GRM6 (glutamate metabotropic receptor 6)

Gene

• Entrez ID: 2916
• Gene name: Glutamate metabotropic receptor 6
• Gene symbol: GRM6
• Synonyms (NCBI Gene): CSNB1B, GPRC1F, MGLUR6, mGlu6
• Chromosome: 5
• Chromosome location: 5q35.3
• Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs62638197	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs62638202	C>T	Not-provided, pathogenic	Coding sequence variant, missense variant
rs62638208	C>T	Not-provided, pathogenic	Coding sequence variant, missense variant
rs62638214	G>A	Pathogenic	Coding sequence variant, stop gained
rs62638619	C>A,T	Benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs62638624	G>A,T	Not-provided, pathogenic	Coding sequence variant, stop gained, missense variant
rs62638625	C>T	Not-provided, pathogenic	Coding sequence variant, missense variant
rs79602188	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs121434304	A>G,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs748979061	G>A	Pathogenic	Coding sequence variant, stop gained
rs756171835	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs781463257	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1237461749	AGCGTCAGGCCGCCC>-,AGCGTCAGGCCGCCCAGCGTCAGGCCGCCC	Likely-pathogenic	Inframe deletion, coding sequence variant, inframe insertion

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT677772	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT677771	hsa-miR-4438	HITS-CLIP	23824327
MIRT677770	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT677769	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677768	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677767	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677766	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677765	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677764	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677763	hsa-miR-1976	HITS-CLIP	23824327
MIRT677762	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT677761	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT677760	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677759	hsa-miR-5095	HITS-CLIP	23824327
MIRT677758	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT677757	hsa-miR-4279	HITS-CLIP	23824327
MIRT677756	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT677765	hsa-miR-150-5p	PAR-CLIP	27292025
MIRT677763	hsa-miR-1976	PAR-CLIP	27292025
MIRT677764	hsa-miR-3653-5p	PAR-CLIP	27292025
MIRT677757	hsa-miR-4279	PAR-CLIP	27292025
MIRT677768	hsa-miR-4722-3p	PAR-CLIP	27292025
MIRT677772	hsa-miR-582-3p	PAR-CLIP	27292025
MIRT677767	hsa-miR-6727-3p	PAR-CLIP	27292025
MIRT677766	hsa-miR-6747-3p	PAR-CLIP	27292025
MIRT677760	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT677769	hsa-miR-6814-5p	PAR-CLIP	27292025
MIRT677772	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT677771	hsa-miR-4438	HITS-CLIP	23824327
MIRT677770	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT677769	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677768	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677767	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677766	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677765	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677764	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677763	hsa-miR-1976	HITS-CLIP	23824327
MIRT677762	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT677761	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT677760	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677759	hsa-miR-5095	HITS-CLIP	23824327
MIRT677758	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT677757	hsa-miR-4279	HITS-CLIP	23824327
MIRT677756	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT1035201	hsa-miR-101	CLIP-seq
MIRT1035202	hsa-miR-105	CLIP-seq
MIRT1035203	hsa-miR-1254	CLIP-seq
MIRT1035204	hsa-miR-1256	CLIP-seq
MIRT1035205	hsa-miR-1286	CLIP-seq
MIRT1035206	hsa-miR-144	CLIP-seq
MIRT1035207	hsa-miR-1827	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT1035210	hsa-miR-197	CLIP-seq
MIRT1035211	hsa-miR-2054	CLIP-seq
MIRT1035212	hsa-miR-3116	CLIP-seq
MIRT1035213	hsa-miR-3120-3p	CLIP-seq
MIRT1035214	hsa-miR-3122	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT1035217	hsa-miR-3153	CLIP-seq
MIRT1035218	hsa-miR-3163	CLIP-seq
MIRT1035219	hsa-miR-3170	CLIP-seq
MIRT1035220	hsa-miR-3187-3p	CLIP-seq
MIRT1035221	hsa-miR-342-5p	CLIP-seq
MIRT1035222	hsa-miR-3612	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035224	hsa-miR-3663-5p	CLIP-seq
MIRT1035225	hsa-miR-3667-5p	CLIP-seq
MIRT1035226	hsa-miR-3687	CLIP-seq
MIRT1035227	hsa-miR-3689a-3p	CLIP-seq
MIRT1035228	hsa-miR-3689c	CLIP-seq
MIRT1035229	hsa-miR-3689d	CLIP-seq
MIRT1035230	hsa-miR-380	CLIP-seq
MIRT1035231	hsa-miR-3908	CLIP-seq
MIRT1035232	hsa-miR-3913-5p	CLIP-seq
MIRT1035233	hsa-miR-3926	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT1035237	hsa-miR-4435	CLIP-seq
MIRT1035238	hsa-miR-4442	CLIP-seq
MIRT1035239	hsa-miR-4443	CLIP-seq
MIRT1035240	hsa-miR-4459	CLIP-seq
MIRT1035241	hsa-miR-451b	CLIP-seq
MIRT1035242	hsa-miR-4641	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT1035244	hsa-miR-4651	CLIP-seq
MIRT1035245	hsa-miR-4664-5p	CLIP-seq
MIRT1035246	hsa-miR-4696	CLIP-seq
MIRT1035247	hsa-miR-4701-5p	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT1035249	hsa-miR-4712-3p	CLIP-seq
MIRT1035250	hsa-miR-4722-5p	CLIP-seq
MIRT1035251	hsa-miR-4728-5p	CLIP-seq
MIRT1035252	hsa-miR-4755-3p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT1035254	hsa-miR-5096	CLIP-seq
MIRT1035255	hsa-miR-545	CLIP-seq
MIRT1035256	hsa-miR-548s	CLIP-seq
MIRT1035257	hsa-miR-558	CLIP-seq
MIRT1035258	hsa-miR-570	CLIP-seq
MIRT1035259	hsa-miR-582-5p	CLIP-seq
MIRT1035260	hsa-miR-588	CLIP-seq
MIRT1035261	hsa-miR-608	CLIP-seq
MIRT1035262	hsa-miR-625	CLIP-seq
MIRT1035263	hsa-miR-650	CLIP-seq
MIRT1035264	hsa-miR-661	CLIP-seq
MIRT1035265	hsa-miR-720	CLIP-seq
MIRT1035266	hsa-miR-940	CLIP-seq
MIRT2006912	hsa-miR-106a	CLIP-seq
MIRT2006913	hsa-miR-106b	CLIP-seq
MIRT2006914	hsa-miR-1234	CLIP-seq
MIRT2006915	hsa-miR-125a-3p	CLIP-seq
MIRT2006916	hsa-miR-128	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT2006918	hsa-miR-17	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2006919	hsa-miR-20a	CLIP-seq
MIRT2006920	hsa-miR-20b	CLIP-seq
MIRT2006921	hsa-miR-302a	CLIP-seq
MIRT2006922	hsa-miR-302b	CLIP-seq
MIRT2006923	hsa-miR-302c	CLIP-seq
MIRT2006924	hsa-miR-302d	CLIP-seq
MIRT2006925	hsa-miR-302e	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035226	hsa-miR-3687	CLIP-seq
MIRT2006926	hsa-miR-372	CLIP-seq
MIRT2006927	hsa-miR-373	CLIP-seq
MIRT2006928	hsa-miR-377	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT1035238	hsa-miR-4442	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2006931	hsa-miR-4772-3p	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT2006933	hsa-miR-513a-5p	CLIP-seq
MIRT2006934	hsa-miR-519d	CLIP-seq
MIRT2006935	hsa-miR-520a-3p	CLIP-seq
MIRT2006936	hsa-miR-520b	CLIP-seq
MIRT2006937	hsa-miR-520c-3p	CLIP-seq
MIRT2006938	hsa-miR-520d-3p	CLIP-seq
MIRT2006939	hsa-miR-520e	CLIP-seq
MIRT2006940	hsa-miR-520g	CLIP-seq
MIRT2006941	hsa-miR-520h	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT2006943	hsa-miR-640	CLIP-seq
MIRT2006944	hsa-miR-764	CLIP-seq
MIRT2006945	hsa-miR-93	CLIP-seq
MIRT1035201	hsa-miR-101	CLIP-seq
MIRT2239455	hsa-miR-1225-3p	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2239457	hsa-miR-1233	CLIP-seq
MIRT1035203	hsa-miR-1254	CLIP-seq
MIRT2239458	hsa-miR-1273e	CLIP-seq
MIRT2006916	hsa-miR-128	CLIP-seq
MIRT1035206	hsa-miR-144	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT1035210	hsa-miR-197	CLIP-seq
MIRT2239459	hsa-miR-3065-5p	CLIP-seq
MIRT1035212	hsa-miR-3116	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT1035220	hsa-miR-3187-3p	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035224	hsa-miR-3663-5p	CLIP-seq
MIRT2239460	hsa-miR-3690	CLIP-seq
MIRT2239461	hsa-miR-378	CLIP-seq
MIRT2239462	hsa-miR-378b	CLIP-seq
MIRT2239463	hsa-miR-378c	CLIP-seq
MIRT2239464	hsa-miR-378d	CLIP-seq
MIRT2239465	hsa-miR-378e	CLIP-seq
MIRT2239466	hsa-miR-378f	CLIP-seq
MIRT2239467	hsa-miR-378h	CLIP-seq
MIRT2239468	hsa-miR-378i	CLIP-seq
MIRT1035233	hsa-miR-3926	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT2239469	hsa-miR-422a	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT2239470	hsa-miR-4434	CLIP-seq
MIRT1035237	hsa-miR-4435	CLIP-seq
MIRT2239471	hsa-miR-4516	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT1035247	hsa-miR-4701-5p	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT1035252	hsa-miR-4755-3p	CLIP-seq
MIRT2006931	hsa-miR-4772-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2239475	hsa-miR-4797-5p	CLIP-seq
MIRT1035254	hsa-miR-5096	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT1035256	hsa-miR-548s	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT1035259	hsa-miR-582-5p	CLIP-seq
MIRT1035260	hsa-miR-588	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2239477	hsa-miR-619	CLIP-seq
MIRT1035264	hsa-miR-661	CLIP-seq
MIRT1035265	hsa-miR-720	CLIP-seq
MIRT2239478	hsa-miR-935	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT1035217	hsa-miR-3153	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT2388793	hsa-miR-4668-5p	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT2388794	hsa-miR-513a-3p	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2450812	hsa-miR-129-5p	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2450813	hsa-miR-2052	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2450815	hsa-miR-4694-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT2450816	hsa-miR-4760-3p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2450817	hsa-miR-485-3p	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2450812	hsa-miR-129-5p	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT2450813	hsa-miR-2052	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2450815	hsa-miR-4694-5p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2006912	hsa-miR-106a	CLIP-seq
MIRT2006913	hsa-miR-106b	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2006914	hsa-miR-1234	CLIP-seq
MIRT2006915	hsa-miR-125a-3p	CLIP-seq
MIRT2543194	hsa-miR-1283	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT2006918	hsa-miR-17	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2006919	hsa-miR-20a	CLIP-seq
MIRT2006920	hsa-miR-20b	CLIP-seq
MIRT2006921	hsa-miR-302a	CLIP-seq
MIRT2006922	hsa-miR-302b	CLIP-seq
MIRT2006923	hsa-miR-302c	CLIP-seq
MIRT2006924	hsa-miR-302d	CLIP-seq
MIRT2006925	hsa-miR-302e	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT2543195	hsa-miR-3174	CLIP-seq
MIRT2543196	hsa-miR-3613-3p	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT2006926	hsa-miR-372	CLIP-seq
MIRT2006927	hsa-miR-373	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT2543197	hsa-miR-4269	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2543198	hsa-miR-4684-5p	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2543199	hsa-miR-4786-5p	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT2006934	hsa-miR-519d	CLIP-seq
MIRT2006935	hsa-miR-520a-3p	CLIP-seq
MIRT2006936	hsa-miR-520b	CLIP-seq
MIRT2006937	hsa-miR-520c-3p	CLIP-seq
MIRT2006938	hsa-miR-520d-3p	CLIP-seq
MIRT2006939	hsa-miR-520e	CLIP-seq
MIRT2006940	hsa-miR-520g	CLIP-seq
MIRT2006941	hsa-miR-520h	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2006943	hsa-miR-640	CLIP-seq
MIRT2006944	hsa-miR-764	CLIP-seq
MIRT2543200	hsa-miR-769-5p	CLIP-seq
MIRT2543201	hsa-miR-921	CLIP-seq
MIRT2006945	hsa-miR-93	CLIP-seq
MIRT2006912	hsa-miR-106a	CLIP-seq
MIRT2006913	hsa-miR-106b	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2006914	hsa-miR-1234	CLIP-seq
MIRT2006915	hsa-miR-125a-3p	CLIP-seq
MIRT2543194	hsa-miR-1283	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT2006918	hsa-miR-17	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2006919	hsa-miR-20a	CLIP-seq
MIRT2006920	hsa-miR-20b	CLIP-seq
MIRT2006921	hsa-miR-302a	CLIP-seq
MIRT2006922	hsa-miR-302b	CLIP-seq
MIRT2006923	hsa-miR-302c	CLIP-seq
MIRT2006924	hsa-miR-302d	CLIP-seq
MIRT2006925	hsa-miR-302e	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT2543196	hsa-miR-3613-3p	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT2006926	hsa-miR-372	CLIP-seq
MIRT2006927	hsa-miR-373	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2543198	hsa-miR-4684-5p	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2543199	hsa-miR-4786-5p	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT2006934	hsa-miR-519d	CLIP-seq
MIRT2006935	hsa-miR-520a-3p	CLIP-seq
MIRT2006936	hsa-miR-520b	CLIP-seq
MIRT2006937	hsa-miR-520c-3p	CLIP-seq
MIRT2006938	hsa-miR-520d-3p	CLIP-seq
MIRT2006939	hsa-miR-520e	CLIP-seq
MIRT2006940	hsa-miR-520g	CLIP-seq
MIRT2006941	hsa-miR-520h	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2006943	hsa-miR-640	CLIP-seq
MIRT2006944	hsa-miR-764	CLIP-seq
MIRT2543200	hsa-miR-769-5p	CLIP-seq
MIRT2006945	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	17405131
GO:0000139	Component	Golgi membrane	IEA
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9215706
GO:0005515	Function	Protein binding	IPI	17405131
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	17405131
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17405131
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9215706
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IMP	23452348
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	TAS	9215706
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007416	Process	Synapse assembly	IEA
GO:0007601	Process	Visual perception	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0008066	Function	Glutamate receptor activity	IEA
GO:0008066	Function	Glutamate receptor activity	IMP	23452348
GO:0008066	Function	Glutamate receptor activity	TAS	9215706
GO:0009584	Process	Detection of visible light	TAS	9215706
GO:0010467	Process	Gene expression	IEA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	IEA
GO:0035841	Component	New growing cell tip	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	17405131
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0050908	Process	Detection of light stimulus involved in visual perception	IMP	17405131
GO:0050953	Process	Sensory perception of light stimulus	IEA
GO:0051286	Component	Cell tip	IEA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:1905665	Process	Positive regulation of calcium ion import across plasma membrane	IMP	23452348

Other IDs

• MIM: 604096
• HGNC: 4598
• e!Ensembl: ENSG00000113262

Protein

• UniProt ID: O15303
• Protein name: Metabotropic glutamate receptor 6 (mGluR6)
• Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Si
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	67 → 479	Receptor family ligand binding region	Family
  PF07562	NCD3G	514 → 564	Nine Cysteines Domain of family 3 GPCR	Family
  PF00003	7tm_3	597 → 842	7 transmembrane sweet-taste receptor of 3 GCPR	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in melanocytes. {ECO:0000269|PubMed:23452348}.
• Sequence:

  MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
  KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
  GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
  LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
  GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
  FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
  WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
  ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
  SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
  EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
  TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
  TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
  PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
  EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
  YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK

• Sequence length: 877

Pathways

KEGG:

Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse

Reactome:

G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Congenital stationary night blindness	Likely pathogenic; Pathogenic	rs62638197, rs781463257, rs777168556, rs769355168	RCV000504939 RCV000505097 RCV000787912 RCV004017782	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Congenital stationary night blindness 1B	Likely pathogenic; Pathogenic	rs755967391, rs281865186, rs764476239, rs766594761, rs62638214, rs62638624, rs62638202, rs62638197, rs1304183009, rs1426740204	RCV001783403 RCV002273817 RCV001810046 RCV001783402 RCV000006197 RCV000006199 RCV000006200 RCV000006201 RCV003447881 RCV003990840	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
GRM6-related disorder	Pathogenic	rs281865186, rs752205220	RCV004755771 RCV004756495	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Leber congenital amaurosis	Pathogenic	rs62638214	RCV000787608	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Retinal dystrophy	Likely pathogenic; Pathogenic	rs539727841, rs62638214, rs62638624, rs1760621228	RCV004817184 RCV001074243 RCV004814843 RCV001074691	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	—	Disgenet, HPO Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OGUCHI DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Optic atrophy	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA 1	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amblyopia	Amblyopia	Pubtator	22008250	Associate	★☆☆☆☆ Found in Text Mining only
Astigmatism	Astigmatism	Pubtator	22008250	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	28281572	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	22008250	Associate	★☆☆☆☆ Found in Text Mining only
Blindness	Blindness	Pubtator	15781871	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	22610075	Associate	★☆☆☆☆ Found in Text Mining only
Cone-rod synaptic disorder, congenital nonprogressive	Congenital stationary night blindness	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Congenital stationary night blindness	Congenital stationary night blindness	Orphanet			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Disorder of eye	Disorder Of Eye	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Hemeralopia	Hemeralopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hereditary Sensory and Autonomic Neuropathies	Hereditary sensory and autonomic neuropathy	Pubtator	32807182	Associate	★☆☆☆☆ Found in Text Mining only
Hypoplasia of optic disc	Hypoplasia Of Optic Disc	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leber Congenital Amaurosis	Leber Congenital Amaurosis	CLINVAR_DG	30718709		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Macular Degeneration	Macular degeneration	Pubtator	22008250	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	BEFREE	19862333		★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	Pubtator	19862333, 27034204, 37191617	Associate	★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20061814		★☆☆☆☆ Found in Text Mining only
Night blindness congenital stationary	Night blindness, congenital stationary	Pubtator	18617546, 19578023, 19862333, 19878917, 19896109, 19896113, 22008250, 22959359, 24397708, 24715752, 31677249, 36499293	Associate	★☆☆☆☆ Found in Text Mining only
Night blindness, congenital stationary	Night blindness	CLINVAR_DG	16249515, 22008250		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Night blindness, congenital stationary	Night blindness	BEFREE	17405131, 19666700, 19862333, 20300565, 22008250, 22325361, 22735794, 24397708, 26628857, 31578364, 31677249		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Night blindness, congenital stationary	Night blindness	ORPHANET_DG	17405131		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Night blindness, congenital stationary	Night blindness	GENOMICS_ENGLAND_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Night blindness, congenital stationary	Night blindness	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Night blindness, congenital stationary	Night blindness	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Night blindness, congenital stationary, type 1	Night blindness	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Night Blindness, Congenital Stationary, Type 1A	Night blindness	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	Night blindness	UNIPROT_DG	15781871, 17405131, 23714322		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	Night blindness	GENOMICS_ENGLAND_DG	17405131		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	Night blindness	BEFREE	19862333		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	Night blindness	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	Night blindness	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A	Night blindness	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)	Night blindness	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Nyctalopia	Nyctalopia	BEFREE	15781871		★☆☆☆☆ Found in Text Mining only
Nyctalopia	Nyctalopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Retinal Diseases	Retinal detachment	Pubtator	37191617	Associate	★☆☆☆☆ Found in Text Mining only
Severe myopia	Myopia	BEFREE	19862333, 27034204		★☆☆☆☆ Found in Text Mining only
Severe myopia	Myopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Stargardt Disease	Stargardt disease	Pubtator	24397708	Associate	★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★☆☆☆☆ Found in Text Mining only
X-Linked Csnb	Congenital stationary night blindness, X-Linked	CTD_human_DG			★☆☆☆☆ Found in Text Mining only