TIMM22 (translocase of inner mitochondrial membrane 22)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 29928 |
| Gene name | Translocase of inner mitochondrial membrane 22 |
| Gene symbol | TIMM22 |
| Synonyms (NCBI Gene) |
COXPD43TEX4TIM22
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| Chromosome | 17 |
| Chromosome location | 17p13.3 |
| Summary | Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of T |
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miRNA
miRNA information provided by mirtarbase database.
370
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9Y584 | ||||||||||
| Protein name | Mitochondrial import inner membrane translocase subunit Tim22 (Testis-expressed protein 4) | ||||||||||
| Protein function | Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gat | ||||||||||
| PDB | 7CGP | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 194 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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