Gene Gene information from NCBI Gene database.
Entrez ID 2932
Gene name Glycogen synthase kinase 3 beta
Gene symbol GSK3B
Synonyms (NCBI Gene)
-
Chromosome 3
Chromosome location 3q13.33
Summary The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction,
miRNA miRNA information provided by mirtarbase database.
1137
miRTarBase ID miRNA Experiments Reference
MIRT004676 hsa-miR-26a-5p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 20525681
MIRT006753 hsa-miR-29b-3p Luciferase reporter assay 21501592
MIRT006753 hsa-miR-29b-3p Luciferase reporter assay 21501592
MIRT021044 hsa-miR-155-5p Proteomics 19289835
MIRT049345 hsa-miR-92a-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
CDX2 Unknown 24501326
CREB1 Unknown 11579131
NFKB1 Unknown 11579131
TFCP2 Unknown 16973241
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
188
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IDA 25438055
GO:0000166 Function Nucleotide binding IEA
GO:0001837 Process Epithelial to mesenchymal transition IDA 16096638
GO:0001837 Process Epithelial to mesenchymal transition IMP 15448698
GO:0001954 Process Positive regulation of cell-matrix adhesion IMP 18156211
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605004 4617 ENSG00000082701
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P49841
Protein name Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Protein function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase
PDB 1GNG , 1H8F , 1I09 , 1J1B , 1J1C , 1O6K , 1O6L , 1O9U , 1PYX , 1Q3D , 1Q3W , 1Q41 , 1Q4L , 1Q5K , 1R0E , 1UV5 , 2JDO , 2JDR , 2JLD , 2O5K , 2OW3 , 2UW9 , 2X39 , 2XH5 , 3CQU , 3CQW , 3DU8 , 3E87 , 3E88 , 3E8D , 3F7Z , 3F88 , 3GB2 , 3I4B , 3L1S , 3M1S , 3MV5 , 3OW4 , 3PUP , 3Q3B , 3QKK , 3QKL , 3SAY , 3SD0 , 3ZDI , 3ZRK , 3ZRL , 3ZRM , 4ACC , 4ACD , 4ACG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 56 340 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. {ECO:0000269|PubMed:21029237}.
Sequence
Sequence length 420
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  EGFR tyrosine kinase inhibitor resistance
ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
mTOR signaling pathway
PI3K-Akt signaling pathway
Wnt signaling pathway
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
IL-17 signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Neurotrophin signaling pathway
Dopaminergic synapse
Insulin signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease
Cushing syndrome
Growth hormone synthesis, secretion and action
Alcoholic liver disease
Alzheimer disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Shigellosis
Yersinia infection
Hepatitis C
Measles
Human cytomegalovirus infection
Human papillomavirus infection
Kaposi sarcoma-associated herpesvirus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
  Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
GLI3 is processed to GLI3R by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
41
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMERS DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMYOTROPHIC LATERAL SCLEROSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Confusional Senile Dementia Senile Dementia CTD_human_DG 17409235, 22944069
★☆☆☆☆
Found in Text Mining only
Acute Kidney Insufficiency Acute Kidney Insufficiency CTD_human_DG 22785175
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 25812605, 28028966
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 22751450
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 16951223
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 21609933
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 27236820, 30496797, 30787996
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of rectum Adenocarcinoma Of Rectum BEFREE 30637920
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 19148484
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 19148484, 21609933, 21880738, 21880954, 22562294, 22751121, 23129580, 24501326, 26992223, 28057765, 29238040, 30033597, 30554113, 30945380, 9601641
★☆☆☆☆
Found in Text Mining only