Gene Gene information from NCBI Gene database.
Entrez ID 29126
Gene name CD274 molecule
Gene symbol CD274
Synonyms (NCBI Gene)
ADMIO5B7-HB7H1PD-L1PDCD1L1PDCD1LG1PDL1hPD-L1
Chromosome 9
Chromosome location 9p24.1
Summary This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobu
miRNA miRNA information provided by mirtarbase database.
202
miRTarBase ID miRNA Experiments Reference
MIRT003923 hsa-miR-513a-5p Luciferase reporter assayWestern blot 19155478
MIRT003923 hsa-miR-513a-5p Luciferase reporter assayWestern blot 19155478
MIRT027156 hsa-miR-103a-3p Sequencing 20371350
MIRT031920 hsa-miR-16-5p Sequencing 20371350
MIRT053484 hsa-miR-570-3p ImmunohistochemistryLuciferase reporter assayqRT-PCR 22190470
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002841 Process Negative regulation of T cell mediated immune response to tumor cell IDA 38377992
GO:0002841 Process Negative regulation of T cell mediated immune response to tumor cell IDA 28813417
GO:0002841 Process Negative regulation of T cell mediated immune response to tumor cell IMP 28813410, 28813417
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605402 17635 ENSG00000120217
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZQ7
Protein name Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Protein function Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cell
PDB 3BIK , 3BIS , 3FN3 , 3SBW , 4Z18 , 4ZQK , 5C3T , 5GGT , 5GRJ , 5IUS , 5J89 , 5J8O , 5JDR , 5JDS , 5N2D , 5N2F , 5NIU , 5O45 , 5O4Y , 5X8L , 5X8M , 5XJ4 , 5XXY , 6L8R , 6NM7 , 6NM8 , 6NNV , 6NOJ , 6NOS , 6NP9 , 6PV9 , 6R3K , 6RPG , 6VQN , 6YCR , 7BEA , 7C88 , 7CZD , 7DCV , 7DY7 , 7NLD , 7OUN , 7SJQ , 7TPS , 7UX5 , 7UXO , 7UXP , 7UXQ , 7VUN , 7XAD , 7XAE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 22 131 Immunoglobulin V-set domain Domain
PF08205 C2-set_2 135 220 CD80-like C2-set immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581
Sequence
Sequence length 290
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules
PD-L1 expression and PD-1 checkpoint pathway in cancer
  PD-1 signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
12
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, DUCTAL, BREAST CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERSENSITIVITY CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acoustic Neuroma Acoustic Neuroma BEFREE 20601920, 31585433
★☆☆☆☆
Found in Text Mining only
Actinic keratosis Actinic keratosis BEFREE 28501937, 29799076
★☆☆☆☆
Found in Text Mining only
Acute intermittent porphyria Intermittent Porphyria BEFREE 31135488
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 31570447
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 30204524
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 28705256
★☆☆☆☆
Found in Text Mining only
Adamantinous Craniopharyngioma Adamantinous Craniopharyngioma BEFREE 29509940
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 24548766, 25009014, 25349974, 26024796, 26081225, 26801886, 27346415, 27393509, 27629881, 27846317, 27976463, 28038981, 28059094, 28104537, 28222308
View all (74 more)
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 30045644, 30959852
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 27777774, 29116900, 29859152, 29872575, 30419350, 30852560, 30902915
★☆☆☆☆
Found in Text Mining only