Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	29950
Gene name	SERTA domain containing 1
Gene symbol	SERTAD1
Synonyms (NCBI Gene)	SEI1TRIP-Br1TRIPBR1
Chromosome	19
Chromosome location	19q13.2

125

Show/Hide all (125)

miRTarBase ID	miRNA	Experiments
MIRT1338990	hsa-miR-1236	CLIP-seq
MIRT1338991	hsa-miR-133a	CLIP-seq
MIRT1338992	hsa-miR-133b	CLIP-seq
MIRT1338993	hsa-miR-151-5p	CLIP-seq
MIRT1338994	hsa-miR-151b	CLIP-seq
MIRT1338995	hsa-miR-184	CLIP-seq
MIRT1338996	hsa-miR-3131	CLIP-seq
MIRT1338997	hsa-miR-3170	CLIP-seq
MIRT1338998	hsa-miR-3611	CLIP-seq
MIRT1338999	hsa-miR-3920	CLIP-seq
MIRT1339000	hsa-miR-4459	CLIP-seq
MIRT1339001	hsa-miR-4670-3p	CLIP-seq
MIRT1339002	hsa-miR-4711-3p	CLIP-seq
MIRT1339003	hsa-miR-4759	CLIP-seq
MIRT1339004	hsa-miR-4764-5p	CLIP-seq
MIRT1339005	hsa-miR-4775	CLIP-seq
MIRT1339006	hsa-miR-509-3p	CLIP-seq
MIRT1339007	hsa-miR-511	CLIP-seq
MIRT1339008	hsa-miR-548c-3p	CLIP-seq
MIRT1339009	hsa-miR-611	CLIP-seq
MIRT1339010	hsa-miR-615-5p	CLIP-seq
MIRT2100184	hsa-miR-146b-3p	CLIP-seq
MIRT2100185	hsa-miR-2117	CLIP-seq
MIRT2100186	hsa-miR-214	CLIP-seq
MIRT2100187	hsa-miR-24	CLIP-seq
MIRT2100188	hsa-miR-3120-5p	CLIP-seq
MIRT2100189	hsa-miR-3136-3p	CLIP-seq
MIRT2100190	hsa-miR-3155	CLIP-seq
MIRT2100191	hsa-miR-3155b	CLIP-seq
MIRT2100192	hsa-miR-3619-5p	CLIP-seq
MIRT2100193	hsa-miR-3677-5p	CLIP-seq
MIRT2100194	hsa-miR-3942-3p	CLIP-seq
MIRT2100195	hsa-miR-4273	CLIP-seq
MIRT2100196	hsa-miR-4277	CLIP-seq
MIRT2100197	hsa-miR-4530	CLIP-seq
MIRT2100198	hsa-miR-4690-5p	CLIP-seq
MIRT2100199	hsa-miR-4778-5p	CLIP-seq
MIRT2100200	hsa-miR-4796-3p	CLIP-seq
MIRT2100201	hsa-miR-484	CLIP-seq
MIRT2100202	hsa-miR-515-5p	CLIP-seq
MIRT2100203	hsa-miR-520g	CLIP-seq
MIRT2100204	hsa-miR-520h	CLIP-seq
MIRT2100205	hsa-miR-593	CLIP-seq
MIRT2100206	hsa-miR-663b	CLIP-seq
MIRT2100207	hsa-miR-761	CLIP-seq
MIRT1338991	hsa-miR-133a	CLIP-seq
MIRT1338992	hsa-miR-133b	CLIP-seq
MIRT1338993	hsa-miR-151-5p	CLIP-seq
MIRT1338994	hsa-miR-151b	CLIP-seq
MIRT2100186	hsa-miR-214	CLIP-seq
MIRT2100187	hsa-miR-24	CLIP-seq
MIRT2100188	hsa-miR-3120-5p	CLIP-seq
MIRT1338996	hsa-miR-3131	CLIP-seq
MIRT2100190	hsa-miR-3155	CLIP-seq
MIRT2100191	hsa-miR-3155b	CLIP-seq
MIRT2325048	hsa-miR-34c-3p	CLIP-seq
MIRT2100192	hsa-miR-3619-5p	CLIP-seq
MIRT2100193	hsa-miR-3677-5p	CLIP-seq
MIRT2100194	hsa-miR-3942-3p	CLIP-seq
MIRT2100196	hsa-miR-4277	CLIP-seq
MIRT2325049	hsa-miR-4278	CLIP-seq
MIRT2100197	hsa-miR-4530	CLIP-seq
MIRT2100198	hsa-miR-4690-5p	CLIP-seq
MIRT1339002	hsa-miR-4711-3p	CLIP-seq
MIRT2325050	hsa-miR-4716-3p	CLIP-seq
MIRT2100199	hsa-miR-4778-5p	CLIP-seq
MIRT2100200	hsa-miR-4796-3p	CLIP-seq
MIRT2100201	hsa-miR-484	CLIP-seq
MIRT1339007	hsa-miR-511	CLIP-seq
MIRT2100202	hsa-miR-515-5p	CLIP-seq
MIRT2100203	hsa-miR-520g	CLIP-seq
MIRT2100204	hsa-miR-520h	CLIP-seq
MIRT2100205	hsa-miR-593	CLIP-seq
MIRT1339009	hsa-miR-611	CLIP-seq
MIRT2325051	hsa-miR-616	CLIP-seq
MIRT2100206	hsa-miR-663b	CLIP-seq
MIRT2100207	hsa-miR-761	CLIP-seq
MIRT2100184	hsa-miR-146b-3p	CLIP-seq
MIRT1338995	hsa-miR-184	CLIP-seq
MIRT2100185	hsa-miR-2117	CLIP-seq
MIRT2620664	hsa-miR-28-3p	CLIP-seq
MIRT2100188	hsa-miR-3120-5p	CLIP-seq
MIRT2100189	hsa-miR-3136-3p	CLIP-seq
MIRT1338998	hsa-miR-3611	CLIP-seq
MIRT2100193	hsa-miR-3677-5p	CLIP-seq
MIRT2100195	hsa-miR-4273	CLIP-seq
MIRT1339000	hsa-miR-4459	CLIP-seq
MIRT1339001	hsa-miR-4670-3p	CLIP-seq
MIRT1339002	hsa-miR-4711-3p	CLIP-seq
MIRT1339003	hsa-miR-4759	CLIP-seq
MIRT1339004	hsa-miR-4764-5p	CLIP-seq
MIRT2100199	hsa-miR-4778-5p	CLIP-seq
MIRT2620665	hsa-miR-4786-3p	CLIP-seq
MIRT2100200	hsa-miR-4796-3p	CLIP-seq
MIRT1339007	hsa-miR-511	CLIP-seq
MIRT2100202	hsa-miR-515-5p	CLIP-seq
MIRT2100203	hsa-miR-520g	CLIP-seq
MIRT2100204	hsa-miR-520h	CLIP-seq
MIRT2100205	hsa-miR-593	CLIP-seq
MIRT2100206	hsa-miR-663b	CLIP-seq
MIRT2620666	hsa-miR-671-5p	CLIP-seq
MIRT2100184	hsa-miR-146b-3p	CLIP-seq
MIRT1338995	hsa-miR-184	CLIP-seq
MIRT2100185	hsa-miR-2117	CLIP-seq
MIRT2620664	hsa-miR-28-3p	CLIP-seq
MIRT2100188	hsa-miR-3120-5p	CLIP-seq
MIRT2100189	hsa-miR-3136-3p	CLIP-seq
MIRT1338998	hsa-miR-3611	CLIP-seq
MIRT2100193	hsa-miR-3677-5p	CLIP-seq
MIRT2100195	hsa-miR-4273	CLIP-seq
MIRT1339000	hsa-miR-4459	CLIP-seq
MIRT1339001	hsa-miR-4670-3p	CLIP-seq
MIRT1339002	hsa-miR-4711-3p	CLIP-seq
MIRT1339003	hsa-miR-4759	CLIP-seq
MIRT1339004	hsa-miR-4764-5p	CLIP-seq
MIRT2100199	hsa-miR-4778-5p	CLIP-seq
MIRT2620665	hsa-miR-4786-3p	CLIP-seq
MIRT2100200	hsa-miR-4796-3p	CLIP-seq
MIRT1339007	hsa-miR-511	CLIP-seq
MIRT2100202	hsa-miR-515-5p	CLIP-seq
MIRT2100203	hsa-miR-520g	CLIP-seq
MIRT2100204	hsa-miR-520h	CLIP-seq
MIRT2100205	hsa-miR-593	CLIP-seq
MIRT2100206	hsa-miR-663b	CLIP-seq
MIRT2620666	hsa-miR-671-5p	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000079	Process	Regulation of cyclin-dependent protein serine/threonine kinase activity	TAS	6434876
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0005515	Function	Protein binding	IPI	16189514, 21988832, 32296183, 32814053, 36217029
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	6434876
GO:0016528	Component	Sarcoplasm	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

MIM	HGNC	e!Ensembl
617850	17932	ENSG00000197019

Q9UHV2

Protein name

SERTA domain-containing protein 1 (CDK4-binding protein p34SEI1) (SEI-1) (p34(SEI-1)) (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1)

Protein function

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the in

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06031	SERTA	45 → 80	SERTA motif	Motif

Sequence

MLSKGLKRKREEEEEKEPLAVDSWWLDPGHTAVAQAPPAVASSSLFDLSVLKLHHSLQQS
EPDLRHLVLVVNTLRRIQASMAPAAALPPVPSPPAAPSVADNLLASSDAALSASMASLLE
DLSHIEGLSQAPQPLADEGPPGRSIGGAAPSLGALDLLGPATGCLLDDGLEGLFEDIDTS
MYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYLMDVLVGTQALERPPGPGR

Sequence length

236

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLONIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (26)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	19176394, 23970032, 26334958, 31084542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31084542, 35813469	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	12499249, 16061626, 27697611		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	21725208		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	CTD_human_DG	18097604		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive Disorder	Major depressive disorder	Pubtator	23064081	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis IGA	Iga nephropathy	Pubtator	39696012	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	29179704	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lipodystrophy	Lipodystrophy	Pubtator	35938957	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36101745	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19176394, 23970032, 26334958, 31084542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	20570897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	12499249, 16061626, 27697611		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30230528		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23970032, 24789658, 30857225		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	CTD_human_DG	18097604		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	21725208		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	PSYGENET_DG	23064081		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood disorder	Pubtator	23064081	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	16061626, 18097604, 19083478, 19176394, 23970032, 24789658, 27697611		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	12499249, 16061626, 27697611		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30230528		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	16201750		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	20570897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	24982332	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	24982332		★★★★★ ★☆☆☆☆ Found in Text Mining only

SERTAD1 (SERTA domain containing 1)