SNX8 (sorting nexin 8)

Gene

• Entrez ID: 29886
• Gene name: Sorting nexin 8
• Gene symbol: SNX8
• Synonyms (NCBI Gene): Mvp1
• Chromosome: 7
• Chromosome location: 7p22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048293	hsa-miR-107	CLASH	23622248
MIRT038133	hsa-miR-423-5p	CLASH	23622248
MIRT719946	hsa-miR-4714-5p	HITS-CLIP	19536157
MIRT719945	hsa-miR-514a-5p	HITS-CLIP	19536157
MIRT719944	hsa-miR-3664-5p	HITS-CLIP	19536157
MIRT719943	hsa-miR-1915-5p	HITS-CLIP	19536157
MIRT719942	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT719941	hsa-miR-24-1-5p	HITS-CLIP	19536157
MIRT719939	hsa-miR-24-2-5p	HITS-CLIP	19536157
MIRT719940	hsa-miR-4312	HITS-CLIP	19536157
MIRT719938	hsa-miR-4774-3p	HITS-CLIP	19536157
MIRT719946	hsa-miR-4714-5p	HITS-CLIP	19536157
MIRT719945	hsa-miR-514a-5p	HITS-CLIP	19536157
MIRT719944	hsa-miR-3664-5p	HITS-CLIP	19536157
MIRT719943	hsa-miR-1915-5p	HITS-CLIP	19536157
MIRT719942	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT719941	hsa-miR-24-1-5p	HITS-CLIP	19536157
MIRT719939	hsa-miR-24-2-5p	HITS-CLIP	19536157
MIRT719940	hsa-miR-4312	HITS-CLIP	19536157
MIRT719938	hsa-miR-4774-3p	HITS-CLIP	19536157
MIRT719946	hsa-miR-4714-5p	HITS-CLIP	19536157
MIRT719945	hsa-miR-514a-5p	HITS-CLIP	19536157
MIRT719944	hsa-miR-3664-5p	HITS-CLIP	19536157
MIRT719943	hsa-miR-1915-5p	HITS-CLIP	19536157
MIRT719942	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT719941	hsa-miR-24-1-5p	HITS-CLIP	19536157
MIRT719939	hsa-miR-24-2-5p	HITS-CLIP	19536157
MIRT719940	hsa-miR-4312	HITS-CLIP	19536157
MIRT719938	hsa-miR-4774-3p	HITS-CLIP	19536157
MIRT719946	hsa-miR-4714-5p	HITS-CLIP	19536157
MIRT719945	hsa-miR-514a-5p	HITS-CLIP	19536157
MIRT719944	hsa-miR-3664-5p	HITS-CLIP	19536157
MIRT719943	hsa-miR-1915-5p	HITS-CLIP	19536157
MIRT719942	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT719941	hsa-miR-24-1-5p	HITS-CLIP	19536157
MIRT719939	hsa-miR-24-2-5p	HITS-CLIP	19536157
MIRT719940	hsa-miR-4312	HITS-CLIP	19536157
MIRT719938	hsa-miR-4774-3p	HITS-CLIP	19536157
MIRT1378321	hsa-miR-1207-5p	CLIP-seq
MIRT1378322	hsa-miR-1470	CLIP-seq
MIRT1378323	hsa-miR-1537	CLIP-seq
MIRT1378324	hsa-miR-15a	CLIP-seq
MIRT1378325	hsa-miR-15b	CLIP-seq
MIRT1378326	hsa-miR-16	CLIP-seq
MIRT1378327	hsa-miR-185	CLIP-seq
MIRT1378328	hsa-miR-195	CLIP-seq
MIRT1378329	hsa-miR-30a	CLIP-seq
MIRT1378330	hsa-miR-30b	CLIP-seq
MIRT1378331	hsa-miR-30c	CLIP-seq
MIRT1378332	hsa-miR-30d	CLIP-seq
MIRT1378333	hsa-miR-30e	CLIP-seq
MIRT1378334	hsa-miR-3135b	CLIP-seq
MIRT1378335	hsa-miR-3607-5p	CLIP-seq
MIRT1378336	hsa-miR-3616-5p	CLIP-seq
MIRT1378337	hsa-miR-3622b-5p	CLIP-seq
MIRT1378338	hsa-miR-3647-5p	CLIP-seq
MIRT1378339	hsa-miR-3652	CLIP-seq
MIRT1378340	hsa-miR-3714	CLIP-seq
MIRT1378341	hsa-miR-424	CLIP-seq
MIRT1378342	hsa-miR-4270	CLIP-seq
MIRT1378343	hsa-miR-4287	CLIP-seq
MIRT1378344	hsa-miR-4306	CLIP-seq
MIRT1378345	hsa-miR-4430	CLIP-seq
MIRT1378346	hsa-miR-4436b-3p	CLIP-seq
MIRT1378347	hsa-miR-4441	CLIP-seq
MIRT1378348	hsa-miR-4469	CLIP-seq
MIRT1378349	hsa-miR-4476	CLIP-seq
MIRT1378350	hsa-miR-4644	CLIP-seq
MIRT1378351	hsa-miR-4667-3p	CLIP-seq
MIRT1378352	hsa-miR-4670-3p	CLIP-seq
MIRT1378353	hsa-miR-4685-3p	CLIP-seq
MIRT1378354	hsa-miR-4690-3p	CLIP-seq
MIRT1378355	hsa-miR-4698	CLIP-seq
MIRT1378356	hsa-miR-4708-5p	CLIP-seq
MIRT1378357	hsa-miR-4763-3p	CLIP-seq
MIRT1378358	hsa-miR-497	CLIP-seq
MIRT1378359	hsa-miR-532-3p	CLIP-seq
MIRT1378360	hsa-miR-573	CLIP-seq
MIRT1378361	hsa-miR-625	CLIP-seq
MIRT1378362	hsa-miR-662	CLIP-seq
MIRT1378363	hsa-miR-922	CLIP-seq
MIRT2112812	hsa-miR-1184	CLIP-seq
MIRT2112813	hsa-miR-1226	CLIP-seq
MIRT2112814	hsa-miR-1275	CLIP-seq
MIRT2112815	hsa-miR-1289	CLIP-seq
MIRT2112816	hsa-miR-146a	CLIP-seq
MIRT2112817	hsa-miR-146b-5p	CLIP-seq
MIRT2112818	hsa-miR-214	CLIP-seq
MIRT2112819	hsa-miR-3127-3p	CLIP-seq
MIRT2112820	hsa-miR-3180-5p	CLIP-seq
MIRT2112821	hsa-miR-3183	CLIP-seq
MIRT2112822	hsa-miR-3189-3p	CLIP-seq
MIRT2112823	hsa-miR-338-3p	CLIP-seq
MIRT2112824	hsa-miR-3615	CLIP-seq
MIRT2112825	hsa-miR-3619-5p	CLIP-seq
MIRT2112826	hsa-miR-3620	CLIP-seq
MIRT1378340	hsa-miR-3714	CLIP-seq
MIRT2112827	hsa-miR-3919	CLIP-seq
MIRT2112828	hsa-miR-3925-5p	CLIP-seq
MIRT2112829	hsa-miR-412	CLIP-seq
MIRT2112830	hsa-miR-4251	CLIP-seq
MIRT1378342	hsa-miR-4270	CLIP-seq
MIRT2112831	hsa-miR-4290	CLIP-seq
MIRT2112832	hsa-miR-4432	CLIP-seq
MIRT2112833	hsa-miR-4433	CLIP-seq
MIRT1378347	hsa-miR-4441	CLIP-seq
MIRT2112834	hsa-miR-4459	CLIP-seq
MIRT2112835	hsa-miR-4488	CLIP-seq
MIRT2112836	hsa-miR-4496	CLIP-seq
MIRT2112837	hsa-miR-4642	CLIP-seq
MIRT2112838	hsa-miR-4665-5p	CLIP-seq
MIRT1378351	hsa-miR-4667-3p	CLIP-seq
MIRT2112839	hsa-miR-4675	CLIP-seq
MIRT1378354	hsa-miR-4690-3p	CLIP-seq
MIRT2112840	hsa-miR-4690-5p	CLIP-seq
MIRT2112841	hsa-miR-4697-5p	CLIP-seq
MIRT2112842	hsa-miR-4706	CLIP-seq
MIRT1378356	hsa-miR-4708-5p	CLIP-seq
MIRT2112843	hsa-miR-4720-5p	CLIP-seq
MIRT2112844	hsa-miR-4722-5p	CLIP-seq
MIRT2112845	hsa-miR-4723-3p	CLIP-seq
MIRT2112846	hsa-miR-4725-5p	CLIP-seq
MIRT2112847	hsa-miR-4741	CLIP-seq
MIRT2112848	hsa-miR-4749-5p	CLIP-seq
MIRT2112849	hsa-miR-4763-5p	CLIP-seq
MIRT2112850	hsa-miR-4768-3p	CLIP-seq
MIRT2112851	hsa-miR-4799-3p	CLIP-seq
MIRT2112852	hsa-miR-504	CLIP-seq
MIRT2112853	hsa-miR-520a-5p	CLIP-seq
MIRT2112854	hsa-miR-525-5p	CLIP-seq
MIRT2112855	hsa-miR-589	CLIP-seq
MIRT2112856	hsa-miR-621	CLIP-seq
MIRT2112857	hsa-miR-634	CLIP-seq
MIRT2112858	hsa-miR-635	CLIP-seq
MIRT2112859	hsa-miR-649	CLIP-seq
MIRT2112860	hsa-miR-761	CLIP-seq
MIRT2112861	hsa-miR-885-3p	CLIP-seq
MIRT2112812	hsa-miR-1184	CLIP-seq
MIRT2112813	hsa-miR-1226	CLIP-seq
MIRT2335810	hsa-miR-1229	CLIP-seq
MIRT2335811	hsa-miR-1291	CLIP-seq
MIRT1378322	hsa-miR-1470	CLIP-seq
MIRT1378327	hsa-miR-185	CLIP-seq
MIRT2335812	hsa-miR-22	CLIP-seq
MIRT2335813	hsa-miR-3065-3p	CLIP-seq
MIRT2112819	hsa-miR-3127-3p	CLIP-seq
MIRT1378334	hsa-miR-3135b	CLIP-seq
MIRT2335814	hsa-miR-328	CLIP-seq
MIRT2112823	hsa-miR-338-3p	CLIP-seq
MIRT1378342	hsa-miR-4270	CLIP-seq
MIRT2335815	hsa-miR-4279	CLIP-seq
MIRT2112831	hsa-miR-4290	CLIP-seq
MIRT1378344	hsa-miR-4306	CLIP-seq
MIRT2335816	hsa-miR-4421	CLIP-seq
MIRT1378346	hsa-miR-4436b-3p	CLIP-seq
MIRT2335817	hsa-miR-4438	CLIP-seq
MIRT1378347	hsa-miR-4441	CLIP-seq
MIRT1378348	hsa-miR-4469	CLIP-seq
MIRT1378350	hsa-miR-4644	CLIP-seq
MIRT1378351	hsa-miR-4667-3p	CLIP-seq
MIRT1378361	hsa-miR-625	CLIP-seq
MIRT2112857	hsa-miR-634	CLIP-seq
MIRT2112812	hsa-miR-1184	CLIP-seq
MIRT2394939	hsa-miR-1976	CLIP-seq
MIRT2394940	hsa-miR-2467-3p	CLIP-seq
MIRT2394941	hsa-miR-3158-5p	CLIP-seq
MIRT2394942	hsa-miR-3184	CLIP-seq
MIRT2394943	hsa-miR-3678-3p	CLIP-seq
MIRT2394944	hsa-miR-370	CLIP-seq
MIRT1378342	hsa-miR-4270	CLIP-seq
MIRT1378347	hsa-miR-4441	CLIP-seq
MIRT2460229	hsa-miR-1224-3p	CLIP-seq
MIRT2460230	hsa-miR-124	CLIP-seq
MIRT2460231	hsa-miR-1293	CLIP-seq
MIRT1378322	hsa-miR-1470	CLIP-seq
MIRT2460232	hsa-miR-1913	CLIP-seq
MIRT2394939	hsa-miR-1976	CLIP-seq
MIRT2394940	hsa-miR-2467-3p	CLIP-seq
MIRT2460233	hsa-miR-3202	CLIP-seq
MIRT2460234	hsa-miR-324-3p	CLIP-seq
MIRT2460235	hsa-miR-4297	CLIP-seq
MIRT2460236	hsa-miR-4313	CLIP-seq
MIRT1378348	hsa-miR-4469	CLIP-seq
MIRT1378349	hsa-miR-4476	CLIP-seq
MIRT2460237	hsa-miR-4483	CLIP-seq
MIRT1378351	hsa-miR-4667-3p	CLIP-seq
MIRT2460238	hsa-miR-4722-3p	CLIP-seq
MIRT2460239	hsa-miR-506	CLIP-seq
MIRT2460230	hsa-miR-124	CLIP-seq
MIRT2630010	hsa-miR-2355-5p	CLIP-seq
MIRT2630011	hsa-miR-3622a-5p	CLIP-seq
MIRT2630012	hsa-miR-3938	CLIP-seq
MIRT1378351	hsa-miR-4667-3p	CLIP-seq
MIRT2460239	hsa-miR-506	CLIP-seq
MIRT2630013	hsa-miR-564	CLIP-seq
MIRT2630010	hsa-miR-2355-5p	CLIP-seq
MIRT2630012	hsa-miR-3938	CLIP-seq
MIRT1378351	hsa-miR-4667-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147, 32296183
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0006886	Process	Intracellular protein transport	IMP	19782049
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0030904	Component	Retromer complex	IDA	19782049
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031901	Component	Early endosome membrane	IBA
GO:0031901	Component	Early endosome membrane	IDA	19782049
GO:0031901	Component	Early endosome membrane	IEA
GO:0034498	Process	Early endosome to Golgi transport	IBA
GO:0034498	Process	Early endosome to Golgi transport	IMP	19782049
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0035091	Function	Phosphatidylinositol binding	IMP	19782049
GO:0042147	Process	Retrograde transport, endosome to Golgi	IEA
GO:0042802	Function	Identical protein binding	IPI	23085988

Other IDs

• MIM: 614905
• HGNC: 14972
• e!Ensembl: ENSG00000106266

Protein

• UniProt ID: Q9Y5X2
• Protein name: Sorting nexin-8
• Protein function: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00787	PX	96 → 178	PX domain	Domain

• Sequence:

  MTGRAMDPLPAAAVGAAAEAEADEEADPPASDLPTPQAIEPQAIVQQVPAPSRMQMPQGN
  PLLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEML
  LHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGS
  DVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAE
  RIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLAD
  KAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMSAT
  AQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHVYLPLTSHILRAFVN
  SQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH

• Sequence length: 465

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	34524084	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Amyloidosis	Amyloidosis	BEFREE	31551717		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Congenital Heart Defects	Congenital heart defects	BEFREE	31568860		★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	29884837		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	29884837	Associate	★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	31551717		★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	29884837		★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	GWASCAT_DG	29884837		★☆☆☆☆ Found in Text Mining only