GSTM3 (glutathione S-transferase mu 3)

Gene

• Entrez ID: 2947
• Gene name: Glutathione S-transferase mu 3
• Gene symbol: GSTM3
• Synonyms (NCBI Gene): GST5, GSTB, GSTM3-3, GSTM3TV2, GTM3, hGSTM3-3
• Chromosome: 1
• Chromosome location: 1p13.3
• Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023377	hsa-miR-122-5p	Proteomics	21750653
MIRT040526	hsa-miR-92b-3p	CLASH	23622248
MIRT676201	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT676200	hsa-miR-5693	HITS-CLIP	23824327
MIRT676199	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT676198	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT676197	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT676196	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT676195	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT676194	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT676193	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT676192	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676191	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676190	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676189	hsa-miR-4284	HITS-CLIP	23824327
MIRT676188	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT676187	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT676186	hsa-miR-7641	HITS-CLIP	23824327
MIRT676185	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT676184	hsa-miR-5698	HITS-CLIP	23824327
MIRT676201	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT676200	hsa-miR-5693	HITS-CLIP	23824327
MIRT676199	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT676198	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT676197	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT676196	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT676195	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT676194	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT676193	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT676192	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676191	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676190	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676189	hsa-miR-4284	HITS-CLIP	23824327
MIRT676188	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT676187	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT676186	hsa-miR-7641	HITS-CLIP	23824327
MIRT676185	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT676184	hsa-miR-5698	HITS-CLIP	23824327
MIRT1036604	hsa-miR-1193	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT1036606	hsa-miR-1206	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT1036608	hsa-miR-1246	CLIP-seq
MIRT1036609	hsa-miR-1260	CLIP-seq
MIRT1036610	hsa-miR-1260b	CLIP-seq
MIRT1036611	hsa-miR-1280	CLIP-seq
MIRT1036612	hsa-miR-1290	CLIP-seq
MIRT1036613	hsa-miR-1343	CLIP-seq
MIRT1036614	hsa-miR-1913	CLIP-seq
MIRT1036615	hsa-miR-192	CLIP-seq
MIRT1036616	hsa-miR-215	CLIP-seq
MIRT1036617	hsa-miR-2355-3p	CLIP-seq
MIRT1036618	hsa-miR-2392	CLIP-seq
MIRT1036619	hsa-miR-3132	CLIP-seq
MIRT1036620	hsa-miR-3167	CLIP-seq
MIRT1036621	hsa-miR-3187-3p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT1036623	hsa-miR-324-3p	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT1036625	hsa-miR-3940-3p	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT1036628	hsa-miR-4435	CLIP-seq
MIRT1036629	hsa-miR-4438	CLIP-seq
MIRT1036630	hsa-miR-4646-3p	CLIP-seq
MIRT1036631	hsa-miR-4701-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT1036633	hsa-miR-490-5p	CLIP-seq
MIRT1036634	hsa-miR-5095	CLIP-seq
MIRT1036635	hsa-miR-532-3p	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT1036637	hsa-miR-548s	CLIP-seq
MIRT1036638	hsa-miR-588	CLIP-seq
MIRT1036639	hsa-miR-876-5p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT738561	hsa-miR-1178	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT2007325	hsa-miR-1245	CLIP-seq
MIRT1036609	hsa-miR-1260	CLIP-seq
MIRT1036610	hsa-miR-1260b	CLIP-seq
MIRT1036611	hsa-miR-1280	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1036613	hsa-miR-1343	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT1036619	hsa-miR-3132	CLIP-seq
MIRT2007328	hsa-miR-3182	CLIP-seq
MIRT2007329	hsa-miR-378g	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT2007331	hsa-miR-4437	CLIP-seq
MIRT2007332	hsa-miR-4674	CLIP-seq
MIRT2007333	hsa-miR-4691-5p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2007335	hsa-miR-4731-5p	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT738560	hsa-miR-513a-5p	CLIP-seq
MIRT1036635	hsa-miR-532-3p	CLIP-seq
MIRT2239957	hsa-miR-106a	CLIP-seq
MIRT2239958	hsa-miR-106b	CLIP-seq
MIRT2239959	hsa-miR-1184	CLIP-seq
MIRT1036604	hsa-miR-1193	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT1036606	hsa-miR-1206	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT2007325	hsa-miR-1245	CLIP-seq
MIRT1036608	hsa-miR-1246	CLIP-seq
MIRT1036609	hsa-miR-1260	CLIP-seq
MIRT1036610	hsa-miR-1260b	CLIP-seq
MIRT1036611	hsa-miR-1280	CLIP-seq
MIRT1036612	hsa-miR-1290	CLIP-seq
MIRT2239961	hsa-miR-1301	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1036613	hsa-miR-1343	CLIP-seq
MIRT2239962	hsa-miR-150	CLIP-seq
MIRT2239963	hsa-miR-17	CLIP-seq
MIRT2239964	hsa-miR-1912	CLIP-seq
MIRT1036614	hsa-miR-1913	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT1036615	hsa-miR-192	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2239965	hsa-miR-20a	CLIP-seq
MIRT2239966	hsa-miR-20b	CLIP-seq
MIRT1036616	hsa-miR-215	CLIP-seq
MIRT1036618	hsa-miR-2392	CLIP-seq
MIRT2239967	hsa-miR-302a	CLIP-seq
MIRT2239968	hsa-miR-302b	CLIP-seq
MIRT2239969	hsa-miR-302c	CLIP-seq
MIRT2239970	hsa-miR-302d	CLIP-seq
MIRT2239971	hsa-miR-302e	CLIP-seq
MIRT2239972	hsa-miR-31	CLIP-seq
MIRT1036619	hsa-miR-3132	CLIP-seq
MIRT1036620	hsa-miR-3167	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT2239974	hsa-miR-3198	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT1036623	hsa-miR-324-3p	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT2239975	hsa-miR-3671	CLIP-seq
MIRT2239976	hsa-miR-3688-5p	CLIP-seq
MIRT2239977	hsa-miR-372	CLIP-seq
MIRT2239978	hsa-miR-373	CLIP-seq
MIRT2007329	hsa-miR-378g	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT2239979	hsa-miR-4309	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT2239980	hsa-miR-4418	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT2239981	hsa-miR-4428	CLIP-seq
MIRT2007331	hsa-miR-4437	CLIP-seq
MIRT1036629	hsa-miR-4438	CLIP-seq
MIRT2239982	hsa-miR-4494	CLIP-seq
MIRT2239983	hsa-miR-4522	CLIP-seq
MIRT2239984	hsa-miR-4660	CLIP-seq
MIRT2007332	hsa-miR-4674	CLIP-seq
MIRT2239985	hsa-miR-4677-3p	CLIP-seq
MIRT2239986	hsa-miR-4679	CLIP-seq
MIRT2239987	hsa-miR-4693-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2007335	hsa-miR-4731-5p	CLIP-seq
MIRT2239988	hsa-miR-488	CLIP-seq
MIRT1036633	hsa-miR-490-5p	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT2239989	hsa-miR-499a-5p	CLIP-seq
MIRT2239990	hsa-miR-5047	CLIP-seq
MIRT2239991	hsa-miR-509-3-5p	CLIP-seq
MIRT1036634	hsa-miR-5095	CLIP-seq
MIRT2239992	hsa-miR-509-5p	CLIP-seq
MIRT2239993	hsa-miR-512-3p	CLIP-seq
MIRT2239994	hsa-miR-519d	CLIP-seq
MIRT2239995	hsa-miR-520a-3p	CLIP-seq
MIRT2239996	hsa-miR-520b	CLIP-seq
MIRT2239997	hsa-miR-520c-3p	CLIP-seq
MIRT2239998	hsa-miR-520d-3p	CLIP-seq
MIRT2239999	hsa-miR-520e	CLIP-seq
MIRT2240000	hsa-miR-520g	CLIP-seq
MIRT2240001	hsa-miR-520h	CLIP-seq
MIRT1036635	hsa-miR-532-3p	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2240002	hsa-miR-607	CLIP-seq
MIRT738562	hsa-miR-767-3p	CLIP-seq
MIRT1036639	hsa-miR-876-5p	CLIP-seq
MIRT2240003	hsa-miR-93	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT2388820	hsa-miR-4514	CLIP-seq
MIRT2239983	hsa-miR-4522	CLIP-seq
MIRT2239985	hsa-miR-4677-3p	CLIP-seq
MIRT2239986	hsa-miR-4679	CLIP-seq
MIRT2388821	hsa-miR-4692	CLIP-seq
MIRT2388822	hsa-miR-4778-3p	CLIP-seq
MIRT2239988	hsa-miR-488	CLIP-seq
MIRT2388823	hsa-miR-508-5p	CLIP-seq
MIRT738562	hsa-miR-767-3p	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2450843	hsa-miR-3135b	CLIP-seq
MIRT2450844	hsa-miR-3137	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2450846	hsa-miR-3652	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT2450848	hsa-miR-4430	CLIP-seq
MIRT2450849	hsa-miR-4676-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450851	hsa-miR-4755-3p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2450853	hsa-miR-575	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq
MIRT2239957	hsa-miR-106a	CLIP-seq
MIRT2239958	hsa-miR-106b	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT2239962	hsa-miR-150	CLIP-seq
MIRT2239963	hsa-miR-17	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2239965	hsa-miR-20a	CLIP-seq
MIRT2239966	hsa-miR-20b	CLIP-seq
MIRT2543615	hsa-miR-2276	CLIP-seq
MIRT2239967	hsa-miR-302a	CLIP-seq
MIRT2239968	hsa-miR-302b	CLIP-seq
MIRT2239969	hsa-miR-302c	CLIP-seq
MIRT2239970	hsa-miR-302d	CLIP-seq
MIRT2239971	hsa-miR-302e	CLIP-seq
MIRT2450843	hsa-miR-3135b	CLIP-seq
MIRT2450844	hsa-miR-3137	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT2543616	hsa-miR-346	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT2450846	hsa-miR-3652	CLIP-seq
MIRT2239977	hsa-miR-372	CLIP-seq
MIRT2239978	hsa-miR-373	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT2450848	hsa-miR-4430	CLIP-seq
MIRT2450849	hsa-miR-4676-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450851	hsa-miR-4755-3p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT2543617	hsa-miR-4788	CLIP-seq
MIRT2543618	hsa-miR-494	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT2239993	hsa-miR-512-3p	CLIP-seq
MIRT2239994	hsa-miR-519d	CLIP-seq
MIRT2239995	hsa-miR-520a-3p	CLIP-seq
MIRT2239996	hsa-miR-520b	CLIP-seq
MIRT2239997	hsa-miR-520c-3p	CLIP-seq
MIRT2239998	hsa-miR-520d-3p	CLIP-seq
MIRT2239999	hsa-miR-520e	CLIP-seq
MIRT2240000	hsa-miR-520g	CLIP-seq
MIRT2240001	hsa-miR-520h	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2450853	hsa-miR-575	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq
MIRT2240003	hsa-miR-93	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2543615	hsa-miR-2276	CLIP-seq
MIRT2450843	hsa-miR-3135b	CLIP-seq
MIRT2450844	hsa-miR-3137	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT2543616	hsa-miR-346	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT2450846	hsa-miR-3652	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT2450848	hsa-miR-4430	CLIP-seq
MIRT2450849	hsa-miR-4676-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450851	hsa-miR-4755-3p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT2543617	hsa-miR-4788	CLIP-seq
MIRT2543618	hsa-miR-494	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2450853	hsa-miR-575	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004364	Function	Glutathione transferase activity	IBA
GO:0004364	Function	Glutathione transferase activity	IDA	8373352, 9545290, 10587441
GO:0004364	Function	Glutathione transferase activity	IEA
GO:0004364	Function	Glutathione transferase activity	TAS	2345169
GO:0005515	Function	Protein binding	IPI	23355646, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IDA	8373352
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006749	Process	Glutathione metabolic process	IBA
GO:0006749	Process	Glutathione metabolic process	IDA	8373352, 10587441
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0008065	Process	Establishment of blood-nerve barrier	TAS	2345169
GO:0016740	Function	Transferase activity	IEA
GO:0018916	Process	Nitrobenzene metabolic process	IDA	8373352
GO:0019899	Function	Enzyme binding	IPI	8373352
GO:0035686	Component	Sperm fibrous sheath	IEA
GO:0042178	Process	Xenobiotic catabolic process	IDA	8373352
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 19060904, 21516116, 31515488, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	9545290
GO:0042803	Function	Protein homodimerization activity	IPI	8373352
GO:0043295	Function	Glutathione binding	IDA	8373352
GO:0043627	Process	Response to estrogen	IEP	10037815
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070458	Process	Cellular detoxification of nitrogen compound	IDA	8373352

Other IDs

• MIM: 138390
• HGNC: 4635
• e!Ensembl: ENSG00000134202

Protein

• UniProt ID: P21266
• Protein name: Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)
• Protein function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. {ECO:0000269|Pub
• PDB: 3GTU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02798	GST_N	7 → 86	Glutathione S-transferase, N-terminal domain	Domain
  PF00043	GST_C	108 → 196	Glutathione S-transferase, C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis and brain.
• Sequence:

  MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
  FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
  SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
  EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC

• Sequence length: 225

Pathways

KEGG:

Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis

Reactome:

Glutathione conjugation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMERS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHLORACNE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CYSTIC FIBROSIS	—	CTD, Disgenet, Orphanet CTD, Disgenet, Orphanet CTD, Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	12492580		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	11740339, 17220350		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	23036584	Associate	★☆☆☆☆ Found in Text Mining only
Anemia Sickle Cell	Sickle cell anemia	Pubtator	30663491	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	31059917	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Astrocytoma	Astrocytoma	BEFREE	26580399, 8824514		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	26580399	Associate	★☆☆☆☆ Found in Text Mining only
Azoospermia, Nonobstructive	Azoospermia	BEFREE	29528137		★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	Pubtator	18664505	Associate	★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	19407363		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	11173863		★☆☆☆☆ Found in Text Mining only
Brain Injuries Traumatic	Brain injuries	Pubtator	29717219	Inhibit	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	16598069, 21914837	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	11303592, 19856098, 26125851, 30054830		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	15084249, 26125851, 30461653	Associate	★☆☆☆☆ Found in Text Mining only
Bronchioloalveolar Adenocarcinoma	Lung adenocarcinoma	BEFREE	18664505		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24157827	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	9077484	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	38320622	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	11173863		★☆☆☆☆ Found in Text Mining only
Carcinoma of larynx	Laryngeal carcinoma	BEFREE	10676631, 24416175		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	11740339, 15069685, 16509765, 17259654, 23167362, 25040976, 9918133		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	24157827, 29569387, 35096270	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	24157827	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	8616834, 9077484		★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	BEFREE	11040079		★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	18177825		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	18177825		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	29774096		★☆☆☆☆ Found in Text Mining only
Cholestasis	Cholelithiasis	Pubtator	25798860	Inhibit	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	11408349, 16328000		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	CTD_human_DG	17892325		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	CTD_human_DG	17892325		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Complete atrioventricular block	Complete Atrioventricular Block	BEFREE	22976281, 26725685		★☆☆☆☆ Found in Text Mining only
Conotruncal cardiac defects	Conotruncal cardiac defect	Pubtator	24585533	Associate	★☆☆☆☆ Found in Text Mining only
Conotruncal defect	Conotruncal defect	BEFREE	24585533		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	24157827, 29569387		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	15115915, 28289476		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystic Fibrosis	Cystic fibrosis	Pubtator	28289476	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Disorder of eye	Disorder Of Eye	BEFREE	11040079		★☆☆☆☆ Found in Text Mining only
Emphysema	Emphysema	Pubtator	19723343	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	17220350, 20661821		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	17220350, 20661821		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	33482859	Associate	★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	16760134		★☆☆☆☆ Found in Text Mining only
gallbladder neoplasm	Neoplasm of gallbladder	LHGDN	16760134		★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	11040079		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	34209254	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	15665284, 16598069, 17372252		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	16598069	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	24416175		★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	24585533	Associate	★☆☆☆☆ Found in Text Mining only
Hereditary pancreatitis	Hereditary Pancreatitis	BEFREE	15338373		★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia	Hypercholesterolemia	Pubtator	40532247	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	15167446		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	LHGDN	17922434		★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	10022746		★☆☆☆☆ Found in Text Mining only
Leukoplakia	Leukoplakia	BEFREE	14735473, 16172217		★☆☆☆☆ Found in Text Mining only
Leukoplakia, Oral	Leukoplakia	BEFREE	16172217		★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	10762000, 12016153, 16488179		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17716224		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	LHGDN	17716224		★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	BEFREE	22976281		★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	28289476	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	19887610, 25040976	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	19822571		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	19822571		★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	24416175		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	11303592, 19856098, 26125851, 30054830		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	17220350, 20661821		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	16760134		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of larynx	Larynx cancer	BEFREE	10067818, 10676631, 24416175		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	11740339, 15069685, 16509765, 17259654, 23167362, 25040976, 9918133		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	10762000, 12016153, 16488179		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of oropharynx	Malignant Neoplasm Of Oropharynx	BEFREE	10077151		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	31514732		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	14968442, 18668224, 27993795		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	14968442		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	10022746		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	11692073		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	11173863		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11173863, 11408349, 14735473, 16172217, 17220350, 18177825, 18569590, 24416175, 26580399, 8616834		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	18177825		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	15084249		★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	16598069		★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	16598069	Associate	★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth Neoplasms	LHGDN	12016153		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11408349, 17220350, 24157827, 24416175, 26125851, 26580399, 29774096, 30054830, 8616834, 9065651		★☆☆☆☆ Found in Text Mining only
Oropharyngeal Carcinoma	Oropharyngeal Carcinoma	BEFREE	10077151		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	22327174		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	24689813		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	38494731	Stimulate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	31514732		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31514732	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	14968442, 18668224, 27993795		★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic hyperplasia	Pubtator	19407363	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	14968442		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27993795	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	21513434	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	10022746, 11740339		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	11692073		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	22468085	Inhibit	★☆☆☆☆ Found in Text Mining only