740575	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT740576	hsa-miR-4683	HITS-CLIP	19536157
MIRT741619	hsa-miR-583	HITS-CLIP	23824327
MIRT741620	hsa-miR-6089	HITS-CLIP	23824327
MIRT741621	hsa-miR-4284	HITS-CLIP	23824327
MIRT741622	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT741623	hsa-miR-1268a	HITS-CLIP	23824327
MIRT741624	hsa-miR-1268b	HITS-CLIP	23824327
MIRT741625	hsa-miR-7977	HITS-CLIP	23824327
MIRT741626	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT741619	hsa-miR-583	HITS-CLIP	23824327
MIRT741620	hsa-miR-6089	HITS-CLIP	23824327
MIRT741621	hsa-miR-4284	HITS-CLIP	23824327
MIRT741622	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT741623	hsa-miR-1268a	HITS-CLIP	23824327
MIRT741624	hsa-miR-1268b	HITS-CLIP	23824327
MIRT741625	hsa-miR-7977	HITS-CLIP	23824327
MIRT741626	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT741619	hsa-miR-583	HITS-CLIP	23824327
MIRT741621	hsa-miR-4284	HITS-CLIP	23824327
MIRT741622	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT741623	hsa-miR-1268a	HITS-CLIP	23824327
MIRT741624	hsa-miR-1268b	HITS-CLIP	23824327
MIRT741625	hsa-miR-7977	HITS-CLIP	23824327
MIRT741626	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT754225	hsa-miR-548p	PAR-CLIP	21572407
MIRT754226	hsa-miR-4433b-3p	PAR-CLIP	21572407
MIRT754227	hsa-miR-4698	PAR-CLIP	21572407
MIRT740565	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT740566	hsa-miR-4459	PAR-CLIP	21572407
MIRT740567	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT754228	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT754229	hsa-miR-3653-3p	PAR-CLIP	21572407

Show/Hide all (1)

Transcription factor	Regulation	Reference
PPARG	Activation	18177270

Show/Hide all (52)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17170699, 20802462, 25416956, 29858230, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IDA	29858230
GO:0005783	Component	Endoplasmic reticulum	IDA	10671517, 29858230
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	10671517
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005796	Component	Golgi lumen	IDA	29858230
GO:0005796	Component	Golgi lumen	IEA
GO:0006457	Process	Protein folding	IDA	11707400
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	IMP	29858230
GO:0006457	Process	Protein folding	TAS	10671517
GO:0006915	Process	Apoptotic process	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007519	Process	Skeletal muscle tissue development	IEA
GO:0009266	Process	Response to temperature stimulus	TAS	10671517
GO:0015035	Function	Protein-disulfide reductase activity	IBA
GO:0015035	Function	Protein-disulfide reductase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10671517
GO:0016491	Function	Oxidoreductase activity	IDA	11707400, 29858230
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016972	Function	Thiol oxidase activity	IEA
GO:0019852	Process	L-ascorbic acid metabolic process	IEA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IEA
GO:0034975	Process	Protein folding in endoplasmic reticulum	IBA
GO:0034975	Process	Protein folding in endoplasmic reticulum	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	ISS
GO:0036211	Process	Protein modification process	TAS	10671517
GO:0042995	Component	Cell projection	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	TAS	10671517
GO:0045454	Process	Cell redox homeostasis	IEA
GO:0045454	Process	Cell redox homeostasis	IMP	29858230
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	ISS
GO:0051604	Process	Protein maturation	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0071949	Function	FAD binding	IEA

MIM	HGNC	e!Ensembl
615435	13280	ENSG00000197930

Q96HE7

Protein name

ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha)

Protein function

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Fol

PDB

3AHQ , 3AHR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04137	ERO1	60 → 457	Endoplasmic Reticulum Oxidoreductin 1 (ERO1)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. {ECO:0000269|PubMed:10818100}.

Sequence

MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLDDCTCDVETIDRFNNYR
LFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVKPCQSDEVPDGIKSASYKY
SEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEYVD
LLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGTSEENTFYSWLEGL
CVEKRAFYRLISGLHASINVHLSARYLLQETWLEKKWGHNITEFQQRFDGILTEGEGPRR
LKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKIQDEENKMLLLEILHEIKSFPLHFDE
NSFFAGDKKEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKL
IANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH

Sequence length

468

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum Vibrio cholerae infection Lipid and atherosclerosis		Insulin processing Detoxification of Reactive Oxygen Species

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (35)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute pancreatitis	Pancreatitis	BEFREE	30851439		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	40183343	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28160557		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28160557, 33751828	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Hemorrhage	Cerebral hemorrhage	Pubtator	37473923	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	30826359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	30826359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	31410063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28839225		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	31410063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	24022479		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	28774960		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperhomocysteinemia	Hyperhomocysteinemia	BEFREE	30292945		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	BEFREE	15592500		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	27244197	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	30867055, 34354701	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	34354701	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	27100727		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30377291		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	28774960	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure, Acute	Liver failure	BEFREE	25387528		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	27161446	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28160557		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	30076651, 31666928		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	26987398, 28962158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15592500, 27100727, 28160557, 28839225, 30826359, 31142270		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	30826359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	30850265		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	30850265	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15592500, 27100727, 28962158, 30076651, 30165193, 30344729, 31142270		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30344729		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	30076651, 31666928		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	26987398, 28962158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	27100727, 28160557		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	28160557	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ERO1A (endoplasmic reticulum oxidoreductase 1 alpha)