Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29964
Gene name	Prickle planar cell polarity protein 4
Gene symbol	PRICKLE4
Synonyms (NCBI Gene)	C6orf49OBTPOEBTTOMM6
Chromosome	6
Chromosome location	6p21.1
Summary	C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]

183

Show/Hide all (183)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046728	hsa-miR-222-3p	CLASH	23622248
MIRT041605	hsa-miR-193b-3p	CLASH	23622248
MIRT040154	hsa-miR-615-3p	CLASH	23622248
MIRT691436	hsa-miR-3929	HITS-CLIP	23313552
MIRT691435	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691434	hsa-miR-4478	HITS-CLIP	23313552
MIRT691433	hsa-miR-581	HITS-CLIP	23313552
MIRT691432	hsa-miR-508-3p	HITS-CLIP	23313552
MIRT691431	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT691430	hsa-miR-323a-5p	HITS-CLIP	23313552
MIRT691429	hsa-miR-876-3p	HITS-CLIP	23313552
MIRT691428	hsa-miR-6806-5p	HITS-CLIP	23313552
MIRT691427	hsa-miR-6079	HITS-CLIP	23313552
MIRT691426	hsa-miR-5587-5p	HITS-CLIP	23313552
MIRT691425	hsa-miR-135b-3p	HITS-CLIP	23313552
MIRT691424	hsa-miR-7850-5p	HITS-CLIP	23313552
MIRT691423	hsa-miR-129-5p	HITS-CLIP	23313552
MIRT627379	hsa-miR-3662	HITS-CLIP	23824327
MIRT627378	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT627377	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT627376	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT627375	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT627374	hsa-miR-623	HITS-CLIP	23824327
MIRT627373	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT627372	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT627371	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT627370	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT627369	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT627379	hsa-miR-3662	HITS-CLIP	23824327
MIRT627378	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT627377	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT627376	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT627375	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT627374	hsa-miR-623	HITS-CLIP	23824327
MIRT627373	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT627372	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT627371	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT627370	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT627369	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT627379	hsa-miR-3662	HITS-CLIP	23824327
MIRT627378	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT627377	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT627376	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT627375	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT627374	hsa-miR-623	HITS-CLIP	23824327
MIRT627373	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT627372	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT627371	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT627370	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT627369	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT465544	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT465543	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT465542	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT465541	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT465540	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT465539	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT465538	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT465537	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT465536	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT465535	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT465534	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT465533	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT465532	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT465531	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT465530	hsa-miR-940	PAR-CLIP	23592263
MIRT465529	hsa-miR-2682-5p	PAR-CLIP	23592263
MIRT465528	hsa-miR-34b-5p	PAR-CLIP	23592263
MIRT465527	hsa-miR-449c-5p	PAR-CLIP	23592263
MIRT465526	hsa-miR-9500	PAR-CLIP	23592263
MIRT465525	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT465524	hsa-miR-371b-3p	PAR-CLIP	23592263
MIRT465523	hsa-miR-4427	PAR-CLIP	23592263
MIRT465522	hsa-miR-5187-3p	PAR-CLIP	23592263
MIRT465521	hsa-miR-4680-3p	PAR-CLIP	23592263
MIRT465520	hsa-miR-3179	PAR-CLIP	23592263
MIRT465519	hsa-miR-15b-3p	PAR-CLIP	23592263
MIRT465518	hsa-miR-4641	PAR-CLIP	23592263
MIRT465517	hsa-miR-3202	PAR-CLIP	23592263
MIRT465516	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT465514	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT465515	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT465513	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT465512	hsa-miR-4271	PAR-CLIP	23592263
MIRT465511	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT465510	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT465509	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT691436	hsa-miR-3929	HITS-CLIP	23313552
MIRT691435	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691434	hsa-miR-4478	HITS-CLIP	23313552
MIRT691433	hsa-miR-581	HITS-CLIP	23313552
MIRT691432	hsa-miR-508-3p	HITS-CLIP	23313552
MIRT691431	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT691430	hsa-miR-323a-5p	HITS-CLIP	23313552
MIRT691429	hsa-miR-876-3p	HITS-CLIP	23313552
MIRT691428	hsa-miR-6806-5p	HITS-CLIP	23313552
MIRT691427	hsa-miR-6079	HITS-CLIP	23313552
MIRT691426	hsa-miR-5587-5p	HITS-CLIP	23313552
MIRT691425	hsa-miR-135b-3p	HITS-CLIP	23313552
MIRT691424	hsa-miR-7850-5p	HITS-CLIP	23313552
MIRT691423	hsa-miR-129-5p	HITS-CLIP	23313552
MIRT627379	hsa-miR-3662	HITS-CLIP	23824327
MIRT627378	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT627377	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT627376	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT627375	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT627374	hsa-miR-623	HITS-CLIP	23824327
MIRT627373	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT627372	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT627371	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT627370	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT627369	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT627379	hsa-miR-3662	HITS-CLIP	23824327
MIRT627378	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT627377	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT627376	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT627375	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT627374	hsa-miR-623	HITS-CLIP	23824327
MIRT627373	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT627372	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT627371	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT627370	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT627369	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT627379	hsa-miR-3662	HITS-CLIP	23824327
MIRT627378	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT627377	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT627376	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT627375	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT627374	hsa-miR-623	HITS-CLIP	23824327
MIRT627373	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT627372	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT627371	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT627370	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT627369	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT465544	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT465543	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT465542	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT465541	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT465540	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT465539	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT465538	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT465537	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT465536	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT465535	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT465534	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT465533	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT465532	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT465531	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT465530	hsa-miR-940	PAR-CLIP	23592263
MIRT465529	hsa-miR-2682-5p	PAR-CLIP	23592263
MIRT465528	hsa-miR-34b-5p	PAR-CLIP	23592263
MIRT465527	hsa-miR-449c-5p	PAR-CLIP	23592263
MIRT465526	hsa-miR-9500	PAR-CLIP	23592263
MIRT465525	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT465524	hsa-miR-371b-3p	PAR-CLIP	23592263
MIRT465523	hsa-miR-4427	PAR-CLIP	23592263
MIRT465522	hsa-miR-5187-3p	PAR-CLIP	23592263
MIRT465521	hsa-miR-4680-3p	PAR-CLIP	23592263
MIRT465520	hsa-miR-3179	PAR-CLIP	23592263
MIRT465519	hsa-miR-15b-3p	PAR-CLIP	23592263
MIRT465518	hsa-miR-4641	PAR-CLIP	23592263
MIRT465517	hsa-miR-3202	PAR-CLIP	23592263
MIRT465516	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT465514	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT465515	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT465513	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT465512	hsa-miR-4271	PAR-CLIP	23592263
MIRT465511	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT465510	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT465509	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT1261635	hsa-miR-1238	CLIP-seq
MIRT1261636	hsa-miR-3124-3p	CLIP-seq
MIRT1261637	hsa-miR-3156-3p	CLIP-seq
MIRT1261638	hsa-miR-4301	CLIP-seq
MIRT1261639	hsa-miR-4480	CLIP-seq
MIRT1261640	hsa-miR-4506	CLIP-seq
MIRT1261641	hsa-miR-4691-5p	CLIP-seq
MIRT1261642	hsa-miR-4776-3p	CLIP-seq
MIRT1261643	hsa-miR-532-3p	CLIP-seq
MIRT1261644	hsa-miR-629	CLIP-seq
MIRT1261639	hsa-miR-4480	CLIP-seq
MIRT1261640	hsa-miR-4506	CLIP-seq
MIRT1261642	hsa-miR-4776-3p	CLIP-seq
MIRT1261644	hsa-miR-629	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IBA
GO:0003779	Function	Actin binding	IBA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005634	Component	Nucleus	NAS	15702247
GO:0005912	Component	Adherens junction	IBA
GO:0007507	Process	Heart development	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0030018	Component	Z disc	IBA
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0031941	Component	Filamentous actin	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051371	Function	Muscle alpha-actinin binding	IBA
GO:0061061	Process	Muscle structure development	IBA

MIM	HGNC	e!Ensembl
611389	16805	ENSG00000278224

Q2TBC4

Protein name

Prickle-like protein 4 (Overexpressed breast tumor protein)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06297	PET	19 → 73	PET Domain	Domain
PF00412	LIM	84 → 145	LIM domain	Domain
PF00412	LIM	149 → 205	LIM domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in a broad range of normal tissues as well as in hepatocellular carcinoma, breast cancer and prostate cancer tissues. {ECO:0000269|PubMed:15702247}.

Sequence

MSPQGPAVLSLGSLCLDTNQAPNWTGLQTLLQQLPPQDIDERYCLALGEEERAELQLFCA
RRKQEALGQGVARLVLPKLEGHTCEKCRELLKPGEYGVFAARAGEQRCWHQPCFACQACG
QALINLIYFYHDGQLYCGRHHAELLRPRCPACDQLIFSWRCTEAEGQRWHENHFCCQDCA
GPLGGGRYALPGGSPCCPSCFENRYSDAGSSWAGALEGQAFLGETGLDRTEGRDQTSVNS
ATLSRTLLAAAGGSSLQTQRGLPGSSPQQENRPGDKAEAPKGQEQCRLETIRDPKDTPFS
TCSSSSDSEPEGFFLGERLPQSWKTPGSLQAEDSNASKTHCTMC

Sequence length

344

Interactions

View interactions

	KEGG
	Wnt signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	18507837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18507837	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	25032869		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18507837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	25032869		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	25032869		★★★★★ ★☆☆☆☆ Found in Text Mining only

PRICKLE4 (prickle planar cell polarity protein 4)