Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29933
Gene name	G protein-coupled receptor 132
Gene symbol	GPR132
Synonyms (NCBI Gene)	G2A
Chromosome	14
Chromosome location	14q32.33
Summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pat

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Show/Hide all (233)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718413	hsa-miR-888-3p	HITS-CLIP	19536157
MIRT718412	hsa-miR-4530	HITS-CLIP	19536157
MIRT718411	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT718410	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT718409	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT718408	hsa-miR-6719-3p	HITS-CLIP	19536157
MIRT718407	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT718406	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT718405	hsa-miR-3907	HITS-CLIP	19536157
MIRT718404	hsa-miR-181b-2-3p	HITS-CLIP	19536157
MIRT718403	hsa-miR-181b-3p	HITS-CLIP	19536157
MIRT718402	hsa-miR-4420	HITS-CLIP	19536157
MIRT718401	hsa-miR-1178-3p	HITS-CLIP	19536157
MIRT718413	hsa-miR-888-3p	HITS-CLIP	19536157
MIRT718412	hsa-miR-4530	HITS-CLIP	19536157
MIRT718411	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT718410	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT718409	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT718408	hsa-miR-6719-3p	HITS-CLIP	19536157
MIRT718407	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT718406	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT718405	hsa-miR-3907	HITS-CLIP	19536157
MIRT718404	hsa-miR-181b-2-3p	HITS-CLIP	19536157
MIRT718403	hsa-miR-181b-3p	HITS-CLIP	19536157
MIRT718402	hsa-miR-4420	HITS-CLIP	19536157
MIRT718401	hsa-miR-1178-3p	HITS-CLIP	19536157
MIRT1030303	hsa-miR-106a	CLIP-seq
MIRT1030304	hsa-miR-106b	CLIP-seq
MIRT1030305	hsa-miR-1178	CLIP-seq
MIRT1030306	hsa-miR-1208	CLIP-seq
MIRT1030307	hsa-miR-1224-5p	CLIP-seq
MIRT1030308	hsa-miR-1225-3p	CLIP-seq
MIRT1030309	hsa-miR-1227	CLIP-seq
MIRT1030310	hsa-miR-1233	CLIP-seq
MIRT1030311	hsa-miR-1272	CLIP-seq
MIRT1030312	hsa-miR-1291	CLIP-seq
MIRT1030313	hsa-miR-1304	CLIP-seq
MIRT1030314	hsa-miR-1322	CLIP-seq
MIRT1030315	hsa-miR-150	CLIP-seq
MIRT1030316	hsa-miR-17	CLIP-seq
MIRT1030317	hsa-miR-20a	CLIP-seq
MIRT1030318	hsa-miR-20b	CLIP-seq
MIRT1030319	hsa-miR-2114	CLIP-seq
MIRT1030320	hsa-miR-2117	CLIP-seq
MIRT1030321	hsa-miR-2467-5p	CLIP-seq
MIRT1030322	hsa-miR-302a	CLIP-seq
MIRT1030323	hsa-miR-302b	CLIP-seq
MIRT1030324	hsa-miR-302c	CLIP-seq
MIRT1030325	hsa-miR-302d	CLIP-seq
MIRT1030326	hsa-miR-302e	CLIP-seq
MIRT1030327	hsa-miR-3180-5p	CLIP-seq
MIRT1030328	hsa-miR-3188	CLIP-seq
MIRT1030329	hsa-miR-3663-3p	CLIP-seq
MIRT1030330	hsa-miR-3664-3p	CLIP-seq
MIRT1030331	hsa-miR-372	CLIP-seq
MIRT1030332	hsa-miR-373	CLIP-seq
MIRT1030333	hsa-miR-3915	CLIP-seq
MIRT1030334	hsa-miR-3922-5p	CLIP-seq
MIRT1030335	hsa-miR-3925-3p	CLIP-seq
MIRT1030336	hsa-miR-3929	CLIP-seq
MIRT1030337	hsa-miR-3975	CLIP-seq
MIRT1030338	hsa-miR-4252	CLIP-seq
MIRT1030339	hsa-miR-4260	CLIP-seq
MIRT1030340	hsa-miR-4267	CLIP-seq
MIRT1030341	hsa-miR-4273	CLIP-seq
MIRT1030342	hsa-miR-4283	CLIP-seq
MIRT1030343	hsa-miR-4290	CLIP-seq
MIRT1030344	hsa-miR-4419b	CLIP-seq
MIRT1030345	hsa-miR-4433	CLIP-seq
MIRT1030346	hsa-miR-4459	CLIP-seq
MIRT1030347	hsa-miR-4478	CLIP-seq
MIRT1030348	hsa-miR-4489	CLIP-seq
MIRT1030349	hsa-miR-4645-5p	CLIP-seq
MIRT1030350	hsa-miR-4663	CLIP-seq
MIRT1030351	hsa-miR-4673	CLIP-seq
MIRT1030352	hsa-miR-4689	CLIP-seq
MIRT1030353	hsa-miR-4690-3p	CLIP-seq
MIRT1030354	hsa-miR-4695-5p	CLIP-seq
MIRT1030355	hsa-miR-4706	CLIP-seq
MIRT1030356	hsa-miR-4708-3p	CLIP-seq
MIRT1030357	hsa-miR-4731-5p	CLIP-seq
MIRT1030358	hsa-miR-4742-5p	CLIP-seq
MIRT1030359	hsa-miR-4749-5p	CLIP-seq
MIRT1030360	hsa-miR-4751	CLIP-seq
MIRT1030361	hsa-miR-4768-3p	CLIP-seq
MIRT1030362	hsa-miR-4781-5p	CLIP-seq
MIRT1030363	hsa-miR-485-5p	CLIP-seq
MIRT1030364	hsa-miR-510	CLIP-seq
MIRT1030365	hsa-miR-511	CLIP-seq
MIRT1030366	hsa-miR-512-3p	CLIP-seq
MIRT1030367	hsa-miR-512-5p	CLIP-seq
MIRT1030368	hsa-miR-515-5p	CLIP-seq
MIRT1030369	hsa-miR-519d	CLIP-seq
MIRT1030370	hsa-miR-520a-3p	CLIP-seq
MIRT1030371	hsa-miR-520a-5p	CLIP-seq
MIRT1030372	hsa-miR-520b	CLIP-seq
MIRT1030373	hsa-miR-520c-3p	CLIP-seq
MIRT1030374	hsa-miR-520d-3p	CLIP-seq
MIRT1030375	hsa-miR-520e	CLIP-seq
MIRT1030376	hsa-miR-520g	CLIP-seq
MIRT1030377	hsa-miR-520h	CLIP-seq
MIRT1030378	hsa-miR-525-5p	CLIP-seq
MIRT1030379	hsa-miR-539	CLIP-seq
MIRT1030380	hsa-miR-610	CLIP-seq
MIRT1030381	hsa-miR-665	CLIP-seq
MIRT1030382	hsa-miR-766	CLIP-seq
MIRT1030383	hsa-miR-93	CLIP-seq
MIRT1030308	hsa-miR-1225-3p	CLIP-seq
MIRT2005694	hsa-miR-1228	CLIP-seq
MIRT1030310	hsa-miR-1233	CLIP-seq
MIRT1030311	hsa-miR-1272	CLIP-seq
MIRT1030313	hsa-miR-1304	CLIP-seq
MIRT1030314	hsa-miR-1322	CLIP-seq
MIRT2005695	hsa-miR-146b-3p	CLIP-seq
MIRT2005696	hsa-miR-218	CLIP-seq
MIRT1030321	hsa-miR-2467-5p	CLIP-seq
MIRT2005697	hsa-miR-3140-3p	CLIP-seq
MIRT2005698	hsa-miR-3173-5p	CLIP-seq
MIRT1030328	hsa-miR-3188	CLIP-seq
MIRT2005699	hsa-miR-323-5p	CLIP-seq
MIRT2005700	hsa-miR-3652	CLIP-seq
MIRT1030337	hsa-miR-3975	CLIP-seq
MIRT2005701	hsa-miR-4263	CLIP-seq
MIRT2005702	hsa-miR-4312	CLIP-seq
MIRT2005703	hsa-miR-4430	CLIP-seq
MIRT1030345	hsa-miR-4433	CLIP-seq
MIRT2005704	hsa-miR-4455	CLIP-seq
MIRT2005705	hsa-miR-4505	CLIP-seq
MIRT2005706	hsa-miR-4687-3p	CLIP-seq
MIRT2005707	hsa-miR-4799-5p	CLIP-seq
MIRT1030363	hsa-miR-485-5p	CLIP-seq
MIRT2005708	hsa-miR-576-5p	CLIP-seq
MIRT2005709	hsa-miR-609	CLIP-seq
MIRT1030380	hsa-miR-610	CLIP-seq
MIRT2005710	hsa-miR-636	CLIP-seq
MIRT2005711	hsa-miR-647	CLIP-seq
MIRT1030381	hsa-miR-665	CLIP-seq
MIRT2005712	hsa-miR-874	CLIP-seq
MIRT2005713	hsa-miR-876-3p	CLIP-seq
MIRT1030308	hsa-miR-1225-3p	CLIP-seq
MIRT2005694	hsa-miR-1228	CLIP-seq
MIRT1030310	hsa-miR-1233	CLIP-seq
MIRT1030311	hsa-miR-1272	CLIP-seq
MIRT1030313	hsa-miR-1304	CLIP-seq
MIRT1030314	hsa-miR-1322	CLIP-seq
MIRT2238354	hsa-miR-2052	CLIP-seq
MIRT1030319	hsa-miR-2114	CLIP-seq
MIRT1030321	hsa-miR-2467-5p	CLIP-seq
MIRT1030328	hsa-miR-3188	CLIP-seq
MIRT2005699	hsa-miR-323-5p	CLIP-seq
MIRT2005700	hsa-miR-3652	CLIP-seq
MIRT1030335	hsa-miR-3925-3p	CLIP-seq
MIRT1030337	hsa-miR-3975	CLIP-seq
MIRT2005703	hsa-miR-4430	CLIP-seq
MIRT1030345	hsa-miR-4433	CLIP-seq
MIRT2005704	hsa-miR-4455	CLIP-seq
MIRT2238355	hsa-miR-4502	CLIP-seq
MIRT2005705	hsa-miR-4505	CLIP-seq
MIRT1030349	hsa-miR-4645-5p	CLIP-seq
MIRT1030351	hsa-miR-4673	CLIP-seq
MIRT2005706	hsa-miR-4687-3p	CLIP-seq
MIRT1030353	hsa-miR-4690-3p	CLIP-seq
MIRT1030358	hsa-miR-4742-5p	CLIP-seq
MIRT1030363	hsa-miR-485-5p	CLIP-seq
MIRT2238356	hsa-miR-501-3p	CLIP-seq
MIRT2238357	hsa-miR-502-3p	CLIP-seq
MIRT1030364	hsa-miR-510	CLIP-seq
MIRT1030367	hsa-miR-512-5p	CLIP-seq
MIRT2005709	hsa-miR-609	CLIP-seq
MIRT1030380	hsa-miR-610	CLIP-seq
MIRT2005711	hsa-miR-647	CLIP-seq
MIRT1030381	hsa-miR-665	CLIP-seq
MIRT1030382	hsa-miR-766	CLIP-seq
MIRT2005713	hsa-miR-876-3p	CLIP-seq
MIRT1030308	hsa-miR-1225-3p	CLIP-seq
MIRT2005694	hsa-miR-1228	CLIP-seq
MIRT1030310	hsa-miR-1233	CLIP-seq
MIRT1030311	hsa-miR-1272	CLIP-seq
MIRT1030313	hsa-miR-1304	CLIP-seq
MIRT1030314	hsa-miR-1322	CLIP-seq
MIRT1030319	hsa-miR-2114	CLIP-seq
MIRT1030321	hsa-miR-2467-5p	CLIP-seq
MIRT1030328	hsa-miR-3188	CLIP-seq
MIRT2388624	hsa-miR-3194-5p	CLIP-seq
MIRT2005699	hsa-miR-323-5p	CLIP-seq
MIRT1030330	hsa-miR-3664-3p	CLIP-seq
MIRT1030337	hsa-miR-3975	CLIP-seq
MIRT1030345	hsa-miR-4433	CLIP-seq
MIRT1030346	hsa-miR-4459	CLIP-seq
MIRT2388625	hsa-miR-4514	CLIP-seq
MIRT1030349	hsa-miR-4645-5p	CLIP-seq
MIRT1030351	hsa-miR-4673	CLIP-seq
MIRT2388626	hsa-miR-4692	CLIP-seq
MIRT2388627	hsa-miR-4755-3p	CLIP-seq
MIRT1030361	hsa-miR-4768-3p	CLIP-seq
MIRT1030363	hsa-miR-485-5p	CLIP-seq
MIRT1030364	hsa-miR-510	CLIP-seq
MIRT1030367	hsa-miR-512-5p	CLIP-seq
MIRT1030380	hsa-miR-610	CLIP-seq
MIRT1030381	hsa-miR-665	CLIP-seq
MIRT2005713	hsa-miR-876-3p	CLIP-seq
MIRT2388628	hsa-miR-940	CLIP-seq
MIRT2238355	hsa-miR-4502	CLIP-seq
MIRT2388625	hsa-miR-4514	CLIP-seq
MIRT2388626	hsa-miR-4692	CLIP-seq
MIRT2450609	hsa-miR-4709-3p	CLIP-seq
MIRT2388628	hsa-miR-940	CLIP-seq
MIRT1030308	hsa-miR-1225-3p	CLIP-seq
MIRT1030310	hsa-miR-1233	CLIP-seq
MIRT1030311	hsa-miR-1272	CLIP-seq
MIRT1030312	hsa-miR-1291	CLIP-seq
MIRT1030313	hsa-miR-1304	CLIP-seq
MIRT1030314	hsa-miR-1322	CLIP-seq
MIRT2005695	hsa-miR-146b-3p	CLIP-seq
MIRT1030321	hsa-miR-2467-5p	CLIP-seq
MIRT1030328	hsa-miR-3188	CLIP-seq
MIRT2542377	hsa-miR-339-5p	CLIP-seq
MIRT1030334	hsa-miR-3922-5p	CLIP-seq
MIRT1030337	hsa-miR-3975	CLIP-seq
MIRT2542378	hsa-miR-4421	CLIP-seq
MIRT1030345	hsa-miR-4433	CLIP-seq
MIRT1030356	hsa-miR-4708-3p	CLIP-seq
MIRT1030363	hsa-miR-485-5p	CLIP-seq
MIRT2542379	hsa-miR-593	CLIP-seq
MIRT1030380	hsa-miR-610	CLIP-seq
MIRT1030381	hsa-miR-665	CLIP-seq
MIRT1030312	hsa-miR-1291	CLIP-seq
MIRT2005695	hsa-miR-146b-3p	CLIP-seq
MIRT2542377	hsa-miR-339-5p	CLIP-seq
MIRT1030334	hsa-miR-3922-5p	CLIP-seq
MIRT2542378	hsa-miR-4421	CLIP-seq
MIRT1030356	hsa-miR-4708-3p	CLIP-seq
MIRT2542379	hsa-miR-593	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	IBA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
606167	17482	ENSG00000183484

Q9UNW8

Protein name

Probable G-protein coupled receptor 132 (G2 accumulation protein)

Protein function

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M

PDB

8HQE , 8HQM , 8HQN , 8HVI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	59 → 308	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder reg

Sequence

MCPMLLKNGYNGNATPVTTTAPWASLGLSAKTCNNVSFEESRIVLVVVYSAVCTLGVPAN
CLTAWLALLQVLQGNVLAVYLLCLALCELLYTGTLPLWVIYIRNQHRWTLGLLACKVTAY
IFFCNIYVSILFLCCISCDRFVAVVYALESRGRRRRRTAILISACIFILVGIVHYPVFQT
EDKETCFDMLQMDSRIAGYYYARFTVGFAIPLSIIAFTNHRIFRSIKQSMGLSAAQKAKV
KHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGDRNAMCGLEERLYTASVVFLCLSTVN
GVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTDVTRLTHSRDTEELQSPVALADHYTFS
RPVHPPGSPCPAKRLIEESC

Sequence length

380

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis		Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	27588474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	27588474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	7526192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	19930466, 26283367, 34346841	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	26283367	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28049847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	32948783	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	34346841	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	27588474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29796244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29796244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	29796244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi Anemia	BEFREE	19065770		★★★★★ ★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	Anemia	BEFREE	19065770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31127149		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	7526192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28049847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28049847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Merkel cell carcinoma	Merkel cell carcinoma	BEFREE	30339292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28049847, 31127149		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	32948783	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPR132 (G protein-coupled receptor 132)