Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29924
Gene name	Epsin 1
Gene symbol	EPN1
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19q13.42
Summary	This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain can

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miRTarBase ID	miRNA	Experiments	Reference
MIRT038071	hsa-miR-423-5p	CLASH	23622248
MIRT037415	hsa-miR-744-5p	CLASH	23622248
MIRT484347	hsa-miR-6784-5p	PAR-CLIP	24398324
MIRT484348	hsa-miR-6777-5p	PAR-CLIP	24398324
MIRT484346	hsa-miR-6889-5p	PAR-CLIP	24398324
MIRT484345	hsa-miR-6845-3p	PAR-CLIP	24398324
MIRT484344	hsa-miR-6134	PAR-CLIP	24398324
MIRT484343	hsa-miR-6077	PAR-CLIP	24398324
MIRT484342	hsa-miR-3689d	PAR-CLIP	24398324
MIRT484341	hsa-miR-6851-5p	PAR-CLIP	24398324
MIRT484340	hsa-miR-4668-5p	PAR-CLIP	24398324
MIRT082754	hsa-miR-3153	PAR-CLIP	24398324
MIRT082764	hsa-miR-6733-5p	PAR-CLIP	24398324
MIRT082766	hsa-miR-6739-5p	PAR-CLIP	24398324
MIRT484338	hsa-miR-6799-5p	PAR-CLIP	24398324
MIRT484339	hsa-miR-6825-5p	PAR-CLIP	24398324
MIRT484337	hsa-miR-342-5p	PAR-CLIP	24398324
MIRT484336	hsa-miR-4664-5p	PAR-CLIP	24398324
MIRT484335	hsa-miR-4651	PAR-CLIP	24398324
MIRT484334	hsa-miR-608	PAR-CLIP	24398324
MIRT484333	hsa-miR-6747-5p	PAR-CLIP	24398324
MIRT484332	hsa-miR-6756-5p	PAR-CLIP	24398324
MIRT484331	hsa-miR-6766-5p	PAR-CLIP	24398324
MIRT484330	hsa-miR-92a-2-5p	PAR-CLIP	24398324
MIRT484329	hsa-miR-6742-5p	PAR-CLIP	24398324
MIRT484328	hsa-miR-6737-5p	PAR-CLIP	24398324
MIRT484327	hsa-miR-6812-5p	PAR-CLIP	24398324
MIRT484325	hsa-miR-6819-5p	PAR-CLIP	24398324
MIRT484347	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT484348	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT484346	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT484345	hsa-miR-6845-3p	PAR-CLIP	23592263
MIRT484344	hsa-miR-6134	PAR-CLIP	23592263
MIRT484343	hsa-miR-6077	PAR-CLIP	23592263
MIRT484342	hsa-miR-3689d	PAR-CLIP	23592263
MIRT484341	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT484340	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT082754	hsa-miR-3153	PAR-CLIP	23592263
MIRT082764	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT082766	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT484338	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT484339	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT484337	hsa-miR-342-5p	PAR-CLIP	23592263
MIRT484336	hsa-miR-4664-5p	PAR-CLIP	23592263
MIRT484335	hsa-miR-4651	PAR-CLIP	23592263
MIRT484334	hsa-miR-608	PAR-CLIP	23592263
MIRT484333	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT484332	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT484331	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT484330	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT484329	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT484328	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT484327	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT484325	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT484347	hsa-miR-6784-5p	PAR-CLIP	24398324
MIRT484348	hsa-miR-6777-5p	PAR-CLIP	24398324
MIRT484346	hsa-miR-6889-5p	PAR-CLIP	24398324
MIRT484345	hsa-miR-6845-3p	PAR-CLIP	24398324
MIRT484344	hsa-miR-6134	PAR-CLIP	24398324
MIRT484343	hsa-miR-6077	PAR-CLIP	24398324
MIRT484342	hsa-miR-3689d	PAR-CLIP	24398324
MIRT484341	hsa-miR-6851-5p	PAR-CLIP	24398324
MIRT484340	hsa-miR-4668-5p	PAR-CLIP	24398324
MIRT082754	hsa-miR-3153	PAR-CLIP	24398324
MIRT082764	hsa-miR-6733-5p	PAR-CLIP	24398324
MIRT082766	hsa-miR-6739-5p	PAR-CLIP	24398324
MIRT484338	hsa-miR-6799-5p	PAR-CLIP	24398324
MIRT484339	hsa-miR-6825-5p	PAR-CLIP	24398324
MIRT484337	hsa-miR-342-5p	PAR-CLIP	24398324
MIRT484336	hsa-miR-4664-5p	PAR-CLIP	24398324
MIRT484335	hsa-miR-4651	PAR-CLIP	24398324
MIRT484334	hsa-miR-608	PAR-CLIP	24398324
MIRT484333	hsa-miR-6747-5p	PAR-CLIP	24398324
MIRT484332	hsa-miR-6756-5p	PAR-CLIP	24398324
MIRT484331	hsa-miR-6766-5p	PAR-CLIP	24398324
MIRT484330	hsa-miR-92a-2-5p	PAR-CLIP	24398324
MIRT484329	hsa-miR-6742-5p	PAR-CLIP	24398324
MIRT484328	hsa-miR-6737-5p	PAR-CLIP	24398324
MIRT484327	hsa-miR-6812-5p	PAR-CLIP	24398324
MIRT484325	hsa-miR-6819-5p	PAR-CLIP	24398324
MIRT484347	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT484348	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT484346	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT484345	hsa-miR-6845-3p	PAR-CLIP	23592263
MIRT484344	hsa-miR-6134	PAR-CLIP	23592263
MIRT484343	hsa-miR-6077	PAR-CLIP	23592263
MIRT484342	hsa-miR-3689d	PAR-CLIP	23592263
MIRT484341	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT484340	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT082754	hsa-miR-3153	PAR-CLIP	23592263
MIRT082764	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT082766	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT484338	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT484339	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT484337	hsa-miR-342-5p	PAR-CLIP	23592263
MIRT484336	hsa-miR-4664-5p	PAR-CLIP	23592263
MIRT484335	hsa-miR-4651	PAR-CLIP	23592263
MIRT484334	hsa-miR-608	PAR-CLIP	23592263
MIRT484333	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT484332	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT484331	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT484330	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT484329	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT484328	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT484327	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT484325	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT967038	hsa-miR-1292	CLIP-seq
MIRT967039	hsa-miR-151-5p	CLIP-seq
MIRT967040	hsa-miR-151b	CLIP-seq
MIRT967041	hsa-miR-3184	CLIP-seq
MIRT967042	hsa-miR-3656	CLIP-seq
MIRT967038	hsa-miR-1292	CLIP-seq
MIRT967043	hsa-miR-141	CLIP-seq
MIRT967039	hsa-miR-151-5p	CLIP-seq
MIRT967040	hsa-miR-151b	CLIP-seq
MIRT967044	hsa-miR-200a	CLIP-seq
MIRT967045	hsa-miR-2467-5p	CLIP-seq
MIRT967046	hsa-miR-3127-3p	CLIP-seq
MIRT967047	hsa-miR-3176	CLIP-seq
MIRT967041	hsa-miR-3184	CLIP-seq
MIRT967048	hsa-miR-365	CLIP-seq
MIRT967042	hsa-miR-3656	CLIP-seq
MIRT967049	hsa-miR-3689a-3p	CLIP-seq
MIRT967050	hsa-miR-3689c	CLIP-seq
MIRT967051	hsa-miR-371-5p	CLIP-seq
MIRT967052	hsa-miR-3922-3p	CLIP-seq
MIRT967053	hsa-miR-3936	CLIP-seq
MIRT967054	hsa-miR-4425	CLIP-seq
MIRT967055	hsa-miR-4435	CLIP-seq
MIRT967056	hsa-miR-4443	CLIP-seq
MIRT967057	hsa-miR-4681	CLIP-seq
MIRT967058	hsa-miR-4691-3p	CLIP-seq
MIRT967059	hsa-miR-4695-5p	CLIP-seq
MIRT967060	hsa-miR-576-5p	CLIP-seq
MIRT967061	hsa-miR-615-5p	CLIP-seq
MIRT967062	hsa-miR-637	CLIP-seq
MIRT967043	hsa-miR-141	CLIP-seq
MIRT967044	hsa-miR-200a	CLIP-seq
MIRT967043	hsa-miR-141	CLIP-seq
MIRT2220972	hsa-miR-145	CLIP-seq
MIRT2220973	hsa-miR-150	CLIP-seq
MIRT2220974	hsa-miR-1915	CLIP-seq
MIRT2220975	hsa-miR-198	CLIP-seq
MIRT967044	hsa-miR-200a	CLIP-seq
MIRT2220976	hsa-miR-3675-5p	CLIP-seq
MIRT2220977	hsa-miR-4270	CLIP-seq
MIRT2220978	hsa-miR-4441	CLIP-seq
MIRT2220979	hsa-miR-4534	CLIP-seq
MIRT2220980	hsa-miR-4695-3p	CLIP-seq
MIRT2220981	hsa-miR-4713-5p	CLIP-seq
MIRT2220982	hsa-miR-4726-3p	CLIP-seq
MIRT2220983	hsa-miR-4768-5p	CLIP-seq
MIRT2220984	hsa-miR-486-3p	CLIP-seq
MIRT2220985	hsa-miR-532-3p	CLIP-seq
MIRT2524734	hsa-miR-3179	CLIP-seq
MIRT2524735	hsa-miR-3202	CLIP-seq
MIRT2524736	hsa-miR-4271	CLIP-seq
MIRT2524737	hsa-miR-4476	CLIP-seq
MIRT2524738	hsa-miR-4725-3p	CLIP-seq
MIRT2524739	hsa-miR-4747-5p	CLIP-seq
MIRT967062	hsa-miR-637	CLIP-seq
MIRT2524734	hsa-miR-3179	CLIP-seq
MIRT2524735	hsa-miR-3202	CLIP-seq
MIRT2524736	hsa-miR-4271	CLIP-seq
MIRT2524737	hsa-miR-4476	CLIP-seq
MIRT2524738	hsa-miR-4725-3p	CLIP-seq
MIRT2524739	hsa-miR-4747-5p	CLIP-seq
MIRT967062	hsa-miR-637	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0005515	Function	Protein binding	IPI	18199683, 18200045, 25036637, 25416956, 32296183, 33961781, 34927784, 35044719, 35271311
GO:0005543	Function	Phospholipid binding	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0006897	Process	Endocytosis	TAS	9723620
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0030125	Component	Clathrin vesicle coat	IBA
GO:0030276	Function	Clathrin binding	IBA
GO:0048568	Process	Embryonic organ development	IEA
GO:0140313	Function	Molecular sequestering activity	EXP	11161217
GO:0140313	Function	Molecular sequestering activity	IPI	11161217
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IGI	28717225

MIM	HGNC	e!Ensembl
607262	21604	ENSG00000063245

Q9Y6I3

Protein name

Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)

Protein function

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:103

PDB

1INZ , 1KYD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01417	ENTH	17 → 140	ENTH domain	Domain

Sequence

MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI
WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG
VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS
SGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQM
AIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPP
VPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPV
SGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSS
AGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAA
LVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPP
VPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL

Sequence length

576

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23187125	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23187125	★★★★★ ★☆☆☆☆ Found in Text Mining only

EPN1 (epsin 1)