RHOD (ras homolog family member D)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 29984
Gene name Ras homolog family member D
Gene symbol RHOD
Synonyms (NCBI Gene)
ARHDRHOHP1RHOMRho
Chromosome 11
Chromosome location 11q13.2
Summary Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It
miRNA miRNA information provided by mirtarbase database.
55
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (55)
miRTarBase ID miRNA Experiments Reference
MIRT1305815 hsa-miR-1207-5p CLIP-seq
MIRT1305816 hsa-miR-2964a-5p CLIP-seq
MIRT1305817 hsa-miR-3126-5p CLIP-seq
MIRT1305818 hsa-miR-3176 CLIP-seq
MIRT1305819 hsa-miR-3179 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (33)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 9116026
GO:0005085 Function Guanyl-nucleotide exchange factor activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605781 670 ENSG00000173156
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00212
Protein name Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
Protein function Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of
PDB 2J1L , 7KDC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 19 → 192 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Sequence
Sequence length 210
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Axon guidance   Rho GTPase cycle
RHO GTPases Activate Formins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (179)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Achromatopsia Achromatopsia BEFREE 29296074
★★★★★
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 26045836
★★★★★
★☆☆☆☆
Found in Text Mining only
Alstrom Syndrome Alstrom Syndrome BEFREE 31302159
★★★★★
★☆☆☆☆
Found in Text Mining only
Amaurosis congenita of Leber, type 1 Leber congenital amaurosis BEFREE 16052170, 31302159
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis, Psoriatic Psoriatic Arthritis BEFREE 28791377
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 25150870
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 39868576 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Atrophoderma maculatum Anetoderma HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Attention Deficit Disorder with Hyperactivity Attention deficit hyperactivity disorder Pubtator 32724127 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Bardet-Biedl Syndrome Bardet-Biedl Syndrome BEFREE 31302159
★★★★★
★☆☆☆☆
Found in Text Mining only