Gene Gene information from NCBI Gene database.
Entrez ID 2950
Gene name Glutathione S-transferase pi 1
Gene symbol GSTP1
Synonyms (NCBI Gene)
DFN7FAEES3GST3GSTPHEL-S-22PI
Chromosome 11
Chromosome location 11q13.2
Summary Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and st
SNPs SNP information provided by dbSNP.
2
SNP ID Visualize variation Clinical significance Consequence
rs1695 A>G Not-provided, drug-response Missense variant, coding sequence variant
rs1555022268 TC>CA Likely-pathogenic Intron variant
miRNA miRNA information provided by mirtarbase database.
5
miRTarBase ID miRNA Experiments Reference
MIRT006966 hsa-miR-513a-3p Luciferase reporter assayqRT-PCRWestern blot 22749944
MIRT006966 hsa-miR-513a-3p Luciferase reporter assayqRT-PCRWestern blot 22749944
MIRT021715 hsa-miR-133a-3p Reporter assay;Microarray 21396852
MIRT029320 hsa-miR-26b-5p Microarray 19088304
MIRT049201 hsa-miR-92a-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
9
Transcription factor Regulation Reference
CDX2 Unknown 22580340
FOS Unknown 8206948
JUN Unknown 8206948
MBD2 Repression 11960994;12543808;19856314
MBD2 Unknown 11406558
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
78
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000302 Process Response to reactive oxygen species ISS
GO:0002674 Process Negative regulation of acute inflammatory response NAS 18962899
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 1540159, 9084911
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
134660 4638 ENSG00000084207
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09211
Protein name Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Particip
PDB 10GS , 11GS , 12GS , 13GS , 14GS , 16GS , 17GS , 18GS , 19GS , 1AQV , 1AQW , 1AQX , 1EOG , 1EOH , 1GSS , 1KBN , 1LBK , 1MD3 , 1MD4 , 1PGT , 1PX6 , 1PX7 , 1ZGN , 20GS , 22GS , 2A2R , 2A2S , 2GSS , 2J9H , 2PGT , 3CSH , 3CSI , 3CSJ , 3DD3 , 3DGQ , 3GSS , 3GUS , 3HJM , 3HJO , 3HKR , 3IE3 , 3KM6 , 3KMN , 3KMO , 3N9J , 3PGT , 4GSS , 4PGT , 5DAK , 5DAL , 5DCG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02798 GST_N 4 75 Glutathione S-transferase, N-terminal domain Domain
PF14497 GST_C_3 98 197 Glutathione S-transferase, C-terminal domain Domain
Sequence
Sequence length 210
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Prostate cancer
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis
  Glutathione conjugation
Detoxification of Reactive Oxygen Species
Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
76
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Kala-azar susceptibility 2 Likely pathogenic rs1555022268 RCV000677248
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Abnormality of immune system physiology Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ALZHEIMERS DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acoustic Neuroma Acoustic Neuroma BEFREE 12540498
★☆☆☆☆
Found in Text Mining only
Acromegaly Acromegaly BEFREE 30488289
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome CTD_human_DG 21751358
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 11239504
★☆☆☆☆
Found in Text Mining only
Acute Kidney Insufficiency Acute Kidney Insufficiency CTD_human_DG 20623750
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 15862746, 24716937, 25799091
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 10666194, 12439226, 12827651, 14991750, 15862746, 17696749, 18385010, 19256768, 20824655, 22930568, 25102096, 27299594, 30659796
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 27984487
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 21875282
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 11550208, 11717336, 11740339, 11857497, 12010858, 12455028, 12937133, 15526353, 22248273, 23736019, 29344347, 9641498
★☆☆☆☆
Found in Text Mining only