SNX11 (sorting nexin 11)

Gene

• Entrez ID: 29916
• Gene name: Sorting nexin 11
• Gene symbol: SNX11
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q21.32
• Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045867	hsa-miR-128-3p	CLASH	23622248
MIRT042365	hsa-miR-484	CLASH	23622248
MIRT038195	hsa-miR-151a-5p	CLASH	23622248
MIRT146496	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT146501	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT146497	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT146502	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT1376713	hsa-miR-1273	CLIP-seq
MIRT1376714	hsa-miR-1323	CLIP-seq
MIRT1376715	hsa-miR-144	CLIP-seq
MIRT1376716	hsa-miR-15a	CLIP-seq
MIRT1376717	hsa-miR-15b	CLIP-seq
MIRT1376718	hsa-miR-16	CLIP-seq
MIRT1376719	hsa-miR-194	CLIP-seq
MIRT1376720	hsa-miR-195	CLIP-seq
MIRT1376721	hsa-miR-214	CLIP-seq
MIRT1376722	hsa-miR-2355-5p	CLIP-seq
MIRT1376723	hsa-miR-2467-3p	CLIP-seq
MIRT1376724	hsa-miR-29a	CLIP-seq
MIRT1376725	hsa-miR-29b	CLIP-seq
MIRT1376726	hsa-miR-29c	CLIP-seq
MIRT1376727	hsa-miR-3064-3p	CLIP-seq
MIRT1376728	hsa-miR-3065-3p	CLIP-seq
MIRT1376729	hsa-miR-3117-5p	CLIP-seq
MIRT1376730	hsa-miR-3130-3p	CLIP-seq
MIRT1376731	hsa-miR-3136-5p	CLIP-seq
MIRT1376732	hsa-miR-3150b-3p	CLIP-seq
MIRT1376733	hsa-miR-3157-5p	CLIP-seq
MIRT1376734	hsa-miR-346	CLIP-seq
MIRT1376735	hsa-miR-3619-5p	CLIP-seq
MIRT1376736	hsa-miR-3622a-3p	CLIP-seq
MIRT1376737	hsa-miR-3622b-3p	CLIP-seq
MIRT1376738	hsa-miR-375	CLIP-seq
MIRT1376739	hsa-miR-377	CLIP-seq
MIRT1376740	hsa-miR-3936	CLIP-seq
MIRT1376741	hsa-miR-3940-3p	CLIP-seq
MIRT1376742	hsa-miR-3974	CLIP-seq
MIRT1376743	hsa-miR-424	CLIP-seq
MIRT1376744	hsa-miR-4257	CLIP-seq
MIRT1376745	hsa-miR-4271	CLIP-seq
MIRT1376746	hsa-miR-4276	CLIP-seq
MIRT1376747	hsa-miR-4288	CLIP-seq
MIRT1376748	hsa-miR-4307	CLIP-seq
MIRT1376749	hsa-miR-4433	CLIP-seq
MIRT1376750	hsa-miR-4439	CLIP-seq
MIRT1376751	hsa-miR-4513	CLIP-seq
MIRT1376752	hsa-miR-4530	CLIP-seq
MIRT1376753	hsa-miR-4533	CLIP-seq
MIRT1376754	hsa-miR-4645-3p	CLIP-seq
MIRT1376755	hsa-miR-4675	CLIP-seq
MIRT1376756	hsa-miR-4689	CLIP-seq
MIRT1376757	hsa-miR-4690-3p	CLIP-seq
MIRT1376758	hsa-miR-4691-3p	CLIP-seq
MIRT1376759	hsa-miR-4701-5p	CLIP-seq
MIRT1376760	hsa-miR-4705	CLIP-seq
MIRT1376761	hsa-miR-4715-3p	CLIP-seq
MIRT1376762	hsa-miR-4722-5p	CLIP-seq
MIRT1376763	hsa-miR-4725-3p	CLIP-seq
MIRT1376764	hsa-miR-4741	CLIP-seq
MIRT1376765	hsa-miR-4747-5p	CLIP-seq
MIRT1376766	hsa-miR-4755-3p	CLIP-seq
MIRT1376767	hsa-miR-4776-3p	CLIP-seq
MIRT1376768	hsa-miR-4784	CLIP-seq
MIRT1376769	hsa-miR-4793-3p	CLIP-seq
MIRT1376770	hsa-miR-497	CLIP-seq
MIRT1376771	hsa-miR-520d-5p	CLIP-seq
MIRT1376772	hsa-miR-524-5p	CLIP-seq
MIRT1376773	hsa-miR-544b	CLIP-seq
MIRT1376774	hsa-miR-548a-3p	CLIP-seq
MIRT1376775	hsa-miR-548e	CLIP-seq
MIRT1376776	hsa-miR-548f	CLIP-seq
MIRT1376777	hsa-miR-548o	CLIP-seq
MIRT1376778	hsa-miR-582-3p	CLIP-seq
MIRT1376779	hsa-miR-588	CLIP-seq
MIRT1376780	hsa-miR-605	CLIP-seq
MIRT1376781	hsa-miR-632	CLIP-seq
MIRT1376782	hsa-miR-654-3p	CLIP-seq
MIRT1376783	hsa-miR-7	CLIP-seq
MIRT1376784	hsa-miR-761	CLIP-seq
MIRT1376785	hsa-miR-802	CLIP-seq
MIRT1376786	hsa-miR-1276	CLIP-seq
MIRT1376787	hsa-miR-1324	CLIP-seq
MIRT1376716	hsa-miR-15a	CLIP-seq
MIRT1376717	hsa-miR-15b	CLIP-seq
MIRT1376718	hsa-miR-16	CLIP-seq
MIRT1376720	hsa-miR-195	CLIP-seq
MIRT1376721	hsa-miR-214	CLIP-seq
MIRT1376722	hsa-miR-2355-5p	CLIP-seq
MIRT1376724	hsa-miR-29a	CLIP-seq
MIRT1376725	hsa-miR-29b	CLIP-seq
MIRT1376726	hsa-miR-29c	CLIP-seq
MIRT1376728	hsa-miR-3065-3p	CLIP-seq
MIRT1376731	hsa-miR-3136-5p	CLIP-seq
MIRT1376735	hsa-miR-3619-5p	CLIP-seq
MIRT1376740	hsa-miR-3936	CLIP-seq
MIRT1376743	hsa-miR-424	CLIP-seq
MIRT1376746	hsa-miR-4276	CLIP-seq
MIRT1376749	hsa-miR-4433	CLIP-seq
MIRT1376750	hsa-miR-4439	CLIP-seq
MIRT1376751	hsa-miR-4513	CLIP-seq
MIRT1376752	hsa-miR-4530	CLIP-seq
MIRT1376755	hsa-miR-4675	CLIP-seq
MIRT1376762	hsa-miR-4722-5p	CLIP-seq
MIRT1376764	hsa-miR-4741	CLIP-seq
MIRT1376770	hsa-miR-497	CLIP-seq
MIRT1376780	hsa-miR-605	CLIP-seq
MIRT1376784	hsa-miR-761	CLIP-seq
MIRT2112072	hsa-miR-139-3p	CLIP-seq
MIRT1376722	hsa-miR-2355-5p	CLIP-seq
MIRT1376731	hsa-miR-3136-5p	CLIP-seq
MIRT2112073	hsa-miR-3173-3p	CLIP-seq
MIRT1376740	hsa-miR-3936	CLIP-seq
MIRT1376750	hsa-miR-4439	CLIP-seq
MIRT1376751	hsa-miR-4513	CLIP-seq
MIRT1376755	hsa-miR-4675	CLIP-seq
MIRT1376764	hsa-miR-4741	CLIP-seq
MIRT2112074	hsa-miR-558	CLIP-seq
MIRT2112075	hsa-miR-922	CLIP-seq
MIRT2112076	hsa-miR-940	CLIP-seq
MIRT1376721	hsa-miR-214	CLIP-seq
MIRT1376731	hsa-miR-3136-5p	CLIP-seq
MIRT1376733	hsa-miR-3157-5p	CLIP-seq
MIRT1376735	hsa-miR-3619-5p	CLIP-seq
MIRT1376740	hsa-miR-3936	CLIP-seq
MIRT1376742	hsa-miR-3974	CLIP-seq
MIRT1376750	hsa-miR-4439	CLIP-seq
MIRT2335299	hsa-miR-4459	CLIP-seq
MIRT1376751	hsa-miR-4513	CLIP-seq
MIRT1376755	hsa-miR-4675	CLIP-seq
MIRT1376758	hsa-miR-4691-3p	CLIP-seq
MIRT1376762	hsa-miR-4722-5p	CLIP-seq
MIRT1376764	hsa-miR-4741	CLIP-seq
MIRT1376766	hsa-miR-4755-3p	CLIP-seq
MIRT2335300	hsa-miR-512-5p	CLIP-seq
MIRT1376780	hsa-miR-605	CLIP-seq
MIRT1376784	hsa-miR-761	CLIP-seq
MIRT2335301	hsa-miR-885-3p	CLIP-seq
MIRT2629322	hsa-miR-1224-3p	CLIP-seq
MIRT2629323	hsa-miR-1260	CLIP-seq
MIRT2629324	hsa-miR-1260b	CLIP-seq
MIRT2629325	hsa-miR-1264	CLIP-seq
MIRT2629326	hsa-miR-1280	CLIP-seq
MIRT1376714	hsa-miR-1323	CLIP-seq
MIRT2629327	hsa-miR-146b-3p	CLIP-seq
MIRT2629328	hsa-miR-1538	CLIP-seq
MIRT2629329	hsa-miR-183	CLIP-seq
MIRT2629330	hsa-miR-188-3p	CLIP-seq
MIRT2629331	hsa-miR-1914	CLIP-seq
MIRT2629332	hsa-miR-1915	CLIP-seq
MIRT2629333	hsa-miR-1976	CLIP-seq
MIRT2629334	hsa-miR-2278	CLIP-seq
MIRT1376723	hsa-miR-2467-3p	CLIP-seq
MIRT2629335	hsa-miR-296-3p	CLIP-seq
MIRT2629336	hsa-miR-298	CLIP-seq
MIRT1376727	hsa-miR-3064-3p	CLIP-seq
MIRT1376729	hsa-miR-3117-5p	CLIP-seq
MIRT1376732	hsa-miR-3150b-3p	CLIP-seq
MIRT2629337	hsa-miR-3158-5p	CLIP-seq
MIRT2629338	hsa-miR-3173-5p	CLIP-seq
MIRT2629339	hsa-miR-3194-5p	CLIP-seq
MIRT1376736	hsa-miR-3622a-3p	CLIP-seq
MIRT1376737	hsa-miR-3622b-3p	CLIP-seq
MIRT2629340	hsa-miR-3661	CLIP-seq
MIRT2629341	hsa-miR-3921	CLIP-seq
MIRT2629342	hsa-miR-4256	CLIP-seq
MIRT1376744	hsa-miR-4257	CLIP-seq
MIRT2629343	hsa-miR-4330	CLIP-seq
MIRT2629344	hsa-miR-4426	CLIP-seq
MIRT2629345	hsa-miR-4450	CLIP-seq
MIRT2629346	hsa-miR-4468	CLIP-seq
MIRT2629347	hsa-miR-4647	CLIP-seq
MIRT2629348	hsa-miR-4652-3p	CLIP-seq
MIRT2629349	hsa-miR-4653-5p	CLIP-seq
MIRT2629350	hsa-miR-4654	CLIP-seq
MIRT2629351	hsa-miR-4662b	CLIP-seq
MIRT1376756	hsa-miR-4689	CLIP-seq
MIRT1376757	hsa-miR-4690-3p	CLIP-seq
MIRT1376760	hsa-miR-4705	CLIP-seq
MIRT2629352	hsa-miR-4726-3p	CLIP-seq
MIRT2629353	hsa-miR-4745-3p	CLIP-seq
MIRT2629354	hsa-miR-4768-3p	CLIP-seq
MIRT2629355	hsa-miR-4769-5p	CLIP-seq
MIRT1376768	hsa-miR-4784	CLIP-seq
MIRT2629356	hsa-miR-4786-3p	CLIP-seq
MIRT2629357	hsa-miR-4803	CLIP-seq
MIRT2629358	hsa-miR-532-3p	CLIP-seq
MIRT1376773	hsa-miR-544b	CLIP-seq
MIRT1376774	hsa-miR-548a-3p	CLIP-seq
MIRT1376775	hsa-miR-548e	CLIP-seq
MIRT1376776	hsa-miR-548f	CLIP-seq
MIRT1376777	hsa-miR-548o	CLIP-seq
MIRT1376778	hsa-miR-582-3p	CLIP-seq
MIRT2629359	hsa-miR-591	CLIP-seq
MIRT2629360	hsa-miR-631	CLIP-seq
MIRT2629361	hsa-miR-665	CLIP-seq
MIRT2629362	hsa-miR-874	CLIP-seq
MIRT2335301	hsa-miR-885-3p	CLIP-seq
MIRT2629363	hsa-miR-942	CLIP-seq
MIRT2629322	hsa-miR-1224-3p	CLIP-seq
MIRT2629323	hsa-miR-1260	CLIP-seq
MIRT2629324	hsa-miR-1260b	CLIP-seq
MIRT2629325	hsa-miR-1264	CLIP-seq
MIRT2691666	hsa-miR-1270	CLIP-seq
MIRT2629326	hsa-miR-1280	CLIP-seq
MIRT1376714	hsa-miR-1323	CLIP-seq
MIRT2691667	hsa-miR-143	CLIP-seq
MIRT2629327	hsa-miR-146b-3p	CLIP-seq
MIRT2691668	hsa-miR-149	CLIP-seq
MIRT2629328	hsa-miR-1538	CLIP-seq
MIRT2629329	hsa-miR-183	CLIP-seq
MIRT2629330	hsa-miR-188-3p	CLIP-seq
MIRT2629331	hsa-miR-1914	CLIP-seq
MIRT2629333	hsa-miR-1976	CLIP-seq
MIRT1376721	hsa-miR-214	CLIP-seq
MIRT1376723	hsa-miR-2467-3p	CLIP-seq
MIRT2629336	hsa-miR-298	CLIP-seq
MIRT1376727	hsa-miR-3064-3p	CLIP-seq
MIRT2691669	hsa-miR-3064-5p	CLIP-seq
MIRT1376729	hsa-miR-3117-5p	CLIP-seq
MIRT1376732	hsa-miR-3150b-3p	CLIP-seq
MIRT2629337	hsa-miR-3158-5p	CLIP-seq
MIRT2629338	hsa-miR-3173-5p	CLIP-seq
MIRT2691670	hsa-miR-3185	CLIP-seq
MIRT2629339	hsa-miR-3194-5p	CLIP-seq
MIRT1376735	hsa-miR-3619-5p	CLIP-seq
MIRT1376736	hsa-miR-3622a-3p	CLIP-seq
MIRT1376737	hsa-miR-3622b-3p	CLIP-seq
MIRT2629340	hsa-miR-3661	CLIP-seq
MIRT1376744	hsa-miR-4257	CLIP-seq
MIRT2691671	hsa-miR-4264	CLIP-seq
MIRT2691672	hsa-miR-4267	CLIP-seq
MIRT2691673	hsa-miR-4289	CLIP-seq
MIRT2629343	hsa-miR-4330	CLIP-seq
MIRT2629344	hsa-miR-4426	CLIP-seq
MIRT2629345	hsa-miR-4450	CLIP-seq
MIRT2335299	hsa-miR-4459	CLIP-seq
MIRT2691674	hsa-miR-4638-5p	CLIP-seq
MIRT2629347	hsa-miR-4647	CLIP-seq
MIRT2629350	hsa-miR-4654	CLIP-seq
MIRT2629351	hsa-miR-4662b	CLIP-seq
MIRT2691675	hsa-miR-4683	CLIP-seq
MIRT1376756	hsa-miR-4689	CLIP-seq
MIRT1376757	hsa-miR-4690-3p	CLIP-seq
MIRT1376760	hsa-miR-4705	CLIP-seq
MIRT1376762	hsa-miR-4722-5p	CLIP-seq
MIRT2629353	hsa-miR-4745-3p	CLIP-seq
MIRT2629355	hsa-miR-4769-5p	CLIP-seq
MIRT2691676	hsa-miR-4770	CLIP-seq
MIRT1376768	hsa-miR-4784	CLIP-seq
MIRT2629356	hsa-miR-4786-3p	CLIP-seq
MIRT2691677	hsa-miR-4794	CLIP-seq
MIRT2691678	hsa-miR-4797-3p	CLIP-seq
MIRT2629357	hsa-miR-4803	CLIP-seq
MIRT2629358	hsa-miR-532-3p	CLIP-seq
MIRT1376773	hsa-miR-544b	CLIP-seq
MIRT1376774	hsa-miR-548a-3p	CLIP-seq
MIRT1376775	hsa-miR-548e	CLIP-seq
MIRT1376776	hsa-miR-548f	CLIP-seq
MIRT1376777	hsa-miR-548o	CLIP-seq
MIRT1376778	hsa-miR-582-3p	CLIP-seq
MIRT2691679	hsa-miR-620	CLIP-seq
MIRT2629360	hsa-miR-631	CLIP-seq
MIRT2691680	hsa-miR-634	CLIP-seq
MIRT2691681	hsa-miR-760	CLIP-seq
MIRT1376784	hsa-miR-761	CLIP-seq
MIRT2629362	hsa-miR-874	CLIP-seq
MIRT2335301	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 26818531, 32296183
GO:0005737	Component	Cytoplasm	IDA	26818531
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA	23615901
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IDA	26818531
GO:0005886	Component	Plasma membrane	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016050	Process	Vesicle organization	IBA
GO:0016050	Process	Vesicle organization	IEA
GO:0016050	Process	Vesicle organization	IMP	23615901
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:1901981	Function	Phosphatidylinositol phosphate binding	IBA
GO:1901981	Function	Phosphatidylinositol phosphate binding	IDA	23615901

Other IDs

• MIM: 614906
• HGNC: 14975
• e!Ensembl: ENSG00000002919

Protein

• UniProt ID: Q9Y5W9
• Protein name: Sorting nexin-11
• Protein function: Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes (PubMed:23615901). Regulates the levels of TRPV3 by promoting its trafficking from the cell membrane to lysosome for degradation (PubMed:26818531)
• PDB: 4IKB, 4IKD, 6KOI, 6KOJ, 6KOK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00787	PX	46 → 129	PX domain	Domain

• Sequence:

  MGFWCRMSENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRY
  REFVWLRKQLQRNAGLVPVPELPGKSTFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDS
  QLHLFLQSQLSVPEIEACVQGRSTMTVSDAILRYAMSNCGWAQEERQSSSHLAKGDQPKS
  CCFLPRSGRRSSPSPPPSEEKDHLEVWAPVVDSEVPSLESPTLPPLSSPLCCDFGRPKEG
  TSTLQSVRRAVGGDHAVPLDPGQLETVLEK

• Sequence length: 270

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	39401154	Associate	★☆☆☆☆ Found in Text Mining only