DPP7 (dipeptidyl peptidase 7)

Gene

• Entrez ID: 29952
• Gene name: Dipeptidyl peptidase 7
• Gene symbol: DPP7
• Synonyms (NCBI Gene): DPP, DPP II, DPP2, DPPII, II, QPP
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001551	hsa-miR-155-5p	pSILAC	18668040
MIRT001551	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT023714	hsa-miR-1-3p	Proteomics	18668040

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005764	Component	Lysosome	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	10567372
GO:0008239	Function	Dipeptidyl-peptidase activity	IBA
GO:0008239	Function	Dipeptidyl-peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031982	Component	Vesicle	IBA
GO:0031982	Component	Vesicle	IDA	11067927
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0070008	Function	Serine-type exopeptidase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1905146	Process	Lysosomal protein catabolic process	IEA

Other IDs

• MIM: 610537
• HGNC: 14892
• e!Ensembl: ENSG00000176978

Protein

• UniProt ID: Q9UHL4
• Protein name: Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase)
• Protein function: Plays an important role in the degradation of some oligopeptides.
• PDB: 3JYH, 3N0T, 4EBB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05577	Peptidase_S28	38 → 465	Serine carboxypeptidase S28	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in seminal plasma (at protein level). {ECO:0000269|PubMed:15487984}.
• Sequence:

  MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
  DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
  TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
  GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
  WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
  QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
  SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
  AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
  QPALRGGPRLSL

• Sequence length: 492

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NECROSIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bullous pemphigoid	Bullous Pemphigoid	BEFREE	31519110		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	20817072		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31387239	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21412686		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	27503084		★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Periodontal Diseases	BEFREE	30203018		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	38631604	Associate	★☆☆☆☆ Found in Text Mining only