PACSIN1 (protein kinase C and casein kinase substrate in neurons 1)

Gene

• Entrez ID: 29993
• Gene name: Protein kinase C and casein kinase substrate in neurons 1
• Gene symbol: PACSIN1
• Synonyms (NCBI Gene): SDPI
• Chromosome: 6
• Chromosome location: 6p21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT484692	hsa-miR-1178-5p	PAR-CLIP	23592263
MIRT484691	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT484690	hsa-miR-4459	PAR-CLIP	23592263
MIRT484689	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT484688	hsa-miR-6087	PAR-CLIP	23592263
MIRT484687	hsa-miR-4533	PAR-CLIP	23592263
MIRT461972	hsa-miR-3202	PAR-CLIP	23592263
MIRT484686	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT484685	hsa-miR-663a	PAR-CLIP	23592263
MIRT484684	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT484683	hsa-miR-4651	PAR-CLIP	23592263
MIRT484682	hsa-miR-608	PAR-CLIP	23592263
MIRT484681	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT484680	hsa-miR-6745	PAR-CLIP	23592263
MIRT484679	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT461996	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT461997	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT461994	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT461995	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT461993	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT461992	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT461991	hsa-miR-3185	PAR-CLIP	23592263
MIRT461990	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT461989	hsa-miR-6132	PAR-CLIP	23592263
MIRT461988	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT461987	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT461986	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT461973	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT461985	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT461984	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT461983	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT461982	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT461981	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT461980	hsa-miR-1258	PAR-CLIP	23592263
MIRT461979	hsa-miR-2278	PAR-CLIP	23592263
MIRT461978	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT461977	hsa-miR-4476	PAR-CLIP	23592263
MIRT461976	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT461974	hsa-miR-9500	PAR-CLIP	23592263
MIRT461975	hsa-miR-7515	PAR-CLIP	23592263
MIRT461973	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT461972	hsa-miR-3202	PAR-CLIP	23592263
MIRT461971	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT461970	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT461969	hsa-miR-765	PAR-CLIP	23592263
MIRT461968	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT461967	hsa-miR-1293	PAR-CLIP	23592263
MIRT461966	hsa-miR-4483	PAR-CLIP	23592263
MIRT461965	hsa-miR-8071	PAR-CLIP	23592263
MIRT461964	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT461963	hsa-miR-3165	PAR-CLIP	23592263
MIRT461962	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT461961	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT447917	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT447916	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447917	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT447916	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT484692	hsa-miR-1178-5p	PAR-CLIP	23592263
MIRT484691	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT484690	hsa-miR-4459	PAR-CLIP	23592263
MIRT484689	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT484688	hsa-miR-6087	PAR-CLIP	23592263
MIRT484687	hsa-miR-4533	PAR-CLIP	23592263
MIRT461972	hsa-miR-3202	PAR-CLIP	23592263
MIRT484686	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT484685	hsa-miR-663a	PAR-CLIP	23592263
MIRT484684	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT484683	hsa-miR-4651	PAR-CLIP	23592263
MIRT484682	hsa-miR-608	PAR-CLIP	23592263
MIRT484681	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT484680	hsa-miR-6745	PAR-CLIP	23592263
MIRT484679	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT461996	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT461997	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT461994	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT461995	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT461993	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT461992	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT461991	hsa-miR-3185	PAR-CLIP	23592263
MIRT461990	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT461989	hsa-miR-6132	PAR-CLIP	23592263
MIRT461988	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT461987	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT461986	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT461973	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT461985	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT461984	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT461983	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT461982	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT461981	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT461980	hsa-miR-1258	PAR-CLIP	23592263
MIRT461979	hsa-miR-2278	PAR-CLIP	23592263
MIRT461978	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT461977	hsa-miR-4476	PAR-CLIP	23592263
MIRT461976	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT461974	hsa-miR-9500	PAR-CLIP	23592263
MIRT461975	hsa-miR-7515	PAR-CLIP	23592263
MIRT461973	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT461972	hsa-miR-3202	PAR-CLIP	23592263
MIRT461971	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT461970	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT461969	hsa-miR-765	PAR-CLIP	23592263
MIRT461968	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT461967	hsa-miR-1293	PAR-CLIP	23592263
MIRT461966	hsa-miR-4483	PAR-CLIP	23592263
MIRT461965	hsa-miR-8071	PAR-CLIP	23592263
MIRT461964	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT461963	hsa-miR-3165	PAR-CLIP	23592263
MIRT461962	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT461961	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT447917	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT447916	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447917	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT447916	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT1210054	hsa-miR-1207-3p	CLIP-seq
MIRT1210055	hsa-miR-3925-3p	CLIP-seq
MIRT1210056	hsa-miR-4539	CLIP-seq
MIRT1210057	hsa-miR-4680-5p	CLIP-seq
MIRT1210058	hsa-miR-4691-5p	CLIP-seq
MIRT1210059	hsa-miR-4712-5p	CLIP-seq
MIRT1210060	hsa-miR-512-5p	CLIP-seq
MIRT1210061	hsa-miR-544	CLIP-seq
MIRT1210062	hsa-miR-665	CLIP-seq
MIRT1210063	hsa-miR-770-5p	CLIP-seq
MIRT1210064	hsa-miR-1224-3p	CLIP-seq
MIRT1210065	hsa-miR-1226	CLIP-seq
MIRT1210066	hsa-miR-1229	CLIP-seq
MIRT1210067	hsa-miR-1231	CLIP-seq
MIRT1210068	hsa-miR-125a-3p	CLIP-seq
MIRT1210069	hsa-miR-1260	CLIP-seq
MIRT1210070	hsa-miR-1260b	CLIP-seq
MIRT1210071	hsa-miR-1280	CLIP-seq
MIRT1210072	hsa-miR-1298	CLIP-seq
MIRT1210073	hsa-miR-1299	CLIP-seq
MIRT1210074	hsa-miR-1324	CLIP-seq
MIRT1210075	hsa-miR-134	CLIP-seq
MIRT1210076	hsa-miR-188-3p	CLIP-seq
MIRT1210077	hsa-miR-205	CLIP-seq
MIRT1210078	hsa-miR-2110	CLIP-seq
MIRT1210079	hsa-miR-2861	CLIP-seq
MIRT1210080	hsa-miR-296-5p	CLIP-seq
MIRT1210081	hsa-miR-3118	CLIP-seq
MIRT1210082	hsa-miR-3121-5p	CLIP-seq
MIRT1210083	hsa-miR-3144-5p	CLIP-seq
MIRT1210084	hsa-miR-3156-3p	CLIP-seq
MIRT1210085	hsa-miR-3161	CLIP-seq
MIRT1210086	hsa-miR-3164	CLIP-seq
MIRT1210087	hsa-miR-3191	CLIP-seq
MIRT1210088	hsa-miR-3607-5p	CLIP-seq
MIRT1210089	hsa-miR-3616-3p	CLIP-seq
MIRT1210090	hsa-miR-3620	CLIP-seq
MIRT1210091	hsa-miR-3919	CLIP-seq
MIRT1210092	hsa-miR-3940-3p	CLIP-seq
MIRT1210093	hsa-miR-4270	CLIP-seq
MIRT1210094	hsa-miR-4271	CLIP-seq
MIRT1210095	hsa-miR-4441	CLIP-seq
MIRT1210096	hsa-miR-4463	CLIP-seq
MIRT1210097	hsa-miR-4475	CLIP-seq
MIRT1210098	hsa-miR-4494	CLIP-seq
MIRT1210099	hsa-miR-4501	CLIP-seq
MIRT1210100	hsa-miR-4512	CLIP-seq
MIRT1210101	hsa-miR-4649-3p	CLIP-seq
MIRT1210102	hsa-miR-4652-5p	CLIP-seq
MIRT1210103	hsa-miR-4656	CLIP-seq
MIRT1210104	hsa-miR-4667-3p	CLIP-seq
MIRT1210105	hsa-miR-4667-5p	CLIP-seq
MIRT1210057	hsa-miR-4680-5p	CLIP-seq
MIRT1210106	hsa-miR-4700-5p	CLIP-seq
MIRT1210107	hsa-miR-4721	CLIP-seq
MIRT1210108	hsa-miR-4725-3p	CLIP-seq
MIRT1210109	hsa-miR-4726-3p	CLIP-seq
MIRT1210110	hsa-miR-4733-3p	CLIP-seq
MIRT1210111	hsa-miR-4747-5p	CLIP-seq
MIRT1210112	hsa-miR-4756-3p	CLIP-seq
MIRT1210113	hsa-miR-4786-5p	CLIP-seq
MIRT1210114	hsa-miR-532-3p	CLIP-seq
MIRT1210115	hsa-miR-541	CLIP-seq
MIRT1210116	hsa-miR-548ag	CLIP-seq
MIRT1210117	hsa-miR-548ai	CLIP-seq
MIRT1210118	hsa-miR-654-3p	CLIP-seq
MIRT1210119	hsa-miR-654-5p	CLIP-seq
MIRT1210120	hsa-miR-875-3p	CLIP-seq
MIRT1210121	hsa-miR-938	CLIP-seq
MIRT2060249	hsa-miR-1291	CLIP-seq
MIRT1210089	hsa-miR-3616-3p	CLIP-seq
MIRT1210107	hsa-miR-4721	CLIP-seq
MIRT2060250	hsa-miR-544b	CLIP-seq
MIRT2060251	hsa-miR-183	CLIP-seq
MIRT2060252	hsa-miR-3622b-5p	CLIP-seq
MIRT2060253	hsa-miR-3910	CLIP-seq
MIRT2060254	hsa-miR-4690-3p	CLIP-seq
MIRT1210113	hsa-miR-4786-5p	CLIP-seq
MIRT2060255	hsa-miR-939	CLIP-seq
MIRT2288615	hsa-miR-1275	CLIP-seq
MIRT2288616	hsa-miR-1321	CLIP-seq
MIRT2288617	hsa-miR-139-3p	CLIP-seq
MIRT2060251	hsa-miR-183	CLIP-seq
MIRT2288618	hsa-miR-1913	CLIP-seq
MIRT2288619	hsa-miR-1972	CLIP-seq
MIRT2288620	hsa-miR-3126-5p	CLIP-seq
MIRT1210083	hsa-miR-3144-5p	CLIP-seq
MIRT2288621	hsa-miR-3150a-3p	CLIP-seq
MIRT2288622	hsa-miR-3169	CLIP-seq
MIRT2288623	hsa-miR-3175	CLIP-seq
MIRT2288624	hsa-miR-3189-5p	CLIP-seq
MIRT2288625	hsa-miR-324-3p	CLIP-seq
MIRT2060252	hsa-miR-3622b-5p	CLIP-seq
MIRT2060253	hsa-miR-3910	CLIP-seq
MIRT2288626	hsa-miR-4260	CLIP-seq
MIRT2288627	hsa-miR-4267	CLIP-seq
MIRT2288628	hsa-miR-4283	CLIP-seq
MIRT2288629	hsa-miR-4419a	CLIP-seq
MIRT2288630	hsa-miR-4481	CLIP-seq
MIRT2288631	hsa-miR-4489	CLIP-seq
MIRT2288632	hsa-miR-4492	CLIP-seq
MIRT2288633	hsa-miR-4498	CLIP-seq
MIRT2288634	hsa-miR-4510	CLIP-seq
MIRT2288635	hsa-miR-4665-5p	CLIP-seq
MIRT1210105	hsa-miR-4667-5p	CLIP-seq
MIRT2288636	hsa-miR-4693-3p	CLIP-seq
MIRT1210106	hsa-miR-4700-5p	CLIP-seq
MIRT2288637	hsa-miR-4723-5p	CLIP-seq
MIRT2288638	hsa-miR-4739	CLIP-seq
MIRT2288639	hsa-miR-4745-5p	CLIP-seq
MIRT2288640	hsa-miR-4756-5p	CLIP-seq
MIRT2288641	hsa-miR-4758-3p	CLIP-seq
MIRT2288642	hsa-miR-4763-5p	CLIP-seq
MIRT2288643	hsa-miR-4773	CLIP-seq
MIRT2288644	hsa-miR-4802-5p	CLIP-seq
MIRT2288645	hsa-miR-491-5p	CLIP-seq
MIRT2288646	hsa-miR-634	CLIP-seq
MIRT2288647	hsa-miR-637	CLIP-seq
MIRT2288648	hsa-miR-762	CLIP-seq
MIRT2060255	hsa-miR-939	CLIP-seq
MIRT2060249	hsa-miR-1291	CLIP-seq
MIRT2288629	hsa-miR-4419a	CLIP-seq
MIRT2288634	hsa-miR-4510	CLIP-seq
MIRT1210102	hsa-miR-4652-5p	CLIP-seq
MIRT1210105	hsa-miR-4667-5p	CLIP-seq
MIRT1210106	hsa-miR-4700-5p	CLIP-seq
MIRT1210107	hsa-miR-4721	CLIP-seq
MIRT2060250	hsa-miR-544b	CLIP-seq
MIRT2455795	hsa-miR-2052	CLIP-seq
MIRT2465788	hsa-miR-122	CLIP-seq
MIRT2465789	hsa-miR-1254	CLIP-seq
MIRT2465790	hsa-miR-3116	CLIP-seq
MIRT2465791	hsa-miR-3665	CLIP-seq
MIRT2465792	hsa-miR-4254	CLIP-seq
MIRT2465793	hsa-miR-764	CLIP-seq
MIRT2586651	hsa-miR-3612	CLIP-seq
MIRT2586652	hsa-miR-3918	CLIP-seq
MIRT1210091	hsa-miR-3919	CLIP-seq
MIRT2465792	hsa-miR-4254	CLIP-seq
MIRT2586653	hsa-miR-4443	CLIP-seq
MIRT2586654	hsa-miR-4640-5p	CLIP-seq
MIRT2586655	hsa-miR-4695-5p	CLIP-seq
MIRT2586656	hsa-miR-4726-5p	CLIP-seq
MIRT2586657	hsa-miR-4751	CLIP-seq
MIRT1210112	hsa-miR-4756-3p	CLIP-seq
MIRT2586658	hsa-miR-619	CLIP-seq
MIRT2586659	hsa-miR-650	CLIP-seq
MIRT1210062	hsa-miR-665	CLIP-seq
MIRT2586651	hsa-miR-3612	CLIP-seq
MIRT2586652	hsa-miR-3918	CLIP-seq
MIRT1210091	hsa-miR-3919	CLIP-seq
MIRT2465792	hsa-miR-4254	CLIP-seq
MIRT2586653	hsa-miR-4443	CLIP-seq
MIRT2586654	hsa-miR-4640-5p	CLIP-seq
MIRT2586655	hsa-miR-4695-5p	CLIP-seq
MIRT2586656	hsa-miR-4726-5p	CLIP-seq
MIRT2586657	hsa-miR-4751	CLIP-seq
MIRT1210112	hsa-miR-4756-3p	CLIP-seq
MIRT2586658	hsa-miR-619	CLIP-seq
MIRT2586659	hsa-miR-650	CLIP-seq
MIRT1210062	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 16318909, 17161366, 17500595, 20936779, 21044950, 25036101, 25416956, 28514442, 31413325, 31515488, 32296183, 32814053, 33961781
GO:0005543	Function	Phospholipid binding	IBA
GO:0005543	Function	Phospholipid binding	IDA	19549836
GO:0005543	Function	Phospholipid binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006897	Process	Endocytosis	IEA
GO:0007010	Process	Cytoskeleton organization	IBA
GO:0007015	Process	Actin filament organization	IEA
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0030100	Process	Regulation of endocytosis	IBA
GO:0030137	Component	COPI-coated vesicle	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0032587	Component	Ruffle membrane	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043679	Component	Axon terminus	ISS
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0045806	Process	Negative regulation of endocytosis	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0048488	Process	Synaptic vesicle endocytosis	IEA
GO:0048488	Process	Synaptic vesicle endocytosis	ISS
GO:0048666	Process	Neuron development	IEA
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0048812	Process	Neuron projection morphogenesis	ISS
GO:0072657	Process	Protein localization to membrane	IEA
GO:0072657	Process	Protein localization to membrane	ISS
GO:0072659	Process	Protein localization to plasma membrane	ISS
GO:0097320	Process	Plasma membrane tubulation	IBA
GO:0097320	Process	Plasma membrane tubulation	IDA	19549836
GO:0097320	Process	Plasma membrane tubulation	IEA
GO:0098684	Component	Photoreceptor ribbon synapse	IEA
GO:0098833	Component	Presynaptic endocytic zone	IEA
GO:1900006	Process	Positive regulation of dendrite development	IBA
GO:1900006	Process	Positive regulation of dendrite development	ISS

Other IDs

• MIM: 606512
• HGNC: 8570
• e!Ensembl: ENSG00000124507

Protein

• UniProt ID: Q9BY11
• Protein name: Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)
• Protein function: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiti
• PDB: 3HAH, 3HAI, 3Q84, 3QNI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00611	FCH	24 → 100	Fes/CIP4, and EFC/F-BAR homology domain	Family
  PF14604	SH3_9	392 → 442	Variant SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain and, at much lower levels, in heart and pancreas. {ECO:0000269|PubMed:11179684}.
• Sequence:

  MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQL
  TDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDA
  YHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTE
  QSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEK
  RLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWP
  QFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEW
  SDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDE
  QGWCRGRLDSGQLGLYPANYVEAI

• Sequence length: 444

Pathways

Reactome:

Clathrin-mediated endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cognition Disorders	Cognition disorder	Pubtator	40494419	Associate	★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	35299244	Associate	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	12354780		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	22761659	Associate	★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	24204982	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	40494419	Associate	★☆☆☆☆ Found in Text Mining only
Varicosity	Vulval varices	BEFREE	12354780		★☆☆☆☆ Found in Text Mining only